Metabotropic glutamate receptor 5

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• A2A adenosine receptor binding Source: RGD <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: implications for striatal neuronal function."
    Ferre S., Karcz-Kubicha M., Hope B.T., Popoli P., Burgueno J., Gutierrez M.A., Casado V., Fuxe K., Goldberg S.R., Lluis C., Franco R., Ciruela F.
    Proc. Natl. Acad. Sci. U.S.A. 99:11940-11945(2002) [PubMed] [Europe PMC] [Abstract]
• calmodulin binding Source: UniProtKB <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "Dissociation of protein kinase-mediated regulation of metabotropic glutamate receptor 7 (mGluR7) interactions with calmodulin and regulation of mGluR7 function."
    Sorensen S.D., Macek T.A., Cai Z., Saugstad J.A., Conn P.J.
    Mol. Pharmacol. 61:1303-1312(2002) [PubMed] [Europe PMC] [Abstract]
• glutamate receptor activity Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.1

    "Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction."
    Abe T., Sugihara H., Nawa H., Shigemoto R., Mizuno N., Nakanishi S.
    J. Biol. Chem. 267:13361-13368(1992) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
• G protein-coupled receptor activity Source: UniProtKB
• G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential Source: RGDInferred from sequence orthologyⁱ
  • "Dopamine modulates an mGluR5-mediated depolarization underlying prefrontal persistent activity."
    Sidiropoulou K., Lu F.M., Fowler M.A., Xiao R., Phillips C., Ozkan E.D., Zhu M.X., White F.J., Cooper D.C.
    Nat. Neurosci. 12:190-199(2009) [PubMed] [Europe PMC] [Abstract]
• identical protein binding Source: RGDInferred from sequence orthologyⁱ
  • "Structural insights into the activation of metabotropic glutamate receptors."
    Koehl A., Hu H., Feng D., Sun B., Zhang Y., Robertson M.J., Chu M., Kobilka T.S., Laeremans T., Steyaert J., Tarrasch J., Dutta S., Fonseca R., Weis W.I., Mathiesen J.M., Skiniotis G., Kobilka B.K.
    Nature 566:79-84(2019) [PubMed] [Europe PMC] [Abstract]
• neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration Source: RGDInferred from sequence orthologyⁱ
  • "Functional coupling of the metabotropic glutamate receptor, InsP3 receptor and L-type Ca2+ channel in mouse CA1 pyramidal cells."
    Kato H.K., Kassai H., Watabe A.M., Aiba A., Manabe T.
    J. Physiol. (Lond.) 590:3019-3034(2012) [PubMed] [Europe PMC] [Abstract]
• PDZ domain binding Source: UniProtKBTraceable author statementⁱ
  • "Regulation of neurotransmitter release by metabotropic glutamate receptors."
    Cartmell J., Schoepp D.D.
    J. Neurochem. 75:889-907(2000) [PubMed] [Europe PMC] [Abstract]
• PLC activating G protein-coupled glutamate receptor activity Source: UniProtKBTraceable author statementⁱ
  • "Distinct functional roles of the metabotropic glutamate receptors 1 and 5 in the rat globus pallidus."
    Poisik O.V., Mannaioni G., Traynelis S., Smith Y., Conn P.J.
    J. Neurosci. 23:122-130(2003) [PubMed] [Europe PMC] [Abstract]
  • "The scaffold protein Homer1b/c links metabotropic glutamate receptor 5 to extracellular signal-regulated protein kinase cascades in neurons."
    Mao L., Yang L., Tang Q., Samdani S., Zhang G., Wang J.Q.
    J. Neurosci. 25:2741-2752(2005) [PubMed] [Europe PMC] [Abstract]
• protein tyrosine kinase binding Source: ARUK-UCLInferred from physical interactionⁱ
  • "Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer abeta oligomer bound to cellular prion protein."
