UniProtKB - P31644 (GBRA5_HUMAN)
Protein
Gamma-aminobutyric acid receptor subunit alpha-5
Gene
GABRA5
Organism
Homo sapiens (Human)
Status
Functioni
Ligand-gated chloride channel subunit which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:29961870, PubMed:31056671). May be involved in GABA-A receptor assembly, and GABA-A receptor immobilization and accumulation by gephyrin at the synapse (PubMed:31056671).2 Publications
GO - Molecular functioni
- chloride channel activity Source: GO_Central
- GABA-A receptor activity Source: Ensembl
- GABA-gated chloride ion channel activity Source: GO_Central
- GABA receptor binding Source: Ensembl
- inhibitory extracellular ligand-gated ion channel activity Source: GO_Central
- neurotransmitter receptor activity Source: GO_Central
- signaling receptor activity Source: ProtInc
- transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Source: GO_Central
- transporter activity Source: ProtInc
GO - Biological processi
- associative learning Source: Ensembl
- behavioral fear response Source: Ensembl
- brain development Source: Ensembl
- chemical synaptic transmission Source: GO_Central
- chloride transmembrane transport Source: GO_Central
- cochlea development Source: Ensembl
- gamma-aminobutyric acid signaling pathway Source: GO_Central
- inner ear receptor cell development Source: Ensembl
- innervation Source: Ensembl
- ion transmembrane transport Source: GO_Central
- negative regulation of neuron apoptotic process Source: Ensembl
- nervous system process Source: GO_Central
- regulation of membrane potential Source: GO_Central
- regulation of postsynaptic membrane potential Source: GO_Central
- sensory perception of sound Source: Ensembl
- signal transduction Source: GO_Central
- synaptic transmission, GABAergic Source: GO_Central
Keywordsi
Molecular function | Chloride channel, Ion channel, Ligand-gated ion channel, Receptor |
Biological process | Ion transport, Transport |
Ligand | Chloride |
Enzyme and pathway databases
PathwayCommonsi | P31644 |
Reactomei | R-HSA-977443, GABA receptor activation |
Names & Taxonomyi
Protein namesi | Recommended name: Gamma-aminobutyric acid receptor subunit alpha-5Alternative name(s): GABA(A) receptor subunit alpha-5 |
Gene namesi | Name:GABRA5Imported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000186297.11 |
HGNCi | HGNC:4079, GABRA5 |
MIMi | 137142, gene |
neXtProti | NX_P31644 |
Subcellular locationi
Plasma membrane
- postsynaptic cell membrane 1 Publication; Multi-pass membrane protein
- Cell membrane 1 Publication; Multi-pass membrane protein
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
Plasma Membrane
- dendrite membrane Source: GO_Central
- integral component of plasma membrane Source: GO_Central
- integral component of postsynaptic specialization membrane Source: Ensembl
- integral component of presynaptic membrane Source: Ensembl
- neuronal cell body membrane Source: Ensembl
- plasma membrane Source: HPA
Other locations
- chloride channel complex Source: UniProtKB-KW
- GABA-A receptor complex Source: GO_Central
- GABA-ergic synapse Source: Ensembl
- neuron projection Source: GO_Central
- postsynapse Source: GO_Central
- synapse Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 32 – 259 | ExtracellularSequence analysisAdd BLAST | 228 | |
