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UniProtKB - P31440 (ADEQ_ECOLI)
Protein
Adenine permease AdeQ
Gene
adeQ
Organism
Escherichia coli (strain K12)
Status
Functioni
High-affinity transporter for adenine.
1 PublicationKineticsi
- KM=6.5 µM for adenine1 Publication
- Vmax=11.0 nmol/min/mg enzyme1 Publication
GO - Molecular functioni
- adenine transmembrane transporter activity Source: EcoCyc
- purine nucleobase transmembrane transporter activity Source: GO_Central
GO - Biological processi
- adenine transport Source: EcoCyc
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:EG11691-MONOMER |
SABIO-RKi | P31440 |
Protein family/group databases
TCDBi | 2.A.40.7.4, the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family |
Names & Taxonomyi
Protein namesi | Recommended name: Adenine permease AdeQ |
Gene namesi | Name:adeQ Synonyms:yicO Ordered Locus Names:b3664, JW5636 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell inner membrane 2 Publications; Multi-pass membrane protein 2 Publications
Plasma Membrane
- integral component of plasma membrane Source: EcoCyc
- plasma membrane Source: EcoCyc
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 29 | CytoplasmicSequence analysisAdd BLAST | 29 | |
Transmembranei | 30 – 53 | HelicalSequence analysisAdd BLAST | 24 | |
Topological domaini | 54 – 63 | PeriplasmicSequence analysis | 10 | |
Transmembranei | 64 – 82 | HelicalSequence analysisAdd BLAST | 19 | |
Topological domaini | 83 – 84 | CytoplasmicSequence analysis | 2 | |
Transmembranei | 85 – 101 | Discontinuously helicalSequence analysisAdd BLAST | 17 | |
Topological domaini | 102 – 113 | PeriplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 114 – 133 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 134 – 145 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 146 – 166 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 167 – 182 | PeriplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 183 – 200 | HelicalSequence analysisAdd BLAST | 18 | |
Topological domaini | 201 – 204 | CytoplasmicSequence analysis | 4 | |
Transmembranei | 205 – 223 | HelicalSequence analysisAdd BLAST | 19 | |
Topological domaini | 224 – 251 | PeriplasmicSequence analysisAdd BLAST | 28 | |
Transmembranei | 252 – 280 | HelicalSequence analysisAdd BLAST | 29 | |
Topological domaini | 281 – 293 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 294 – 309 | HelicalSequence analysisAdd BLAST | 16 | |
Topological domaini | 310 – 311 | PeriplasmicSequence analysis | 2 | |
Transmembranei | 312 – 327 | Discontinuously helicalSequence analysisAdd BLAST | 16 | |
Topological domaini | 328 – 331 | CytoplasmicSequence analysis | 4 | |
Transmembranei | 332 – 346 | HelicalSequence analysisAdd BLAST | 15 | |
Topological domaini | 347 – 357 | PeriplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 358 – 377 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 378 – 382 | CytoplasmicSequence analysis | 5 | |
Intramembranei | 383 – 418 | Discontinuously helicalSequence analysisAdd BLAST | 36 | |
Topological domaini | 419 – 444 | CytoplasmicSequence analysisAdd BLAST | 26 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000169621 | 1 – 444 | Adenine permease AdeQAdd BLAST | 444 |
Proteomic databases
PaxDbi | P31440 |
PRIDEi | P31440 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4260893, 115 interactors |
IntActi | P31440, 1 interactor |
STRINGi | 511145.b3664 |
Structurei
Family & Domainsi
Sequence similaritiesi
Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG2252, Bacteria |
HOGENOMi | CLU_024508_0_1_6 |
InParanoidi | P31440 |
PhylomeDBi | P31440 |
Family and domain databases
InterProi | View protein in InterPro IPR045018, Azg-like IPR026033, Azg-like_bact_archaea IPR006043, NCS2 |
PANTHERi | PTHR43337, PTHR43337, 1 hit |
Pfami | View protein in Pfam PF00860, Xan_ur_permease, 1 hit |
PIRSFi | PIRSF005353, PbuG, 1 hit |
i Sequence
Sequence statusi: Complete.
