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Protein

Fatty acid-binding protein 2

Gene

MFB2

Organism
Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds fatty acids in a 1:1 molar ratio.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei40Fatty acid1 Publication1

GO - Molecular functioni

Keywordsi

Biological processTransport
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid-binding protein 2
Short name:
FABP 2
Gene namesi
Name:MFB2
OrganismiManduca sexta (Tobacco hawkmoth) (Tobacco hornworm)
Taxonomic identifieri7130 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaLepidopteraGlossataDitrysiaBombycoideaSphingidaeSphinginaeSphinginiManduca

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00000673612 – 132Fatty acid-binding protein 2Add BLAST131

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1

Keywords - PTMi

Acetylation

PTM databases

iPTMnetiP31417

Expressioni

Tissue specificityi

Midgut.

Interactioni

Subunit structurei

Monomer.1 Publication

Structurei

Secondary structure

1132
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi8 – 15Combined sources8
Helixi16 – 21Combined sources6
Turni22 – 24Combined sources3
Helixi27 – 35Combined sources9
Beta strandi39 – 45Combined sources7
Beta strandi48 – 55Combined sources8
Beta strandi60 – 64Combined sources5
Beta strandi70 – 74Combined sources5
Turni75 – 77Combined sources3
Beta strandi78 – 87Combined sources10
Beta strandi90 – 97Combined sources8
Beta strandi100 – 109Combined sources10
Beta strandi112 – 119Combined sources8
Beta strandi122 – 131Combined sources10

3D structure databases

ProteinModelPortaliP31417
SMRiP31417
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP31417

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni128 – 130Fatty acid binding3

Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.

Sequence similaritiesi

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR000463 Fatty_acid-bd
IPR031259 ILBP
IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERiPTHR11955 PTHR11955, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR00178 FATTYACIDBP
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00214 FABP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31417-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYLGKVYSL VKQENFDGFL KSAGLSDDKI QALVSDKPTQ KMEANGDSYS
60 70 80 90 100
ITSTGIGGER TVSFKSGVEF DDVIGAGESV KSMYTVDGNV VTHVVKGDAG
110 120 130
VATFKKEYNG DDLVVTITSS NWDGVARRYY KA
Length:132
Mass (Da):14,212
Last modified:January 23, 2007 - v3
Checksum:i6971DFF301FE9F29
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77755 mRNA Translation: AAA29314.1
PIRiB41749

Similar proteinsi

Entry informationi

Entry nameiFABP2_MANSE
AccessioniPrimary (citable) accession number: P31417
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: January 31, 2018
This is version 92 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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