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Protein

Gamma-aminobutyric acid receptor subunit alpha-5

Gene

GABRA5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

GO - Molecular functioni

  • chloride channel activity Source: UniProtKB-KW
  • extracellular ligand-gated ion channel activity Source: InterPro
  • GABA-A receptor activity Source: Ensembl
  • GABA receptor binding Source: Ensembl
  • signaling receptor activity Source: ProtInc
  • transporter activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionChloride channel, Ion channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport
LigandChloride

Enzyme and pathway databases

ReactomeiR-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-977441 GABA A receptor activation

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit alpha-5
Alternative name(s):
GABA(A) receptor subunit alpha-5
Gene namesi
Name:GABRA5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000186297.11
HGNCiHGNC:4079 GABRA5
MIMi137142 gene
neXtProtiNX_P31644

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini32 – 259ExtracellularSequence analysisAdd BLAST228
Transmembranei260 – 281HelicalSequence analysisAdd BLAST22
Transmembranei286 – 307HelicalSequence analysisAdd BLAST22
Transmembranei319 – 341HelicalSequence analysisAdd BLAST23
Topological domaini342 – 427CytoplasmicSequence analysisAdd BLAST86
Transmembranei428 – 449HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi2558
GeneReviewsiGABRA5
OpenTargetsiENSG00000186297
PharmGKBiPA28493

Chemistry databases

ChEMBLiCHEMBL5112
DrugBankiDB00659 Acamprosate
DB00546 Adinazolam
DB06579 Adipiplon
DB00404 Alprazolam
DB01351 Amobarbital
DB00543 Amoxapine
DB01352 Aprobarbital
DB01483 Barbital
DB01496 Barbituric acid derivative
DB01558 Bromazepam
DB00237 Butabarbital
DB00241 Butalbital
DB01353 Butethal
DB00475 Chlordiazepoxide
DB01594 Cinolazepam
DB00349 Clobazam
DB01068 Clonazepam
DB00628 Clorazepate
DB01559 Clotiazepam
DB01189 Desflurane
DB00829 Diazepam
DB00228 Enflurane
DB01049 Ergoloid mesylate
DB01215 Estazolam
DB00402 Eszopiclone
DB00898 Ethanol
DB00189 Ethchlorvynol
DB00292 Etomidate
DB01567 Fludiazepam
DB01205 Flumazenil
DB01544 Flunitrazepam
DB00690 Flurazepam
DB05087 Ganaxolone
DB01437 Glutethimide
DB00801 Halazepam
DB01159 Halothane
DB01354 Heptabarbital
DB01355 Hexobarbital
DB00753 Isoflurane
DB00186 Lorazepam
DB00371 Meprobamate
DB00463 Metharbital
DB01028 Methoxyflurane
DB00849 Methylphenobarbital
DB01107 Methyprylon
DB00683 Midazolam
DB01595 Nitrazepam
DB00334 Olanzapine
DB00842 Oxazepam
DB00312 Pentobarbital
DB01708 Prasterone
DB01588 Prazepam
DB00794 Primidone
DB00818 Propofol
DB01589 Quazepam
DB00418 Secobarbital
DB01236 Sevoflurane
DB00306 Talbutal
DB00231 Temazepam
DB11582 Thiocolchicoside
DB00599 Thiopental
DB00273 Topiramate
DB00897 Triazolam
DB01198 Zopiclone
GuidetoPHARMACOLOGYi408

Polymorphism and mutation databases

BioMutaiGABRA5
DMDMi399519

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000000044432 – 462Gamma-aminobutyric acid receptor subunit alpha-5Add BLAST431

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi45N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi145N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi173 ↔ 187By similarity
Glycosylationi207N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi236N-linked (GlcNAc...) asparagineSequence analysis1
Cross-linki355Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiP31644
PaxDbiP31644
PeptideAtlasiP31644
PRIDEiP31644
ProteomicsDBi54797

PTM databases

iPTMnetiP31644
PhosphoSitePlusiP31644

Expressioni

Gene expression databases

BgeeiENSG00000186297
CleanExiHS_GABRA5
ExpressionAtlasiP31644 baseline and differential
GenevisibleiP31644 HS

