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Entry version 155 (18 Sep 2019)
Sequence version 1 (01 Jul 1993)
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Protein

Pyrophosphate-energized vacuolar membrane proton pump 1

Gene

AVP1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Contributes to the transtonoplast (from cytosol to vacuole lumen) H+-electrochemical potential difference. It establishes a proton gradient of similar and often greater magnitude than the H+-ATPase on the same membrane. In addition, facilitates auxin transport by modulating apoplastic pH and regulates auxin-mediated developmental processes. Confers tolerance to NaCl and to drought by increasing ion retention.3 Publications

Miscellaneous

Has few direct interactions with pyrophosphate. Interacts with the substrate via divalent metal cations, such as magnesium ions, that are bound to the pyrophosphate (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by K+ and Mg2+. Inhibited by Ca2+, N,N'-dicyclohexylcarbodiimide (DCCD), N-ethylmaleimide (NEM) and aminomethylenediphosphonate (AMDP), and, to a lower extent, by fluoride (KF).4 Publications

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=110 µM for PPi (at pH 8 and 37 degrees Celsius)2 Publications
  1. Vmax=0.5 µmol/min/mg enzyme (at pH 8 and 37 degrees Celsius)2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei246Important for proton transportBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei254SubstrateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi257Magnesium 1By similarity1
Metal bindingi257Magnesium 2By similarity1
Metal bindingi261Magnesium 1By similarity1
Metal bindingi287Magnesium 3By similarity1
Sitei291Important for proton transportBy similarity1
Sitei298Important for proton transportBy similarity1
Sitei305Important for proton transportBy similarity1
Metal bindingi511Magnesium 3By similarity1
Metal bindingi538Magnesium 4By similarity1
Metal bindingi695Magnesium 4By similarity1
Metal bindingi731Magnesium 2By similarity1
Binding sitei734SubstrateBy similarity1
Sitei735Important for proton transportBy similarity1
Sitei746Important for proton transportBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTranslocase
Biological processHydrogen ion transport, Ion transport, Transport
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
ARA:AT1G15690-MONOMER
MetaCyc:AT1G15690-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.6.1.1 399

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P31414

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.10.1.1 the h(+), na(+)-translocating pyrophosphatase (m(+)-ppase) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pyrophosphate-energized vacuolar membrane proton pump 1 (EC:7.1.3.1)
Alternative name(s):
Pyrophosphate-energized inorganic pyrophosphatase 1
Short name:
H(+)-PPase 1
Vacuolar proton pyrophosphatase 1
Vacuolar proton pyrophosphatase 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AVP1
Synonyms:AVP, AVP-3, AVP3
Ordered Locus Names:At1g15690
ORF Names:F7H2.3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT1G15690

The Arabidopsis Information Resource

More...
TAIRi
locus:2036134 AT1G15690

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 9IntravacuolarBy similarity9
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei10 – 36HelicalBy similarityAdd BLAST27
Topological domaini37 – 88CytoplasmicBy similarityAdd BLAST52
Transmembranei89 – 118HelicalBy similarityAdd BLAST30
Topological domaini119 – 139IntravacuolarBy similarityAdd BLAST21
Transmembranei140 – 167HelicalBy similarityAdd BLAST28
Topological domaini168 – 190CytoplasmicBy similarityAdd BLAST23
Transmembranei191 – 220HelicalBy similarityAdd BLAST30
Topological domaini221 – 223IntravacuolarBy similarity3
Transmembranei224 – 252HelicalBy similarityAdd BLAST29
Topological domaini253 – 290CytoplasmicBy similarityAdd BLAST38
Transmembranei291 – 316HelicalBy similarityAdd BLAST26
Topological domaini317 – 324IntravacuolarBy similarity8
Transmembranei325 – 350HelicalBy similarityAdd BLAST26
Topological domaini351 – 358CytoplasmicBy similarity8
Transmembranei359 – 386HelicalBy similarityAdd BLAST28
Topological domaini387 – 405IntravacuolarBy similarityAdd BLAST19
Transmembranei406 – 429HelicalBy similarityAdd BLAST24
Topological domaini430 – 451CytoplasmicBy similarityAdd BLAST22
Transmembranei452 – 476HelicalBy similarityAdd BLAST25
Topological domaini477 – 482IntravacuolarBy similarity6
Transmembranei483 – 509HelicalBy similarityAdd BLAST27
Topological domaini510 – 538CytoplasmicBy similarityAdd BLAST29
Transmembranei539 – 567HelicalBy similarityAdd BLAST29
Topological domaini568 – 577IntravacuolarBy similarity10
Transmembranei578 – 606HelicalBy similarityAdd BLAST29
Topological domaini607 – 635CytoplasmicBy similarityAdd BLAST29
Transmembranei636 – 664HelicalBy similarityAdd BLAST29
Topological domaini665IntravacuolarBy similarity1
Transmembranei666 – 693HelicalBy similarityAdd BLAST28
Topological domaini694 – 736CytoplasmicBy similarityAdd BLAST43
Transmembranei737 – 762HelicalBy similarityAdd BLAST26
Topological domaini763 – 770IntravacuolarBy similarity8

