UniProtKB - P31450 (GLVG_ECOLI)
Protein
Putative inactive 6-phospho-alpha-glucosidase
Gene
glvG
Organism
Escherichia coli (strain K12)
Status
Functioni
Miscellaneous
The GlvG polypeptide of 212 residues cross-reacts with antibodies prepared against the full-length 6-phospho-alpha-D-glucosidase (MalH) from Fusobacterium mortiferum. This operon may be cryptic in wild-type K12 strains (Probable).1 Publication
Caution
Could be the product of a pseudogene. Lacks the C-terminal half of the catalytic domain found in other members of this family. This truncated polypeptide does not display phospho-alpha- or phospho-beta-glucosidase activity (PubMed:9209025).1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 169 | ManganeseBy similarity | 1 | |
Metal bindingi | 200 | ManganeseBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 4 – 70 | NADBy similarityAdd BLAST | 67 |
GO - Molecular functioni
- hydrolase activity, hydrolyzing O-glycosyl compounds Source: InterPro
- metal ion binding Source: UniProtKB-KW
- oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Source: InterPro
GO - Biological processi
- carbohydrate metabolic process Source: InterPro
Keywordsi
Ligand | Manganese, Metal-binding, NAD |
Enzyme and pathway databases
BioCyci | EcoCyc:EG11708-MONOMER |
Protein family/group databases
CAZyi | GH4, Glycoside Hydrolase Family 4 |
Names & Taxonomyi
Protein namesi | Recommended name: Putative inactive 6-phospho-alpha-glucosidase |
Gene namesi | Name:glvG1 Publication Ordered Locus Names:b4556 ORF Names:b3681 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000169860 | 1 – 212 | Putative inactive 6-phospho-alpha-glucosidaseAdd BLAST | 212 |
Proteomic databases
PRIDEi | P31450 |
Family & Domainsi
Sequence similaritiesi
Belongs to the glycosyl hydrolase 4 family.Curated
Phylogenomic databases
PhylomeDBi | P31450 |
Family and domain databases
Gene3Di | 3.90.110.10, 1 hit |
InterProi | View protein in InterPro IPR019802, GlycHydrolase_4_CS IPR001088, Glyco_hydro_4 IPR015955, Lactate_DH/Glyco_Ohase_4_C IPR036291, NAD(P)-bd_dom_sf |
PANTHERi | PTHR32092, PTHR32092, 1 hit |
Pfami | View protein in Pfam PF02056, Glyco_hydro_4, 1 hit |
PRINTSi | PR00732, GLHYDRLASE4 |
SUPFAMi | SSF51735, SSF51735, 1 hit SSF56327, SSF56327, 1 hit |
PROSITEi | View protein in PROSITE PS01324, GLYCOSYL_HYDROL_F4, 1 hit |
i Sequence
Sequence statusi: Complete.
P31450-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTKFSVVVAG GGSTFTPGIV LMLLANQDRF PLRALKFYDN DGARQEVIAE
60 70 80 90 100
ACKVILKEKA PDIAFSYTTD PEVAFSDVDF VMAHIRVGKY PMRELDEKIP
110 120 130 140 150
LRHGVVGQET CGPGGIAYGM RSIGGVLELV DYMEKYSPNA WMLNYSNPAA
160 170 180 190 200
IVAEATRRLR PNAKILNICD MPIGIESRMA QIVGLQDRKQ MRVRYYGLNH
210
WWSAISRSFR KG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L10328 Genomic DNA Translation: AAA62033.1 U00096 Genomic DNA Translation: AYC08251.1 |
PIRi | B65170 |
Genome annotation databases
EnsemblBacteriai | AYC08251; AYC08251; b3681 |
PATRICi | fig|83333.103.peg.4616 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L10328 Genomic DNA Translation: AAA62033.1 U00096 Genomic DNA Translation: AYC08251.1 |
PIRi | B65170 |
3D structure databases
SMRi | P31450 |
ModBasei | Search... |
Protein-protein interaction databases
DIPi | DIP-9813N |
IntActi | P31450, 7 interactors |
Protein family/group databases
CAZyi | GH4, Glycoside Hydrolase Family 4 |
Proteomic databases
PRIDEi | P31450 |
Genome annotation databases
EnsemblBacteriai | AYC08251; AYC08251; b3681 |
PATRICi | fig|83333.103.peg.4616 |
Organism-specific databases
EchoBASEi | EB1659 |
Phylogenomic databases
PhylomeDBi | P31450 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG11708-MONOMER |
Family and domain databases
Gene3Di | 3.90.110.10, 1 hit |
InterProi | View protein in InterPro IPR019802, GlycHydrolase_4_CS IPR001088, Glyco_hydro_4 IPR015955, Lactate_DH/Glyco_Ohase_4_C IPR036291, NAD(P)-bd_dom_sf |
PANTHERi | PTHR32092, PTHR32092, 1 hit |
Pfami | View protein in Pfam PF02056, Glyco_hydro_4, 1 hit |
PRINTSi | PR00732, GLHYDRLASE4 |
SUPFAMi | SSF51735, SSF51735, 1 hit SSF56327, SSF56327, 1 hit |
PROSITEi | View protein in PROSITE PS01324, GLYCOSYL_HYDROL_F4, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GLVG_ECOLI | |
Accessioni | P31450Primary (citable) accession number: P31450 Secondary accession number(s): A0A385XMQ3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | July 1, 1993 | |
Last modified: | April 7, 2021 | |
This is version 130 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Glycosyl hydrolases
Classification of glycosyl hydrolase families and list of entries - SIMILARITY comments
Index of protein domains and families