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Entry version 155 (16 Oct 2019)
Sequence version 1 (01 Jul 1993)
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Protein

Sodium-dependent serotonin transporter

Gene

Slc6a4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.5 Publications

Miscellaneous

This protein is the target of psychomotor stimulants such as amphetamines or cocaine.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi94Sodium 1; via carbonyl oxygenBy similarity1
Metal bindingi96Sodium 2; via carbonyl oxygenBy similarity1
Metal bindingi97Sodium 1; via carbonyl oxygenBy similarity1
Metal bindingi101Sodium 2By similarity1
Metal bindingi336Sodium 2By similarity1
Metal bindingi368Sodium 2By similarity1
Metal bindingi434Sodium 1; via carbonyl oxygenBy similarity1
Metal bindingi437Sodium 1By similarity1
Metal bindingi438Sodium 1By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processNeurotransmitter transport, Symport, Transport
LigandMetal-binding, Sodium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-380615 Serotonin clearance from the synaptic cleft

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium-dependent serotonin transporter
Short name:
SERT1 Publication
Alternative name(s):
5HT transporter
Short name:
5HTT
Solute carrier family 6 member 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Slc6a4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Rat genome database

More...
RGDi
3714 Slc6a4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 87CytoplasmicCuratedAdd BLAST87
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei88 – 112Helical; Name=1By similarityAdd BLAST25
Topological domaini113 – 115ExtracellularCurated3
Transmembranei116 – 135Helical; Name=2By similarityAdd BLAST20
Topological domaini136 – 160CytoplasmicCuratedAdd BLAST25
Transmembranei161 – 186Helical; Name=3By similarityAdd BLAST26
Topological domaini187 – 252ExtracellularCuratedAdd BLAST66
Transmembranei253 – 271Helical; Name=4By similarityAdd BLAST19
Topological domaini272 – 277CytoplasmicCurated6
Transmembranei278 – 297Helical; Name=5By similarityAdd BLAST20
Topological domaini298 – 324ExtracellularCuratedAdd BLAST27
Transmembranei325 – 347Helical; Name=6By similarityAdd BLAST23
Topological domaini348 – 360CytoplasmicCuratedAdd BLAST13
Transmembranei361 – 380Helical; Name=7By similarityAdd BLAST20
Topological domaini381 – 421ExtracellularCuratedAdd BLAST41
Transmembranei422 – 443Helical; Name=8By similarityAdd BLAST22
Topological domaini444 – 463CytoplasmicCuratedAdd BLAST20
Transmembranei464 – 483Helical; Name=9By similarityAdd BLAST20
Topological domaini484 – 494ExtracellularCuratedAdd BLAST11
Transmembranei495 – 516Helical; Name=10By similarityAdd BLAST22
Topological domaini517 – 538CytoplasmicCuratedAdd BLAST22
Transmembranei539 – 558Helical; Name=11By similarityAdd BLAST20
Topological domaini559 – 574ExtracellularCuratedAdd BLAST16
Transmembranei575 – 595Helical; Name=12By similarityAdd BLAST21
Topological domaini596 – 630CytoplasmicCuratedAdd BLAST35

Keywords - Cellular componenti

Cell junction, Cell membrane, Endosome, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi109C → A: Cocaine is effective at blocking transport. 1 Publication1
Mutagenesisi172I → C: Cocaine is effective at blocking transport. 1 Publication1
Mutagenesisi208N → Q: No change in transport function. Important decrease of transport function and serotonin uptake function; when associated with Q-217. 1 Publication1
Mutagenesisi217N → Q: No change in transport function. Important decrease of transport function and serotonin uptake function; when associated with Q-208. 1 Publication1

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL313

DrugCentral

More...
DrugCentrali
P31652

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
928

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002147601 – 630Sodium-dependent serotonin transporterAdd BLAST630

