UniProtKB - P31391 (SSR4_HUMAN)
Protein
Somatostatin receptor type 4
Gene
SSTR4
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumor cells.
GO - Molecular functioni
- G protein-coupled receptor activity Source: GO_Central
- neuropeptide binding Source: GO_Central
- peptide binding Source: GO_Central
- somatostatin receptor activity Source: GO_Central
GO - Biological processi
- cell migration Source: Ensembl
- cellular response to glucocorticoid stimulus Source: GO_Central
- forebrain development Source: Ensembl
- G protein-coupled receptor signaling pathway Source: Reactome
- G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
- negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: Ensembl
- negative regulation of cell population proliferation Source: ProtInc
- neuropeptide signaling pathway Source: GO_Central
- positive regulation of arachidonic acid secretion Source: Ensembl
- positive regulation of ERK1 and ERK2 cascade Source: Ensembl
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | P31391 |
Reactomei | R-HSA-375276, Peptide ligand-binding receptors R-HSA-418594, G alpha (i) signalling events |
SIGNORi | P31391 |
Names & Taxonomyi
Protein namesi | Recommended name: Somatostatin receptor type 4Short name: SS-4-R Short name: SS4-R Short name: SS4R |
Gene namesi | Name:SSTR4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000132671.5 |
HGNCi | HGNC:11333, SSTR4 |
MIMi | 182454, gene |
neXtProti | NX_P31391 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: Reactome
Other locations
- cytoplasm Source: Ensembl
- neuron projection Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 46 | ExtracellularSequence analysisAdd BLAST | 46 | |
Transmembranei | 47 – 73 | Helical; Name=1Sequence analysisAdd BLAST | 27 | |
Topological domaini | 74 – 83 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 84 – 104 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 105 – 120 | ExtracellularSequence analysisAdd BLAST | 16 | |
Transmembranei | 121 – 142 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 143 – 161 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 162 – 185 | Helical; Name=4Sequence analysisAdd BLAST | 24 | |
Topological domaini | 186 – 208 | ExtracellularSequence analysisAdd BLAST | 23 | |
Transmembranei | 209 – 232 | Helical; Name=5Sequence analysisAdd BLAST | 24 | |
Topological domaini | 233 – 260 | CytoplasmicSequence analysisAdd BLAST | 28 | |
Transmembranei | 261 – 280 | Helical; Name=6Sequence analysisAdd BLAST | 20 | |
Topological domaini | 281 – 291 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 292 – 314 | Helical; Name=7Sequence analysisAdd BLAST | 23 | |
Topological domaini | 315 – 388 | CytoplasmicSequence analysisAdd BLAST | 74 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 6754 |
OpenTargetsi | ENSG00000132671 |
PharmGKBi | PA36157 |
Miscellaneous databases
Pharosi | P31391, Tclin |
Chemistry databases
ChEMBLi | CHEMBL1853 |
DrugBanki | DB13985, Lutetium Lu 177 dotatate DB09099, Somatostatin |
DrugCentrali | P31391 |
GuidetoPHARMACOLOGYi | 358 |
Polymorphism and mutation databases
BioMutai | SSTR4 |
DMDMi | 206729897 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000070127 | 1 – 388 | Somatostatin receptor type 4Add BLAST | 388 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 24 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 119 ↔ 198 | PROSITE-ProRule annotation | ||
Lipidationi | 327 | S-palmitoyl cysteineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, PalmitateProteomic databases
PaxDbi | P31391 |
PeptideAtlasi | P31391 |
PRIDEi | P31391 |
ProteomicsDBi | 54787 |
PTM databases
GlyGeni | P31391, 1 site |
iPTMneti | P31391 |
PhosphoSitePlusi | P31391 |
Expressioni
Tissue specificityi
Specifically expressed in fetal and adult brain, lung tissue, stomach, and in lesser quantities in the kidney, pituitary and adrenals.