Transmembranei | 260 – 281 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 286 – 307 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 319 – 341 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 342 – 427 | CytoplasmicSequence analysisAdd BLAST | 86 | |
Transmembranei | 428 – 449 | HelicalSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, SynapsePathology & Biotechi
Involvement in diseasei
Epileptic encephalopathy, early infantile, 79 (EIEE79)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of epileptic encephalopathy, a heterogeneous group of severe early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. EIEE79 is an autosomal dominant form characterized by onset of refractory seizures in the first months of life. Brain imaging may show hypomyelination, cerebral atrophy and thinning of the corpus callosum.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_083201 | 294 | V → F in EIEE79; decreased subcellular localization to the cell membrane resulting in altered protein localization to the synapse and altered gamma-aminobutyric acid signaling pathway. 1 Publication | 1 | |
Natural variantiVAR_083202 | 294 | V → L in EIEE79; increased affinity to GABA; decreased maximal GABA-evoked current density. 1 Publication | 1 | |
Natural variantiVAR_083203 | 413 | S → F in EIEE79; decreased subcellular localization to the cell membrane resulting in altered protein localization to the synapse and altered gamma-aminobutyric acid signaling pathway; the mutant subunit decreases the trafficking of the partnering GABRB3 subunit to the cell membrane with no effect on other subunits. 1 Publication | 1 |
Keywords - Diseasei
Disease mutation, EpilepsyOrganism-specific databases
DisGeNETi | 2558 |
GeneReviewsi | GABRA5 |
MalaCardsi | GABRA5 |
MIMi | 618559, phenotype |
OpenTargetsi | ENSG00000186297 |
Orphaneti | 442835, Undetermined early-onset epileptic encephalopathy |
PharmGKBi | PA28493 |
Miscellaneous databases
Pharosi | P31644, Tclin |
Chemistry databases
ChEMBLi | CHEMBL5112 |
DrugBanki | DB00659, Acamprosate DB00546, Adinazolam DB06579, Adipiplon DB00404, Alprazolam DB01351, Amobarbital DB00543, Amoxapine DB11901, Apalutamide DB01352, Aprobarbital DB01483, Barbital DB14719, Bentazepam DB12537, Benzodiazepine DB11859, Brexanolone DB01558, Bromazepam DB09017, Brotizolam DB00237, Butabarbital DB00241, Butalbital DB01353, Butobarbital DB01489, Camazepam DB00395, Carisoprodol DB00475, Chlordiazepoxide DB14715, Cinazepam DB01594, Cinolazepam DB00349, Clobazam DB01068, Clonazepam DB00628, Clorazepic acid DB01559, Clotiazepam DB01553, Cloxazolam DB01511, Delorazepam DB01189, Desflurane DB00829, Diazepam DB01496, Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione DB13837, Doxefazepam DB00228, Enflurane DB01215, Estazolam DB00402, Eszopiclone DB00898, Ethanol DB00189, Ethchlorvynol DB01545, Ethyl loflazepate DB09166, Etizolam DB00292, Etomidate DB01567, Fludiazepam DB01205, Flumazenil DB01544, Flunitrazepam DB00690, Flurazepam DB05087, Ganaxolone DB01437, Glutethimide DB00801, Halazepam DB01159, Halothane DB01354, Heptabarbital DB01355, Hexobarbital DB00753, Isoflurane DB01587, Ketazolam DB00555, Lamotrigine DB13643, Loprazolam DB00186, Lorazepam DB13872, Lormetazepam