P31440-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNNDNTDYVS NESGTLSRLF KLPQHGTTVR TELIAGMTTF LTMVYIVFVN
60 70 80 90 100
PQILGAAQMD PKVVFVTTCL IAGIGSIAMG IFANLPVALA PAMGLNAFFA
110 120 130 140 150
FVVVGAMGIS WQTGMGAIFW GAVGLFLLTL FRIRYWMISN IPLSLRIGIT
160 170 180 190 200
SGIGLFIALM GLKNTGVIVA NKDTLVMIGD LSSHGVLLGI LGFFIITVLS
210 220 230 240 250
SRHFHAAVLV SIVVTSCCGL FFGDVHFSGV YSIPPDISGV IGEVDLSGAL
260 270 280 290 300
TLELAGIIFS FMLINLFDSS GTLIGVTDKA GLIDGNGKFP NMNKALYVDS
310 320 330 340 350
VSSVAGAFIG TSSVTAYIES TSGVAVGGRT GLTAVVVGVM FLLVMFFSPL
360 370 380 390 400
VAIVPPYATA GALIFVGVLM TSSLARVNWD DFTESVPAFI TTVMMPFTFS
410 420 430 440
ITEGIALGFM SYCIMKVCTG RWRDLNLCVV VVAALFALKI ILVD
Sequence cautioni
The sequence AAA62016 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L10328 Genomic DNA Translation: AAA62016.1 Different initiation. U00096 Genomic DNA Translation: AAC76687.2 AP009048 Genomic DNA Translation: BAE77629.1 |
PIRi | A65168 |
RefSeqi | NP_418120.2, NC_000913.3 WP_001403836.1, NZ_SSZK01000043.1 |
Genome annotation databases
EnsemblBacteriai | AAC76687; AAC76687; b3664 BAE77629; BAE77629; BAE77629 |
GeneIDi | 948174 |
KEGGi | ecj:JW5636 eco:b3664 |
PATRICi | fig|511145.12.peg.3786 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L10328 Genomic DNA Translation: AAA62016.1 Different initiation. U00096 Genomic DNA Translation: AAC76687.2 AP009048 Genomic DNA Translation: BAE77629.1 |
PIRi | A65168 |
RefSeqi | NP_418120.2, NC_000913.3 WP_001403836.1, NZ_SSZK01000043.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4260893, 115 interactors |
IntActi | P31440, 1 interactor |
STRINGi | 511145.b3664 |
Protein family/group databases
TCDBi | 2.A.40.7.4, the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family |
Proteomic databases
PaxDbi | P31440 |
PRIDEi | P31440 |
Protocols and materials databases
DNASUi | 948174 |
Genome annotation databases
EnsemblBacteriai | AAC76687; AAC76687; b3664 BAE77629; BAE77629; BAE77629 |
GeneIDi | 948174 |
KEGGi | ecj:JW5636 eco:b3664 |
PATRICi | fig|511145.12.peg.3786 |
Organism-specific databases
EchoBASEi | EB1642 |
Phylogenomic databases
eggNOGi | COG2252, Bacteria |
HOGENOMi | CLU_024508_0_1_6 |
InParanoidi | P31440 |
PhylomeDBi | P31440 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG11691-MONOMER |
SABIO-RKi | P31440 |
Miscellaneous databases
PROi | PR:P31440 |
Family and domain databases
InterProi | View protein in InterPro IPR045018, Azg-like IPR026033, Azg-like_bact_archaea IPR006043, NCS2 |
PANTHERi | PTHR43337, PTHR43337, 1 hit |
Pfami | View protein in Pfam PF00860, Xan_ur_permease, 1 hit |
PIRSFi | PIRSF005353, PbuG, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ADEQ_ECOLI | |
Accessioni | P31440Primary (citable) accession number: P31440 Secondary accession number(s): P76726, Q2M7X7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | December 4, 2007 | |
Last modified: | February 23, 2022 | |
This is version 145 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families