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UniProtKB - P31391 (SSR4_HUMAN)

Entry version 185 (02 Dec 2020)
Sequence version 2 (23 Sep 2008)
Previous versions | rss
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Protein

Somatostatin receptor type 4

Gene

SSTR4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumor cells.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P31391

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-375276, Peptide ligand-binding receptors
R-HSA-418594, G alpha (i) signalling events

SIGNOR Signaling Network Open Resource

More...SIGNORi		P31391

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Somatostatin receptor type 4
Short name:
SS-4-R
Short name:
SS4-R
Short name:
SS4R
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SSTR4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000132671.5

Human Gene Nomenclature Database

More...HGNCi		HGNC:11333, SSTR4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		182454, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P31391

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 46ExtracellularSequence analysisAdd BLAST46
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei47 – 73Helical; Name=1Sequence analysisAdd BLAST27
Topological domaini74 – 83CytoplasmicSequence analysis10
Transmembranei84 – 104Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini105 – 120ExtracellularSequence analysisAdd BLAST16
Transmembranei121 – 142Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini143 – 161CytoplasmicSequence analysisAdd BLAST19
Transmembranei162 – 185Helical; Name=4Sequence analysisAdd BLAST24
Topological domaini186 – 208ExtracellularSequence analysisAdd BLAST23
Transmembranei209 – 232Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini233 – 260CytoplasmicSequence analysisAdd BLAST28
Transmembranei261 – 280Helical; Name=6Sequence analysisAdd BLAST20
Topological domaini281 – 291ExtracellularSequence analysisAdd BLAST11
Transmembranei292 – 314Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini315 – 388CytoplasmicSequence analysisAdd BLAST74

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		6754

Open Targets

More...OpenTargetsi		ENSG00000132671

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36157

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P31391, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1853

Drug and drug target database

More...DrugBanki		DB13985, Lutetium Lu 177 dotatate
DB09099, Somatostatin

DrugCentral

More...DrugCentrali		P31391

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		358

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SSTR4

Domain mapping of disease mutations (DMDM)

More...DMDMi		206729897

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000701271 – 388Somatostatin receptor type 4Add BLAST388

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi24N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi119 ↔ 198PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi327S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P31391

PeptideAtlas

More...PeptideAtlasi		P31391

PRoteomics IDEntifications database

More...PRIDEi		P31391

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		54787

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P31391, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P31391

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P31391

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Specifically expressed in fetal and adult brain, lung tissue, stomach, and in lesser quantities in the kidney, pituitary and adrenals.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000132671, Expressed in pancreas and 26 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P31391, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000132671, Tissue enriched (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112632, 4 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P31391

Protein interaction database and analysis system

More...IntActi		P31391, 3 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000255008

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P31391

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P31391, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P31391

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3656, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156819

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009579_8_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P31391

Identification of Orthologs from Complete Genome Data

More...OMAi		LIVGKMR

Database of Orthologous Groups

More...OrthoDBi		1011272at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P31391

TreeFam database of animal gene trees

More...TreeFami		TF315737

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
IPR000586, Somatstn_rcpt
IPR001512, Somatstn_rcpt_4

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00001, 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00237, GPCRRHODOPSN
PR00246, SOMATOSTATNR
PR00590, SOMATOSTTN4R

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01381, 7TM_GPCR_Srsx, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P31391-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAPSTLPPG GEEGLGTAWP SAANASSAPA EAEEAVAGPG DARAAGMVAI 
        60         70         80         90        100
QCIYALVCLV GLVGNALVIF VILRYAKMKT ATNIYLLNLA VADELFMLSV 
       110        120        130        140        150
PFVASSAALR HWPFGSVLCR AVLSVDGLNM FTSVFCLTVL SVDRYVAVVH 
       160        170        180        190        200
PLRAATYRRP SVAKLINLGV WLASLLVTLP IAIFADTRPA RGGQAVACNL 
       210        220        230        240        250
QWPHPAWSAV FVVYTFLLGF LLPVLAIGLC YLLIVGKMRA VALRAGWQQR 
       260        270        280        290        300
RRSEKKITRL VLMVVVVFVL CWMPFYVVQL LNLFVTSLDA TVNHVSLILS 
       310        320        330        340        350
YANSCANPIL YGFLSDNFRR FFQRVLCLRC CLLEGAGGAE EEPLDYYATA 
       360        370        380 
LKSKGGAGCM CPPLPCQQEA LQPEPGRKRI PLTRTTTF
Length:388
Mass (Da):42,003
Last modified:September 23, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDFCD9393620EDFC9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti365P → K in AAA60565 (PubMed:8483934).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01170383N → T1 PublicationCorresponds to variant dbSNP:rs1065191Ensembl.1
Natural variantiVAR_049441236G → D. Corresponds to variant dbSNP:rs35601930Ensembl.1
Natural variantiVAR_021560284F → V4 PublicationsCorresponds to variant dbSNP:rs3746726Ensembl.1
Natural variantiVAR_021561321F → S4 PublicationsCorresponds to variant dbSNP:rs2567608Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
D16826 Genomic DNA Translation: BAA04106.1
L14856 Genomic DNA Translation: AAA36623.1
L07833 Genomic DNA Translation: AAA60565.1
L07061 Genomic DNA No translation available.
AY548169 Genomic DNA Translation: AAS55648.1
AL049651 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10170.1
BC069063 mRNA Translation: AAH69063.1
BC117270 mRNA Translation: AAI17271.1
BC117272 mRNA Translation: AAI17273.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS42856.1