DB13437, Medazepam DB00603, Medroxyprogesterone acetate DB01043, Memantine DB00371, Meprobamate DB00463, Metharbital DB01028, Methoxyflurane DB00849, Methylphenobarbital DB01107, Methyprylon DB15489, Mexazolam DB00683, Midazolam DB01595, Nitrazepam DB14028, Nordazepam DB00334, Olanzapine DB00842, Oxazepam DB14672, Oxazepam acetate DB00312, Pentobarbital DB00252, Phenytoin DB13335, Pinazepam DB01708, Prasterone DB01588, Prazepam DB00794, Primidone DB00818, Propofol DB01589, Quazepam DB00418, Secobarbital DB01236, Sevoflurane DB09118, Stiripentol DB00306, Talbutal DB01956, Taurine DB00231, Temazepam DB11582, Thiocolchicoside DB00599, Thiopental DB00897, Triazolam DB01198, Zopiclone |
DrugCentrali | P31644 |
GuidetoPHARMACOLOGYi | 408 |
Polymorphism and mutation databases
BioMutai | GABRA5 |
DMDMi | 399519 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 31 | Sequence analysisAdd BLAST | 31 | |
ChainiPRO_0000000444 | 32 – 462 | Gamma-aminobutyric acid receptor subunit alpha-5Add BLAST | 431 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 45 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 145 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 173 ↔ 187 | By similarity | ||
Glycosylationi | 207 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 236 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Cross-linki | 355 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication |
Keywords - PTMi
Disulfide bond, Glycoprotein, Isopeptide bond, Ubl conjugationProteomic databases
MassIVEi | P31644 |
MaxQBi | P31644 |
PaxDbi | P31644 |
PeptideAtlasi | P31644 |
PRIDEi | P31644 |
ProteomicsDBi | 54797 |
PTM databases
GlyGeni | P31644, 4 sites |
iPTMneti | P31644 |
PhosphoSitePlusi | P31644 |
Expressioni
Gene expression databases
Bgeei | ENSG00000186297, Expressed in nucleus accumbens and 112 other tissues |
ExpressionAtlasi | P31644, baseline and differential |
Genevisiblei | P31644, HS |
Organism-specific databases
HPAi | ENSG00000186297, Tissue enriched (brain) |
Interactioni
Subunit structurei
Generally pentameric. There are five types of GABA(A) receptor subunits: alpha, beta, gamma, delta, and rho.
GO - Molecular functioni
- GABA receptor binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 108832, 1 interactor |
ComplexPortali | CPX-2168, GABA-A receptor, alpha-5/beta-3/gamma-2 |
IntActi | P31644, 1 interactor |
STRINGi | 9606.ENSP00000335592 |
Chemistry databases
BindingDBi | P31644 |
Miscellaneous databases
RNActi | P31644, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P31644 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA5 sub-subfamily. [View classification]Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3642, Eukaryota |
GeneTreei | ENSGT00940000156234 |
HOGENOMi | CLU_010920_2_1_1 |
InParanoidi | P31644 |
OMAi | WDGKKAQ |
OrthoDBi | 1057372at2759 |
PhylomeDBi | P31644 |
TreeFami | TF315453 |
Family and domain databases
Gene3Di | 2.70.170.10, 1 hit |
InterProi | View protein in InterPro IPR006028, GABAA/Glycine_rcpt IPR001390, GABAAa_rcpt IPR005435, GABBAa5_rcpt IPR006202, Neur_chan_lig-bd IPR036734, Neur_chan_lig-bd_sf IPR006201, Neur_channel IPR036719, Neuro-gated_channel_TM_sf IPR006029, Neurotrans-gated_channel_TM IPR018000, Neurotransmitter_ion_chnl_CS |
