UniProtKB - P31388 (5HT6R_RAT)
5-hydroxytryptamine receptor 6
Htr6
Functioni
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (PubMed:7680751).
Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity).
Is an activator of TOR signaling (By similarity).
By similarity1 PublicationGO - Molecular functioni
- G protein-coupled serotonin receptor activity Source: RGD
- neurotransmitter receptor activity Source: GO_Central
GO - Biological processi
- brain development Source: RGD
- cerebral cortex cell migration Source: UniProtKB
- chemical synaptic transmission Source: GO_Central
- G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: RGD
- learning Source: RGD
- long-term synaptic potentiation Source: RGD
- negative regulation of acetylcholine secretion, neurotransmission Source: RGD
- negative regulation of gamma-aminobutyric acid secretion Source: RGD
- negative regulation of glutamate secretion Source: RGD
- positive regulation of dopamine secretion Source: RGD
- positive regulation of gamma-aminobutyric acid secretion Source: RGD
- positive regulation of TOR signaling Source: UniProtKB
- response to estradiol Source: RGD
- response to xenobiotic stimulus Source: RGD
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-RNO-390666, Serotonin receptors |
Names & Taxonomyi
Protein namesi | Recommended name: 5-hydroxytryptamine receptor 6Short name: 5-HT-6 Short name: 5-HT6 Alternative name(s): ST-B17 Serotonin receptor 6 |
Gene namesi | Name:Htr6 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 62044, Htr6 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: RGD
Other locations
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 34 | ExtracellularBy similarityAdd BLAST | 34 | |
Transmembranei | 35 – 57 | Helical; Name=1By similarityAdd BLAST | 23 | |
Topological domaini | 58 – 64 | CytoplasmicBy similarity | 7 | |
Transmembranei | 65 – 85 | Helical; Name=2By similarityAdd BLAST | 21 | |
Topological domaini | 86 – 100 | ExtracellularBy similarityAdd BLAST | 15 | |
Transmembranei | 101 – 122 | Helical; Name=3By similarityAdd BLAST | 22 | |
Topological domaini | 123 – 144 | CytoplasmicBy similarityAdd BLAST | 22 | |
Transmembranei | 145 – 166 | Helical; Name=4By similarityAdd BLAST | 22 | |
Topological domaini | 167 – 184 | ExtracellularBy similarityAdd BLAST | 18 | |
Transmembranei | 185 – 208 | Helical; Name=5By similarityAdd BLAST | 24 | |
Topological domaini | 209 – 265 | CytoplasmicBy similarityAdd BLAST | 57 | |
Transmembranei | 266 – 290 | Helical; Name=6By similarityAdd BLAST | 25 | |
Topological domaini | 291 – 295 | ExtracellularBy similarity | 5 | |
Transmembranei | 296 – 320 | Helical; Name=7By similarityAdd BLAST | 25 | |
Topological domaini | 321 – 436 | CytoplasmicBy similarityAdd BLAST | 116 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000068977 | 1 – 436 | 5-hydroxytryptamine receptor 6Add BLAST | 436 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 9 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 99 ↔ 180 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P31388 |
PTM databases
GlyGeni | P31388, 1 site |
iPTMneti | P31388 |
PhosphoSitePlusi | P31388 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSRNOG00000049761, Expressed in frontal cortex and 5 other tissues |
ExpressionAtlasi | P31388, baseline and differential |
Genevisiblei | P31388, RN |
Interactioni
Subunit structurei
Interacts with MTOR, RPTOR and NF1 (By similarity).
Interacts with CDK5 (By similarity).
