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Entry version 159 (23 Feb 2022)
Sequence version 1 (01 Jul 1993)
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Protein

V-type proton ATPase catalytic subunit A

Gene

vma1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity).

V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (By similarity).

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi258 – 265ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTranslocase
Biological processHydrogen ion transport, Ion transport, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SPO-1222556, ROS and RNS production in phagocytes
R-SPO-77387, Insulin receptor recycling
R-SPO-917977, Transferrin endocytosis and recycling
R-SPO-9639288, Amino acids regulate mTORC1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
V-type proton ATPase catalytic subunit A1 Publication (EC:7.1.2.2By similarity)
Short name:
V-ATPase subunit A
Alternative name(s):
V-ATPase 67 kDa subunit
Vacuolar proton pump subunit alpha
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:vma1Imported
ORF Names:SPAC343.05Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

Schizosaccharomyces pombe database

More...
PomBasei
SPAC343.05, vma1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:SPAC343.05

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Membrane, Vacuole

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001445901 – 619V-type proton ATPase catalytic subunit AAdd BLAST619

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P31406

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P31406

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P31406

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
278156, 4 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPAC343.05.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P31406

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ATPase alpha/beta chains family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1352, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_008162_3_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P31406

Identification of Orthologs from Complete Genome Data

More...
OMAi
RIVKTFW

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P31406

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1140.10, 1 hit
2.40.30.20, 1 hit
3.40.50.300, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00309, ATP_synth_A_arch, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031686, ATP-synth_a_Xtn
IPR023366, ATP_synth_asu-like_sf
IPR020003, ATPase_a/bsu_AS
IPR004100, ATPase_F1/V1/A1_a/bsu_N
IPR036121, ATPase_F1/V1/A1_a/bsu_N_sf
IPR000194, ATPase_F1/V1/A1_a/bsu_nucl-bd
IPR024034, ATPase_F1/V1_b/a_C
IPR005725, ATPase_V1-cplx_asu
IPR027417, P-loop_NTPase
IPR022878, V-ATPase_asu

The PANTHER Classification System

More...
PANTHERi
PTHR43607, PTHR43607, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00006, ATP-synt_ab, 1 hit
PF02874, ATP-synt_ab_N, 1 hit
PF16886, ATP-synt_ab_Xtn, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50615, SSF50615, 1 hit
SSF52540, SSF52540, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01042, V-ATPase_V1_A, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00152, ATPASE_ALPHA_BETA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P31406-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGGIELAKK AIRSLKNYDE HENRYGSIFS VSGPVVVAAN MLGCSMYELV
60 70 80 90 100
RVGHEELVGE VIRIHQDKCT IQVYEETSGL TVGDPVQRTG KPLSVELGPG
110 120 130 140 150
LAETIYDGIQ RPLKQIFDKS QSIYIPRGIN TESLNREHKW DFTPNKDLRI
160 170 180 190 200
GDHVSGGDVF GSVFENSLFN DHKIMLPPRA RGTVTYIAEA GSYHVDEKLL
210 220 230 240 250
EVEFNGKKHS FSMLHTWPVR AARPVADNLT ANQPLLTGQR VLDALYPCVQ
260 270 280 290 300
GGTTAIPGAF GCGKTVISQS LSKYSNSDLI VYVGCGERGN EMAEVLMDFP
310 320 330 340 350
ELTIDINGKP EPIMKRTTLV ANTSNMPVAA REASIYTGIT LAEYYRDQGK
360 370 380 390 400
NVSMMADSTS RWAEALREIS GRLAEMPADS GYPAYLGAKL ASFYERAGRA
410 420 430 440 450
RCLGSPDREG TVSIVGAVSP PGGDFSDPVT SATLGIVQVF WGLDKKLAQR
460 470 480 490 500
KHFPSINTSL SYSKYINALQ PWYEERVPGF NTLRDQIKQI IQQEDSMLEI
510 520 530 540 550
IQLVGKSALS ETDKVTLDIA GIIKNDFLQQ NGYSDYDRCC PLYKTYHMMR
560 570 580 590 600
NMIAYYTKAK SAVETGSVPW SKIKESTSDI FYELTSMKFE NPNEGEKEIV
610
EHYETLHKKI EDKFHTLTE
Length:619
Mass (Da):68,806
Last modified:July 1, 1993 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i785A6F291609DF73
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X68580 Genomic DNA Translation: CAA48573.1
CU329670 Genomic DNA Translation: CAB52268.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S25334

NCBI Reference Sequences

More...
RefSeqi
NP_593425.1, NM_001018858.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPAC343.05.1; SPAC343.05.1:pep; SPAC343.05

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2541660

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPAC343.05

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68580 Genomic DNA Translation: CAA48573.1
CU329670 Genomic DNA Translation: CAB52268.1
PIRiS25334
RefSeqiNP_593425.1, NM_001018858.2

3D structure databases

SMRiP31406
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi278156, 4 interactors
STRINGi4896.SPAC343.05.1

PTM databases

iPTMnetiP31406

Proteomic databases

MaxQBiP31406
PaxDbiP31406

Genome annotation databases

EnsemblFungiiSPAC343.05.1; SPAC343.05.1:pep; SPAC343.05
GeneIDi2541660
KEGGispo:SPAC343.05

Organism-specific databases

PomBaseiSPAC343.05, vma1
VEuPathDBiFungiDB:SPAC343.05

Phylogenomic databases

eggNOGiKOG1352, Eukaryota
HOGENOMiCLU_008162_3_1_1
InParanoidiP31406
OMAiRIVKTFW
PhylomeDBiP31406

Enzyme and pathway databases

ReactomeiR-SPO-1222556, ROS and RNS production in phagocytes
R-SPO-77387, Insulin receptor recycling
R-SPO-917977, Transferrin endocytosis and recycling
R-SPO-9639288, Amino acids regulate mTORC1

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P31406

Family and domain databases

Gene3Di1.10.1140.10, 1 hit
2.40.30.20, 1 hit
3.40.50.300, 1 hit
HAMAPiMF_00309, ATP_synth_A_arch, 1 hit
InterProiView protein in InterPro
IPR031686, ATP-synth_a_Xtn
IPR023366, ATP_synth_asu-like_sf
IPR020003, ATPase_a/bsu_AS
IPR004100, ATPase_F1/V1/A1_a/bsu_N
IPR036121, ATPase_F1/V1/A1_a/bsu_N_sf
IPR000194, ATPase_F1/V1/A1_a/bsu_nucl-bd
IPR024034, ATPase_F1/V1_b/a_C
IPR005725, ATPase_V1-cplx_asu
IPR027417, P-loop_NTPase
IPR022878, V-ATPase_asu
PANTHERiPTHR43607, PTHR43607, 1 hit
PfamiView protein in Pfam
PF00006, ATP-synt_ab, 1 hit
PF02874, ATP-synt_ab_N, 1 hit
PF16886, ATP-synt_ab_Xtn, 1 hit
SUPFAMiSSF50615, SSF50615, 1 hit
SSF52540, SSF52540, 1 hit
TIGRFAMsiTIGR01042, V-ATPase_V1_A, 1 hit
PROSITEiView protein in PROSITE
PS00152, ATPASE_ALPHA_BETA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVATA_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P31406
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: February 23, 2022
This is version 159 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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