PANTHERi | PTHR18945, PTHR18945, 1 hit |
Pfami | View protein in Pfam PF02931, Neur_chan_LBD, 1 hit PF02932, Neur_chan_memb, 1 hit |
PRINTSi | PR01079, GABAARALPHA PR01618, GABAARALPHA5 PR00253, GABAARECEPTR PR00252, NRIONCHANNEL |
SUPFAMi | SSF63712, SSF63712, 1 hit SSF90112, SSF90112, 1 hit |
TIGRFAMsi | TIGR00860, LIC, 1 hit |
PROSITEi | View protein in PROSITE PS00236, NEUROTR_ION_CHANNEL, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
P31644-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDNGMFSGFI MIKNLLLFCI SMNLSSHFGF SQMPTSSVKD ETNDNITIFT
60 70 80 90 100
RILDGLLDGY DNRLRPGLGE RITQVRTDIY VTSFGPVSDT EMEYTIDVFF
110 120 130 140 150
RQSWKDERLR FKGPMQRLPL NNLLASKIWT PDTFFHNGKK SIAHNMTTPN
160 170 180 190 200
KLLRLEDDGT LLYTMRLTIS AECPMQLEDF PMDAHACPLK FGSYAYPNSE
210 220 230 240 250
VVYVWTNGST KSVVVAEDGS RLNQYHLMGQ TVGTENISTS TGEYTIMTAH
260 270 280 290 300
FHLKRKIGYF VIQTYLPCIM TVILSQVSFW LNRESVPART VFGVTTVLTM
310 320 330 340 350
TTLSISARNS LPKVAYATAM DWFIAVCYAF VFSALIEFAT VNYFTKRGWA
360 370 380 390 400
WDGKKALEAA KIKKKREVIL NKSTNAFTTG KMSHPPNIPK EQTPAGTSNT
410 420 430 440 450
TSVSVKPSEE KTSESKKTYN SISKIDKMSR IVFPVLFGTF NLVYWATYLN
460
REPVIKGAAS PK
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG3V2K2 | G3V2K2_HUMAN | Gamma-aminobutyric acid receptor su... | GABRA5 | 165 | Annotation score: | ||
G3V2Q9 | G3V2Q9_HUMAN | Gamma-aminobutyric acid receptor su... | GABRA5 | 148 | Annotation score: | ||
G3V408 | G3V408_HUMAN | Gamma-aminobutyric acid receptor su... | GABRA5 | 86 | Annotation score: | ||
G3V2G8 | G3V2G8_HUMAN | Gamma-aminobutyric acid receptor su... | GABRA5 | 166 | Annotation score: | ||
G3V296 | G3V296_HUMAN | Gamma-aminobutyric acid receptor su... | GABRA5 | 85 | Annotation score: | ||
G3V2Y5 | G3V2Y5_HUMAN | Gamma-aminobutyric acid receptor su... | GABRA5 | 16 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_083201 | 294 | V → F in EIEE79; decreased subcellular localization to the cell membrane resulting in altered protein localization to the synapse and altered gamma-aminobutyric acid signaling pathway. 1 Publication | 1 | |
Natural variantiVAR_083202 | 294 | V → L in EIEE79; increased affinity to GABA; decreased maximal GABA-evoked current density. 1 Publication | 1 | |
Natural variantiVAR_083203 | 413 | S → F in EIEE79; decreased subcellular localization to the cell membrane resulting in altered protein localization to the synapse and altered gamma-aminobutyric acid signaling pathway; the mutant subunit decreases the trafficking of the partnering GABRB3 subunit to the cell membrane with no effect on other subunits. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L08485 mRNA Translation: AAA58490.1 AK290453 mRNA Translation: BAF83142.1 BT009830 mRNA Translation: AAP88832.1 BC111979 mRNA Translation: AAI11980.1 BC113422 mRNA Translation: AAI13423.1 AF061785 Genomic DNA Translation: AAC31809.1 AF228447 Genomic DNA Translation: AAF62508.1 AF228448 Genomic DNA Translation: AAF62509.1 AF228449 Genomic DNA Translation: AAF62510.1 |
CCDSi | CCDS45194.1 |
PIRi | A48933 |
RefSeqi | NP_000801.1, NM_000810.3 NP_001158509.1, NM_001165037.1 XP_005268315.1, XM_005268258.2 XP_006720522.1, XM_006720459.2 |
Genome annotation databases