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei47PhosphotyrosineBy similarity1
Modified residuei142PhosphotyrosineBy similarity1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi200 ↔ 209By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi208N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi217N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei276Phosphothreonine1 Publication1
Modified residuei611PhosphoserineSequence analysisBy similarity1
Modified residuei613PhosphothreonineSequence analysisBy similarity1
Modified residuei616PhosphothreonineSequence analysisBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylated; modification with sialylated N-glycans is a requirement for transporters to associate with each other and to function as homooligomeric forms.1 Publication
Phosphorylation upon PKC stimulation modifies the SERT distribution and density in the membrane, and diminishes the uptake capacity (By similarity). Phosphorylation at Thr-276 increases 5-HT uptake and is required for cGMP-mediated SERT regulation.By similarity1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P31652

PRoteomics IDEntifications database

More...
PRIDEi
P31652

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P31652

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P31652

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000003476 Expressed in 9 organ(s), highest expression level in lung

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P31652 RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer or homooligomer (PubMed:10716733).

Interacts with TGFB1I1.

Interacts (via C-terminus) with VIM.

Interacts with RAB4 (GTP-bound form); the interaction retains transporter molecules intracellularly.

Interacts with SEC23A, SEC24C and PATJ.

Interacts with NOS1; the interaction may diminish the cell surface localization of SERT in the brain and, correspondingly, reduce serotonin reuptake (By similarity).

Interacts (via C-terminus) with SCAMP2; the interaction is direct and retains transporter molecules intracellularly (PubMed:16870614).

Interacts with filamentous actin and STX1A (PubMed:11709063).

Interacts (via sialylated form) with MYH9 (PubMed:12944413).

Interacts with ITGAV:ITGB3 (By similarity).

By similarity4 Publications

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
P31652, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000004717

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P31652

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P31652

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni611 – 630Required for serotonin uptake activityBy similarityAdd BLAST20
Regioni616 – 624Interaction with RAB4ABy similarity9

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3659 Eukaryota
COG0733 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157855

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000116406

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P31652

KEGG Orthology (KO)

More...
KOi
K05037

Identification of Orthologs from Complete Genome Data

More...
OMAi
STTVWID

Database of Orthologous Groups

More...
OrthoDBi
1221585at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P31652

TreeFam database of animal gene trees

More...
TreeFami
TF343812

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000175 Na/ntran_symport
IPR013086 Na/ntran_symport_serotonin_N
IPR037272 SNS_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11616 PTHR11616, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03491 5HT_transport_N, 1 hit
PF00209 SNF, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01203 5HTTRANSPORT
PR00176 NANEUSMPORT

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF161070 SSF161070, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00610 NA_NEUROTRAN_SYMP_1, 1 hit
PS00754 NA_NEUROTRAN_SYMP_2, 1 hit
PS50267 NA_NEUROTRAN_SYMP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P31652-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METTPLNSQK VLSECKDRED CQENGVLQKG VPTTADRAEP SQISNGYSAV
60 70 80 90 100
PSTSAGDEAS HSIPAATTTL VAEIRQGERE TWGKKMDFLL SVIGYAVDLG
110 120 130 140 150
NIWRFPYICY QNGGGAFLLP YTIMAIFGGI PLFYMELALG QYHRNGCISI
160 170 180 190 200
WRKICPIFKG IGYAICIIAF YIASYYNTII AWALYYLISS LTDRLPWTSC
210 220 230 240 250
TNSWNTGNCT NYFAQDNITW TLHSTSPAEE FYLRHVLQIH QSKGLQDLGT
260 270 280 290 300
ISWQLTLCIV LIFTVIYFSI WKGVKTSGKV VWVTATFPYI VLSVLLVRGA
310 320 330 340 350
TLPGAWRGVV FYLKPNWQKL LETGVWVDAA AQIFFSLGPG FGVLLAFASY
360 370 380 390 400
NKFNNNCYQD ALVTSVVNCM TSFVSGFVIF TVLGYMAEMR NEDVSEVAKD
410 420 430 440 450
AGPSLLFITY AEAIANMPAS TFFAIIFFLM LITLGLDSTF AGLEGVITAV
460 470 480 490 500
LDEFPHIWAK RREWFVLIVV ITCVLGSLLT LTSGGAYVVT LLEEYATGPA
510 520 530 540 550
VLTVALIEAV AVSWFYGITQ FCSDVKEMLG FSPGWFWRIC WVAISPLFLL
560 570 580 590 600
FIICSFLMSP PQLRLFQYNY PHWSIVLGYC IGMSSVICIP TYIIYRLIST
610 620 630
PGTLKERIIK SITPETPTEI PCGDIRMNAV
Length:630
Mass (Da):70,172
Last modified:July 1, 1993 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i44DA7C5888C403EE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti415A → G in AAA42186 (PubMed:1948036).Curated1
Sequence conflicti533 – 536PGWF → GMV in AAA42186 (PubMed:1948036).Curated4
Sequence conflicti621 – 630PCGDIRMNAV → RVGHPHECCVTHPGRGHLFP ATSLSSEKPTGLLL in AAA42186 (PubMed:1948036).Curated10

