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UniProtKB - P31645 (SC6A4_HUMAN)

Protein

Sodium-dependent serotonin transporter

Gene

SLC6A4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.4 Publications

Miscellaneous

This protein is the target of psychomotor stimulants such as amphetamines or cocaine.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi94Sodium 1; via carbonyl oxygenBy similarity1
Metal bindingi96Sodium 2; via carbonyl oxygen1 Publication1
Metal bindingi97Sodium 1; via carbonyl oxygenBy similarity1
Metal bindingi101Sodium 21 Publication1
Metal bindingi336Sodium 21 Publication1
Metal bindingi368Sodium 21 Publication1
Metal bindingi434Sodium 1; via carbonyl oxygenBy similarity1
Metal bindingi437Sodium 1By similarity1
Metal bindingi438Sodium 1By similarity1

GO - Molecular functioni

  • actin filament binding Source: UniProtKB
  • cocaine binding Source: Ensembl
  • metal ion binding Source: UniProtKB-KW
  • monoamine transmembrane transporter activity Source: MGI
  • myosin binding Source: Ensembl
  • nitric-oxide synthase binding Source: Ensembl
  • protein homodimerization activity Source: Ensembl
  • Rab GTPase binding Source: UniProtKB
  • serotonin:sodium symporter activity Source: UniProtKB
  • serotonin binding Source: GO_Central
  • syntaxin-1 binding Source: Ensembl
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Biological processNeurotransmitter transport, Symport, Transport
LigandMetal-binding, Sodium

Enzyme and pathway databases

ReactomeiR-HSA-380615 Serotonin clearance from the synaptic cleft
SIGNORiP31645

Protein family/group databases

TCDBi2.A.22.1.1 the neurotransmitter:sodium symporter (nss) family

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent serotonin transporter
Short name:
SERTBy similarity
Alternative name(s):
5HT transporter
Short name:
5HTT
Solute carrier family 6 member 4
Gene namesi
Name:SLC6A4
Synonyms:HTT, SERT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000108576.9
HGNCiHGNC:11050 SLC6A4
MIMi182138 gene
neXtProtiNX_P31645

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 87CytoplasmicCuratedAdd BLAST87
Transmembranei88 – 112Helical; Name=11 PublicationAdd BLAST25
Topological domaini113 – 115ExtracellularCurated3
Transmembranei116 – 135Helical; Name=21 PublicationAdd BLAST20
Topological domaini136 – 160CytoplasmicCuratedAdd BLAST25
Transmembranei161 – 186Helical; Name=31 PublicationAdd BLAST26
Topological domaini187 – 252ExtracellularCuratedAdd BLAST66
Transmembranei253 – 271Helical; Name=41 PublicationAdd BLAST19
Topological domaini272 – 277CytoplasmicCurated6
Transmembranei278 – 297Helical; Name=51 PublicationAdd BLAST20
Topological domaini298 – 324ExtracellularCuratedAdd BLAST27
Transmembranei325 – 347Helical; Name=61 PublicationAdd BLAST23
Topological domaini348 – 360CytoplasmicCuratedAdd BLAST13
Transmembranei361 – 380Helical; Name=71 PublicationAdd BLAST20
Topological domaini381 – 421ExtracellularCuratedAdd BLAST41
Transmembranei422 – 443Helical; Name=81 PublicationAdd BLAST22
Topological domaini444 – 463CytoplasmicCuratedAdd BLAST20
Transmembranei464 – 483Helical; Name=91 PublicationAdd BLAST20
Topological domaini484 – 494ExtracellularCuratedAdd BLAST11
Transmembranei495 – 516Helical; Name=101 PublicationAdd BLAST22
Topological domaini517 – 538CytoplasmicCuratedAdd BLAST22
Transmembranei539 – 558Helical; Name=111 PublicationAdd BLAST20
Topological domaini559 – 574ExtracellularCuratedAdd BLAST16
Transmembranei575 – 595Helical; Name=121 PublicationAdd BLAST21
Topological domaini596 – 630CytoplasmicCuratedAdd BLAST35