    Um J.W., Kaufman A.C., Kostylev M., Heiss J.K., Stagi M., Takahashi H., Kerrisk M.E., Vortmeyer A., Wisniewski T., Koleske A.J., Gunther E.C., Nygaard H.B., Strittmatter S.M.
    Neuron 79:887-902(2013) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• activation of MAPKKK activity Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "The scaffold protein Homer1b/c links metabotropic glutamate receptor 5 to extracellular signal-regulated protein kinase cascades in neurons."
    Mao L., Yang L., Tang Q., Samdani S., Zhang G., Wang J.Q.
    J. Neurosci. 25:2741-2752(2005) [PubMed] [Europe PMC] [Abstract]
• calcium-mediated signaling using intracellular calcium source Source: RGDInferred from sequence orthologyⁱ
  • "Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer abeta oligomer bound to cellular prion protein."
    Um J.W., Kaufman A.C., Kostylev M., Heiss J.K., Stagi M., Takahashi H., Kerrisk M.E., Vortmeyer A., Wisniewski T., Koleske A.J., Gunther E.C., Nygaard H.B., Strittmatter S.M.
    Neuron 79:887-902(2013) [PubMed] [Europe PMC] [Abstract]
• cellular response to amyloid-beta Source: RGDInferred from sequence orthologyⁱ
  • "Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer abeta oligomer bound to cellular prion protein."
    Um J.W., Kaufman A.C., Kostylev M., Heiss J.K., Stagi M., Takahashi H., Kerrisk M.E., Vortmeyer A., Wisniewski T., Koleske A.J., Gunther E.C., Nygaard H.B., Strittmatter S.M.
    Neuron 79:887-902(2013) [PubMed] [Europe PMC] [Abstract]
• chemical synaptic transmission Source: RGDInferred from mutant phenotypeⁱ
  • "Distinct functional roles of the metabotropic glutamate receptors 1 and 5 in the rat globus pallidus."
    Poisik O.V., Mannaioni G., Traynelis S., Smith Y., Conn P.J.
    J. Neurosci. 23:122-130(2003) [PubMed] [Europe PMC] [Abstract]
• cognition Source: RGDInferred from sequence orthologyⁱ
  • "Analysis of copy number variation in Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals."
    Swaminathan S., Huentelman M.J., Corneveaux J.J., Myers A.J., Faber K.M., Foroud T., Mayeux R., Shen L., Kim S., Turk M., Hardy J., Reiman E.M., Saykin A.J., Weiner M., Aisen P., Weiner M., Aisen P., Petersen R.

    , Jack C.R. Jr., Jagust W., Trojanowki J.Q., Toga A.W., Beckett L., Green R.C., Saykin A.J., Morris J., Liu E., Green R.C., Montine T., Petersen R., Aisen P., Gamst A., Thomas R.G., Donohue M., Walter S., Gessert D., Sather T., Beckett L., Harvey D., Gamst A., Donohue M., Kornak J., Jack C.R. Jr., Dale A., Bernstein M., Felmlee J., Fox N., Thompson P., Schuff N., Alexander G., DeCarli C., Jagust W., Bandy D., Koeppe R.A., Foster N., Reiman E.M., Chen K., Mathis C., Morris J., Cairns N.J., Taylor-Reinwald L., Trojanowki J.Q., Shaw L., Lee V.M., Korecka M., Toga A.W., Crawford K., Neu S., Saykin A.J., Foroud T.M., Potkin S., Shen L., Kachaturian Z., Frank R., Snyder P.J., Molchan S., Kaye J., Quinn J., Lind