Organism-specific databases

HPAiCAB079022
HPA077031

Interactioni

Subunit structurei

Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108832, 1 interactor
ComplexPortaliCPX-2168 GABA-A receptor alpha-5/beta-3/gamma-2
STRINGi9606.ENSP00000335592

Chemistry databases

BindingDBiP31644

Structurei

Secondary structure

1462
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi265 – 275Combined sources11
Helixi276 – 280Combined sources5
Helixi286 – 308Combined sources23
Helixi319 – 344Combined sources26
Helixi424 – 447Combined sources24

3D structure databases

ProteinModelPortaliP31644
SMRiP31644
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3642 Eukaryota
ENOG410XNQG LUCA
GeneTreeiENSGT00760000119010
HOGENOMiHOG000231337
HOVERGENiHBG051707
InParanoidiP31644
KOiK05175
OMAiMTHPPNI
OrthoDBiEOG091G0805
PhylomeDBiP31644
TreeFamiTF315453

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006028 GABAA/Glycine_rcpt
IPR001390 GABAAa_rcpt
IPR005435 GABBAa5_rcpt
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR01079 GABAARALPHA
PR01618 GABAARALPHA5
PR00253 GABAARECEPTR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31644-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNGMFSGFI MIKNLLLFCI SMNLSSHFGF SQMPTSSVKD ETNDNITIFT
60 70 80 90 100
RILDGLLDGY DNRLRPGLGE RITQVRTDIY VTSFGPVSDT EMEYTIDVFF
110 120 130 140 150
RQSWKDERLR FKGPMQRLPL NNLLASKIWT PDTFFHNGKK SIAHNMTTPN
160 170 180 190 200
KLLRLEDDGT LLYTMRLTIS AECPMQLEDF PMDAHACPLK FGSYAYPNSE
210 220 230 240 250
VVYVWTNGST KSVVVAEDGS RLNQYHLMGQ TVGTENISTS TGEYTIMTAH
260 270 280 290 300
FHLKRKIGYF VIQTYLPCIM TVILSQVSFW LNRESVPART VFGVTTVLTM
310 320 330 340 350
TTLSISARNS LPKVAYATAM DWFIAVCYAF VFSALIEFAT VNYFTKRGWA
360 370 380 390 400
WDGKKALEAA KIKKKREVIL NKSTNAFTTG KMSHPPNIPK EQTPAGTSNT
410 420 430 440 450
TSVSVKPSEE KTSESKKTYN SISKIDKMSR IVFPVLFGTF NLVYWATYLN
460
REPVIKGAAS PK
Length:462
Mass (Da):52,146
Last modified:July 1, 1993 - v1
Checksum:i260A8B554113AFF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08485 mRNA Translation: AAA58490.1
AK290453 mRNA Translation: BAF83142.1
BT009830 mRNA Translation: AAP88832.1
BC111979 mRNA Translation: AAI11980.1
BC113422 mRNA Translation: AAI13423.1
AF061785 Genomic DNA Translation: AAC31809.1
AF228447 Genomic DNA Translation: AAF62508.1
AF228448 Genomic DNA Translation: AAF62509.1
AF228449 Genomic DNA Translation: AAF62510.1
CCDSiCCDS45194.1
PIRiA48933
RefSeqiNP_000801.1, NM_000810.3
NP_001158509.1, NM_001165037.1
XP_005268315.1, XM_005268258.2
XP_006720522.1, XM_006720459.2
UniGeneiHs.24969

Genome annotation databases

EnsembliENST00000335625; ENSP00000335592; ENSG00000186297
ENST00000355395; ENSP00000347557; ENSG00000186297
ENST00000400081; ENSP00000382953; ENSG00000186297
GeneIDi2558
KEGGihsa:2558
UCSCiuc001zbd.3 human

Similar proteinsi

Entry informationi

Entry nameiGBRA5_HUMAN
AccessioniPrimary (citable) accession number: P31644
Secondary accession number(s): A8K338
, Q14DC2, Q53XL6, Q9NYT3, Q9NYT4, Q9NYT5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: June 20, 2018
This is version 183 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  5. SIMILARITY comments
    Index of protein domains and families

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