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi611S → A: Loss of 10 % of serotonin uptake activity. Loss of 5 % of serotonin uptake activity; when associated with A-613 and A-616. 1 Publication1
Mutagenesisi611S → D: Loss of 61 % of serotonin uptake activity. Loss of 95 % of serotonin uptake activity and lack of association between VIM and the plasma membrane; when associated with D-613 and D-616. 1 Publication1
Mutagenesisi613T → A: Loss of 26 % of serotonin uptake activity. Loss of 5 % of serotonin uptake activity; when associated with A-611 and A-616. 1 Publication1
Mutagenesisi613T → D: Loss of 26 % of serotonin uptake activity. Loss of 95 % of serotonin uptake activity and lack of association between VIM and the plasma membrane; when associated with D-611 and D-616. 1 Publication1
Mutagenesisi616T → A: No change. Loss of 5 % of serotonin uptake activity; when associated with A-611 and A-613. 1 Publication1
Mutagenesisi616T → D: No change. Loss of 95 % of serotonin uptake activity and lack of association between VIM and the plasma membrane; when associated with D-611 and D-613. 1 Publication1

Organism-specific databases

DisGeNETi6532
MalaCardsiSLC6A4
MIMi103780 phenotype
164230 phenotype
OpenTargetsiENSG00000108576
PharmGKBiPA312

Chemistry databases

ChEMBLiCHEMBL228
DrugBankiDB01472 4-Methoxyamphetamine
DB04836 Amineptine
DB00321 Amitriptyline
DB00543 Amoxapine
DB00182 Amphetamine
DB00289 Atomoxetine
DB04889 Bicifadine
DB09016 Butriptyline
DB01114 Chlorphenamine
DB00215 Citalopram
DB01242 Clomipramine
DB00907 Cocaine
DB05688 CRx-119
DB01151 Desipramine
DB06700 Desvenlafaxine
DB01191 Dexfenfluramine
DB06701 Dexmethylphenidate
DB00514 Dextromethorphan
DB00988 Dopamine
DB01142 Doxepin
DB00476 Duloxetine
DB01363 Ephedra
DB01175 Escitalopram
DB00574 Fenfluramine
DB00472 Fluoxetine
DB00176 Fluvoxamine
DB00458 Imipramine
DB08918 Levomilnacipran
DB00408 Loxapine
DB00579 Mazindol
DB01577 Methamphetamine
DB09543 Methyl salicylate
DB00422 Methylphenidate
DB06148 Mianserin
DB04896 Milnacipran
DB00805 Minaprine
DB00370 Mirtazapine
DB01442 MMDA
DB01149 Nefazodone
DB00540 Nortriptyline
DB05422 OPC-14523
DB00715 Paroxetine
DB00454 Pethidine
DB00191 Phentermine
DB00344 Protriptyline
DB00852 Pseudoephedrine
DB01104 Sertraline
DB01105 Sibutramine
DB06204 Tapentadol
DB01079 Tegaserod
DB00193 Tramadol
DB00656 Trazodone
DB00726 Trimipramine
DB00285 Venlafaxine
DB00661 Verapamil
DB06684 Vilazodone
DB09068 Vortioxetine
DB04832 Zimelidine
GuidetoPHARMACOLOGYi928

Polymorphism and mutation databases

DMDMi400630

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002147571 – 630Sodium-dependent serotonin transporterAdd BLAST630

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei47Phosphotyrosine1 Publication1
Modified residuei142Phosphotyrosine1 Publication1
Disulfide bondi200 ↔ 209Combined sources
Glycosylationi208N-linked (GlcNAc...) asparagineSequence analysis1 Publication1
Glycosylationi217N-linked (GlcNAc...) asparagineSequence analysis1 Publication1
Modified residuei276Phosphothreonine; by PKG1 Publication1
Modified residuei611Phosphoserine1 Publication1
Modified residuei613Phosphothreonine1 Publication1
Modified residuei616Phosphothreonine1 Publication1

Post-translational modificationi

Glycosylated; modification with sialylated N-glycans is a requirement for transporters to associate with each other and to function as homooligomeric forms.By similarity
Phosphorylation at Thr-276 increases 5-HT uptake and is required for cGMP-mediated SERT regulation. Phosphorylation upon PKC stimulation modifies the SERT distribution and density in the membrane, and diminishes the uptake capacity.3 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP31645
PeptideAtlasiP31645
PRIDEiP31645
ProteomicsDBi54798

PTM databases

iPTMnetiP31645
PhosphoSitePlusiP31645

Expressioni

Tissue specificityi

Expressed in platelets (at protein level).1 Publication

Inductioni

Down-regulated when plasma serotonin is elevated.2 Publications

Gene expression databases

BgeeiENSG00000108576 Expressed in 105 organ(s), highest expression level in upper lobe of lung
CleanExiHS_HTT
HS_SLC6A4
ExpressionAtlasiP31645 baseline and differential
GenevisibleiP31645 HS