Gene expression databases
Bgeei | ENSG00000132671, Expressed in pancreas and 26 other tissues |
Genevisiblei | P31391, HS |
Organism-specific databases
HPAi | ENSG00000132671, Tissue enriched (brain) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 112632, 4 interactors |
CORUMi | P31391 |
IntActi | P31391, 3 interactors |
STRINGi | 9606.ENSP00000255008 |
Chemistry databases
BindingDBi | P31391 |
Miscellaneous databases
RNActi | P31391, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000156819 |
HOGENOMi | CLU_009579_8_1_1 |
InParanoidi | P31391 |
OMAi | LIVGKMR |
OrthoDBi | 1011272at2759 |
PhylomeDBi | P31391 |
TreeFami | TF315737 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000586, Somatstn_rcpt IPR001512, Somatstn_rcpt_4 |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00246, SOMATOSTATNR PR00590, SOMATOSTTN4R |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P31391-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSAPSTLPPG GEEGLGTAWP SAANASSAPA EAEEAVAGPG DARAAGMVAI
60 70 80 90 100
QCIYALVCLV GLVGNALVIF VILRYAKMKT ATNIYLLNLA VADELFMLSV
110 120 130 140 150
PFVASSAALR HWPFGSVLCR AVLSVDGLNM FTSVFCLTVL SVDRYVAVVH
160 170 180 190 200
PLRAATYRRP SVAKLINLGV WLASLLVTLP IAIFADTRPA RGGQAVACNL
210 220 230 240 250
QWPHPAWSAV FVVYTFLLGF LLPVLAIGLC YLLIVGKMRA VALRAGWQQR
260 270 280 290 300
RRSEKKITRL VLMVVVVFVL CWMPFYVVQL LNLFVTSLDA TVNHVSLILS
310 320 330 340 350
YANSCANPIL YGFLSDNFRR FFQRVLCLRC CLLEGAGGAE EEPLDYYATA
360 370 380
LKSKGGAGCM CPPLPCQQEA LQPEPGRKRI PLTRTTTF
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 365 | P → K in AAA60565 (PubMed:8483934).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_011703 | 83 | N → T1 PublicationCorresponds to variant dbSNP:rs1065191Ensembl. | 1 | |
Natural variantiVAR_049441 | 236 | G → D. Corresponds to variant dbSNP:rs35601930Ensembl. | 1 | |
Natural variantiVAR_021560 | 284 | F → V4 PublicationsCorresponds to variant dbSNP:rs3746726Ensembl. | 1 | |
Natural variantiVAR_021561 | 321 | F → S4 PublicationsCorresponds to variant dbSNP:rs2567608Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D16826 Genomic DNA Translation: BAA04106.1 L14856 Genomic DNA Translation: AAA36623.1 L07833 Genomic DNA Translation: AAA60565.1 L07061 Genomic DNA No translation available. AY548169 Genomic DNA Translation: AAS55648.1 AL049651 Genomic DNA No translation available. CH471133 Genomic DNA Translation: EAX10170.1 BC069063 mRNA Translation: AAH69063.1 BC117270 mRNA Translation: AAI17271.1 BC117272 mRNA Translation: AAI17273.1 |
CCDSi | CCDS42856.1 |
PIRi | JN0605 |
RefSeqi | NP_001043.2, NM_001052.2 |
Genome annotation databases
Ensembli | ENST00000255008; ENSP00000255008; ENSG00000132671 |
GeneIDi | 6754 |
KEGGi | hsa:6754 |
UCSCi | uc002wsr.3, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D16826 Genomic DNA Translation: BAA04106.1 L14856 Genomic DNA Translation: AAA36623.1 L07833 Genomic DNA Translation: AAA60565.1 L07061 Genomic DNA No translation available. AY548169 Genomic DNA Translation: AAS55648.1 AL049651 Genomic DNA No translation available. CH471133 Genomic DNA Translation: EAX10170.1 BC069063 mRNA Translation: AAH69063.1 BC117270 mRNA Translation: AAI17271.1 BC117272 mRNA Translation: AAI17273.1 |
CCDSi | CCDS42856.1 |
PIRi | JN0605 |
RefSeqi | NP_001043.2, NM_001052.2 |
3D structure databases
SMRi | P31391 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 112632, 4 interactors |
CORUMi | P31391 |
IntActi | P31391, 3 interactors |
STRINGi | 9606.ENSP00000255008 |
Chemistry databases
BindingDBi | P31391 |
ChEMBLi | CHEMBL1853 |
DrugBanki | DB13985, Lutetium Lu 177 dotatate DB09099, Somatostatin |
DrugCentrali | P31391 |
GuidetoPHARMACOLOGYi | 358 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P31391, 1 site |
iPTMneti | P31391 |
PhosphoSitePlusi | P31391 |
Polymorphism and mutation databases
BioMutai | SSTR4 |
DMDMi | 206729897 |
Proteomic databases
PaxDbi | P31391 |
PeptideAtlasi | P31391 |
PRIDEi | P31391 |
ProteomicsDBi | 54787 |
Protocols and materials databases
Antibodypediai | 20974, 223 antibodies |
Genome annotation databases
Ensembli | ENST00000255008; ENSP00000255008; ENSG00000132671 |
GeneIDi | 6754 |
KEGGi | hsa:6754 |
UCSCi | uc002wsr.3, human |
Organism-specific databases
CTDi | 6754 |
DisGeNETi | 6754 |
EuPathDBi | HostDB:ENSG00000132671.5 |
GeneCardsi | SSTR4 |
HGNCi | HGNC:11333, SSTR4 |
HPAi | ENSG00000132671, Tissue enriched (brain) |
MIMi | 182454, gene |
neXtProti | NX_P31391 |
OpenTargetsi | ENSG00000132671 |
PharmGKBi | PA36157 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000156819 |
HOGENOMi | CLU_009579_8_1_1 |
InParanoidi | P31391 |
OMAi | LIVGKMR |
OrthoDBi | 1011272at2759 |
PhylomeDBi | P31391 |
TreeFami | TF315737 |
Enzyme and pathway databases
PathwayCommonsi | P31391 |
Reactomei | R-HSA-375276, Peptide ligand-binding receptors R-HSA-418594, G alpha (i) signalling events |
SIGNORi | P31391 |
Miscellaneous databases
BioGRID-ORCSi | 6754, 6 hits in 839 CRISPR screens |
GeneWikii | Somatostatin_receptor_4 |
GenomeRNAii | 6754 |
Pharosi | P31391, Tclin |
PROi | PR:P31391 |
RNActi | P31391, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000132671, Expressed in pancreas and 26 other tissues |
Genevisiblei | P31391, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000586, Somatstn_rcpt IPR001512, Somatstn_rcpt_4 |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00246, SOMATOSTATNR PR00590, SOMATOSTTN4R |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SSR4_HUMAN | |
Accessioni | P31391Primary (citable) accession number: P31391 Secondary accession number(s): Q17RM1, Q17RM3, Q9UIY1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | September 23, 2008 | |
Last modified: | December 2, 2020 | |
This is version 185 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries