UniProtKB - P31645 (SC6A4_HUMAN)
Sodium-dependent serotonin transporter
SLC6A4
Functioni
Miscellaneous
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 94 | Sodium 1; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 96 | Sodium 2; via carbonyl oxygen1 Publication | 1 | |
Metal bindingi | 97 | Sodium 1; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 101 | Sodium 21 Publication | 1 | |
Metal bindingi | 336 | Sodium 21 Publication | 1 | |
Metal bindingi | 368 | Sodium 21 Publication | 1 | |
Metal bindingi | 434 | Sodium 1; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 437 | Sodium 1By similarity | 1 | |
Metal bindingi | 438 | Sodium 1By similarity | 1 |
GO - Molecular functioni
- actin filament binding Source: UniProtKB
- cocaine binding Source: Ensembl
- identical protein binding Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
- monoamine transmembrane transporter activity Source: MGI
- neurotransmitter transmembrane transporter activity Source: ARUK-UCL
- nitric-oxide synthase binding Source: Ensembl
- serotonin:sodium symporter activity Source: UniProtKB
- serotonin binding Source: GO_Central
- syntaxin-1 binding Source: Ensembl
GO - Biological processi
- brain morphogenesis Source: BHF-UCL
- cellular response to cGMP Source: Ensembl
- cellular response to retinoic acid Source: Ensembl
- circadian rhythm Source: Ensembl
- memory Source: Ensembl
- monoamine transport Source: MGI
- negative regulation of cerebellar granule cell precursor proliferation Source: Ensembl
- negative regulation of neuron differentiation Source: Ensembl
- negative regulation of organ growth Source: BHF-UCL
- negative regulation of synaptic transmission, dopaminergic Source: Ensembl
- neurotransmitter biosynthetic process Source: Reactome
- neurotransmitter transport Source: ARUK-UCL
- positive regulation of cell cycle Source: Ensembl
- positive regulation of gene expression Source: Ensembl
- positive regulation of serotonin secretion Source: Ensembl
- regulation of thalamus size Source: UniProtKB
- response to drug Source: Ensembl
- response to estradiol Source: Ensembl
- response to hypoxia Source: Ensembl
- response to nutrient Source: Ensembl
- response to toxic substance Source: UniProtKB
- serotonin uptake Source: UniProtKB
- social behavior Source: BHF-UCL
- sodium ion transmembrane transport Source: GO_Central
- sperm ejaculation Source: Ensembl
- vasoconstriction Source: Ensembl
Keywordsi
Biological process | Neurotransmitter transport, Symport, Transport |
Ligand | Metal-binding, Sodium |
Enzyme and pathway databases
PathwayCommonsi | P31645 |
Reactomei | R-HSA-380615, Serotonin clearance from the synaptic cleft |
SIGNORi | P31645 |
Protein family/group databases
TCDBi | 2.A.22.1.1, the neurotransmitter:sodium symporter (nss) family |
Names & Taxonomyi
Protein namesi | Recommended name: Sodium-dependent serotonin transporterShort name: SERTBy similarity Alternative name(s): 5HT transporter Short name: 5HTT Solute carrier family 6 member 4 |
Gene namesi | Name:SLC6A4 Synonyms:HTT, SERT |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11050, SLC6A4 |
MIMi | 182138, gene |
neXtProti | NX_P31645 |
VEuPathDBi | HostDB:ENSG00000108576.9 |
Subcellular locationi
Plasma membrane
- Cell membrane 5 Publications; Multi-pass membrane protein By similarity1 Publication
Endosome
- Endosome membrane 2 Publications; Multi-pass membrane protein Sequence analysis
Other locations
- Endomembrane system 1 Publication; Multi-pass membrane protein Sequence analysis
- synapse By similarity
- focal adhesion By similarity
Note: Could be part of recycling endosomes (PubMed:18227069, PubMed:16870614). Density of transporter molecules on the plasma membrane is itself regulated by STX1A (By similarity). Density of transporter molecules on the plasma membrane is also regulated by serotonin (PubMed:17506858) (PubMed:18227069). Density of transporter molecules seems to be modulated by ITGAV:ITGB3 (By similarity).By similarity3 Publications
Endosome
- endosome membrane Source: UniProtKB-SubCell
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- integral component of postsynaptic membrane Source: Ensembl
- integral component of presynaptic membrane Source: Ensembl
- plasma membrane Source: UniProtKB
Other locations
- endomembrane system Source: UniProtKB
- focal adhesion Source: UniProtKB
- membrane raft Source: UniProtKB
- neuron projection Source: GO_Central
- serotonergic synapse Source: Ensembl
- synapse Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 87 | CytoplasmicCuratedAdd BLAST | 87 | |
Transmembranei | 88 – 112 | Helical; Name=11 PublicationAdd BLAST | 25 | |
Topological domaini | 113 – 115 | ExtracellularCurated | 3 | |
Transmembranei | 116 – 135 | Helical; Name=21 PublicationAdd BLAST | 20 | |
Topological domaini | 136 – 160 | CytoplasmicCuratedAdd BLAST | 25 | |
Transmembranei | 161 – 186 | Helical; Name=31 PublicationAdd BLAST | 26 | |
Topological domaini | 187 – 252 | ExtracellularCuratedAdd BLAST | 66 | |
Transmembranei | 253 – 271 | Helical; Name=41 PublicationAdd BLAST | 19 | |
Topological domaini | 272 – 277 | CytoplasmicCurated | 6 | |
Transmembranei | 278 – 297 | Helical; Name=51 PublicationAdd BLAST | 20 | |
Topological domaini | 298 – 324 | ExtracellularCuratedAdd BLAST | 27 | |
Transmembranei | 325 – 347 | Helical; Name=61 PublicationAdd BLAST | 23 | |
Topological domaini | 348 – 360 | CytoplasmicCuratedAdd BLAST | 13 | |
Transmembranei | 361 – 380 | Helical; Name=71 PublicationAdd BLAST | 20 | |
Topological domaini | 381 – 421 | ExtracellularCuratedAdd BLAST | 41 | |
Transmembranei | 422 – 443 | Helical; Name=81 PublicationAdd BLAST | 22 | |
Topological domaini | 444 – 463 | CytoplasmicCuratedAdd BLAST | 20 | |
Transmembranei | 464 – 483 | Helical; Name=91 PublicationAdd BLAST | 20 | |
Topological domaini | 484 – 494 | ExtracellularCuratedAdd BLAST | 11 | |
Transmembranei | 495 – 516 | Helical; Name=101 PublicationAdd BLAST | 22 | |
Topological domaini | 517 – 538 | CytoplasmicCuratedAdd BLAST | 22 | |
Transmembranei | 539 – 558 | Helical; Name=111 PublicationAdd BLAST | 20 | |
Topological domaini | 559 – 574 | ExtracellularCuratedAdd BLAST | 16 | |
Transmembranei | 575 – 595 | Helical; Name=121 PublicationAdd BLAST | 21 | |
Topological domaini | 596 – 630 | CytoplasmicCuratedAdd BLAST | 35 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Endosome, Membrane, SynapsePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 611 | S → A: Loss of 10 % of serotonin uptake activity. Loss of 5 % of serotonin uptake activity; when associated with A-613 and A-616. 1 Publication | 1 | |
Mutagenesisi | 611 | S → D: Loss of 61 % of serotonin uptake activity. Loss of 95 % of serotonin uptake activity and lack of association between VIM and the plasma membrane; when associated with D-613 and D-616. 1 Publication | 1 | |
Mutagenesisi | 613 | T → A: Loss of 26 % of serotonin uptake activity. Loss of 5 % of serotonin uptake activity; when associated with A-611 and A-616. 1 Publication | 1 | |
Mutagenesisi | 613 | T → D: Loss of 26 % of serotonin uptake activity. Loss of 95 % of serotonin uptake activity and lack of association between VIM and the plasma membrane; when associated with D-611 and D-616. 1 Publication | 1 | |