Organism-specific databases

HPAiHPA071354
HPA074728

Interactioni

Subunit structurei

Monomer or homooligomer (By similarity). Interacts with TGFB1I1. Interacts (via sialylated form) with MYH9. Interacts with SEC23A, SEC24C and PATJ. Interacts with NOS1; the interaction may diminish the cell surface localization of SERT in the brain and, correspondingly, reduce serotonin reuptake. Interacts with filamentous actin and STX1A (By similarity). Interacts (via C-terminus) with VIM. Interacts (via C-terminus) with SCAMP2; the interaction is direct and retains transporter molecules intracellularly. Interacts with RAB4 (GTP-bound form); the interaction retains transporter molecules intracellularly.By similarity4 Publications

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi112423, 11 interactors
IntActiP31645, 2 interactors
MINTiP31645
STRINGi9606.ENSP00000261707

Chemistry databases

BindingDBiP31645

Structurei

Secondary structure

1630
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP31645
SMRiP31645
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni611 – 630Required for serotonin uptake activity1 PublicationAdd BLAST20
Regioni616 – 624Interaction with RAB4A9

Sequence similaritiesi

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3659 Eukaryota
COG0733 LUCA
GeneTreeiENSGT00760000118857
HOGENOMiHOG000116406
HOVERGENiHBG071421
InParanoidiP31645
KOiK05037
OMAiNMPAATF
OrthoDBiEOG091G08PX
PhylomeDBiP31645
TreeFamiTF343812

Family and domain databases

InterProiView protein in InterPro
IPR000175 Na/ntran_symport
IPR013086 Na/ntran_symport_serotonin_N
IPR037272 SNS_sf
PANTHERiPTHR11616 PTHR11616, 1 hit
PfamiView protein in Pfam
PF03491 5HT_transport_N, 1 hit
PF00209 SNF, 1 hit
PRINTSiPR01203 5HTTRANSPORT
PR00176 NANEUSMPORT
SUPFAMiSSF161070 SSF161070, 1 hit
PROSITEiView protein in PROSITE
PS00610 NA_NEUROTRAN_SYMP_1, 1 hit
PS00754 NA_NEUROTRAN_SYMP_2, 1 hit
PS50267 NA_NEUROTRAN_SYMP_3, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P31645-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
METTPLNSQK QLSACEDGED CQENGVLQKV VPTPGDKVES GQISNGYSAV 
        60         70         80         90        100
PSPGAGDDTR HSIPATTTTL VAELHQGERE TWGKKVDFLL SVIGYAVDLG 
       110        120        130        140        150
NVWRFPYICY QNGGGAFLLP YTIMAIFGGI PLFYMELALG QYHRNGCISI 
       160        170        180        190        200
WRKICPIFKG IGYAICIIAF YIASYYNTIM AWALYYLISS FTDQLPWTSC 
       210        220        230        240        250
KNSWNTGNCT NYFSEDNITW TLHSTSPAEE FYTRHVLQIH RSKGLQDLGG 
       260        270        280        290        300
ISWQLALCIM LIFTVIYFSI WKGVKTSGKV VWVTATFPYI ILSVLLVRGA 
       310        320        330        340        350
TLPGAWRGVL FYLKPNWQKL LETGVWIDAA AQIFFSLGPG FGVLLAFASY 
       360        370        380        390        400
NKFNNNCYQD ALVTSVVNCM TSFVSGFVIF TVLGYMAEMR NEDVSEVAKD 
       410        420        430        440        450
AGPSLLFITY AEAIANMPAS TFFAIIFFLM LITLGLDSTF AGLEGVITAV 
       460        470        480        490        500
LDEFPHVWAK RRERFVLAVV ITCFFGSLVT LTFGGAYVVK LLEEYATGPA 
       510        520        530        540        550
VLTVALIEAV AVSWFYGITQ FCRDVKEMLG FSPGWFWRIC WVAISPLFLL 
       560        570        580        590        600
FIICSFLMSP PQLRLFQYNY PYWSIILGYC IGTSSFICIP TYIAYRLIIT 
       610        620        630
PGTFKERIIK SITPETPTEI PCGDIRLNAV
Length:630
Mass (Da):70,325
Last modified:July 1, 1993 - v1
Checksum:i0EB535B0A579BDA2
GO
Isoform 2 (identifier: P31645-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSQSRRVNPDDRELGGDLQIQAPRDQLGSLADGHQCHLLTSRM

