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Protein

Sodium/glucose cotransporter 2

Gene

SLC5A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sodium-dependent glucose transporter. Has a Na+ to glucose coupling ratio of 1:1.
Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na+/glucose cotransporter arranged in series along kidney proximal tubules.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei40Implicated in sodium couplingBy similarity1
Sitei300Implicated in sodium couplingBy similarity1

GO - Molecular functioni

  • glucose:sodium symporter activity Source: Reactome
  • low-affinity glucose:sodium symporter activity Source: ProtInc

GO - Biological processi

  • carbohydrate metabolic process Source: ProtInc
  • hexose transmembrane transport Source: Reactome

Keywordsi

Biological processIon transport, Sodium transport, Sugar transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

ReactomeiR-HSA-189200 Cellular hexose transport
R-HSA-5658208 Defective SLC5A2 causes renal glucosuria (GLYS1)
SABIO-RKiP31639
SIGNORiP31639

Protein family/group databases

TCDBi2.A.21.3.16 the solute:sodium symporter (sss) family

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/glucose cotransporter 2
Short name:
Na(+)/glucose cotransporter 2
Alternative name(s):
Low affinity sodium-glucose cotransporter
Solute carrier family 5 member 2
Gene namesi
Name:SLC5A2
Synonyms:SGLT21 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000140675.12
HGNCiHGNC:11037 SLC5A2
MIMi182381 gene
neXtProtiNX_P31639

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25CytoplasmicSequence analysisAdd BLAST25
Transmembranei26 – 44HelicalSequence analysisAdd BLAST19
Topological domaini45 – 61ExtracellularSequence analysisAdd BLAST17
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Topological domaini83 – 102CytoplasmicSequence analysisAdd BLAST20
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Topological domaini124 – 168ExtracellularSequence analysisAdd BLAST45
Transmembranei169 – 188HelicalSequence analysisAdd BLAST20
Topological domaini189 – 205CytoplasmicSequence analysisAdd BLAST17
Transmembranei206 – 226HelicalSequence analysisAdd BLAST21
Topological domaini227 – 270ExtracellularSequence analysisAdd BLAST44
Transmembranei271 – 291HelicalSequence analysisAdd BLAST21
Topological domaini292 – 314CytoplasmicSequence analysisAdd BLAST23
Transmembranei315 – 334HelicalSequence analysisAdd BLAST20
Topological domaini335 – 423ExtracellularSequence analysisAdd BLAST89
Transmembranei424 – 443HelicalSequence analysisAdd BLAST20
Topological domaini444 – 455CytoplasmicSequence analysisAdd BLAST12
Transmembranei456 – 476HelicalSequence analysisAdd BLAST21
Topological domaini477 – 526ExtracellularSequence analysisAdd BLAST50
Transmembranei527 – 547HelicalSequence analysisAdd BLAST21
Topological domaini548 – 650CytoplasmicSequence analysisAdd BLAST103
Transmembranei651 – 671HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Renal glucosuria (GLYS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by persistent isolated glucosuria, normal fasting serum glucose concentration, decreased renal tubular resorption of glucose from the urine, and absence of any other signs of tubular dysfunction.
See also OMIM:233100
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019310654N → S in GLYS. 1 PublicationCorresponds to variant dbSNP:rs61742739EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi6524
MalaCardsiSLC5A2
MIMi233100 phenotype
OpenTargetsiENSG00000140675
Orphaneti69076 Renal glucosuria
PharmGKBiPA35902

Chemistry databases

ChEMBLiCHEMBL3884
DrugBankiDB08907 Canagliflozin
DB06292 Dapagliflozin
DB09038 Empagliflozin
GuidetoPHARMACOLOGYi916

Polymorphism and mutation databases

BioMutaiSLC5A2
DMDMi400337

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001053721 – 672Sodium/glucose cotransporter 2Add BLAST672

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi250N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi399N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP31639
PeptideAtlasiP31639
PRIDEiP31639
ProteomicsDBi54795

PTM databases

CarbonylDBiP31639
iPTMnetiP31639
PhosphoSitePlusiP31639

Expressioni

Gene expression databases

BgeeiENSG00000140675
CleanExiHS_SLC5A2
ExpressionAtlasiP31639 baseline and differential
GenevisibleiP31639 HS

Organism-specific databases

HPAiHPA041603

Interactioni

Protein-protein interaction databases

BioGridi112415, 1 interactor
STRINGi9606.ENSP00000327943

Chemistry databases

BindingDBiP31639

Structurei

3D structure databases

ProteinModelPortaliP31639
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IP49 Eukaryota
COG4146 LUCA
GeneTreeiENSGT00760000118955
HOGENOMiHOG000025422
HOVERGENiHBG052859
InParanoidiP31639
KOiK14382
OMAiGWYWCSD
OrthoDBiEOG091G077U
PhylomeDBiP31639
TreeFamiTF352855

Family and domain databases

Gene3Di1.20.1730.10, 1 hit
InterProiView protein in InterPro
IPR038377 Na/Glc_symporter_sf
IPR001734 Na/solute_symporter
IPR018212 Na/solute_symporter_CS
PfamiView protein in Pfam
PF00474 SSF, 1 hit
TIGRFAMsiTIGR00813 sss, 1 hit
PROSITEiView protein in PROSITE
PS00456 NA_SOLUT_SYMP_1, 1 hit
PS00457 NA_SOLUT_SYMP_2, 1 hit
PS50283 NA_SOLUT_SYMP_3, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P31639-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEHTEAGSA PEMGAQKALI DNPADILVIA AYFLLVIGVG LWSMCRTNRG
60 70 80 90 100
TVGGYFLAGR SMVWWPVGAS LFASNIGSGH FVGLAGTGAA SGLAVAGFEW
110 120 130 140 150
NALFVVLLLG WLFAPVYLTA GVITMPQYLR KRFGGRRIRL YLSVLSLFLY
160 170 180 190 200
IFTKISVDMF SGAVFIQQAL GWNIYASVIA LLGITMIYTV TGGLAALMYT
210 220 230 240 250
DTVQTFVILG GACILMGYAF HEVGGYSGLF DKYLGAATSL TVSEDPAVGN
260 270 280 290 300
ISSFCYRPRP DSYHLLRHPV TGDLPWPALL LGLTIVSGWY WCSDQVIVQR
310 320 330 340 350
CLAGKSLTHI KAGCILCGYL KLTPMFLMVM PGMISRILYP DEVACVVPEV
360 370 380 390 400
CRRVCGTEVG CSNIAYPRLV VKLMPNGLRG LMLAVMLAAL MSSLASIFNS
410 420 430 440 450
SSTLFTMDIY TRLRPRAGDR ELLLVGRLWV VFIVVVSVAW LPVVQAAQGG
460 470 480 490 500
QLFDYIQAVS SYLAPPVSAV FVLALFVPRV NEQGAFWGLI GGLLMGLARL
510 520 530 540 550
IPEFSFGSGS CVQPSACPAF LCGVHYLYFA IVLFFCSGLL TLTVSLCTAP
560 570 580 590 600
IPRKHLHRLV FSLRHSKEER EDLDADEQQG SSLPVQNGCP ESAMEMNEPQ
610 620 630 640 650
APAPSLFRQC LLWFCGMSRG GVGSPPPLTQ EEAAAAARRL EDISEDPSWA
660 670
RVVNLNALLM MAVAVFLWGF YA
Length:672
Mass (Da):72,897
Last modified:July 1, 1993 - v1
Checksum:i233C65F1601B0337
GO
Isoform 2 (identifier: P31639-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     378-458: LRGLMLAVML...GGQLFDYIQA → RLLGTHRGPA...PPPPGLQSPA
     459-672: Missing.

Note: No experimental confirmation available.
Show »
Length:458
Mass (Da):49,357
Checksum:iB8FE8FA645AA481A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019310654N → S in GLYS. 1 PublicationCorresponds to variant dbSNP:rs61742739EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056333378 – 458LRGLM…DYIQA → RLLGTHRGPADGPGTPDSRV LLRLGQLCAALGVPSFPLRR ALPLLRHCAVLLLWPPHPHG LPVHRAHPQKAPPPPGLQSP A in isoform 2. 1 PublicationAdd BLAST81
Alternative sequenceiVSP_056334459 – 672Missing in isoform 2. 1 PublicationAdd BLAST214

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95549 mRNA Translation: AAA36608.1
AC026471 Genomic DNA No translation available.
BC131542 mRNA Translation: AAI31543.1
CCDSiCCDS10714.1 [P31639-1]
PIRiA56765
RefSeqiNP_003032.1, NM_003041.3 [P31639-1]
UniGeneiHs.709195

Genome annotation databases

EnsembliENST00000330498; ENSP00000327943; ENSG00000140675 [P31639-1]
ENST00000419665; ENSP00000410601; ENSG00000140675 [P31639-2]
GeneIDi6524
KEGGihsa:6524
UCSCiuc002ecf.5 human [P31639-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSC5A2_HUMAN
AccessioniPrimary (citable) accession number: P31639
Secondary accession number(s): A2RRD2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: June 20, 2018
This is version 164 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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