B., Dolen S., Schneider L.S., Pawluczyk S., Spann B.M., Brewer J., Vanderswag H., Heidebrink J.L., Lord J.L., Petersen R., Johnson K., Doody R.S., Villanueva-Meyer J., Chowdhury M., Stern Y., Honig L.S., Bell K.L., Morris J.C., Ances B., Carroll M., Leon S., Mintun M.A., Schneider S., Marson D., Griffith R., Clark D., Grossman H., Mitsis E., Romirowsky A., deToledo-Morrell L., Shah R.C., Duara R., Varon D., Roberts P., Albert M., Onyike C., Kielb S., Rusinek H., de Leon M.J., Glodzik L., De Santi S., Doraiswamy P., Petrella J.R., Coleman R., Arnold S.E., Karlawish J.H., Wolk D., Smith C.D., Jicha G., Hardy P., Lopez O.L., Oakley M., Simpson D.M., Porsteinsson A.P., Goldstein B.S., Martin K., Makino K.M., Ismail M., Brand C., Mulnard R.A., Thai G., Mc-Adams-Ortiz C., Womack K., Mathews D., Quiceno M., Diaz-Arrastia R., King R., Weiner M., Martin-Cook K., DeVous M., Levey A.I., Lah J.J., Cellar J.S., Burns J.M., Anderson H.S., Swerdlow R.H., Apostolova L., Lu P.H., Bartzokis G., Silverman D.H., Graff-Radford N.R., Parfitt F., Johnson H., Farlow M.R., Hake A.M., Matthews B.R., Herring S., van Dyck C.H., Carson R.E., MacAvoy M.G., Chertkow H., Bergman H., Hosein C., Black S., Stefanovic B., Caldwell C., Hsiung G.Y., Feldman H., Mudge B., Assaly M., Kertesz A., Rogers J., Trost D., Bernick C., Munic D., Kerwin D., Mesulam M.M., Lipowski K., Wu C.K., Johnson N., Sadowsky C., Martinez W., Villena T., Turner R.S., Johnson K., Reynolds B., Sperling R.A., Johnson K.A., Marshall G., Frey M., Yesavage J., Taylor J.L., Lane B., Rosen A., Tinklenberg J., Sabbagh M., Belden C., Jacobson S., Kowall N., Killiany R., Budson A.E., Norbash A., Johnson P.L., Obisesan T.O., Wolday S., Bwayo S.K., Lerner A., Hudson L., Ogrocki P., Fletcher E., Carmichael O., Olichney J., DeCarli C., Kittur S., Borrie M., Lee T.Y., Bartha R., Johnson S., Asthana S., Carlsson C.M., Potkin S.G., Preda A., Nguyen D., Tariot P., Fleisher A., Reeder S., Bates V., Capote H., Rainka M., Scharre D.W., Kataki M., Zimmerman E.A., Celmins D., Brown A.D., Pearlson G.D., Blank K., Anderson K., Saykin A.J., Santulli R.B., Schwartz E.S., Sink K.M., Williamson J.D., Garg P., Watkins F., Ott B.R., Querfurth H., Tremont G., Salloway S., Malloy P., Correia S., Rosen H.J., Miller B.L., Mintzer J., Spicer K., Rachinsky I., Rogers J., Kertesz A., Drost D., Mayeux R., Foroud T., Lee J.H., Wijsman E.M., Green R., Kowall N., Farrer L., Schmechel D.E., Blacker D., Growdon J., Hyman B.T., Tanzi R.E., Boeve B., Graff-Radford N., Pericak-Vance M., Silverman J.M., Beeri M.S., Sano M., Johnson N., Mesulam M., Weintraub S., Bigio E., Kaye J., Kramer P., Bennett D.A., Harrell L.E., Bartzokis G., Geffen D., Markesbery W., Smith C., Trojanowski J.Q., Van Deerlin V., DeKosky S.T., Sweet R., Chui I., Varpetian A., Diaz-Arrastia R., Rosenberg R., Bird T., Raskind M., Schellenberg G.D., Goate A., Morris J., Morrison-Bogorad M., Miller M.