Show »
Length:672
Mass (Da):74,979
Checksum:i142F04437BA1DE39
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KPR9J3KPR9_HUMAN
Transporter
SLC6A4
618Annotation score:
J3QKP3J3QKP3_HUMAN
Sodium-dependent serotonin transpor...
SLC6A4
72Annotation score:

Polymorphismi

A polymorphism in the promoter region (5-HTT gene-linked polymorphic region, 5-HTTLPR) is located approximately 1 kb upstream of the transcription initiation site and is composed of 16 repeat elements. The polymorphism consists of a 44-bp insertion or deletion involving repeat elements 6 to 8. The short allele is associated with lower transcriptional efficiency of the promoter compared with the long allele. Over half of the Caucasian population has a short allele. Individuals with one or two copies of the short allele exhibit more depressive symptoms, diagnosable depression and suicidality in relation to stressful life events than individuals homozygous for the long allele.1 Publication
The polymorphism Val-425 seems to be linked to a susceptibility to obsessive-compulsive disorder (OCD) [MIMi:164230].3 Publications
Genetic variations in SLC6A4 determine the genetic susceptibility to alcoholism [MIMi:103780].1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01418156G → A1 PublicationCorresponds to variant dbSNP:rs6355Ensembl.1
Natural variantiVAR_029158201K → N. Corresponds to variant dbSNP:rs2228673Ensembl.1
Natural variantiVAR_036788425I → L. Corresponds to variant dbSNP:rs28914832EnsemblClinVar.1
Natural variantiVAR_026751425I → V Polymorphism linked with susceptibility to obsessive-compulsive disorder; increased serotonin transport capacity. 3 PublicationsCorresponds to variant dbSNP:rs28914832EnsemblClinVar.1
Natural variantiVAR_036789465F → L. Corresponds to variant dbSNP:rs28914833Ensembl.1
Natural variantiVAR_036790550L → V. Corresponds to variant dbSNP:rs28914834Ensembl.1
Natural variantiVAR_014182605K → N1 PublicationCorresponds to variant dbSNP:rs6352EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0465531M → MSQSRRVNPDDRELGGDLQI QAPRDQLGSLADGHQCHLLT SRM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70697 mRNA Translation: CAA50029.1
L05568 mRNA Translation: AAA35492.1
AY902473 mRNA Translation: AAW80933.1
EU099989 Genomic DNA Translation: ABV02581.1
BC069484 mRNA Translation: AAH69484.1
U79746 Genomic DNA Translation: AAB93475.1
AK308014 mRNA No translation available.
CCDSiCCDS11256.1 [P31645-1]
PIRiA47398
RefSeqiNP_001036.1, NM_001045.5 [P31645-1]
UniGeneiHs.134662
Hs.29792

Genome annotation databases

EnsembliENST00000261707; ENSP00000261707; ENSG00000108576 [P31645-1]
ENST00000401766; ENSP00000385822; ENSG00000108576 [P31645-1]
GeneIDi6532
KEGGihsa:6532
UCSCiuc002hey.6 human [P31645-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Wikipedia

Serotonin transporter entry

Protein Spotlight

Love, love, love... -Issue 123 of November 2010

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70697 mRNA Translation: CAA50029.1
L05568 mRNA Translation: AAA35492.1
AY902473 mRNA Translation: AAW80933.1
EU099989 Genomic DNA Translation: ABV02581.1
BC069484 mRNA Translation: AAH69484.1
U79746 Genomic DNA Translation: AAB93475.1
AK308014 mRNA No translation available.
CCDSiCCDS11256.1 [P31645-1]
PIRiA47398
RefSeqiNP_001036.1, NM_001045.5 [P31645-1]
UniGeneiHs.134662
Hs.29792

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5I6XX-ray3.14A76-618[»]
5I6ZX-ray4.53A76-618[»]
5I71X-ray3.15A76-618[»]
5I73X-ray3.24A76-618[»]
5I74X-ray3.40A76-618[»]
5I75X-ray3.49A76-618[»]
6AWNX-ray3.62A76-618[»]
6AWOX-ray3.53A76-618[»]
6AWPX-ray3.80A76-618[»]
6AWQX-ray4.05A76-618[»]
ProteinModelPortaliP31645
SMRiP31645
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112423, 11 interactors
IntActiP31645, 2 interactors
MINTiP31645
STRINGi9606.ENSP00000261707

