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Protein

Putative inactive 6-phospho-alpha-glucosidase

Gene

glvG

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

Miscellaneous

The GlvG polypeptide of 212 residues cross-reacts with anti-body prepared against the full-length 6-phospho-alpha-D-glucosidase (MalH) from Fusobacterium mortiferum. This operon may be cryptic in wild-type K12 strains (Probable).1 Publication

Caution

Could be the product of a pseudogene. Lacks the C-terminal half of the catalytic domain found in other members of this family. This truncated polypeptide does not display phospho-alpha- or phospho-beta-glucosidase activity (PubMed:9209025).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi169ManganeseBy similarity1
Metal bindingi200ManganeseBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi4 – 70NADBy similarityAdd BLAST67

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandManganese, Metal-binding, NAD

Enzyme and pathway databases

BioCyciEcoCyc:EG11708-MONOMER

Protein family/group databases

CAZyiGH4 Glycoside Hydrolase Family 4

Names & Taxonomyi

Protein namesi
Recommended name:
Putative inactive 6-phospho-alpha-glucosidase
Gene namesi
Name:glvG1 Publication
Ordered Locus Names:b4556
ORF Names:b3681
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11708 glvG

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001698601 – 212Putative inactive 6-phospho-alpha-glucosidaseAdd BLAST212

Proteomic databases

PRIDEiP31450

Interactioni

Protein-protein interaction databases

DIPiDIP-9813N
IntActiP31450, 7 interactors

Structurei

3D structure databases

ProteinModelPortaliP31450
SMRiP31450
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 4 family.Curated

Phylogenomic databases

HOGENOMiHOG000202516
PhylomeDBiP31450

Family and domain databases

Gene3Di3.90.110.10, 1 hit
InterProiView protein in InterPro
IPR019802 GlycHydrolase_4_CS
IPR001088 Glyco_hydro_4
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR32092 PTHR32092, 1 hit
PfamiView protein in Pfam
PF02056 Glyco_hydro_4, 1 hit
PRINTSiPR00732 GLHYDRLASE4
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
PROSITEiView protein in PROSITE
PS01324 GLYCOSYL_HYDROL_F4, 1 hit

Sequencei

Sequence statusi: Complete.

P31450-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTKFSVVVAG GGSTFTPGIV LMLLANQDRF PLRALKFYDN DGARQEVIAE
60 70 80 90 100
ACKVILKEKA PDIAFSYTTD PEVAFSDVDF VMAHIRVGKY PMRELDEKIP
110 120 130 140 150
LRHGVVGQET CGPGGIAYGM RSIGGVLELV DYMEKYSPNA WMLNYSNPAA
160 170 180 190 200
IVAEATRRLR PNAKILNICD MPIGIESRMA QIVGLQDRKQ MRVRYYGLNH
210
WWSAISRSFR KG
Length:212
Mass (Da):23,724
Last modified:July 1, 1993 - v1
Checksum:i43FAD27B6D83FD1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10328 Genomic DNA Translation: AAA62033.1
U00096 Genomic DNA No translation available.
PIRiB65170

Genome annotation databases

PATRICifig|83333.103.peg.4616

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10328 Genomic DNA Translation: AAA62033.1
U00096 Genomic DNA No translation available.
PIRiB65170

3D structure databases

ProteinModelPortaliP31450
SMRiP31450
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-9813N
IntActiP31450, 7 interactors

Protein family/group databases

CAZyiGH4 Glycoside Hydrolase Family 4

Proteomic databases

PRIDEiP31450

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

PATRICifig|83333.103.peg.4616

Organism-specific databases

EchoBASEiEB1659
EcoGeneiEG11708 glvG

Phylogenomic databases

HOGENOMiHOG000202516
PhylomeDBiP31450

Enzyme and pathway databases

BioCyciEcoCyc:EG11708-MONOMER

Family and domain databases

Gene3Di3.90.110.10, 1 hit
InterProiView protein in InterPro
IPR019802 GlycHydrolase_4_CS
IPR001088 Glyco_hydro_4
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR32092 PTHR32092, 1 hit
PfamiView protein in Pfam
PF02056 Glyco_hydro_4, 1 hit
PRINTSiPR00732 GLHYDRLASE4
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
PROSITEiView protein in PROSITE
PS01324 GLYCOSYL_HYDROL_F4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGLVG_ECOLI
AccessioniPrimary (citable) accession number: P31450
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 7, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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