    PLoS ONE 7:e50640-e50640(2012) [PubMed] [Europe PMC] [Abstract]
• desensitization of G protein-coupled receptor signaling pathway Source: UniProtKBInferred from direct assayⁱ
  • "Distinct functional roles of the metabotropic glutamate receptors 1 and 5 in the rat globus pallidus."
    Poisik O.V., Mannaioni G., Traynelis S., Smith Y., Conn P.J.
    J. Neurosci. 23:122-130(2003) [PubMed] [Europe PMC] [Abstract]
• G protein-coupled glutamate receptor signaling pathway Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.1

    "Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction."
    Abe T., Sugihara H., Nawa H., Shigemoto R., Mizuno N., Nakanishi S.
    J. Biol. Chem. 267:13361-13368(1992) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
• learning Source: RGDInferred from sequence orthologyⁱ
  • "Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP."
    Lu Y.M., Jia Z., Janus C., Henderson J.T., Gerlai R., Wojtowicz J.M., Roder J.C.
    J. Neurosci. 17:5196-5205(1997) [PubMed] [Europe PMC] [Abstract]
• learning or memory Source: RGDInferred from sequence orthologyⁱ
  • "Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer abeta oligomer bound to cellular prion protein."
    Um J.W., Kaufman A.C., Kostylev M., Heiss J.K., Stagi M., Takahashi H., Kerrisk M.E., Vortmeyer A., Wisniewski T., Koleske A.J., Gunther E.C., Nygaard H.B., Strittmatter S.M.
    Neuron 79:887-902(2013) [PubMed] [Europe PMC] [Abstract]
• locomotory behavior Source: RGDInferred from sequence orthologyⁱ
  • "Interactions between metabotropic glutamate 5 and adenosine A2A receptors in normal and parkinsonian mice."
    Kachroo A., Orlando L.R., Grandy D.K., Chen J.F., Young A.B., Schwarzschild M.A.
    J. Neurosci. 25:10414-10419(2005) [PubMed] [Europe PMC] [Abstract]
• modulation of age-related behavioral decline Source: RGDInferred from sequence orthologyⁱ
  • "Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer abeta oligomer bound to cellular prion protein."
    Um J.W., Kaufman A.C., Kostylev M., Heiss J.K., Stagi M., Takahashi H., Kerrisk M.E., Vortmeyer A., Wisniewski T., Koleske A.J., Gunther E.C., Nygaard H.B., Strittmatter S.M.
    Neuron 79:887-902(2013) [PubMed] [Europe PMC] [Abstract]
• negative regulation of locomotion Source: RGDInferred from direct assayⁱ
  • "Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: implications for striatal neuronal function."
    Ferre S., Karcz-Kubicha M., Hope B.T., Popoli P., Burgueno J., Gutierrez M.A., Casado V., Fuxe K., Goldberg S.R., Lluis C., Franco R., Ciruela F.
    Proc. Natl. Acad. Sci. U.S.A. 99:11940-11945(2002) [PubMed] [Europe PMC] [Abstract]
• phosphatidylinositol-mediated signaling Source: UniProtKBTraceable author statementⁱ
  • "The scaffold protein Homer1b/c links metabotropic glutamate receptor 5 to extracellular signal-regulated protein kinase cascades in neurons."
    Mao L., Yang L., Tang Q., Samdani S., Zhang G., Wang J.Q.
    J. Neurosci. 25:2741-2752(2005) [PubMed] [Europe PMC] [Abstract]
• phospholipase C-activating G protein-coupled glutamate receptor signaling pathway Source: UniProtKBTraceable author statementⁱ
  • "Distinct functional roles of the metabotropic glutamate receptors 1 and 5 in the rat globus pallidus."
    Poisik O.V., Mannaioni G., Traynelis S., Smith Y., Conn P.J.
    J. Neurosci. 23:122-130(2003) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway Source: UniProtKBTraceable author statementⁱ
  • "The scaffold protein Homer1b/c links metabotropic glutamate receptor 5 to extracellular signal-regulated protein kinase cascades in neurons."
    Mao L., Yang L., Tang Q., Samdani S., Zhang G., Wang J.Q.
    J. Neurosci. 25:2741-2752(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of long-term neuronal synaptic plasticity Source: RGDInferred from direct assayⁱ
  • "Co-stimulation of mGluR5 and N-methyl-D-aspartate receptors is required for potentiation of excitatory synaptic transmission in hippocampal neurons."
    Kotecha S.A., Jackson M.F., Al-Mahrouki A., Roder J.C., Orser B.A., MacDonald J.F.
    J. Biol. Chem. 278:27742-27749(2003) [PubMed] [Europe PMC] [Abstract]
• positive regulation of protein tyrosine kinase activity Source: ARUK-UCL <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer abeta oligomer bound to cellular prion protein."
    Um J.W., Kaufman A.C., Kostylev M., Heiss J.K., Stagi M., Takahashi H., Kerrisk M.E., Vortmeyer A., Wisniewski T., Koleske A.J., Gunther E.C., Nygaard H.B., Strittmatter S.M.
    Neuron 79:887-902(2013) [PubMed] [Europe PMC] [Abstract]
• postsynaptic modulation of chemical synaptic transmission Source: RGDInferred from sequence orthologyⁱ
  • "Chemical induction of mGluR5- and protein synthesis--dependent long-term depression in hippocampal area CA1."
    Huber K.M., Roder J.C., Bear M.F.
    J. Neurophysiol. 86:321-325(2001) [PubMed] [Europe PMC] [Abstract]
• protein kinase C-activating G protein-coupled receptor signaling pathway Source: UniProtKBInferred from direct assayⁱ
  • "Distinct functional roles of the metabotropic glutamate receptors 1 and 5 in the rat globus pallidus."
    Poisik O.V., Mannaioni G., Traynelis S., Smith Y., Conn P.J.
    J. Neurosci. 23:122-130(2003) [PubMed] [Europe PMC] [Abstract]
• protein phosphorylation Source: UniProtKBInferred from direct assayⁱ
  • "The scaffold protein Homer1b/c links metabotropic glutamate receptor 5 to extracellular signal-regulated protein kinase cascades in neurons."
    Mao L., Yang L., Tang Q., Samdani S., Zhang G., Wang J.Q.
    J. Neurosci. 25:2741-2752(2005) [PubMed] [Europe PMC] [Abstract]
• regulation of intracellular calcium activated chloride channel activity Source: RGDInferred from sequence orthologyⁱ
  • "Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer abeta oligomer bound to cellular prion protein."
    Um J.W., Kaufman A.C., Kostylev M., Heiss J.K., Stagi M., Takahashi H., Kerrisk M.E., Vortmeyer A., Wisniewski T., Koleske A.J., Gunther E.C., Nygaard H.B., Strittmatter S.M.
    Neuron 79:887-902(2013) [PubMed] [Europe PMC] [Abstract]
• regulation of long-term neuronal synaptic plasticity Source: RGDInferred from sequence orthologyⁱ
  • "The regulation of hippocampal LTP by the molecular switch, a form of metaplasticity, requires mGlu5 receptors."
    Bortolotto Z.A., Collett V.J., Conquet F., Jia Z., van der Putten H., Collingridge G.L.
    Neuropharmacology 49 Suppl 1:13-25(2005) [PubMed] [Europe PMC] [Abstract]
• regulation of protein phosphorylation Source: RGDInferred from sequence orthologyⁱ
  • "Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer abeta oligomer bound to cellular prion protein."
    Um J.W., Kaufman A.C., Kostylev M., Heiss J.K., Stagi M., Takahashi H., Kerrisk M.E., Vortmeyer A., Wisniewski T., Koleske A.J., Gunther E.C., Nygaard H.B., Strittmatter S.M.
    Neuron 79:887-902(2013) [PubMed] [Europe PMC] [Abstract]
• regulation of synaptic transmission, glutamatergic Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription, DNA-templated Source: RGDInferred from direct assayⁱ
  • "Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: implications for striatal neuronal function."
    Ferre S., Karcz-Kubicha M., Hope B.T., Popoli P., Burgueno J., Gutierrez M.A., Casado V., Fuxe K., Goldberg S.R., Lluis C., Franco R., Ciruela F.
    Proc. Natl. Acad. Sci. U.S.A. 99:11940-11945(2002) [PubMed] [Europe PMC] [Abstract]
• regulation of translational elongation Source: RGDInferred from sequence orthologyⁱ
  • "Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer abeta oligomer bound to cellular prion protein."
    Um J.W., Kaufman A.C., Kostylev M., Heiss J.K., Stagi M., Takahashi H., Kerrisk M.E., Vortmeyer A., Wisniewski T., Koleske A.J., Gunther E.C., Nygaard H.B., Strittmatter S.M.
    Neuron 79:887-902(2013) [PubMed] [Europe PMC] [Abstract]
• synapse organization Source: RGDInferred from sequence orthologyⁱ
  • "Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer abeta oligomer bound to cellular prion protein."
    Um J.W., Kaufman A.C., Kostylev M., Heiss J.K., Stagi M., Takahashi H., Kerrisk M.E., Vortmeyer A., Wisniewski T., Koleske A.J., Gunther E.C., Nygaard H.B., Strittmatter S.M.
    Neuron 79:887-902(2013) [PubMed] [Europe PMC] [Abstract]
• trans-synaptic signaling by endocannabinoid, modulating synaptic transmission Source: SynGOInferred from mutant phenotypeⁱ
  • "NMDA receptors, mGluR5, and endocannabinoids are involved in a cascade leading to hippocampal long-term depression."
    Izumi Y., Zorumski C.F.
    Neuropsychopharmacology 37:609-617(2012) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• A2A adenosine receptor binding Source: RGDInferred from physical interactionⁱ
  • "Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: implications for striatal neuronal function."
    Ferre S., Karcz-Kubicha M., Hope B.T., Popoli P., Burgueno J., Gutierrez M.A., Casado V., Fuxe K., Goldberg S.R., Lluis C., Franco R., Ciruela F.
    Proc. Natl. Acad. Sci. U.S.A. 99:11940-11945(2002) [PubMed] [Europe PMC] [Abstract]
• calmodulin binding Source: UniProtKBTraceable author statementⁱ
  • "Dissociation of protein kinase-mediated regulation of metabotropic glutamate receptor 7 (mGluR7) interactions with calmodulin and regulation of mGluR7 function."
    Sorensen S.D., Macek T.A., Cai Z., Saugstad J.A., Conn P.J.
    Mol. Pharmacol. 61:1303-1312(2002) [PubMed] [Europe PMC] [Abstract]
• identical protein binding Source: RGDInferred from sequence orthologyⁱ
  • "Structural insights into the activation of metabotropic glutamate receptors."
    Koehl A., Hu H., Feng D., Sun B., Zhang Y., Robertson M.J., Chu M., Kobilka T.S., Laeremans T., Steyaert J., Tarrasch J., Dutta S., Fonseca R., Weis W.I., Mathiesen J.M., Skiniotis G., Kobilka B.K.
    Nature 566:79-84(2019) [PubMed] [Europe PMC] [Abstract]
• PDZ domain binding Source: UniProtKBTraceable author statementⁱ
  • "Regulation of neurotransmitter release by metabotropic glutamate receptors."
    Cartmell J., Schoepp D.D.
    J. Neurochem. 75:889-907(2000) [PubMed] [Europe PMC] [Abstract]
• protein tyrosine kinase binding Source: ARUK-UCLInferred from physical interactionⁱ
  • "Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer abeta oligomer bound to cellular prion protein."
