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Entry version 145 (02 Dec 2020)
Sequence version 2 (15 Jul 1998)
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Protein

Inner membrane symporter YicJ

Gene

yicJ

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processSymport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:YICJ-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.2.3.4, the glycoside-pentoside-hexuronide (gph):cation symporter family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inner membrane symporter YicJ
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:yicJ
Ordered Locus Names:b3657, JW5939
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 11PeriplasmicSequence analysisAdd BLAST11
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Transmembranei33 – 53HelicalSequence analysisAdd BLAST21
Topological domaini54 – 80PeriplasmicSequence analysisAdd BLAST27
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Topological domaini102 – 116CytoplasmicSequence analysisAdd BLAST15
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Topological domaini138 – 152PeriplasmicSequence analysisAdd BLAST15
Transmembranei153 – 173HelicalSequence analysisAdd BLAST21
Topological domaini174 – 181CytoplasmicSequence analysis8
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21
Topological domaini203 – 248PeriplasmicSequence analysisAdd BLAST46
Transmembranei249 – 269HelicalSequence analysisAdd BLAST21
Topological domaini270 – 288CytoplasmicSequence analysisAdd BLAST19
Transmembranei289 – 309HelicalSequence analysisAdd BLAST21
Topological domaini310PeriplasmicSequence analysis1
Transmembranei311 – 331HelicalSequence analysisAdd BLAST21
Topological domaini332 – 366CytoplasmicSequence analysisAdd BLAST35
Transmembranei367 – 387HelicalSequence analysisAdd BLAST21
Topological domaini388 – 403PeriplasmicSequence analysisAdd BLAST16
Transmembranei404 – 424HelicalSequence analysisAdd BLAST21
Topological domaini425 – 460CytoplasmicSequence analysisAdd BLAST36

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001707661 – 460Inner membrane symporter YicJAdd BLAST460

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P31435

PRoteomics IDEntifications database

More...
PRIDEi
P31435

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
4261976, 177 interactors

STRING: functional protein association networks

More...
STRINGi
511145.b3657

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG2211, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_027408_0_2_6

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P31435

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P31435

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039672, MFS_2
IPR036259, MFS_trans_sf
IPR001927, Na/Gal_symport
IPR018043, Na/Gal_symport_CS

The PANTHER Classification System

More...
PANTHERi
PTHR11328, PTHR11328, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103473, SSF103473, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00792, gph, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00872, NA_GALACTOSIDE_SYMP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P31435-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKSEVLSVKE KIGYGMGDAA SHIIFDNVML YMMFFYTDIF GIPAGFVGTM
60 70 80 90 100
FLVARALDAI SDPCMGLLAD RTRSRWGKFR PWVLFGALPF GIVCVLAYST
110 120 130 140 150
PDLSMNGKMI YAAITYTLLT LLYTVVNIPY CALGGVITND PTQRISLQSW
160 170 180 190 200
RFVLATAGGM LSTVLMMPLV NLIGGDNKPL GFQGGIAVLS VVAFMMLAFC
210 220 230 240 250
FFTTKERVEA PPTTTSMRED LRDIWQNDQW RIVGLLTIFN ILAVCVRGGA
260 270 280 290 300
MMYYVTWILG TPEVFVAFLT TYCVGNLIGS ALAKPLTDWK CKVTIFWWTN
310 320 330 340 350
ALLAVISLAM FFVPMQASIT MFVFIFVIGV LHQLVTPIQW VMMSDTVDYG
360 370 380 390 400
EWCNGKRLTG ISFAGTLFVL KLGLAFGGAL IGWMLAYGGY DAAEKAQNSA
410 420 430 440 450
TISIIIALFT IVPAICYLLS AIIAKRYYSL TTHNLKTVME QLAQGKRRCQ
460
QQFTSQEVQN
Length:460
Mass (Da):50,948
Last modified:July 15, 1998 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBBDDC8BC7D2D2B13
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA62010 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L10328 Genomic DNA Translation: AAA62010.1 Different initiation.
U00096 Genomic DNA Translation: AAC76681.2
AP009048 Genomic DNA Translation: BAE77636.1

NCBI Reference Sequences

More...
RefSeqi
NP_418114.4, NC_000913.3
WP_000834439.1, NZ_STEB01000024.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC76681; AAC76681; b3657
BAE77636; BAE77636; BAE77636

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
948168

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW5939
eco:b3657

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|511145.12.peg.3777

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10328 Genomic DNA Translation: AAA62010.1 Different initiation.
U00096 Genomic DNA Translation: AAC76681.2
AP009048 Genomic DNA Translation: BAE77636.1
RefSeqiNP_418114.4, NC_000913.3
WP_000834439.1, NZ_STEB01000024.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi4261976, 177 interactors
STRINGi511145.b3657

Protein family/group databases

TCDBi2.A.2.3.4, the glycoside-pentoside-hexuronide (gph):cation symporter family

Proteomic databases

PaxDbiP31435
PRIDEiP31435

Genome annotation databases

EnsemblBacteriaiAAC76681; AAC76681; b3657
BAE77636; BAE77636; BAE77636
GeneIDi948168
KEGGiecj:JW5939
eco:b3657
PATRICifig|511145.12.peg.3777

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB1637

Phylogenomic databases

eggNOGiCOG2211, Bacteria
HOGENOMiCLU_027408_0_2_6
InParanoidiP31435
PhylomeDBiP31435

Enzyme and pathway databases

BioCyciEcoCyc:YICJ-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P31435

Family and domain databases

InterProiView protein in InterPro
IPR039672, MFS_2
IPR036259, MFS_trans_sf
IPR001927, Na/Gal_symport
IPR018043, Na/Gal_symport_CS
PANTHERiPTHR11328, PTHR11328, 1 hit
SUPFAMiSSF103473, SSF103473, 1 hit
TIGRFAMsiTIGR00792, gph, 1 hit
PROSITEiView protein in PROSITE
PS00872, NA_GALACTOSIDE_SYMP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYICJ_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P31435
Secondary accession number(s): P76724, Q2M7X0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 15, 1998
Last modified: December 2, 2020
This is version 145 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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