Ensembli | ENST00000335625; ENSP00000335592; ENSG00000186297 ENST00000355395; ENSP00000347557; ENSG00000186297 ENST00000400081; ENSP00000382953; ENSG00000186297 |
GeneIDi | 2558 |
KEGGi | hsa:2558 |
UCSCi | uc001zbd.3, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Protein Spotlight Forbidden fruit - Issue 56 of March 2005 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L08485 mRNA Translation: AAA58490.1 AK290453 mRNA Translation: BAF83142.1 BT009830 mRNA Translation: AAP88832.1 BC111979 mRNA Translation: AAI11980.1 BC113422 mRNA Translation: AAI13423.1 AF061785 Genomic DNA Translation: AAC31809.1 AF228447 Genomic DNA Translation: AAF62508.1 AF228448 Genomic DNA Translation: AAF62509.1 AF228449 Genomic DNA Translation: AAF62510.1 |
CCDSi | CCDS45194.1 |
PIRi | A48933 |
RefSeqi | NP_000801.1, NM_000810.3 NP_001158509.1, NM_001165037.1 XP_005268315.1, XM_005268258.2 XP_006720522.1, XM_006720459.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5O8F | X-ray | 3.20 | A/B/C/D/E | 261-346 | [»] | |
A/B/C/D/E | 424-462 | [»] | ||||
5OJM | X-ray | 3.30 | A/B/C/D/E | 257-346 | [»] | |
A/B/C/D/E | 424-462 | [»] | ||||
6A96 | electron microscopy | 3.51 | A | 1-346 | [»] | |
A | 424-462 | [»] | ||||
SMRi | P31644 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108832, 1 interactor |
ComplexPortali | CPX-2168, GABA-A receptor, alpha-5/beta-3/gamma-2 |
IntActi | P31644, 1 interactor |
STRINGi | 9606.ENSP00000335592 |
Chemistry databases
BindingDBi | P31644 |
ChEMBLi | CHEMBL5112 |
DrugBanki | DB00659, Acamprosate DB00546, Adinazolam DB06579, Adipiplon DB00404, Alprazolam DB01351, Amobarbital DB00543, Amoxapine DB11901, Apalutamide DB01352, Aprobarbital DB01483, Barbital DB14719, Bentazepam DB12537, Benzodiazepine DB11859, Brexanolone DB01558, Bromazepam DB09017, Brotizolam DB00237, Butabarbital DB00241, Butalbital DB01353, Butobarbital DB01489, Camazepam DB00395, Carisoprodol DB00475, Chlordiazepoxide DB14715, Cinazepam DB01594, Cinolazepam DB00349, Clobazam DB01068, Clonazepam DB00628, Clorazepic acid DB01559, Clotiazepam DB01553, Cloxazolam DB01511, Delorazepam DB01189, Desflurane DB00829, Diazepam DB01496, Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione DB13837, Doxefazepam DB00228, Enflurane DB01215, Estazolam DB00402, Eszopiclone DB00898, Ethanol DB00189, Ethchlorvynol DB01545, Ethyl loflazepate DB09166, Etizolam DB00292, Etomidate DB01567, Fludiazepam DB01205, Flumazenil DB01544, Flunitrazepam DB00690, Flurazepam DB05087, Ganaxolone DB01437, Glutethimide DB00801, Halazepam DB01159, Halothane DB01354, Heptabarbital DB01355, Hexobarbital DB00753, Isoflurane DB01587, Ketazolam DB00555, Lamotrigine DB13643, Loprazolam DB00186, Lorazepam DB13872, Lormetazepam DB13437, Medazepam DB00603, Medroxyprogesterone acetate DB01043, Memantine DB00371, Meprobamate DB00463, Metharbital DB01028, Methoxyflurane DB00849, Methylphenobarbital DB01107, Methyprylon DB15489, Mexazolam DB00683, Midazolam DB01595, Nitrazepam DB14028, Nordazepam DB00334, Olanzapine DB00842, Oxazepam DB14672, Oxazepam acetate DB00312, Pentobarbital DB00252, Phenytoin DB13335, Pinazepam DB01708, Prasterone DB01588, Prazepam DB00794, Primidone DB00818, Propofol DB01589, Quazepam DB00418, Secobarbital DB01236, Sevoflurane DB09118, Stiripentol DB00306, Talbutal DB01956, Taurine DB00231, Temazepam DB11582, Thiocolchicoside DB00599, Thiopental DB00897, Triazolam DB01198, Zopiclone |