    Um J.W., Kaufman A.C., Kostylev M., Heiss J.K., Stagi M., Takahashi H., Kerrisk M.E., Vortmeyer A., Wisniewski T., Koleske A.J., Gunther E.C., Nygaard H.B., Strittmatter S.M.
    Neuron 79:887-902(2013) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MVLLLILSVL LLKEDVRGSA QSSERRVVAH MPGDIIIGAL FSVHHQPTVD 
        60         70         80         90        100
KVHERKCGAV REQYGIQRVE AMLHTLERIN SDPTLLPNIT LGCEIRDSCW 
       110        120        130        140        150
HSAVALEQSI EFIRDSLISS EEEEGLVRCV DGSSSFRSKK PIVGVIGPGS 
       160        170        180        190        200
SSVAIQVQNL LQLFNIPQIA YSATSMDLSD KTLFKYFMRV VPSDAQQARA 
       210        220        230        240        250
MVDIVKRYNW TYVSAVHTEG NYGESGMEAF KDMSAKEGIC IAHSYKIYSN 
       260        270        280        290        300
AGEQSFDKLL KKLRSHLPKA RVVACFCEGM TVRGLLMAMR RLGLAGEFLL 
       310        320        330        340        350
LGSDGWADRY DVTDGYQREA VGGITIKLQS PDVKWFDDYY LKLRPETNLR 
       360        370        380        390        400
NPWFQEFWQH RFQCRLEGFA QENSKYNKTC NSSLTLRTHH VQDSKMGFVI 
       410        420        430        440        450
NAIYSMAYGL HNMQMSLCPG YAGLCDAMKP IDGRKLLDSL MKTNFTGVSG 
       460        470        480        490        500
DMILFDENGD SPGRYEIMNF KEMGKDYFDY INVGSWDNGE LKMDDDEVWS 
       510        520        530        540        550
KKNNIIRSVC SEPCEKGQIK VIRKGEVSCC WTCTPCKENE YVFDEYTCKA 
       560        570        580        590        600
CQLGSWPTDD LTGCDLIPVQ YLRWGDPEPI AAVVFACLGL LATLFVTVIF 
       610        620        630        640        650
IIYRDTPVVK SSSRELCYII LAGICLGYLC TFCLIAKPKQ IYCYLQRIGI 
       660        670        680        690        700
GLSPAMSYSA LVTKTNRIAR ILAGSKKKIC TKKPRFMSAC AQLVIAFILI 
       710        720        730        740        750
CIQLGIIVAL FIMEPPDIMH DYPSIREVYL ICNTTNLGVV TPLGYNGLLI 
       760        770        780        790        800
LSCTFYAFKT RNVPANFNEA KYIAFTMYTT CIIWLAFVPI YFGSNYKIIT 
       810        820        830        840        850
MCFSVSLSAT VALGCMFVPK VYIILAKPER NVRSAFTTST VVRMHVGDGK 
       860        870        880        890        900
SSSAASRSSS LVNLWKRRGS SGETLRYKDR RLAQHKSEIE CFTPKGSMGN 
       910        920        930        940        950
GGRATMSSSN GKSVTWAQNE KSTRGQHLWQ RLSVHINKKE NPNQTAVIKP 
       960        970        980        990       1000
FPKSTENRGP GAAAGGGSGP GVAGAGNAGC TATGGPEPPD AGPKALYDVA 
      1010       1020       1030       1040       1050
EAEESFPAAA RPRSPSPIST LSHLAGSAGR TDDDAPSLHS ETAARSSSSQ 
      1060       1070       1080       1090       1100
GSLMEQISSV VTRFTANISE LNSMMLSTAA TPGPPGTPIC SSYLIPKEIQ 
      1110       1120       1130       1140       1150
LPTTMTTFAE IQPLPAIEVT GGAQGATGVS PAQETPTGAE SAPGKPDLEE 
      1160       1170       1180       1190       1200
LVALTPPSPF RDSVDSGSTT PNSPVSESAL CIPSSPKYDT LIIRDYTQSS 

