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UniProtKB - P31462 (MDTL_ECOLI)
Protein
Multidrug resistance protein MdtL
Gene
mdtL
Organism
Escherichia coli (strain K12)
Status
Functioni
Confers resistance to chloramphenicol.
1 PublicationGO - Molecular functioni
- transmembrane transporter activity Source: GO_Central
GO - Biological processi
- response to antibiotic Source: UniProtKB-KW
- transmembrane transport Source: GO_Central
- xenobiotic detoxification by transmembrane export across the plasma membrane Source: GO_Central
Keywordsi
Biological process | Antibiotic resistance, Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:YIDY-MONOMER |
Protein family/group databases
TCDBi | 2.A.1.2.22, the major facilitator superfamily (mfs) |
Names & Taxonomyi
Protein namesi | Recommended name: Multidrug resistance protein MdtL |
Gene namesi | Name:mdtL Synonyms:yidY Ordered Locus Names:b3710, JW3688 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: EcoCyc
- plasma membrane Source: EcoCyc
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 3 | CytoplasmicSequence analysis | 3 | |
Transmembranei | 4 – 24 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 25 – 41 | PeriplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 42 – 62 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 63 – 68 | CytoplasmicSequence analysis | 6 | |
Transmembranei | 69 – 89 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 90 – 92 | PeriplasmicSequence analysis | 3 | |
Transmembranei | 93 – 113 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 114 – 130 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 131 – 151 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 152 – 157 | PeriplasmicSequence analysis | 6 | |
Transmembranei | 158 – 178 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 179 – 202 | CytoplasmicSequence analysisAdd BLAST | 24 | |
Transmembranei | 203 – 222 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 223 – 244 | PeriplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 245 – 265 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 266 – 268 | CytoplasmicSequence analysis | 3 | |
Transmembranei | 269 – 289 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 290 – 292 | PeriplasmicSequence analysis | 3 | |
Transmembranei | 293 – 313 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 314 – 330 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 331 – 351 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 352 – 355 | PeriplasmicSequence analysis | 4 | |
Transmembranei | 356 – 376 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 377 – 391 | CytoplasmicSequence analysisAdd BLAST | 15 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000173354 | 1 – 391 | Multidrug resistance protein MdtLAdd BLAST | 391 |
Proteomic databases
PaxDbi | P31462 |
PRIDEi | P31462 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4262213, 171 interactors |
DIPi | DIP-12457N |
IntActi | P31462, 1 interactor |
STRINGi | 511145.b3710 |
Family & Domainsi
Sequence similaritiesi
Belongs to the major facilitator superfamily. DHA1 family. MdtL (TC 2.A.1.2.22) subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG2814, Bacteria |
HOGENOMi | CLU_001265_47_1_6 |
InParanoidi | P31462 |
OMAi | AGSCYVV |
PhylomeDBi | P31462 |
Family and domain databases
HAMAPi | MF_01530, MFS_MdtL, 1 hit |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf IPR023697, Multidrug-R_MdtL |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
i Sequence
Sequence statusi: Complete.
P31462-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSRFLICSFA LVLLYPAGID MYLVGLPRIA ADLNASEAQL HIAFSVYLAG
60 70 80 90 100
MAAAMLFAGK VADRSGRKPV AIPGAALFII ASVFCSLAET STLFLAGRFL
110 120 130 140 150
QGLGAGCCYV VAFAILRDTL DDRRRAKVLS LLNGITCIIP VLAPVLGHLI
160 170 180 190 200
MLKFPWQSLF WAMAMMGIAV LMLSLFILKE TRPAAPAASD KPRENSESLL
210 220 230 240 250
NRFFLSRVVI TTLSVSVILT FVNTSPVLLM EIMGFERGEY ATIMALTAGV
260 270 280 290 300
SMTVSFSTPF ALGIFKPRTL MITSQVLFLA AGITLAVSPS HAVSLFGITL
310 320 330 340 350
ICAGFSVGFG VAMSQALGPF SLRAGVASST LGIAQVCGSS LWIWLAAVVG
360 370 380 390
IGAWNMLIGI LIACSIVSLL LIMFVAPGRP VAAHEEIHHH A
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L10328 Genomic DNA Translation: AAA62061.1 U00096 Genomic DNA Translation: AAC76733.1 AP009048 Genomic DNA Translation: BAE77580.1 |
PIRi | G65173 |
RefSeqi | NP_418166.1, NC_000913.3 WP_000085982.1, NZ_STEB01000015.1 |
Genome annotation databases
EnsemblBacteriai | AAC76733; AAC76733; b3710 BAE77580; BAE77580; BAE77580 |
GeneIDi | 948219 |
KEGGi | ecj:JW3688 eco:b3710 |
PATRICi | fig|1411691.4.peg.2991 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L10328 Genomic DNA Translation: AAA62061.1 U00096 Genomic DNA Translation: AAC76733.1 AP009048 Genomic DNA Translation: BAE77580.1 |
PIRi | G65173 |
RefSeqi | NP_418166.1, NC_000913.3 WP_000085982.1, NZ_STEB01000015.1 |
3D structure databases
AlphaFoldDBi | P31462 |
SMRi | P31462 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4262213, 171 interactors |
DIPi | DIP-12457N |
IntActi | P31462, 1 interactor |
STRINGi | 511145.b3710 |
Protein family/group databases
TCDBi | 2.A.1.2.22, the major facilitator superfamily (mfs) |
Proteomic databases
PaxDbi | P31462 |
PRIDEi | P31462 |
Genome annotation databases
EnsemblBacteriai | AAC76733; AAC76733; b3710 BAE77580; BAE77580; BAE77580 |
GeneIDi | 948219 |
KEGGi | ecj:JW3688 eco:b3710 |
PATRICi | fig|1411691.4.peg.2991 |
Organism-specific databases
EchoBASEi | EB1671 |
Phylogenomic databases
eggNOGi | COG2814, Bacteria |
HOGENOMi | CLU_001265_47_1_6 |
InParanoidi | P31462 |
OMAi | AGSCYVV |
PhylomeDBi | P31462 |
Enzyme and pathway databases
BioCyci | EcoCyc:YIDY-MONOMER |
Miscellaneous databases
PROi | PR:P31462 |
Family and domain databases
HAMAPi | MF_01530, MFS_MdtL, 1 hit |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf IPR023697, Multidrug-R_MdtL |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MDTL_ECOLI | |
Accessioni | P31462Primary (citable) accession number: P31462 Secondary accession number(s): P76739, Q2M826 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | November 1, 1997 | |
Last modified: | May 25, 2022 | |
This is version 157 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families