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UniProtKB - P31549 (THIP_ECOLI)

Entry version 149 (02 Dec 2020)
Sequence version 2 (01 Nov 1997)
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Protein

Thiamine transport system permease protein ThiP

Gene

thiP

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Part of the ABC transporter complex ThiBPQ involved in thiamine import (PubMed:12175925). Probably responsible for the translocation of the substrate across the membrane (Probable).Curated1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Transport is inhibited by the sulfhydryl-specific modifier N-ethylmaleimide.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:SFUB-MONOMER
MetaCyc:SFUB-MONOMER

Protein family/group databases

Transport Classification Database

More...TCDBi		3.A.1.19.1, the atp-binding cassette (abc) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Thiamine transport system permease protein ThiP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:thiP
Synonyms:yabK
Ordered Locus Names:b0067, JW0066
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei12 – 32HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei58 – 78HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei95 – 115HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei134 – 154HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei199 – 219HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei240 – 260HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei293 – 313HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei334 – 354HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei374 – 394HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei404 – 424HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei463 – 483HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei506 – 526HelicalPROSITE-ProRule annotationAdd BLAST21

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000602301 – 536Thiamine transport system permease protein ThiPAdd BLAST536

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P31549

PRoteomics IDEntifications database

More...PRIDEi		P31549

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The complex is composed of two ATP-binding proteins (ThiQ), two transmembrane proteins (ThiP) and a solute-binding protein (ThiB).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		4263358, 12 interactors
849186, 1 interactor

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-4387, Thiamine ABC transporter complex

Database of interacting proteins

More...DIPi		DIP-10989N

Protein interaction database and analysis system

More...IntActi		P31549, 1 interactor

STRING: functional protein association networks

More...STRINGi		511145.b0067

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P31549

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini56 – 261ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST206
Domaini331 – 525ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST195

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG1178, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_021838_5_3_6

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P31549

Database for complete collections of gene phylogenies

More...PhylomeDBi		P31549

Family and domain databases

Conserved Domains Database

More...CDDi		cd06261, TM_PBP2, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.3720.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000515, MetI-like
IPR035906, MetI-like_sf
IPR005947, ThiP_ABC_transpt

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00528, BPD_transp_1, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF161098, SSF161098, 2 hits

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01253, thiP, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50928, ABC_TM1, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P31549-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATRRQPLIP GWLIPGVSAT TLVVAVALAA FLALWWNAPQ DDWVAVWQDS 
        60         70         80         90        100
YLWHVVRFSF WQAFLSALLS VIPAIFLARA LYRRRFPGRL ALLRLCAMTL 
       110        120        130        140        150
ILPVLVAVFG ILSVYGRQGW LATLCQSLGL EWTFSPYGLQ GILLAHVFFN 
       160        170        180        190        200
LPMASRLLLQ ALENIPGEQR QLAAQLGMRS WHFFRFVEWP WLRRQIPPVA 
       210        220        230        240        250
ALIFMLCFAS FATVLSLGGG PQATTIELAI YQALSYDYDP ARAAMLALLQ 
       260        270        280        290        300
MVCCLGLVLL SQRLSKAIAP GTTLLQGWRD PDDRLHSRIC DTVLIVLALL 
       310        320        330        340        350
LLLPPLLAVI VDGVNRQLPE VLAQPVLWQA LWTSLRIALA AGVLCVVLTM 
       360        370        380        390        400
MLLWSSRELR ARQKMLAGQV LEMSGMLILA MPGIVLATGF FLLLNNTIGL 
       410        420        430        440        450
PQSADGIVIF TNALMAIPYA LKVLENPMRD ITARYSMLCQ SLGIEGWSRL 
       460        470        480        490        500
KVVELRALKR PLAQALAFAC VLSIGDFGVV ALFGNDDFRT LPFYLYQQIG 
       510        520        530 
SYRSQDGAVT ALILLLLCFL LFTVIEKLPG RNVKTD
Length:536
Mass (Da):59,533
Last modified:November 1, 1997 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF6F559EDA92B8C2A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC73178.1
AP009048 Genomic DNA Translation: BAB96636.2

Protein sequence database of the Protein Information Resource

More...PIRi		C64728

NCBI Reference Sequences

More...RefSeqi		NP_414609.1, NC_000913.3
WP_000235721.1, NZ_STEB01000010.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC73178; AAC73178; b0067
BAB96636; BAB96636; BAB96636

Database of genes from NCBI RefSeq genomes

More...GeneIDi		944784

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW0066
eco:b0067

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|1411691.4.peg.2215

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC73178.1
AP009048 Genomic DNA Translation: BAB96636.2
PIRiC64728
RefSeqiNP_414609.1, NC_000913.3
WP_000235721.1, NZ_STEB01000010.1

3D structure databases

SMRiP31549
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi4263358, 12 interactors
849186, 1 interactor
ComplexPortaliCPX-4387, Thiamine ABC transporter complex
DIPiDIP-10989N
IntActiP31549, 1 interactor
STRINGi511145.b0067

Protein family/group databases

TCDBi3.A.1.19.1, the atp-binding cassette (abc) superfamily

Proteomic databases

PaxDbiP31549
PRIDEiP31549

Genome annotation databases

EnsemblBacteriaiAAC73178; AAC73178; b0067
BAB96636; BAB96636; BAB96636
GeneIDi944784
KEGGiecj:JW0066
eco:b0067
PATRICifig|1411691.4.peg.2215

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB1533

Phylogenomic databases

eggNOGiCOG1178, Bacteria
HOGENOMiCLU_021838_5_3_6
InParanoidiP31549
PhylomeDBiP31549

Enzyme and pathway databases

BioCyciEcoCyc:SFUB-MONOMER
MetaCyc:SFUB-MONOMER

Miscellaneous databases

Protein Ontology

More...PROi		PR:P31549

Family and domain databases

CDDicd06261, TM_PBP2, 2 hits
Gene3Di1.10.3720.10, 2 hits
InterProiView protein in InterPro
IPR000515, MetI-like
IPR035906, MetI-like_sf
IPR005947, ThiP_ABC_transpt
PfamiView protein in Pfam
PF00528, BPD_transp_1, 2 hits
SUPFAMiSSF161098, SSF161098, 2 hits
TIGRFAMsiTIGR01253, thiP, 1 hit
PROSITEiView protein in PROSITE
PS50928, ABC_TM1, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTHIP_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P31549
Secondary accession number(s): P75636
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: November 1, 1997
Last modified: December 2, 2020
This is version 149 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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