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Entry version 96 (02 Jun 2021)
Sequence version 2 (15 Dec 1998)
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Protein

Hemin receptor

Gene

hemR

Organism
Yersinia enterocolitica
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This protein is involved in the initial step of iron uptake by binding hemin, an iron chelatin siderophore that allows the bacteria to extract iron from the environment.

Miscellaneous

Weakly expressed by yersiniae located in the liver and the intestinal lumen. Strongly expressed in yersiniae located in the peritoneal cavity. Moderately expressed in yersiniae located in the spleen. This probably reflects the availability of iron for yersiniae.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processIon transport, Iron transport, Transport
LigandIron

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.B.14.2.2, the outer membrane receptor (omr) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Hemin receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:hemR
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiYersinia enterocolitica
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri630 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell outer membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28Sequence analysisAdd BLAST28
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003475829 – 687Hemin receptorAdd BLAST659

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced in absence of iron.

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P31499

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni319 – 338DisorderedSequence analysisAdd BLAST20

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi44 – 51TonB box8
Motifi670 – 687TonB C-terminal boxAdd BLAST18

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TonB-dependent receptor family.Curated

Keywords - Domaini

Signal, TonB box, Transmembrane, Transmembrane beta strand

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.170.130.10, 1 hit
2.40.170.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039426, BtuB-like
IPR012910, Plug_dom
IPR037066, Plug_dom_sf
IPR000531, TonB-dep_rcpt_b-brl
IPR010916, TonB_box_CS
IPR011276, TonB_haem/Hb_rcpt
IPR010949, TonB_Hb/transfer/lactofer_rcpt
IPR036942, TonB_rcpt_b-brl_sf

The PANTHER Classification System

More...
PANTHERi
PTHR30069, PTHR30069, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07715, Plug, 1 hit
PF00593, TonB_dep_Rec, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01785, TonB-hemin, 1 hit
TIGR01786, TonB-hemlactrns, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00430, TONB_DEPENDENT_REC_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P31499-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRSTSDRFR WSPLSLAIAC TLSLAVQAAD TSSTQTNSKK RIADTMVVTA
60 70 80 90 100
TGNERSSFEA PMMVTVVEAD TPTSETATSA TDMLRNIPGL TVTGSGRVNG
110 120 130 140 150
QDVTLRGYGK QGVLTLVDGI RQGTDTGHLN STFLDPALVK RVEIVRGPSA
160 170 180 190 200
LLYGSGALGG VISYETVDAA DLLLPGQNSG YRVYSAAATG DHSFGLGASA
210 220 230 240 250
FGRTDDVDGI LSFGTRDIGN IRQSDGFNAP NDETISNVLA KGTWRIDQIQ
260 270 280 290 300
SLSANLRYYN NSALEPKNPQ TSAASSTNLM TDRSTIQRDA QLKYNIKPLD
310 320 330 340 350
QEWLNATAQV YYSEVEINAR PQGTPEEGRK QTTKGGKLEN RTRLFTDSFA
360 370 380 390 400
SHLLTYGTEA YKQEQTPSGA TESFPQADIR FGSGWLQDEI TLRDLPVSIL
410 420 430 440 450
AGTRYDNYRG SSEGYADVDA DKWSSRGAVS VTPTDWLMLF GSYAQAFRAP
460 470 480 490 500
TMGEMYNDSK HFSMNIMGNT LTNYWVPNPN LKPETNETQE YGFGLRFNDL
510 520 530 540 550
MMAEDDLQFK ASYFDTNAKD YISTGVTMDF GFGPGGLYCK NCSTYSTNID
560 570 580 590 600
RAKIWGWDAT MTYQTQWFNL GLAYNRTRGK NQNTNEWLDT INPDTVTSTL
610 620 630 640 650
DVPVANSGFA VGWIGTFADR SSRVSSSGTP QAGYGVNDFY VSYKGQEQFK
660 670 680
GMTTTVVLGN AFDKGYYGPQ GVPQDGRNAK FFVSYQW
Length:687
Mass (Da):75,226
Last modified:December 15, 1998 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i69092EF97F5DC08A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X68147 Genomic DNA Translation: CAA48250.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S28042

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68147 Genomic DNA Translation: CAA48250.1
PIRiS28042

3D structure databases

SMRiP31499
ModBaseiSearch...

Protein family/group databases

TCDBi1.B.14.2.2, the outer membrane receptor (omr) family

Family and domain databases

Gene3Di2.170.130.10, 1 hit
2.40.170.20, 1 hit
InterProiView protein in InterPro
IPR039426, BtuB-like
IPR012910, Plug_dom
IPR037066, Plug_dom_sf
IPR000531, TonB-dep_rcpt_b-brl
IPR010916, TonB_box_CS
IPR011276, TonB_haem/Hb_rcpt
IPR010949, TonB_Hb/transfer/lactofer_rcpt
IPR036942, TonB_rcpt_b-brl_sf
PANTHERiPTHR30069, PTHR30069, 1 hit
PfamiView protein in Pfam
PF07715, Plug, 1 hit
PF00593, TonB_dep_Rec, 1 hit
TIGRFAMsiTIGR01785, TonB-hemin, 1 hit
TIGR01786, TonB-hemlactrns, 1 hit
PROSITEiView protein in PROSITE
PS00430, TONB_DEPENDENT_REC_1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHEMR_YEREN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P31499
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: December 15, 1998
Last modified: June 2, 2021
This is version 96 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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