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X63995 mRNA Translation: CAA45401.1
X63253 mRNA Translation: CAA44913.1
M79450 mRNA Translation: AAA42186.1
Y11024 mRNA Translation: CAA71909.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S19585
S30604

NCBI Reference Sequences

More...
RefSeqi
NP_037166.2, NM_013034.4
XP_008766172.1, XM_008767950.2
XP_017452530.1, XM_017597041.1
XP_017452531.1, XM_017597042.1
XP_017452532.1, XM_017597043.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000004717; ENSRNOP00000004717; ENSRNOG00000003476

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
25553

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:25553

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63995 mRNA Translation: CAA45401.1
X63253 mRNA Translation: CAA44913.1
M79450 mRNA Translation: AAA42186.1
Y11024 mRNA Translation: CAA71909.1
PIRiS19585
S30604
RefSeqiNP_037166.2, NM_013034.4
XP_008766172.1, XM_008767950.2
XP_017452530.1, XM_017597041.1
XP_017452531.1, XM_017597042.1
XP_017452532.1, XM_017597043.1

3D structure databases

SMRiP31652
ModBaseiSearch...

Protein-protein interaction databases

IntActiP31652, 1 interactor
STRINGi10116.ENSRNOP00000004717

Chemistry databases

BindingDBiP31652
ChEMBLiCHEMBL313
DrugCentraliP31652
GuidetoPHARMACOLOGYi928

PTM databases

iPTMnetiP31652
SwissPalmiP31652

Proteomic databases

PaxDbiP31652
PRIDEiP31652

Genome annotation databases

EnsembliENSRNOT00000004717; ENSRNOP00000004717; ENSRNOG00000003476
GeneIDi25553
KEGGirno:25553

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6532
RGDi3714 Slc6a4

Phylogenomic databases

eggNOGiKOG3659 Eukaryota
COG0733 LUCA
GeneTreeiENSGT00940000157855
HOGENOMiHOG000116406
InParanoidiP31652
KOiK05037
OMAiSTTVWID
OrthoDBi1221585at2759
PhylomeDBiP31652
TreeFamiTF343812

Enzyme and pathway databases

ReactomeiR-RNO-380615 Serotonin clearance from the synaptic cleft

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P31652

Gene expression databases

BgeeiENSRNOG00000003476 Expressed in 9 organ(s), highest expression level in lung
GenevisibleiP31652 RN

Family and domain databases

InterProiView protein in InterPro
IPR000175 Na/ntran_symport
IPR013086 Na/ntran_symport_serotonin_N
IPR037272 SNS_sf
PANTHERiPTHR11616 PTHR11616, 1 hit
PfamiView protein in Pfam
PF03491 5HT_transport_N, 1 hit
PF00209 SNF, 1 hit
PRINTSiPR01203 5HTTRANSPORT
PR00176 NANEUSMPORT
SUPFAMiSSF161070 SSF161070, 1 hit
PROSITEiView protein in PROSITE
PS00610 NA_NEUROTRAN_SYMP_1, 1 hit
PS00754 NA_NEUROTRAN_SYMP_2, 1 hit
PS50267 NA_NEUROTRAN_SYMP_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSC6A4_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P31652
Secondary accession number(s): P23976
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: October 16, 2019
This is version 155 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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