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UniProtKB - P31448 (YIDK_ECOLI)

Entry version 155 (25 May 2022)
Sequence version 1 (01 Jul 1993)
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Protein

Uncharacterized symporter YidK

Gene

yidK

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Sodium transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:YIDK-MONOMER

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.21.3.21, the solute:sodium symporter (sss) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized symporter YidK
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:yidK
Ordered Locus Names:b3679, JW3655
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 3CytoplasmicSequence analysis3
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei4 – 24HelicalSequence analysisAdd BLAST21
Topological domaini25 – 74PeriplasmicSequence analysisAdd BLAST50
Transmembranei75 – 95HelicalSequence analysisAdd BLAST21
Topological domaini96 – 118CytoplasmicSequence analysisAdd BLAST23
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Topological domaini140 – 162PeriplasmicSequence analysisAdd BLAST23
Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Topological domaini184 – 191CytoplasmicSequence analysis8
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21
Topological domaini213 – 240PeriplasmicSequence analysisAdd BLAST28
Transmembranei241 – 261HelicalSequence analysisAdd BLAST21
Topological domaini262 – 283CytoplasmicSequence analysisAdd BLAST22
Transmembranei284 – 304HelicalSequence analysisAdd BLAST21
Topological domaini305 – 324PeriplasmicSequence analysisAdd BLAST20
Transmembranei325 – 345HelicalSequence analysisAdd BLAST21
Topological domaini346 – 380CytoplasmicSequence analysisAdd BLAST35
Transmembranei381 – 401HelicalSequence analysisAdd BLAST21
Topological domaini402 – 415PeriplasmicSequence analysisAdd BLAST14
Transmembranei416 – 436HelicalSequence analysisAdd BLAST21
Topological domaini437CytoplasmicSequence analysis1
Transmembranei438 – 458HelicalSequence analysisAdd BLAST21
Topological domaini459 – 460PeriplasmicSequence analysis2
Transmembranei461 – 481HelicalSequence analysisAdd BLAST21
Topological domaini482 – 505CytoplasmicSequence analysisAdd BLAST24
Transmembranei506 – 526HelicalSequence analysisAdd BLAST21
Topological domaini527 – 532PeriplasmicSequence analysis6
Transmembranei533 – 553HelicalSequence analysisAdd BLAST21
Topological domaini554 – 571CytoplasmicSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001054061 – 571Uncharacterized symporter YidKAdd BLAST571

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P31448

PRoteomics IDEntifications database

More...PRIDEi		P31448

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		4261452, 162 interactors

Database of interacting proteins

More...DIPi		DIP-12450N

Protein interaction database and analysis system

More...IntActi		P31448, 5 interactors

STRING: functional protein association networks

More...STRINGi		511145.b3679

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P31448

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P31448

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG4146, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_018808_9_3_6

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P31448

Identification of Orthologs from Complete Genome Data

More...OMAi		MFFVVMP

Database for complete collections of gene phylogenies

More...PhylomeDBi		P31448

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1730.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR038377, Na/Glc_symporter_sf
IPR001734, Na/solute_symporter
IPR018212, Na/solute_symporter_CS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00474, SSF, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00813, sss, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00456, NA_SOLUT_SYMP_1, 1 hit
PS50283, NA_SOLUT_SYMP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P31448-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNSLQILSFV GFTLLVAVIT WWKVRKTDTG SQQGYFLAGR SLKAPVIAAS 
        60         70         80         90        100
LMLTNLSTEQ LVGLSGQAYK SGMSVMGWEV TSAVTLIFLA LIFLPRYLKR 
       110        120        130        140        150
GIATIPDFLE ERYDKTTRII IDFCFLIATG VCFLPIVLYS GALALNSLFH 
       160        170        180        190        200
VGESLQISHG AAIWLLVILL GLAGILYAVI GGLRAMAVAD SINGIGLVIG 
       210        220        230        240        250
GLMVPVFGLI AMGKGSFMQG IEQLTTVHAE KLNSIGGPTD PLPIGAAFTG 
       260        270        280        290        300
LILVNTFYWC TNQGIVQRTL ASKSLAEGQK GALLTAVLKM LDPLVLVLPG 
       310        320        330        340        350
LIAFHLYQDL PKADMAYPTL VNNVLPVPMV GFFGAVLFGA VISTFNGFLN 
       360        370        380        390        400
SASTLFSMGI YRRIINQNAE PQQLVTVGRK FGFFIAIVSV LVAPWIANAP 
       410        420        430        440        450
QGLYSWMKQL NGIYNVPLVT IIIMGFFFPR IPALAAKVAM GIGIISYITI 
       460        470        480        490        500
NYLVKFDFHF LYVLACTFCI NVVVMLVIGF IKPRATPFTF KDAFAVDMKP 
       510        520        530        540        550
WKNVKIASIG ILFAMIGVYA GLAEFGGYGT RWLAMISYFI AAVVIVYLIF 
       560        570 
DSWRHRHDPA VTFTPDGKDS L
Length:571
Mass (Da):62,085
Last modified:July 1, 1993 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i486AB89A6A2EACCF
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L10328 Genomic DNA Translation: AAA62031.1
U00096 Genomic DNA Translation: AAC76702.1
AP009048 Genomic DNA Translation: BAE77614.1

Protein sequence database of the Protein Information Resource

More...PIRi		H65169

NCBI Reference Sequences

More...RefSeqi		NP_418135.1, NC_000913.3
WP_001087145.1, NZ_SSZK01000035.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC76702; AAC76702; b3679
BAE77614; BAE77614; BAE77614

Database of genes from NCBI RefSeq genomes

More...GeneIDi		948185

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW3655
eco:b3679

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|1411691.4.peg.3025

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10328 Genomic DNA Translation: AAA62031.1
U00096 Genomic DNA Translation: AAC76702.1
AP009048 Genomic DNA Translation: BAE77614.1
PIRiH65169
RefSeqiNP_418135.1, NC_000913.3
WP_001087145.1, NZ_SSZK01000035.1

3D structure databases

AlphaFoldDBiP31448
SMRiP31448
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi4261452, 162 interactors
DIPiDIP-12450N
IntActiP31448, 5 interactors
STRINGi511145.b3679

Protein family/group databases

TCDBi2.A.21.3.21, the solute:sodium symporter (sss) family

Proteomic databases

PaxDbiP31448
PRIDEiP31448

Genome annotation databases

EnsemblBacteriaiAAC76702; AAC76702; b3679
BAE77614; BAE77614; BAE77614
GeneIDi948185
KEGGiecj:JW3655
eco:b3679
PATRICifig|1411691.4.peg.3025

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB1657

Phylogenomic databases

eggNOGiCOG4146, Bacteria
HOGENOMiCLU_018808_9_3_6
InParanoidiP31448
OMAiMFFVVMP
PhylomeDBiP31448

Enzyme and pathway databases

BioCyciEcoCyc:YIDK-MONOMER

Miscellaneous databases

Protein Ontology

More...PROi		PR:P31448

Family and domain databases

Gene3Di1.20.1730.10, 1 hit
InterProiView protein in InterPro
IPR038377, Na/Glc_symporter_sf
IPR001734, Na/solute_symporter
IPR018212, Na/solute_symporter_CS
PfamiView protein in Pfam
PF00474, SSF, 1 hit
TIGRFAMsiTIGR00813, sss, 1 hit
PROSITEiView protein in PROSITE
PS00456, NA_SOLUT_SYMP_1, 1 hit
PS50283, NA_SOLUT_SYMP_3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYIDK_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P31448
Secondary accession number(s): Q2M7Z2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: May 25, 2022
This is version 155 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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