By similarityBinary interactionsi
P31388
With | #Exp. | IntAct |
---|---|---|
Map1b [P15205] | 2 | EBI-21279242,EBI-349666 |
Protein-protein interaction databases
BioGRIDi | 249039, 2 interactors |
IntActi | P31388, 3 interactors |
STRINGi | 10116.ENSRNOP00000064366 |
Chemistry databases
BindingDBi | P31388 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000154484 |
InParanoidi | P31388 |
OMAi | FQCRLQV |
OrthoDBi | 800636at2759 |
Family and domain databases
CDDi | cd15054, 7tmA_5-HT6, 1 hit |
InterProi | View protein in InterPro IPR002232, 5HT6_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MVPEPGPVNS STPAWGPGPP PAPGGSGWVA AALCVVIVLT AAANSLLIVL
60 70 80 90 100
ICTQPALRNT SNFFLVSLFT SDLMVGLVVM PPAMLNALYG RWVLARGLCL
110 120 130 140 150
LWTAFDVMCC SASILNLCLI SLDRYLLILS PLRYKLRMTA PRALALILGA
160 170 180 190 200
WSLAALASFL PLLLGWHELG KARTPAPGQC RLLASLPFVL VASGVTFFLP
210 220 230 240 250
SGAICFTYCR ILLAARKQAV QVASLTTGTA GQALETLQVP RTPRPGMESA
260 270 280 290 300
DSRRLATKHS RKALKASLTL GILLGMFFVT WLPFFVANIA QAVCDCISPG
310 320 330 340 350
LFDVLTWLGY CNSTMNPIIY PLFMRDFKRA LGRFLPCVHC PPEHRPALPP
360 370 380 390 400
PPCGPLTAVP DQASACSRCC LCLCRQTQIQ TPLQGAPRAC SSQPSFCCLE
410 420 430
RPPGTPRHPP GPPLWSTSLS QTLWSLRYGR IHSVPP
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JYX7 | A0A0G2JYX7_RAT | 5-hydroxytryptamine receptor 6 | Htr6 | 437 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 57 | L → V in AAA40618 (PubMed:7680751).Curated | 1 | |
Sequence conflicti | 336 – 436 | PCVHC…HSVPP → HASTVPRSTGQPCLPLHVDL SQRCQTRPQLQQVLALPLPP NSDSDSASGGTSGLQLTAQL LLPGEATRDPPPPTRATTVV NFFVTDSVEPEIRPHPLSSP VN in AAA40618 (PubMed:7680751).CuratedAdd BLAST | 101 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L03202 mRNA Translation: AAA40618.1 S62043 mRNA Translation: AAB26908.1 L19656 mRNA Translation: AAA40611.1 |
PIRi | I57942 JN0591 |
Genome annotation databases
Ensembli | ENSRNOT00000070865; ENSRNOP00000064366; ENSRNOG00000049761 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L03202 mRNA Translation: AAA40618.1 S62043 mRNA Translation: AAB26908.1 L19656 mRNA Translation: AAA40611.1 |
PIRi | I57942 JN0591 |
3D structure databases
SMRi | P31388 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 249039, 2 interactors |
IntActi | P31388, 3 interactors |
STRINGi | 10116.ENSRNOP00000064366 |
Chemistry databases
BindingDBi | P31388 |
ChEMBLi | CHEMBL3372 |
DrugCentrali | P31388 |
GuidetoPHARMACOLOGYi | 11 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P31388, 1 site |
iPTMneti | P31388 |
PhosphoSitePlusi | P31388 |
Proteomic databases
PaxDbi | P31388 |
Genome annotation databases
Ensembli | ENSRNOT00000070865; ENSRNOP00000064366; ENSRNOG00000049761 |
Organism-specific databases
RGDi | 62044, Htr6 |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000154484 |
InParanoidi | P31388 |
OMAi | FQCRLQV |
OrthoDBi | 800636at2759 |
Enzyme and pathway databases
Reactomei | R-RNO-390666, Serotonin receptors |
Miscellaneous databases
PROi | PR:P31388 |
Gene expression databases
Bgeei | ENSRNOG00000049761, Expressed in frontal cortex and 5 other tissues |
ExpressionAtlasi | P31388, baseline and differential |
Genevisiblei | P31388, RN |
Family and domain databases
CDDi | cd15054, 7tmA_5-HT6, 1 hit |
InterProi | View protein in InterPro IPR002232, 5HT6_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | 5HT6R_RAT | |
Accessioni | P31388Primary (citable) accession number: P31388 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | November 1, 1995 | |
Last modified: | February 23, 2022 | |
This is version 145 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - SIMILARITY comments
Index of protein domains and families