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane, Vacuole

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi119E → Q: Slight reduction of PPi hydrolysis and H(+) translocation. 1 Publication1
Mutagenesisi229E → D: Slight increased PPi hydrolysis and H(+) translocation. 1 Publication1
Mutagenesisi229E → Q: Slight reduction of PPi hydrolysis and H(+) translocation. 1 Publication1
Mutagenesisi305E → D: Abolishes H(+) translocation and strong reduction of PPi hydrolysis. 1 Publication1
Mutagenesisi305E → Q: Abolishes H(+) translocation and strong reduction of PPi hydrolysis, reduced sensitivity to DCCD. 1 Publication1
Mutagenesisi427E → D: Increases H(+) translocation, normal PPi hydrolysis. 1 Publication1
Mutagenesisi427E → Q: Strong reduction of PPi hydrolysis and H(+) translocation. 1 Publication1
Mutagenesisi504D → E: Abolishes H(+) translocation and strong reduction of PPi hydrolysis. 1 Publication1
Mutagenesisi504D → N: Abolishes H(+) translocation and strong reduction of PPi hydrolysis, reduced sensitivity to DCCD. 1 Publication1
Mutagenesisi573D → N: Increases H(+) translocation, normal PPi hydrolysis. 1 Publication1
Mutagenesisi634C → A or S: Reduced sensitivity to NEM. 1 Publication1
Mutagenesisi667E → Q: Slight reduction of PPi hydrolysis and H(+) translocation. 1 Publication1
Mutagenesisi751E → Q: Slight reduction of PPi hydrolysis and H(+) translocation. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002170391 – 770Pyrophosphate-energized vacuolar membrane proton pump 1Add BLAST770

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi128 ↔ 136By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P31414

PRoteomics IDEntifications database

More...
PRIDEi
P31414

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P31414

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P31414

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous (at protein level). Mostly expressed in vascular tissues, meristems and root pericycle.2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Increase of expression in pollen during flower development. Expressed in developing leaves, sepals, petals, stamens and carpels.2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Repressed by light. Induced by CAMTA1 and/or CAMTA5 in pollen.2 Publications

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P31414 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P31414 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
23378, 13 interactors

Protein interaction database and analysis system

More...
IntActi
P31414, 10 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT1G15690.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P31414

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Has 16 transmembrane helices and a cytoplasmic domain that contains the active site.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IFIU Eukaryota
COG3808 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P31414

KEGG Orthology (KO)

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KOi
K23025

Identification of Orthologs from Complete Genome Data

More...
OMAi
DATRMCK

Database of Orthologous Groups

More...
OrthoDBi
257116at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P31414

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_01129 PPase_energized_pump, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004131 PPase-energised_H-pump

The PANTHER Classification System

More...
PANTHERi
PTHR31998 PTHR31998, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03030 H_PPase, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001265 H+-PPase, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01104 V_PPase, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 1 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoform i produced by alternative splicing. AlignAdd to basket
Note: A number of isoforms are produced. According to EST sequences.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P31414-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVAPALLPEL WTEILVPICA VIGIAFSLFQ WYVVSRVKLT SDLGASSSGG
60 70 80 90 100
ANNGKNGYGD YLIEEEEGVN DQSVVAKCAE IQTAISEGAT SFLFTEYKYV
110 120 130 140 150
GVFMIFFAAV IFVFLGSVEG FSTDNKPCTY DTTRTCKPAL ATAAFSTIAF
160 170 180 190 200
VLGAVTSVLS GFLGMKIATY ANARTTLEAR KGVGKAFIVA FRSGAVMGFL
210 220 230 240 250
LAASGLLVLY ITINVFKIYY GDDWEGLFEA ITGYGLGGSS MALFGRVGGG
260 270 280 290 300
IYTKAADVGA DLVGKIERNI PEDDPRNPAV IADNVGDNVG DIAGMGSDLF
310 320 330 340 350
GSYAEASCAA LVVASISSFG INHDFTAMCY PLLISSMGIL VCLITTLFAT
360 370 380 390 400
DFFEIKLVKE IEPALKNQLI ISTVIMTVGI AIVSWVGLPT SFTIFNFGTQ
410 420 430 440 450
KVVKNWQLFL CVCVGLWAGL IIGFVTEYYT SNAYSPVQDV ADSCRTGAAT
460 470 480 490 500
NVIFGLALGY KSVIIPIFAI AISIFVSFSF AAMYGVAVAA LGMLSTIATG
510 520 530 540 550
LAIDAYGPIS DNAGGIAEMA GMSHRIRERT DALDAAGNTT AAIGKGFAIG
560 570 580 590 600
SAALVSLALF GAFVSRAGIH TVDVLTPKVI IGLLVGAMLP YWFSAMTMKS
610 620 630 640 650
VGSAALKMVE EVRRQFNTIP GLMEGTAKPD YATCVKISTD ASIKEMIPPG
660 670 680 690 700
CLVMLTPLIV GFFFGVETLS GVLAGSLVSG VQIAISASNT GGAWDNAKKY
710 720 730 740 750
IEAGVSEHAK SLGPKGSEPH KAAVIGDTIG DPLKDTSGPS LNILIKLMAV
760 770
ESLVFAPFFA THGGILFKYF
Length:770
Mass (Da):80,820
Last modified:July 1, 1993 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCE7132B42B299860
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MQH1A8MQH1_ARATH
Inorganic H pyrophosphatase family ...
AVP1 ARABIDOPSIS THALIANA V-PPASE 3, AtAVP1, ATAVP3, AtVHP1;1, AVP-3
642Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD94555 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA79039 differs from that shown. Reason: Frameshift at position 718.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti8P → L in BAA32210 (PubMed:11442058).Curated1
Sequence conflicti576T → A in CAA79038 (PubMed:8281187).Curated1
Sequence conflicti584L → P in CAA79038 (PubMed:8281187).Curated1
Sequence conflicti624E → K in AAL57660 (PubMed:14593172).Curated1
Sequence conflicti685I → T in AAL84953 (PubMed:14593172).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M81892 mRNA Translation: AAA32754.1
AB015138 Genomic DNA Translation: BAA32210.1
AC034256 Genomic DNA Translation: AAF82139.1
CP002684 Genomic DNA Translation: AEE29349.1
AY065016 mRNA Translation: AAL57660.1
AY078953 mRNA Translation: AAL84953.1
BT002481 mRNA Translation: AAO00841.1
Z17694 mRNA Translation: CAA79038.1
Z17695 mRNA Translation: CAA79039.1 Frameshift.
AK221989 mRNA Translation: BAD94555.1 Different initiation.

