Htr6

Functionⁱ

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (PubMed:7680751). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of TOR signaling (By similarity).By similarity1 Publication

GO - Molecular functionⁱ

G-protein coupled serotonin receptor activity
Source: RGD
Inferred from direct assayⁱ
- 7680751
neurotransmitter receptor activity Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

brain development
Source: RGD
Inferred from expression patternⁱ
- 9606024
cerebral cortex cell migration Source: UniProtKB
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
Source: RGD
Inferred from mutant phenotypeⁱ
- 7680751
learning
Source: RGD
Inferred from direct assayⁱ
- 17192775
long-term synaptic potentiation
Source: RGD
Inferred from mutant phenotypeⁱ
- 19660530
negative regulation of acetylcholine secretion, neurotransmission
Source: RGD
Inferred from mutant phenotypeⁱ
- 16987217
negative regulation of gamma-aminobutyric acid secretion
Source: RGD
Inferred from mutant phenotypeⁱ
- 16987217
negative regulation of glutamate secretion
Source: RGD
Inferred from mutant phenotypeⁱ
- 16987217
positive regulation of dopamine secretion
Source: RGD
Inferred from mutant phenotypeⁱ
- 16987217
positive regulation of gamma-aminobutyric acid secretion
Source: RGD
Inferred from mutant phenotypeⁱ
- 19660530
positive regulation of TOR signaling Source: UniProtKB
response to drug
Source: RGD
Inferred from expression patternⁱ
- 10427606
response to estradiol
Source: RGD
Inferred from expression patternⁱ
- 17122082

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactomeⁱ	R-RNO-390666 Serotonin receptors

Reactomeⁱ

R-RNO-390666 Serotonin receptors

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 5-hydroxytryptamine receptor 6 Short name: 5-HT-6 Short name: 5-HT6 Alternative name(s): ST-B17 Serotonin receptor 6
Gene namesⁱ	Name:Htr6
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 5

Organism-specific databases

Rat genome database More...RGDⁱ	62044 Htr6

RGDⁱ

62044 Htr6

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 34	ExtracellularBy similarityAdd BLAST	34
Transmembraneⁱ	35 – 57	Helical; Name=1By similarityAdd BLAST	23
Topological domainⁱ	58 – 64	CytoplasmicBy similarity	7
Transmembraneⁱ	65 – 85	Helical; Name=2By similarityAdd BLAST	21
Topological domainⁱ	86 – 100	ExtracellularBy similarityAdd BLAST	15
Transmembraneⁱ	101 – 122	Helical; Name=3By similarityAdd BLAST	22
Topological domainⁱ	123 – 144	CytoplasmicBy similarityAdd BLAST	22
Transmembraneⁱ	145 – 166	Helical; Name=4By similarityAdd BLAST	22
Topological domainⁱ	167 – 184	ExtracellularBy similarityAdd BLAST	18
Transmembraneⁱ	185 – 208	Helical; Name=5By similarityAdd BLAST	24
Topological domainⁱ	209 – 265	CytoplasmicBy similarityAdd BLAST	57
Transmembraneⁱ	266 – 290	Helical; Name=6By similarityAdd BLAST	25
Topological domainⁱ	291 – 295	ExtracellularBy similarity	5
Transmembraneⁱ	296 – 320	Helical; Name=7By similarityAdd BLAST	25
Topological domainⁱ	321 – 436	CytoplasmicBy similarityAdd BLAST	116

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL3372
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	11

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000068977	1 – 436	5-hydroxytryptamine receptor 6Add BLAST		436

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	9	N-linked (GlcNAc...) asparagineSequence analysis		1
Disulfide bondⁱ	99 ↔ 180	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	P31388
PRIDEⁱ	P31388

PTM databases

iPTMnetⁱ	P31388
PhosphoSitePlusⁱ	P31388

Expressionⁱ

Tissue specificityⁱ

Localized exclusively in the central nervous system, predominantly in the corpus striatum but also in various limbic and cortical regions.

Gene expression databases

Bgeeⁱ	ENSRNOG00000049761 Expressed in 1 organ(s), highest expression level in brain
ExpressionAtlasⁱ	P31388 baseline and differential
Genevisibleⁱ	P31388 RN

Interactionⁱ

Subunit structureⁱ

Interacts with MTOR, RPTOR and NF1 (By similarity). Interacts with CDK5 (By similarity).By similarity

Protein-protein interaction databases

BioGridⁱ	249039, 1 interactor
STRINGⁱ	10116.ENSRNOP00000064366

Chemistry databases

BindingDBⁱ

P31388

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P31388
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00890000139331
HOVERGENⁱ	HBG106962
InParanoidⁱ	P31388