Mutagenesisi | 616 | T → A: No change. Loss of 5 % of serotonin uptake activity; when associated with A-611 and A-613. 1 Publication | 1 | |
Mutagenesisi | 616 | T → D: No change. Loss of 95 % of serotonin uptake activity and lack of association between VIM and the plasma membrane; when associated with D-611 and D-613. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 6532 |
MalaCardsi | SLC6A4 |
MIMi | 103780, phenotype 164230, phenotype 607834, phenotype |
OpenTargetsi | ENSG00000108576 |
PharmGKBi | PA312 |
Miscellaneous databases
Pharosi | P31645, Tclin |
Chemistry databases
ChEMBLi | CHEMBL228 |
DrugBanki | DB01472, 4-Methoxyamphetamine DB04836, Amineptine DB05964, Amitifadine DB00321, Amitriptyline DB00543, Amoxapine DB00182, Amphetamine DB01238, Aripiprazole DB00289, Atomoxetine DB00245, Benzatropine DB04889, Bicifadine DB09016, Butriptyline DB01114, Chlorpheniramine DB00215, Citalopram DB01242, Clomipramine DB00907, Cocaine DB05688, CRx-119 DB00924, Cyclobenzaprine DB12305, Dasotraline DB01151, Desipramine DB06700, Desvenlafaxine DB01191, Dexfenfluramine DB06701, Dexmethylphenidate DB00514, Dextromethorphan DB00988, Dopamine DB09167, Dosulepin DB01142, Doxepin DB00476, Duloxetine DB01363, Ephedra sinica root DB01175, Escitalopram DB09194, Etoperidone DB00574, Fenfluramine DB00472, Fluoxetine DB00176, Fluvoxamine DB00458, Imipramine DB08918, Levomilnacipran DB09195, Lorpiprazole DB00408, Loxapine DB06077, Lumateperone DB00579, Mazindol DB00454, Meperidine DB01577, Metamfetamine DB06148, Mianserin DB01454, Midomafetamine DB04896, Milnacipran DB00805, Minaprine DB00370, Mirtazapine DB01442, MMDA DB01149, Nefazodone DB09186, Nisoxetine DB04821, Nomifensine DB00540, Nortriptyline DB05422, OPC-14523 DB00715, Paroxetine DB00191, Phentermine DB00721, Procaine DB00344, Protriptyline DB00852, Pseudoephedrine DB08839, Serotonin DB01104, Sertraline DB01105, Sibutramine DB06204, Tapentadol DB01079, Tegaserod DB06156, Tesofensine DB00193, Tramadol DB00656, Trazodone DB00726, Trimipramine DB00285, Venlafaxine DB00661, Verapamil DB06684, Vilazodone DB09068, Vortioxetine DB04832, Zimelidine DB09225, Zotepine |
DrugCentrali | P31645 |
GuidetoPHARMACOLOGYi | 928 |
Genetic variation databases
BioMutai | SLC6A4 |
DMDMi | 400630 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000214757 | 1 – 630 | Sodium-dependent serotonin transporterAdd BLAST | 630 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 47 | Phosphotyrosine1 Publication | 1 | |
Modified residuei | 142 | Phosphotyrosine1 Publication | 1 | |
Disulfide bondi | 200 ↔ 209 | Combined sources | ||
Glycosylationi | 208 | N-linked (GlcNAc...) asparagineSequence analysis1 Publication | 1 | |
Glycosylationi | 217 | N-linked (GlcNAc...) asparagineSequence analysis1 Publication | 1 | |
Modified residuei | 276 | Phosphothreonine; by PKG1 Publication | 1 | |
Modified residuei | 611 | Phosphoserine1 Publication | 1 | |
Modified residuei | 613 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 616 | Phosphothreonine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
MassIVEi | P31645 |
PaxDbi | P31645 |
PeptideAtlasi | P31645 |
PRIDEi | P31645 |
ProteomicsDBi | 54798 [P31645-1] |
PTM databases
GlyGeni | P31645, 2 sites |
iPTMneti | P31645 |
PhosphoSitePlusi | P31645 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000108576, Expressed in upper lobe of lung and 130 other tissues |
ExpressionAtlasi | P31645, baseline and differential |
Genevisiblei | P31645, HS |
Organism-specific databases
HPAi | ENSG00000108576, Tissue enhanced (intestine, lung) |
Interactioni
Subunit structurei
Monomer or homooligomer (By similarity).