Protein sequence database of the Protein Information Resource

More...PIRi		JN0605

NCBI Reference Sequences

More...RefSeqi		NP_001043.2, NM_001052.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000255008; ENSP00000255008; ENSG00000132671

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6754

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6754

UCSC genome browser

More...UCSCi		uc002wsr.3, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16826 Genomic DNA Translation: BAA04106.1
L14856 Genomic DNA Translation: AAA36623.1
L07833 Genomic DNA Translation: AAA60565.1
L07061 Genomic DNA No translation available.
AY548169 Genomic DNA Translation: AAS55648.1
AL049651 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10170.1
BC069063 mRNA Translation: AAH69063.1
BC117270 mRNA Translation: AAI17271.1
BC117272 mRNA Translation: AAI17273.1
CCDSiCCDS42856.1
PIRiJN0605
RefSeqiNP_001043.2, NM_001052.2

3D structure databases

SMRiP31391
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi112632, 4 interactors
CORUMiP31391
IntActiP31391, 3 interactors
STRINGi9606.ENSP00000255008

Chemistry databases

BindingDBiP31391
ChEMBLiCHEMBL1853
DrugBankiDB13985, Lutetium Lu 177 dotatate
DB09099, Somatostatin
DrugCentraliP31391
GuidetoPHARMACOLOGYi358

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

GlyGeniP31391, 1 site
iPTMnetiP31391
PhosphoSitePlusiP31391

Polymorphism and mutation databases

BioMutaiSSTR4
DMDMi206729897

Proteomic databases

PaxDbiP31391
PeptideAtlasiP31391
PRIDEiP31391
ProteomicsDBi54787

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		20974, 223 antibodies

Genome annotation databases

EnsembliENST00000255008; ENSP00000255008; ENSG00000132671
GeneIDi6754
KEGGihsa:6754
UCSCiuc002wsr.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6754
DisGeNETi6754
EuPathDBiHostDB:ENSG00000132671.5

GeneCards: human genes, protein and diseases

More...GeneCardsi		SSTR4
HGNCiHGNC:11333, SSTR4
HPAiENSG00000132671, Tissue enriched (brain)
MIMi182454, gene
neXtProtiNX_P31391
OpenTargetsiENSG00000132671
PharmGKBiPA36157

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3656, Eukaryota
GeneTreeiENSGT00940000156819
HOGENOMiCLU_009579_8_1_1
InParanoidiP31391
OMAiLIVGKMR
OrthoDBi1011272at2759
PhylomeDBiP31391
TreeFamiTF315737

Enzyme and pathway databases

PathwayCommonsiP31391
ReactomeiR-HSA-375276, Peptide ligand-binding receptors
R-HSA-418594, G alpha (i) signalling events
SIGNORiP31391

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6754, 6 hits in 839 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Somatostatin_receptor_4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6754
PharosiP31391, Tclin

Protein Ontology

More...PROi		PR:P31391
RNActiP31391, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000132671, Expressed in pancreas and 26 other tissues
GenevisibleiP31391, HS

Family and domain databases

InterProiView protein in InterPro
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
IPR000586, Somatstn_rcpt
IPR001512, Somatstn_rcpt_4
PfamiView protein in Pfam
PF00001, 7tm_1, 1 hit
PRINTSiPR00237, GPCRRHODOPSN
PR00246, SOMATOSTATNR
PR00590, SOMATOSTTN4R
SMARTiView protein in SMART
SM01381, 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSSR4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P31391
Secondary accession number(s): Q17RM1, Q17RM3, Q9UIY1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: September 23, 2008
Last modified: December 2, 2020
This is version 185 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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