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Protein

Multidrug resistance protein D

Gene

emrD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Multidrug resistance pump that participates in a low energy shock adaptive response.

GO - Molecular functioni

  • drug transmembrane transporter activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciEcoCyc:EMRD-MONOMER
MetaCyc:EMRD-MONOMER

Protein family/group databases

TCDBi2.A.1.2.9 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance protein D
Gene namesi
Name:emrD
Synonyms:yicQ
Ordered Locus Names:b3673, JW5634
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11693 emrD

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8CytoplasmicSequence analysis8
Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Topological domaini30 – 46PeriplasmicSequence analysisAdd BLAST17
Transmembranei47 – 67HelicalSequence analysisAdd BLAST21
Topological domaini68 – 73CytoplasmicSequence analysis6
Transmembranei74 – 94HelicalSequence analysisAdd BLAST21
Topological domaini95PeriplasmicSequence analysis1
Transmembranei96 – 116HelicalSequence analysisAdd BLAST21
Topological domaini117 – 134CytoplasmicSequence analysisAdd BLAST18
Transmembranei135 – 155HelicalSequence analysisAdd BLAST21
Topological domaini156 – 162PeriplasmicSequence analysis7
Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Topological domaini184 – 212CytoplasmicSequence analysisAdd BLAST29
Transmembranei213 – 233HelicalSequence analysisAdd BLAST21
Topological domaini234 – 242PeriplasmicSequence analysis9
Transmembranei243 – 263HelicalSequence analysisAdd BLAST21
Topological domaini264 – 276CytoplasmicSequence analysisAdd BLAST13
Transmembranei277 – 297HelicalSequence analysisAdd BLAST21
Topological domaini298PeriplasmicSequence analysis1
Transmembranei299 – 319HelicalSequence analysisAdd BLAST21
Topological domaini320 – 329CytoplasmicSequence analysis10
Transmembranei330 – 350HelicalSequence analysisAdd BLAST21
Topological domaini351 – 364PeriplasmicSequence analysisAdd BLAST14
Transmembranei365 – 385HelicalSequence analysisAdd BLAST21
Topological domaini386 – 394CytoplasmicSequence analysis9

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001733261 – 394Multidrug resistance protein DAdd BLAST394

Proteomic databases

PaxDbiP31442
PRIDEiP31442

Interactioni

Protein-protein interaction databases

BioGridi4261242, 128 interactors
STRINGi316385.ECDH10B_3856

Structurei

Secondary structure

1394
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP31442
SMRiP31442
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP31442

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105E5M Bacteria
ENOG410XQPV LUCA
HOGENOMiHOG000276020
InParanoidiP31442
KOiK08154
PhylomeDBiP31442

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR004734 Multidrug-R
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00880 2_A_01_02, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

P31442-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKRQRNVNLL LMLVLLVAVG QMAQTIYIPA IADMARDLNV REGAVQSVMG
60 70 80 90 100
AYLLTYGVSQ LFYGPISDRV GRRPVILVGM SIFMLATLVA VTTSSLTVLI
110 120 130 140 150
AASAMQGMGT GVGGVMARTL PRDLYERTQL RHANSLLNMG ILVSPLLAPL
160 170 180 190 200
IGGLLDTMWN WRACYLFLLV LCAGVTFSMA RWMPETRPVD APRTRLLTSY
210 220 230 240 250
KTLFGNSGFN CYLLMLIGGL AGIAAFEACS GVLMGAVLGL SSMTVSILFI
260 270 280 290 300
LPIPAAFFGA WFAGRPNKRF STLMWQSVIC CLLAGLLMWI PDWFGVMNVW
310 320 330 340 350
TLLVPAALFF FGAGMLFPLA TSGAMEPFPF LAGTAGALVG GLQNIGSGVL
360 370 380 390
ASLSAMLPQT GQGSLGLLMT LMGLLIVLCW LPLATRMSHQ GQPV
Length:394
Mass (Da):42,216
Last modified:April 27, 2001 - v2
Checksum:i342339DC7265A30B
GO

Sequence cautioni

The sequence AAA62025 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10328 Genomic DNA Translation: AAA62025.1 Different initiation.
U00096 Genomic DNA Translation: AAC76696.2
AP009048 Genomic DNA Translation: BAE77620.1
PIRiB65169
RefSeqiNP_418129.2, NC_000913.3
WP_000828746.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76696; AAC76696; b3673
BAE77620; BAE77620; BAE77620
GeneIDi948180
KEGGiecj:JW5634
eco:b3673
PATRICifig|511145.12.peg.3794

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10328 Genomic DNA Translation: AAA62025.1 Different initiation.
U00096 Genomic DNA Translation: AAC76696.2
AP009048 Genomic DNA Translation: BAE77620.1
PIRiB65169
RefSeqiNP_418129.2, NC_000913.3
WP_000828746.1, NZ_LN832404.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GFPX-ray3.50A/B9-383[»]
ProteinModelPortaliP31442
SMRiP31442
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261242, 128 interactors
STRINGi316385.ECDH10B_3856

Protein family/group databases

TCDBi2.A.1.2.9 the major facilitator superfamily (mfs)

Proteomic databases

PaxDbiP31442
PRIDEiP31442

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76696; AAC76696; b3673
BAE77620; BAE77620; BAE77620
GeneIDi948180
KEGGiecj:JW5634
eco:b3673
PATRICifig|511145.12.peg.3794

Organism-specific databases

EchoBASEiEB1644
EcoGeneiEG11693 emrD

Phylogenomic databases

eggNOGiENOG4105E5M Bacteria
ENOG410XQPV LUCA
HOGENOMiHOG000276020
InParanoidiP31442
KOiK08154
PhylomeDBiP31442

Enzyme and pathway databases

BioCyciEcoCyc:EMRD-MONOMER
MetaCyc:EMRD-MONOMER

Miscellaneous databases

EvolutionaryTraceiP31442
PROiPR:P31442

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR004734 Multidrug-R
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00880 2_A_01_02, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEMRD_ECOLI
AccessioniPrimary (citable) accession number: P31442
Secondary accession number(s): Q2M7Y6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: April 27, 2001
Last modified: November 7, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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