Interacts with TGFB1I1 (PubMed:16803896).
Interacts (via sialylated form) with MYH9.
Interacts with SEC23A, SEC24C and PATJ.
Interacts with NOS1; the interaction may diminish the cell surface localization of SERT in the brain and, correspondingly, reduce serotonin reuptake.
Interacts with filamentous actin and STX1A (By similarity).
Interacts (via C-terminus) with VIM (PubMed:19270731).
Interacts (via C-terminus) with SCAMP2; the interaction is direct and retains transporter molecules intracellularly (PubMed:16870614).
Interacts with RAB4 (GTP-bound form); the interaction retains transporter molecules intracellularly (PubMed:18227069).
Interacts with ITGAV:ITGB3 (By similarity).
By similarity4 PublicationsGO - Molecular functioni
- actin filament binding Source: UniProtKB
- identical protein binding Source: UniProtKB
- nitric-oxide synthase binding Source: Ensembl
- syntaxin-1 binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 112423, 18 interactors |
IntActi | P31645, 2 interactors |
MINTi | P31645 |
STRINGi | 9606.ENSP00000261707 |
Chemistry databases
BindingDBi | P31645 |
Miscellaneous databases
RNActi | P31645, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P31645 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 611 – 630 | Required for serotonin uptake activity1 PublicationAdd BLAST | 20 | |
Regioni | 616 – 624 | Interaction with RAB4A | 9 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3659, Eukaryota |
GeneTreei | ENSGT00940000157855 |
InParanoidi | P31645 |
OMAi | PFMIMEF |
PhylomeDBi | P31645 |
TreeFami | TF343812 |
Family and domain databases
InterProi | View protein in InterPro IPR000175, Na/ntran_symport IPR013086, Na/ntran_symport_serotonin_N IPR037272, SNS_sf |
PANTHERi | PTHR11616, PTHR11616, 1 hit |
Pfami | View protein in Pfam PF03491, 5HT_transport_N, 1 hit PF00209, SNF, 1 hit |
PRINTSi | PR01203, 5HTTRANSPORT PR00176, NANEUSMPORT |
SUPFAMi | SSF161070, SSF161070, 1 hit |
PROSITEi | View protein in PROSITE PS00610, NA_NEUROTRAN_SYMP_1, 1 hit PS00754, NA_NEUROTRAN_SYMP_2, 1 hit PS50267, NA_NEUROTRAN_SYMP_3, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
METTPLNSQK QLSACEDGED CQENGVLQKV VPTPGDKVES GQISNGYSAV
60 70 80 90 100
PSPGAGDDTR HSIPATTTTL VAELHQGERE TWGKKVDFLL SVIGYAVDLG
110 120 130 140 150
NVWRFPYICY QNGGGAFLLP YTIMAIFGGI PLFYMELALG QYHRNGCISI
160 170 180 190 200
WRKICPIFKG IGYAICIIAF YIASYYNTIM AWALYYLISS FTDQLPWTSC
210 220 230 240 250
KNSWNTGNCT NYFSEDNITW TLHSTSPAEE FYTRHVLQIH RSKGLQDLGG
260 270 280 290 300
ISWQLALCIM LIFTVIYFSI WKGVKTSGKV VWVTATFPYI ILSVLLVRGA
310 320 330 340 350
TLPGAWRGVL FYLKPNWQKL LETGVWIDAA AQIFFSLGPG FGVLLAFASY
360 370 380 390 400
NKFNNNCYQD ALVTSVVNCM TSFVSGFVIF TVLGYMAEMR NEDVSEVAKD
410 420 430 440 450
AGPSLLFITY AEAIANMPAS TFFAIIFFLM LITLGLDSTF AGLEGVITAV
460 470 480 490 500