DrugCentrali | P31644 |
GuidetoPHARMACOLOGYi | 408 |
PTM databases
GlyGeni | P31644, 4 sites |
iPTMneti | P31644 |
PhosphoSitePlusi | P31644 |
Polymorphism and mutation databases
BioMutai | GABRA5 |
DMDMi | 399519 |
Proteomic databases
MassIVEi | P31644 |
MaxQBi | P31644 |
PaxDbi | P31644 |
PeptideAtlasi | P31644 |
PRIDEi | P31644 |
ProteomicsDBi | 54797 |
Protocols and materials databases
ABCDi | P31644, 1 sequenced antibody |
Antibodypediai | 22325, 350 antibodies |
DNASUi | 2558 |
Genome annotation databases
Ensembli | ENST00000335625; ENSP00000335592; ENSG00000186297 ENST00000355395; ENSP00000347557; ENSG00000186297 ENST00000400081; ENSP00000382953; ENSG00000186297 |
GeneIDi | 2558 |
KEGGi | hsa:2558 |
UCSCi | uc001zbd.3, human |
Organism-specific databases
CTDi | 2558 |
DisGeNETi | 2558 |
EuPathDBi | HostDB:ENSG00000186297.11 |
GeneCardsi | GABRA5 |
GeneReviewsi | GABRA5 |
HGNCi | HGNC:4079, GABRA5 |
HPAi | ENSG00000186297, Tissue enriched (brain) |
MalaCardsi | GABRA5 |
MIMi | 137142, gene 618559, phenotype |
neXtProti | NX_P31644 |
OpenTargetsi | ENSG00000186297 |
Orphaneti | 442835, Undetermined early-onset epileptic encephalopathy |
PharmGKBi | PA28493 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3642, Eukaryota |
GeneTreei | ENSGT00940000156234 |
HOGENOMi | CLU_010920_2_1_1 |
InParanoidi | P31644 |
OMAi | WDGKKAQ |
OrthoDBi | 1057372at2759 |
PhylomeDBi | P31644 |
TreeFami | TF315453 |
Enzyme and pathway databases
PathwayCommonsi | P31644 |
Reactomei | R-HSA-977443, GABA receptor activation |
Miscellaneous databases
BioGRID-ORCSi | 2558, 6 hits in 843 CRISPR screens |
ChiTaRSi | GABRA5, human |
GeneWikii | GABRA5 |
GenomeRNAii | 2558 |
Pharosi | P31644, Tclin |
PROi | PR:P31644 |
RNActi | P31644, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000186297, Expressed in nucleus accumbens and 112 other tissues |
ExpressionAtlasi | P31644, baseline and differential |
Genevisiblei | P31644, HS |
Family and domain databases
Gene3Di | 2.70.170.10, 1 hit |
InterProi | View protein in InterPro IPR006028, GABAA/Glycine_rcpt IPR001390, GABAAa_rcpt IPR005435, GABBAa5_rcpt IPR006202, Neur_chan_lig-bd IPR036734, Neur_chan_lig-bd_sf IPR006201, Neur_channel IPR036719, Neuro-gated_channel_TM_sf IPR006029, Neurotrans-gated_channel_TM IPR018000, Neurotransmitter_ion_chnl_CS |
PANTHERi | PTHR18945, PTHR18945, 1 hit |
Pfami | View protein in Pfam PF02931, Neur_chan_LBD, 1 hit PF02932, Neur_chan_memb, 1 hit |
PRINTSi | PR01079, GABAARALPHA PR01618, GABAARALPHA5 PR00253, GABAARECEPTR PR00252, NRIONCHANNEL |
SUPFAMi | SSF63712, SSF63712, 1 hit SSF90112, SSF90112, 1 hit |
TIGRFAMsi | TIGR00860, LIC, 1 hit |
PROSITEi | View protein in PROSITE PS00236, NEUROTR_ION_CHANNEL, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GBRA5_HUMAN | |
Accessioni | P31644Primary (citable) accession number: P31644 Secondary accession number(s): A8K338 Q9NYT5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | July 1, 1993 | |
Last modified: | December 2, 2020 | |
This is version 199 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Protein Spotlight
Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries - Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations