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Protein

Dimethylaniline monooxygenase [N-oxide-forming] 4

Gene

FMO4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides.

Caution

Was originally termed FMO2.1 Publication

Catalytic activityi

N,N-dimethylaniline + NADPH + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei32FADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 13FADBy similarity5
Nucleotide bindingi40 – 41FADBy similarity2
Nucleotide bindingi60 – 61NADPBy similarity2
Nucleotide bindingi195 – 198NADPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandFAD, Flavoprotein, NADP

Enzyme and pathway databases

BRENDAi1.14.13.8 2681

Names & Taxonomyi

Protein namesi
Recommended name:
Dimethylaniline monooxygenase [N-oxide-forming] 4 (EC:1.14.13.8)
Alternative name(s):
Dimethylaniline oxidase 4
Hepatic flavin-containing monooxygenase 4
Short name:
FMO 4
Gene namesi
Name:FMO4
Synonyms:FMO2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000076258.9
HGNCiHGNC:3772 FMO4
MIMi136131 gene
neXtProtiNX_P31512

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei517 – 537HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

DisGeNETi2329
OpenTargetsiENSG00000076258
PharmGKBiPA28188

Chemistry databases

ChEMBLiCHEMBL3542432

Polymorphism and mutation databases

BioMutaiFMO4
DMDMi399506

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001476601 – 558Dimethylaniline monooxygenase [N-oxide-forming] 4Add BLAST558

Proteomic databases

PaxDbiP31512
PeptideAtlasiP31512
PRIDEiP31512
ProteomicsDBi54792

PTM databases

iPTMnetiP31512
PhosphoSitePlusiP31512

Expressioni

Tissue specificityi

Liver.

Gene expression databases

BgeeiENSG00000076258
CleanExiHS_FMO2
HS_FMO4
GenevisibleiP31512 HS

Organism-specific databases

HPAiHPA049100

Interactioni

Protein-protein interaction databases

BioGridi108616, 1 interactor
STRINGi9606.ENSP00000356723

Structurei

3D structure databases

ProteinModelPortaliP31512
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FMO family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1399 Eukaryota
COG2072 LUCA
GeneTreeiENSGT00760000119232
HOGENOMiHOG000076537
HOVERGENiHBG002037
InParanoidiP31512
KOiK00485
OMAiPLKSLCT
OrthoDBiEOG091G0465
PhylomeDBiP31512
TreeFamiTF105285

Family and domain databases

Gene3Di3.50.50.60, 4 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR000960 Flavin_mOase
IPR020946 Flavin_mOase-like
IPR002256 Flavin_mOase_4
PfamiView protein in Pfam
PF00743 FMO-like, 1 hit
PIRSFiPIRSF000332 FMO, 1 hit
PRINTSiPR00370 FMOXYGENASE
PR01124 FMOXYGENASE4
SUPFAMiSSF51905 SSF51905, 2 hits

Sequencei

Sequence statusi: Complete.

P31512-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKKVAVIGA GVSGLSSIKC CVDEDLEPTC FERSDDIGGL WKFTESSKDG
60 70 80 90 100
MTRVYKSLVT NVCKEMSCYS DFPFHEDYPN FMNHEKFWDY LQEFAEHFDL
110 120 130 140 150
LKYIQFKTTV CSITKRPDFS ETGQWDVVTE TEGKQNRAVF DAVMVCTGHF
160 170 180 190 200
LNPHLPLEAF PGIHKFKGQI LHSQEYKIPE GFQGKRVLVI GLGNTGGDIA
210 220 230 240 250
VELSRTAAQV LLSTRTGTWV LGRSSDWGYP YNMMVTRRCC SFIAQVLPSR
260 270 280 290 300
FLNWIQERKL NKRFNHEDYG LSITKGKKAK FIVNDELPNC ILCGAITMKT
310 320 330 340 350
SVIEFTETSA VFEDGTVEEN IDVVIFTTGY TFSFPFFEEP LKSLCTKKIF
360 370 380 390 400
LYKQVFPLNL ERATLAIIGL IGLKGSILSG TELQARWVTR VFKGLCKIPP
410 420 430 440 450
SQKLMMEATE KEQLIKRGVF KDTSKDKFDY IAYMDDIAAC IGTKPSIPLL
460 470 480 490 500
FLKDPRLAWE VFFGPCTPYQ YRLMGPGKWD GARNAILTQW DRTLKPLKTR
510 520 530 540 550
IVPDSSKPAS MSHYLKAWGA PVLLASLLLI CKSSLFLKLV RDKLQDRMSP

YLVSLWRG
Length:558
Mass (Da):63,343
Last modified:January 23, 2007 - v3
Checksum:i6981AE9180C07802
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01536737I → T1 PublicationCorresponds to variant dbSNP:rs72549338Ensembl.1
Natural variantiVAR_049090308T → S. Corresponds to variant dbSNP:rs3737925Ensembl.1
Natural variantiVAR_015368323V → A2 PublicationsCorresponds to variant dbSNP:rs1042767Ensembl.1
Natural variantiVAR_015369339E → Q1 PublicationCorresponds to variant dbSNP:rs61342270Ensembl.1
Natural variantiVAR_022305372G → S1 PublicationCorresponds to variant dbSNP:rs45599742Ensembl.1
Natural variantiVAR_022306536F → L1 PublicationCorresponds to variant dbSNP:rs45487792Ensembl.1
Natural variantiVAR_022307544L → R1 PublicationCorresponds to variant dbSNP:rs45528740Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11737 mRNA Translation: CAA77797.1
AY882422 Genomic DNA Translation: AAW56938.1
BT007444 mRNA Translation: AAP36112.1
AL031274 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90896.1
BC002780 mRNA Translation: AAH02780.1
CCDSiCCDS1295.1
PIRiS29125
RefSeqiNP_002013.1, NM_002022.2
UniGeneiHs.386502

Genome annotation databases

EnsembliENST00000367749; ENSP00000356723; ENSG00000076258
GeneIDi2329
KEGGihsa:2329
UCSCiuc001gho.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFMO4_HUMAN
AccessioniPrimary (citable) accession number: P31512
Secondary accession number(s): Q53XR0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 163 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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