LDEFPHVWAK RRERFVLAVV ITCFFGSLVT LTFGGAYVVK LLEEYATGPA
510 520 530 540 550
VLTVALIEAV AVSWFYGITQ FCRDVKEMLG FSPGWFWRIC WVAISPLFLL
560 570 580 590 600
FIICSFLMSP PQLRLFQYNY PYWSIILGYC IGTSSFICIP TYIAYRLIIT
610 620 630
PGTFKERIIK SITPETPTEI PCGDIRLNAV
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3KPR9 | J3KPR9_HUMAN | Transporter | SLC6A4 | 618 | Annotation score: | ||
J3QKP3 | J3QKP3_HUMAN | Sodium-dependent serotonin transpor... | SLC6A4 | 72 | Annotation score: |
Polymorphismi
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_014181 | 56 | G → A1 PublicationCorresponds to variant dbSNP:rs6355Ensembl. | 1 | |
Natural variantiVAR_029158 | 201 | K → N. Corresponds to variant dbSNP:rs2228673Ensembl. | 1 | |
Natural variantiVAR_036788 | 425 | I → L. Corresponds to variant dbSNP:rs28914832EnsemblClinVar. | 1 | |
Natural variantiVAR_026751 | 425 | I → V Linked with susceptibility to obsessive-compulsive disorder; increased serotonin transport capacity. 3 PublicationsCorresponds to variant dbSNP:rs28914832EnsemblClinVar. | 1 | |
Natural variantiVAR_036789 | 465 | F → L. Corresponds to variant dbSNP:rs28914833Ensembl. | 1 | |
Natural variantiVAR_036790 | 550 | L → V. Corresponds to variant dbSNP:rs28914834Ensembl. | 1 | |
Natural variantiVAR_014182 | 605 | K → N1 PublicationCorresponds to variant dbSNP:rs6352EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_046553 | 1 | M → MSQSRRVNPDDRELGGDLQI QAPRDQLGSLADGHQCHLLT SRM in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X70697 mRNA Translation: CAA50029.1 L05568 mRNA Translation: AAA35492.1 AY902473 mRNA Translation: AAW80933.1 EU099989 Genomic DNA Translation: ABV02581.1 BC069484 mRNA Translation: AAH69484.1 U79746 Genomic DNA Translation: AAB93475.1 AK308014 mRNA No translation available. |
CCDSi | CCDS11256.1 [P31645-1] |
PIRi | A47398 |
RefSeqi | NP_001036.1, NM_001045.5 [P31645-1] |
Genome annotation databases
Ensembli | ENST00000261707; ENSP00000261707; ENSG00000108576 [P31645-1] ENST00000401766; ENSP00000385822; ENSG00000108576 [P31645-1] ENST00000650711; ENSP00000498537; ENSG00000108576 [P31645-1] |
GeneIDi | 6532 |
KEGGi | hsa:6532 |
UCSCi | uc002hey.6, human [P31645-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
SHMPD The Singapore human mutation and polymorphism database |
Wikipedia Serotonin transporter entry |
Protein Spotlight Love, love, love... -Issue 123 of November 2010 |
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X70697 mRNA Translation: CAA50029.1 L05568 mRNA Translation: AAA35492.1 AY902473 mRNA Translation: AAW80933.1 EU099989 Genomic DNA Translation: ABV02581.1 BC069484 mRNA Translation: AAH69484.1 U79746 Genomic DNA Translation: AAB93475.1 AK308014 mRNA No translation available. |
CCDSi | CCDS11256.1 [P31645-1] |
PIRi | A47398 |
RefSeqi | NP_001036.1, NM_001045.5 [P31645-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5I6X | X-ray | 3.14 | A | 76-618 | [»] | |
5I6Z | X-ray | 4.53 | A | 76-618 | [»] | |
5I71 | X-ray | 3.15 | A | 76-618 | [»] | |
5I73 | X-ray | 3.24 | A | 76-618 | [»] | |
5I74 | X-ray | 3.40 | A | 76-618 | [»] | |
5I75 | X-ray | 3.49 | A | 76-618 | [»] | |
6AWN | X-ray | 3.62 | A | 76-618 | [»] | |
6AWO | X-ray | 3.53 | A | 76-618 | [»] | |
6AWP | X-ray | 3.80 | A | 76-618 | [»] | |
6AWQ | X-ray | 4.05 | A | 76-618 | [»] | |
6DZV | electron microscopy | 4.20 | A | 79-615 | [»] | |
6DZW | electron microscopy | 4.30 | A | 79-615 | [»] | |
6DZY | electron microscopy | 4.10 | A | 79-615 | [»] | |
6DZZ | electron microscopy | 3.60 | A | 78-617 | [»] | |
6VRH | electron microscopy | 3.30 | A | 1-630 | [»] | |
6VRK | electron microscopy | 4.10 | A | 1-630 | [»] | |
6VRL | electron microscopy | 3.80 | A | 1-630 | [»] | |
6W2B | X-ray | 4.70 | A | 76-618 | [»] | |
6W2C | X-ray | 6.30 | A | 76-618 | [»] | |
SMRi | P31645 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112423, 18 interactors |
IntActi | P31645, 2 interactors |
MINTi | P31645 |
STRINGi | 9606.ENSP00000261707 |
Chemistry databases
BindingDBi | P31645 |
ChEMBLi | CHEMBL228 |
DrugBanki | DB01472, 4-Methoxyamphetamine DB04836, Amineptine DB05964, Amitifadine DB00321, Amitriptyline DB00543, Amoxapine DB00182, Amphetamine DB01238, Aripiprazole DB00289, Atomoxetine DB00245, Benzatropine DB04889, Bicifadine DB09016, Butriptyline DB01114, Chlorpheniramine DB00215, Citalopram DB01242, Clomipramine DB00907, Cocaine DB05688, CRx-119 DB00924, Cyclobenzaprine DB12305, Dasotraline DB01151, Desipramine DB06700, Desvenlafaxine DB01191, Dexfenfluramine DB06701, Dexmethylphenidate DB00514, Dextromethorphan DB00988, Dopamine DB09167, Dosulepin DB01142, Doxepin DB00476, Duloxetine DB01363, Ephedra sinica root DB01175, Escitalopram DB09194, Etoperidone DB00574, Fenfluramine DB00472, Fluoxetine DB00176, Fluvoxamine DB00458, Imipramine DB08918, Levomilnacipran DB09195, Lorpiprazole DB00408, Loxapine DB06077, Lumateperone DB00579, Mazindol DB00454, Meperidine DB01577, Metamfetamine DB06148, Mianserin DB01454, Midomafetamine DB04896, Milnacipran DB00805, Minaprine DB00370, Mirtazapine DB01442, MMDA DB01149, Nefazodone DB09186, Nisoxetine DB04821, Nomifensine DB00540, Nortriptyline DB05422, OPC-14523 DB00715, Paroxetine DB00191, Phentermine DB00721, Procaine DB00344, Protriptyline DB00852, Pseudoephedrine DB08839, Serotonin DB01104, Sertraline DB01105, Sibutramine DB06204, Tapentadol DB01079, Tegaserod DB06156, Tesofensine DB00193, Tramadol DB00656, Trazodone DB00726, Trimipramine DB00285, Venlafaxine DB00661, Verapamil DB06684, Vilazodone DB09068, Vortioxetine DB04832, Zimelidine DB09225, Zotepine |
DrugCentrali | P31645 |