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd15054 7tmA_5-HT6, 1 hit
InterProⁱ	View protein in InterPro IPR002232 5HT6_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P31388-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVPEPGPVNS STPAWGPGPP PAPGGSGWVA AALCVVIVLT AAANSLLIVL 
        60         70         80         90        100
ICTQPALRNT SNFFLVSLFT SDLMVGLVVM PPAMLNALYG RWVLARGLCL 
       110        120        130        140        150
LWTAFDVMCC SASILNLCLI SLDRYLLILS PLRYKLRMTA PRALALILGA 
       160        170        180        190        200
WSLAALASFL PLLLGWHELG KARTPAPGQC RLLASLPFVL VASGVTFFLP 
       210        220        230        240        250
SGAICFTYCR ILLAARKQAV QVASLTTGTA GQALETLQVP RTPRPGMESA 
       260        270        280        290        300
DSRRLATKHS RKALKASLTL GILLGMFFVT WLPFFVANIA QAVCDCISPG 
       310        320        330        340        350
LFDVLTWLGY CNSTMNPIIY PLFMRDFKRA LGRFLPCVHC PPEHRPALPP 
       360        370        380        390        400
PPCGPLTAVP DQASACSRCC LCLCRQTQIQ TPLQGAPRAC SSQPSFCCLE 
       410        420        430 
RPPGTPRHPP GPPLWSTSLS QTLWSLRYGR IHSVPP

Length:436

Mass (Da):46,923

Last modified:November 1, 1995 - v2

Checksum:ⁱ6BC00F6A3CBA5FB4

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A0G2JYX7	A0A0G2JYX7_RAT		5-hydroxytryptamine receptor 6 5-hydroxytryptamine receptor 6	Htr6	437	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	57	L → V in AAA40618 (PubMed:7680751).Curated		1
Sequence conflictⁱ	336 – 436	PCVHC…HSVPP → HASTVPRSTGQPCLPLHVDL SQRCQTRPQLQQVLALPLPP NSDSDSASGGTSGLQLTAQL LLPGEATRDPPPPTRATTVV NFFVTDSVEPEIRPHPLSSP VN in AAA40618 (PubMed:7680751).CuratedAdd BLAST		101

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L03202 mRNA Translation: AAA40618.1 S62043 mRNA Translation: AAB26908.1 L19656 mRNA Translation: AAA40611.1
PIRⁱ	I57942 JN0591
UniGeneⁱ	Rn.10552

Genome annotation databases

Ensemblⁱ	ENSRNOT00000070865; ENSRNOP00000064366; ENSRNOG00000049761

Ensemblⁱ

ENSRNOT00000070865; ENSRNOP00000064366; ENSRNOG00000049761

Similar proteinsⁱ

50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P31388	5-hydroxytryptamine receptor 6		MOUSE		440	UniRef50_P31388
5-hydroxytryptamine receptor 6		HUMAN		440
5-hydroxytryptamine receptor 6		PANTR		440
5-hydroxytryptamine receptor 6		PTEAL		438
5-hydroxytryptamine receptor 6		DIPOR		438
+188

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L03202 mRNA Translation: AAA40618.1 S62043 mRNA Translation: AAB26908.1 L19656 mRNA Translation: AAA40611.1
PIRⁱ	I57942 JN0591
UniGeneⁱ	Rn.10552

3D structure databases

ProteinModelPortalⁱ	P31388
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	249039, 1 interactor
STRINGⁱ	10116.ENSRNOP00000064366

Chemistry databases

BindingDBⁱ	P31388
ChEMBLⁱ	CHEMBL3372
GuidetoPHARMACOLOGYⁱ	11

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

iPTMnetⁱ	P31388
PhosphoSitePlusⁱ	P31388

Proteomic databases

PaxDbⁱ	P31388
PRIDEⁱ	P31388

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000070865; ENSRNOP00000064366; ENSRNOG00000049761

Ensemblⁱ

ENSRNOT00000070865; ENSRNOP00000064366; ENSRNOG00000049761

Organism-specific databases

RGDⁱ	62044 Htr6

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
GeneTreeⁱ	ENSGT00890000139331
HOVERGENⁱ	HBG106962
InParanoidⁱ	P31388

Enzyme and pathway databases

Reactomeⁱ	R-RNO-390666 Serotonin receptors

Reactomeⁱ

R-RNO-390666 Serotonin receptors

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P31388

PROⁱ

PR:P31388

Gene expression databases

Bgeeⁱ	ENSRNOG00000049761 Expressed in 1 organ(s), highest expression level in brain
ExpressionAtlasⁱ	P31388 baseline and differential
Genevisibleⁱ	P31388 RN

Family and domain databases

CDDⁱ	cd15054 7tmA_5-HT6, 1 hit
InterProⁱ	View protein in InterPro IPR002232 5HT6_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	5HT6R_RAT
Accessionⁱ	P31388Primary (citable) accession number: P31388
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
	Last sequence update:	November 1, 1995
	Last modified:	September 12, 2018
	This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P31388 (5HT6R_RAT)

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5-hydroxytryptamine receptor 6

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