SSL                                                    

        10         20         30         40         50
MVLLLILSVL LLKEDVRGSA QSSERRVVAH MPGDIIIGAL FSVHHQPTVD 
        60         70         80         90        100
KVHERKCGAV REQYGIQRVE AMLHTLERIN SDPTLLPNIT LGCEIRDSCW 
       110        120        130        140        150
HSAVALEQSI EFIRDSLISS EEEEGLVRCV DGSSSFRSKK PIVGVIGPGS 
       160        170        180        190        200
SSVAIQVQNL LQLFNIPQIA YSATSMDLSD KTLFKYFMRV VPSDAQQARA 
       210        220        230        240        250
MVDIVKRYNW TYVSAVHTEG NYGESGMEAF KDMSAKEGIC IAHSYKIYSN 
       260        270        280        290        300
AGEQSFDKLL KKLRSHLPKA RVVACFCEGM TVRGLLMAMR RLGLAGEFLL 
       310        320        330        340        350
LGSDGWADRY DVTDGYQREA VGGITIKLQS PDVKWFDDYY LKLRPETNLR 
       360        370        380        390        400
NPWFQEFWQH RFQCRLEGFA QENSKYNKTC NSSLTLRTHH VQDSKMGFVI 
       410        420        430        440        450
NAIYSMAYGL HNMQMSLCPG YAGLCDAMKP IDGRKLLDSL MKTNFTGVSG 
       460        470        480        490        500
DMILFDENGD SPGRYEIMNF KEMGKDYFDY INVGSWDNGE LKMDDDEVWS 
       510        520        530        540        550
KKNNIIRSVC SEPCEKGQIK VIRKGEVSCC WTCTPCKENE YVFDEYTCKA 
       560        570        580        590        600
CQLGSWPTDD LTGCDLIPVQ YLRWGDPEPI AAVVFACLGL LATLFVTVIF 
       610        620        630        640        650
IIYRDTPVVK SSSRELCYII LAGICLGYLC TFCLIAKPKQ IYCYLQRIGI 
       660        670        680        690        700
GLSPAMSYSA LVTKTNRIAR ILAGSKKKIC TKKPRFMSAC AQLVIAFILI 
       710        720        730        740        750
CIQLGIIVAL FIMEPPDIMH DYPSIREVYL ICNTTNLGVV TPLGYNGLLI 
       760        770        780        790        800
LSCTFYAFKT RNVPANFNEA KYIAFTMYTT CIIWLAFVPI YFGSNYKIIT 
       810        820        830        840        850
MCFSVSLSAT VALGCMFVPK VYIILAKPER NVRSAFTTST VVRMHVGDGK 
       860        870        880        890        900
SSSAASRSSS LVNLWKRRGS SGETLSSNGK SVTWAQNEKS TRGQHLWQRL 
       910        920        930        940        950
SVHINKKENP NQTAVIKPFP KSTENRGPGA AAGGGSGPGV AGAGNAGCTA 
       960        970        980        990       1000
TGGPEPPDAG PKALYDVAEA EESFPAAARP RSPSPISTLS HLAGSAGRTD 
      1010       1020       1030       1040       1050
DDAPSLHSET AARSSSSQGS LMEQISSVVT RFTANISELN SMMLSTAATP 
      1060       1070       1080       1090       1100
GPPGTPICSS YLIPKEIQLP TTMTTFAEIQ PLPAIEVTGG AQGATGVSPA 
      1110       1120       1130       1140       1150
QETPTGAESA PGKPDLEELV ALTPPSPFRD SVDSGSTTPN SPVSESALCI 
      1160       1170 
PSSPKYDTLI IRDYTQSSSS L                                

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
2. SIMILARITY comments
   Index of protein domains and families
3. 7-transmembrane G-linked receptors
   List of 7-transmembrane G-linked receptor entries