GuidetoPHARMACOLOGYi | 928 |
Protein family/group databases
TCDBi | 2.A.22.1.1, the neurotransmitter:sodium symporter (nss) family |
PTM databases
GlyGeni | P31645, 2 sites |
iPTMneti | P31645 |
PhosphoSitePlusi | P31645 |
Genetic variation databases
BioMutai | SLC6A4 |
DMDMi | 400630 |
Proteomic databases
MassIVEi | P31645 |
PaxDbi | P31645 |
PeptideAtlasi | P31645 |
PRIDEi | P31645 |
ProteomicsDBi | 54798 [P31645-1] |
Protocols and materials databases
ABCDi | P31645, 2 sequenced antibodies |
Antibodypediai | 26840, 339 antibodies |
Genome annotation databases
Ensembli | ENST00000261707; ENSP00000261707; ENSG00000108576 [P31645-1] ENST00000401766; ENSP00000385822; ENSG00000108576 [P31645-1] ENST00000650711; ENSP00000498537; ENSG00000108576 [P31645-1] |
GeneIDi | 6532 |
KEGGi | hsa:6532 |
UCSCi | uc002hey.6, human [P31645-1] |
Organism-specific databases
CTDi | 6532 |
DisGeNETi | 6532 |
GeneCardsi | SLC6A4 |
HGNCi | HGNC:11050, SLC6A4 |
HPAi | ENSG00000108576, Tissue enhanced (intestine, lung) |
MalaCardsi | SLC6A4 |
MIMi | 103780, phenotype 164230, phenotype 182138, gene 607834, phenotype |
neXtProti | NX_P31645 |
OpenTargetsi | ENSG00000108576 |
PharmGKBi | PA312 |
VEuPathDBi | HostDB:ENSG00000108576.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3659, Eukaryota |
GeneTreei | ENSGT00940000157855 |
InParanoidi | P31645 |
OMAi | PFMIMEF |
PhylomeDBi | P31645 |
TreeFami | TF343812 |
Enzyme and pathway databases
PathwayCommonsi | P31645 |
Reactomei | R-HSA-380615, Serotonin clearance from the synaptic cleft |
SIGNORi | P31645 |
Miscellaneous databases
BioGRID-ORCSi | 6532, 5 hits in 986 CRISPR screens |
GeneWikii | Serotonin_transporter |
GenomeRNAii | 6532 |
Pharosi | P31645, Tclin |
PROi | PR:P31645 |
RNActi | P31645, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000108576, Expressed in upper lobe of lung and 130 other tissues |
ExpressionAtlasi | P31645, baseline and differential |
Genevisiblei | P31645, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000175, Na/ntran_symport IPR013086, Na/ntran_symport_serotonin_N IPR037272, SNS_sf |
PANTHERi | PTHR11616, PTHR11616, 1 hit |
Pfami | View protein in Pfam PF03491, 5HT_transport_N, 1 hit PF00209, SNF, 1 hit |
PRINTSi | PR01203, 5HTTRANSPORT PR00176, NANEUSMPORT |
SUPFAMi | SSF161070, SSF161070, 1 hit |
PROSITEi | View protein in PROSITE PS00610, NA_NEUROTRAN_SYMP_1, 1 hit PS00754, NA_NEUROTRAN_SYMP_2, 1 hit PS50267, NA_NEUROTRAN_SYMP_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SC6A4_HUMAN | |
Accessioni | P31645Primary (citable) accession number: P31645 Secondary accession number(s): Q5EE02 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | July 1, 1993 | |
Last modified: | April 7, 2021 | |
This is version 203 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families