Protein sequence database of the Protein Information Resource

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PIRi
A38230

NCBI Reference Sequences

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RefSeqi
NP_173021.1, NM_101437.5 [P31414-1]

Genome annotation databases

Ensembl plant genome annotation project

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EnsemblPlantsi
AT1G15690.1; AT1G15690.1; AT1G15690 [P31414-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
838138

Gramene; a comparative resource for plants

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Gramenei
AT1G15690.1; AT1G15690.1; AT1G15690 [P31414-1]

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
ath:AT1G15690

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81892 mRNA Translation: AAA32754.1
AB015138 Genomic DNA Translation: BAA32210.1
AC034256 Genomic DNA Translation: AAF82139.1
CP002684 Genomic DNA Translation: AEE29349.1
AY065016 mRNA Translation: AAL57660.1
AY078953 mRNA Translation: AAL84953.1
BT002481 mRNA Translation: AAO00841.1
Z17694 mRNA Translation: CAA79038.1
Z17695 mRNA Translation: CAA79039.1 Frameshift.
AK221989 mRNA Translation: BAD94555.1 Different initiation.
PIRiA38230
RefSeqiNP_173021.1, NM_101437.5 [P31414-1]

3D structure databases

SMRiP31414
ModBaseiSearch...

Protein-protein interaction databases

BioGridi23378, 13 interactors
IntActiP31414, 10 interactors
STRINGi3702.AT1G15690.1

Protein family/group databases

TCDBi3.A.10.1.1 the h(+), na(+)-translocating pyrophosphatase (m(+)-ppase) family

PTM databases

iPTMnetiP31414
SwissPalmiP31414

Proteomic databases

PaxDbiP31414
PRIDEiP31414

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G15690.1; AT1G15690.1; AT1G15690 [P31414-1]
GeneIDi838138
GrameneiAT1G15690.1; AT1G15690.1; AT1G15690 [P31414-1]
KEGGiath:AT1G15690

Organism-specific databases

AraportiAT1G15690
TAIRilocus:2036134 AT1G15690

Phylogenomic databases

eggNOGiENOG410IFIU Eukaryota
COG3808 LUCA
InParanoidiP31414
KOiK23025
OMAiDATRMCK
OrthoDBi257116at2759
PhylomeDBiP31414

Enzyme and pathway databases

BioCyciARA:AT1G15690-MONOMER
MetaCyc:AT1G15690-MONOMER
BRENDAi3.6.1.1 399
SABIO-RKiP31414

Miscellaneous databases

Protein Ontology

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PROi
PR:P31414

Gene expression databases

ExpressionAtlasiP31414 baseline and differential
GenevisibleiP31414 AT

Family and domain databases

HAMAPiMF_01129 PPase_energized_pump, 1 hit
InterProiView protein in InterPro
IPR004131 PPase-energised_H-pump
PANTHERiPTHR31998 PTHR31998, 1 hit
PfamiView protein in Pfam
PF03030 H_PPase, 1 hit
PIRSFiPIRSF001265 H+-PPase, 1 hit
TIGRFAMsiTIGR01104 V_PPase, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAVP1_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P31414
Secondary accession number(s): O80390
, Q41919, Q41920, Q56WP6, Q8RY20, Q8VZE3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: September 18, 2019
This is version 155 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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