Chemistry databases

BindingDBiP31645
ChEMBLiCHEMBL228
DrugBankiDB01472 4-Methoxyamphetamine
DB04836 Amineptine
DB00321 Amitriptyline
DB00543 Amoxapine
DB00182 Amphetamine
DB00289 Atomoxetine
DB04889 Bicifadine
DB09016 Butriptyline
DB01114 Chlorphenamine
DB00215 Citalopram
DB01242 Clomipramine
DB00907 Cocaine
DB05688 CRx-119
DB01151 Desipramine
DB06700 Desvenlafaxine
DB01191 Dexfenfluramine
DB06701 Dexmethylphenidate
DB00514 Dextromethorphan
DB00988 Dopamine
DB01142 Doxepin
DB00476 Duloxetine
DB01363 Ephedra
DB01175 Escitalopram
DB00574 Fenfluramine
DB00472 Fluoxetine
DB00176 Fluvoxamine
DB00458 Imipramine
DB08918 Levomilnacipran
DB00408 Loxapine
DB00579 Mazindol
DB01577 Methamphetamine
DB09543 Methyl salicylate
DB00422 Methylphenidate
DB06148 Mianserin
DB04896 Milnacipran
DB00805 Minaprine
DB00370 Mirtazapine
DB01442 MMDA
DB01149 Nefazodone
DB00540 Nortriptyline
DB05422 OPC-14523
DB00715 Paroxetine
DB00454 Pethidine
DB00191 Phentermine
DB00344 Protriptyline
DB00852 Pseudoephedrine
DB01104 Sertraline
DB01105 Sibutramine
DB06204 Tapentadol
DB01079 Tegaserod
DB00193 Tramadol
DB00656 Trazodone
DB00726 Trimipramine
DB00285 Venlafaxine
DB00661 Verapamil
DB06684 Vilazodone
DB09068 Vortioxetine
DB04832 Zimelidine
GuidetoPHARMACOLOGYi928

Protein family/group databases

TCDBi2.A.22.1.1 the neurotransmitter:sodium symporter (nss) family

PTM databases

iPTMnetiP31645
PhosphoSitePlusiP31645

Polymorphism and mutation databases

DMDMi400630

Proteomic databases

PaxDbiP31645
PeptideAtlasiP31645
PRIDEiP31645
ProteomicsDBi54798

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261707; ENSP00000261707; ENSG00000108576 [P31645-1]
ENST00000401766; ENSP00000385822; ENSG00000108576 [P31645-1]
GeneIDi6532
KEGGihsa:6532
UCSCiuc002hey.6 human [P31645-1]

Organism-specific databases

CTDi6532
DisGeNETi6532
EuPathDBiHostDB:ENSG00000108576.9
GeneCardsiSLC6A4
HGNCiHGNC:11050 SLC6A4
HPAiHPA071354
HPA074728
MalaCardsiSLC6A4
MIMi103780 phenotype
164230 phenotype
182138 gene
neXtProtiNX_P31645
OpenTargetsiENSG00000108576
PharmGKBiPA312
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3659 Eukaryota
COG0733 LUCA
GeneTreeiENSGT00760000118857
HOGENOMiHOG000116406
HOVERGENiHBG071421
InParanoidiP31645
KOiK05037
OMAiNMPAATF
OrthoDBiEOG091G08PX
PhylomeDBiP31645
TreeFamiTF343812

Enzyme and pathway databases

ReactomeiR-HSA-380615 Serotonin clearance from the synaptic cleft
SIGNORiP31645

Miscellaneous databases

GeneWikiiSerotonin_transporter
GenomeRNAii6532
PROiPR:P31645
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000108576 Expressed in 105 organ(s), highest expression level in upper lobe of lung
CleanExiHS_HTT
HS_SLC6A4
ExpressionAtlasiP31645 baseline and differential
GenevisibleiP31645 HS

Family and domain databases

InterProiView protein in InterPro
IPR000175 Na/ntran_symport
IPR013086 Na/ntran_symport_serotonin_N
IPR037272 SNS_sf
PANTHERiPTHR11616 PTHR11616, 1 hit
PfamiView protein in Pfam
PF03491 5HT_transport_N, 1 hit
PF00209 SNF, 1 hit
PRINTSiPR01203 5HTTRANSPORT
PR00176 NANEUSMPORT
SUPFAMiSSF161070 SSF161070, 1 hit
PROSITEiView protein in PROSITE
PS00610 NA_NEUROTRAN_SYMP_1, 1 hit
PS00754 NA_NEUROTRAN_SYMP_2, 1 hit
PS50267 NA_NEUROTRAN_SYMP_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSC6A4_HUMAN
AccessioniPrimary (citable) accession number: P31645
Secondary accession number(s): Q5EE02
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 7, 2018
This is version 184 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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