UniProtKB - P31459 (DGOK_ECOLI)
Protein
2-dehydro-3-deoxygalactonokinase
Gene
dgoK
Organism
Escherichia coli (strain K12)
Status
Functioni
Catalytic activityi
- EC:2.7.1.58
: D-galactonate degradation Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and pyruvate from D-galactonate.Proteins known to be involved in the 3 steps of the subpathway in this organism are:
- D-galactonate dehydratase (dgoD), D-galactonate dehydratase (dgoD)
- 2-dehydro-3-deoxygalactonokinase (dgoK)
- 2-dehydro-3-deoxy-6-phosphogalactonate aldolase (dgoA)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and pyruvate from D-galactonate, the pathway D-galactonate degradation and in Carbohydrate acid metabolism.
GO - Molecular functioni
- 2-dehydro-3-deoxygalactonokinase activity Source: EcoCyc
- ATP binding Source: UniProtKB-KW
GO - Biological processi
- D-galactonate catabolic process Source: EcoCyc
Keywordsi
Molecular function | Kinase, Transferase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | EcoCyc:DEHYDDEOXGALACTKIN-MONOMER MetaCyc:DEHYDDEOXGALACTKIN-MONOMER |
UniPathwayi | UPA00081;UER00519 |
Names & Taxonomyi
Protein namesi | Recommended name: 2-dehydro-3-deoxygalactonokinase (EC:2.7.1.58)Alternative name(s): 2-keto-3-deoxy-galactonokinase 2-oxo-3-deoxygalactonate kinase |
Gene namesi | Name:dgoK Synonyms:yidV Ordered Locus Names:b3693, JW3670 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000079881 | 1 – 292 | 2-dehydro-3-deoxygalactonokinaseAdd BLAST | 292 |
Proteomic databases
PaxDbi | P31459 |
PRIDEi | P31459 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4263413, 153 interactors |
IntActi | P31459, 3 interactors |
STRINGi | 511145.b3693 |
Family & Domainsi
Sequence similaritiesi
Belongs to the DgoK family.Curated
Phylogenomic databases
eggNOGi | COG3734, Bacteria |
HOGENOMi | CLU_058005_2_0_6 |
InParanoidi | P31459 |
PhylomeDBi | P31459 |
Family and domain databases
Gene3Di | 3.30.420.300, 1 hit 3.30.420.310, 1 hit |
InterProi | View protein in InterPro IPR007729, DGOK IPR042257, DGOK_C IPR042258, DGOK_N |
Pfami | View protein in Pfam PF05035, DGOK, 1 hit |
i Sequence
Sequence statusi: Complete.
P31459-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTARYIAIDW GSTNLRAWLY QGDHCLESRQ SEAGVTRLNG KSPAAVLAEV
60 70 80 90 100
TTDWREEKTP VVMAGMVGSN VGWKVAPYLS VPACFSSIGE QLTSVGDNIW
110 120 130 140 150
IIPGLCVSHD DNHNVMRGEE TQLIGARALA PSSLYVMPGT HCKWVQADSQ
160 170 180 190 200
QINDFRTVMT GELHHLLLNH SLIGAGLPPQ ENSADAFTAG LERGLNTPAI
210 220 230 240 250
LPQLFEVRAS HVLGTLPREQ VSEFLSGLLI GAEVASMRDY VAHQHAITLV
260 270 280 290
AGTSLTARYQ QAFQAMGCDV TAVAGDTAFQ AGIRSIAHAV AN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L10328 Genomic DNA Translation: AAA62045.1 U00096 Genomic DNA Translation: AAC76716.1 AP009048 Genomic DNA Translation: BAE77600.1 |
PIRi | F65171 |
RefSeqi | NP_418148.1, NC_000913.3 WP_000127091.1, NZ_SSZK01000035.1 |
Genome annotation databases
EnsemblBacteriai | AAC76716; AAC76716; b3693 BAE77600; BAE77600; BAE77600 |
GeneIDi | 948207 |
KEGGi | ecj:JW3670 eco:b3693 |
PATRICi | fig|1411691.4.peg.3009 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L10328 Genomic DNA Translation: AAA62045.1 U00096 Genomic DNA Translation: AAC76716.1 AP009048 Genomic DNA Translation: BAE77600.1 |
PIRi | F65171 |
RefSeqi | NP_418148.1, NC_000913.3 WP_000127091.1, NZ_SSZK01000035.1 |
3D structure databases
SMRi | P31459 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4263413, 153 interactors |
IntActi | P31459, 3 interactors |
STRINGi | 511145.b3693 |
Proteomic databases
PaxDbi | P31459 |
PRIDEi | P31459 |
Genome annotation databases
EnsemblBacteriai | AAC76716; AAC76716; b3693 BAE77600; BAE77600; BAE77600 |
GeneIDi | 948207 |
KEGGi | ecj:JW3670 eco:b3693 |
PATRICi | fig|1411691.4.peg.3009 |
Organism-specific databases
EchoBASEi | EB1668 |
Phylogenomic databases
eggNOGi | COG3734, Bacteria |
HOGENOMi | CLU_058005_2_0_6 |
InParanoidi | P31459 |
PhylomeDBi | P31459 |
Enzyme and pathway databases
UniPathwayi | UPA00081;UER00519 |
BioCyci | EcoCyc:DEHYDDEOXGALACTKIN-MONOMER MetaCyc:DEHYDDEOXGALACTKIN-MONOMER |
Miscellaneous databases
PROi | PR:P31459 |
Family and domain databases
Gene3Di | 3.30.420.300, 1 hit 3.30.420.310, 1 hit |
InterProi | View protein in InterPro IPR007729, DGOK IPR042257, DGOK_C IPR042258, DGOK_N |
Pfami | View protein in Pfam PF05035, DGOK, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DGOK_ECOLI | |
Accessioni | P31459Primary (citable) accession number: P31459 Secondary accession number(s): Q2M806 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | July 1, 1993 | |
Last modified: | December 2, 2020 | |
This is version 128 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families