UniProtKB - P31381 (FUN26_YEAST)
Protein
Nucleoside transporter FUN26
Gene
FUN26
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Has broad nucleoside selectivity (uridine, adenosine and cytidine) and most likely functions to transport nucleosides across intracellular membranes.
Miscellaneous
Present with 217 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- nicotinamide riboside transmembrane transporter activity Source: SGD
- nucleobase transmembrane transporter activity Source: SGD
- nucleoside transmembrane transporter activity Source: SGD
GO - Biological processi
- nicotinamide riboside transport Source: SGD
- nucleobase transport Source: SGD
- nucleoside transport Source: SGD
- transmembrane transport Source: SGD
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
Reactomei | R-SCE-83936, Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane |
Protein family/group databases
TCDBi | 2.A.57.3.1, the equilibrative nucleoside transporter (ent) family |
Names & Taxonomyi
Protein namesi | Recommended name: Nucleoside transporter FUN26 |
Gene namesi | Name:FUN26 Ordered Locus Names:YAL022C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YAL022C |
SGDi | S000000020, FUN26 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Plasma Membrane
- plasma membrane Source: GO_Central
Vacuole
- fungal-type vacuole membrane Source: SGD
Other locations
- integral component of membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 76 – 96 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 116 – 136 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 151 – 171 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 174 – 194 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 214 – 234 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 243 – 263 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 344 – 364 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 367 – 387 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 411 – 431 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 446 – 466 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 492 – 512 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000209346 | 1 – 517 | Nucleoside transporter FUN26Add BLAST | 517 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 45 | PhosphoserineCombined sources | 1 | |
Modified residuei | 58 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P31381 |
PaxDbi | P31381 |
PRIDEi | P31381 |
PTM databases
iPTMneti | P31381 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 31744, 55 interactors |
DIPi | DIP-5495N |
IntActi | P31381, 6 interactors |
MINTi | P31381 |
STRINGi | 4932.YAL022C |
Miscellaneous databases
RNActi | P31381, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1479, Eukaryota |
GeneTreei | ENSGT00950000182898 |
HOGENOMi | CLU_021611_3_0_1 |
InParanoidi | P31381 |
OMAi | MTPWNFF |
Family and domain databases
InterProi | View protein in InterPro IPR034764, ENT1/ENT2 IPR002259, Eqnu_transpt IPR036259, MFS_trans_sf |
PANTHERi | PTHR10332, PTHR10332, 1 hit |
Pfami | View protein in Pfam PF01733, Nucleoside_tran, 1 hit |
PIRSFi | PIRSF016379, ENT, 1 hit |
PRINTSi | PR01130, DERENTRNSPRT |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00939, 2a57, 1 hit |
i Sequence
Sequence statusi: Complete.
P31381-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSTSADTDTI KKPILAVPEP ALADTHSEEI SRSGEEHESE NNEHSDEEGD
60 70 80 90 100
NYSEREQSVS TEPLDTLPLR KKLKNLSYIT FFAIGIGLLW PWNCILSASQ
110 120 130 140 150
YFKHDIFKDT SIWAKIFTSS MMSFSTISSM LFNIYLAKRQ YKYSRRVING
160 170 180 190 200
LVWEIIVFTV MCFFTILHFL LPKWFNFMFI MMLVVISSMG TAMTQNGIMA
210 220 230 240 250
IANVFGSEYS QGVMVGQAVA GVLPSLVLFA LAFIENSSVS TTGGILLYFF
260 270 280 290 300
TTTLVVTICV VMFSVSKISR KVNENWNVED GHITDVLLGS LRSNEEEIRI
310 320 330 340 350
VGRIDQMEDE DHRRTNGTRD DNDEGEELQL KVPFEVLFAK LKYLVLSIFT
360 370 380 390 400
TFVVTLVFPV FASATYVTGL PLSNAQYIPL IFTLWNLGDL YGRVIADWPM
410 420 430 440 450
FRDQKFTPRK TFIYSLLRVA AIPLFLMFTA ITSSSSGDEE HNGSVIVDLC
460 470 480 490 500
YMLLQFLFGV TNGHVISMSF MKVPEQLDND DEKEAAGGFT NIFVSTGLAL
510
GSIISYVFVF IIDFIIR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L05146 Genomic DNA Translation: AAC04935.1 BK006935 Genomic DNA Translation: DAA06966.1 |
PIRi | S36712 |
RefSeqi | NP_009380.1, NM_001178167.1 |
Genome annotation databases
EnsemblFungii | YAL022C_mRNA; YAL022C; YAL022C |
GeneIDi | 851211 |
KEGGi | sce:YAL022C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L05146 Genomic DNA Translation: AAC04935.1 BK006935 Genomic DNA Translation: DAA06966.1 |
PIRi | S36712 |
RefSeqi | NP_009380.1, NM_001178167.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 31744, 55 interactors |
DIPi | DIP-5495N |
IntActi | P31381, 6 interactors |
MINTi | P31381 |
STRINGi | 4932.YAL022C |
Protein family/group databases
TCDBi | 2.A.57.3.1, the equilibrative nucleoside transporter (ent) family |
PTM databases
iPTMneti | P31381 |
Proteomic databases
MaxQBi | P31381 |
PaxDbi | P31381 |
PRIDEi | P31381 |
Genome annotation databases
EnsemblFungii | YAL022C_mRNA; YAL022C; YAL022C |
GeneIDi | 851211 |
KEGGi | sce:YAL022C |
Organism-specific databases
EuPathDBi | FungiDB:YAL022C |
SGDi | S000000020, FUN26 |
Phylogenomic databases
eggNOGi | KOG1479, Eukaryota |
GeneTreei | ENSGT00950000182898 |
HOGENOMi | CLU_021611_3_0_1 |
InParanoidi | P31381 |
OMAi | MTPWNFF |
Enzyme and pathway databases
Reactomei | R-SCE-83936, Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane |
Miscellaneous databases
PROi | PR:P31381 |
RNActi | P31381, protein |
Family and domain databases
InterProi | View protein in InterPro IPR034764, ENT1/ENT2 IPR002259, Eqnu_transpt IPR036259, MFS_trans_sf |
PANTHERi | PTHR10332, PTHR10332, 1 hit |
Pfami | View protein in Pfam PF01733, Nucleoside_tran, 1 hit |
PIRSFi | PIRSF016379, ENT, 1 hit |
PRINTSi | PR01130, DERENTRNSPRT |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00939, 2a57, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FUN26_YEAST | |
Accessioni | P31381Primary (citable) accession number: P31381 Secondary accession number(s): D6VPJ6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | July 1, 1993 | |
Last modified: | December 2, 2020 | |
This is version 158 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome I
Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names