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Protein

5-hydroxytryptamine receptor 6

Gene

Htr6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (PubMed:7680751). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of TOR signaling (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • brain development Source: RGD
  • cerebral cortex cell migration Source: UniProtKB
  • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: RGD
  • learning Source: RGD
  • long-term synaptic potentiation Source: RGD
  • negative regulation of acetylcholine secretion, neurotransmission Source: RGD
  • negative regulation of gamma-aminobutyric acid secretion Source: RGD
  • negative regulation of glutamate secretion Source: RGD
  • positive regulation of dopamine secretion Source: RGD
  • positive regulation of gamma-aminobutyric acid secretion Source: RGD
  • positive regulation of TOR signaling Source: UniProtKB
  • response to drug Source: RGD
  • response to estradiol Source: RGD

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-390666 Serotonin receptors
R-RNO-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 6
Short name:
5-HT-6
Short name:
5-HT6
Alternative name(s):
ST-B17
Serotonin receptor 6
Gene namesi
Name:Htr6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi62044 Htr6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34ExtracellularBy similarityAdd BLAST34
Transmembranei35 – 57Helical; Name=1By similarityAdd BLAST23
Topological domaini58 – 64CytoplasmicBy similarity7
Transmembranei65 – 85Helical; Name=2By similarityAdd BLAST21
Topological domaini86 – 100ExtracellularBy similarityAdd BLAST15
Transmembranei101 – 122Helical; Name=3By similarityAdd BLAST22
Topological domaini123 – 144CytoplasmicBy similarityAdd BLAST22
Transmembranei145 – 166Helical; Name=4By similarityAdd BLAST22
Topological domaini167 – 184ExtracellularBy similarityAdd BLAST18
Transmembranei185 – 208Helical; Name=5By similarityAdd BLAST24
Topological domaini209 – 265CytoplasmicBy similarityAdd BLAST57
Transmembranei266 – 290Helical; Name=6By similarityAdd BLAST25
Topological domaini291 – 295ExtracellularBy similarity5
Transmembranei296 – 320Helical; Name=7By similarityAdd BLAST25
Topological domaini321 – 436CytoplasmicBy similarityAdd BLAST116

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3372
GuidetoPHARMACOLOGYi11

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000689771 – 4365-hydroxytryptamine receptor 6Add BLAST436

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi9N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi99 ↔ 180PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP31388
PRIDEiP31388

PTM databases

iPTMnetiP31388
PhosphoSitePlusiP31388

Expressioni

Tissue specificityi

Localized exclusively in the central nervous system, predominantly in the corpus striatum but also in various limbic and cortical regions.

Gene expression databases

BgeeiENSRNOG00000049761
ExpressionAtlasiP31388 baseline and differential
GenevisibleiP31388 RN

Interactioni

Subunit structurei

Interacts with MTOR, RPTOR and NF1 (By similarity). Interacts with CDK5 (By similarity).By similarity

Protein-protein interaction databases

BioGridi249039, 1 interactor
STRINGi10116.ENSRNOP00000064366

Chemistry databases

BindingDBiP31388

Structurei

3D structure databases

ProteinModelPortaliP31388
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00890000139331
HOVERGENiHBG106962
InParanoidiP31388

Family and domain databases

CDDicd15054 7tmA_5-HT6, 1 hit
InterProiView protein in InterPro
IPR002232 5HT6_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P31388-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPEPGPVNS STPAWGPGPP PAPGGSGWVA AALCVVIVLT AAANSLLIVL
60 70 80 90 100
ICTQPALRNT SNFFLVSLFT SDLMVGLVVM PPAMLNALYG RWVLARGLCL
110 120 130 140 150
LWTAFDVMCC SASILNLCLI SLDRYLLILS PLRYKLRMTA PRALALILGA
160 170 180 190 200
WSLAALASFL PLLLGWHELG KARTPAPGQC RLLASLPFVL VASGVTFFLP
210 220 230 240 250
SGAICFTYCR ILLAARKQAV QVASLTTGTA GQALETLQVP RTPRPGMESA
260 270 280 290 300
DSRRLATKHS RKALKASLTL GILLGMFFVT WLPFFVANIA QAVCDCISPG
310 320 330 340 350
LFDVLTWLGY CNSTMNPIIY PLFMRDFKRA LGRFLPCVHC PPEHRPALPP
360 370 380 390 400
PPCGPLTAVP DQASACSRCC LCLCRQTQIQ TPLQGAPRAC SSQPSFCCLE
410 420 430
RPPGTPRHPP GPPLWSTSLS QTLWSLRYGR IHSVPP
Length:436
Mass (Da):46,923
Last modified:November 1, 1995 - v2
Checksum:i6BC00F6A3CBA5FB4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti57L → V in AAA40618 (PubMed:7680751).Curated1
Sequence conflicti336 – 436PCVHC…HSVPP → HASTVPRSTGQPCLPLHVDL SQRCQTRPQLQQVLALPLPP NSDSDSASGGTSGLQLTAQL LLPGEATRDPPPPTRATTVV NFFVTDSVEPEIRPHPLSSP VN in AAA40618 (PubMed:7680751).CuratedAdd BLAST101

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L03202 mRNA Translation: AAA40618.1
S62043 mRNA Translation: AAB26908.1
L19656 mRNA Translation: AAA40611.1
PIRiI57942
JN0591
UniGeneiRn.10552

Genome annotation databases

EnsembliENSRNOT00000070865; ENSRNOP00000064366; ENSRNOG00000049761

Similar proteinsi

Entry informationi

Entry namei5HT6R_RAT
AccessioniPrimary (citable) accession number: P31388
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

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