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Protein

Protein nubbin

Gene

nub

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

DNA-binding regulatory protein implicated in early development. Involved in neuronal cell fate decision. Repressed directly or indirectly by the BX-C homeotic proteins.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi523 – 582HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • dendrite morphogenesis Source: FlyBase
  • ganglion mother cell fate determination Source: FlyBase
  • heterochromatin organization involved in chromatin silencing Source: FlyBase
  • limb joint morphogenesis Source: FlyBase
  • negative regulation of antibacterial peptide biosynthetic process Source: FlyBase
  • pattern specification process Source: FlyBase
  • regulation of neural precursor cell proliferation Source: FlyBase
  • regulation of neurogenesis Source: FlyBase
  • regulation of transcription by RNA polymerase II Source: FlyBase
  • ventral cord development Source: FlyBase

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-DME-6807505 RNA polymerase II transcribes snRNA genes
SignaLinkiP31368

Names & Taxonomyi

Protein namesi
Recommended name:
Protein nubbin
Alternative name(s):
POU domain protein 1
Short name:
PDM-1
Protein twain
dOCT1
dPOU-19
Gene namesi
Name:nub
Synonyms:OCT1, pdm-1, POU-19, TWN
ORF Names:CG34395
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0085424 nub

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001007771 – 601Protein nubbinAdd BLAST601

Proteomic databases

PaxDbiP31368
PRIDEiP31368

Expressioni

Tissue specificityi

Initial expression in cellular blastoderm stage, then in ectodermal stripes during germband extension. Broad expression in the neuroectoderm followed by limitation to discrete subsets of CNS cells, and expression in specific PNS neurons and support cells.2 Publications

Developmental stagei

Expressed both maternally and zygotically.3 Publications

Gene expression databases

BgeeiFBgn0085424 Expressed in 67 organ(s), highest expression level in embryo
ExpressionAtlasiP31368 baseline and differential
GenevisibleiP31368 DM

Interactioni

Protein-protein interaction databases

BioGridi60715, 32 interactors
IntActiP31368, 4 interactors
STRINGi7227.FBpp0111554

Structurei

3D structure databases

ProteinModelPortaliP31368
SMRiP31368
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini421 – 495POU-specificPROSITE-ProRule annotationAdd BLAST75

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi104 – 107Poly-His4
Compositional biasi191 – 201Poly-AlaAdd BLAST11
Compositional biasi359 – 364Poly-His6
Compositional biasi407 – 415Poly-Ala9

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG3802 Eukaryota
ENOG410XQ7X LUCA
InParanoidiP31368
KOiK09364
OMAiQNRYISR
OrthoDBiEOG091G0U0S

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR010982 Lambda_DNA-bd_dom_sf
IPR013847 POU
IPR000327 POU_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF00157 Pou, 1 hit
PRINTSiPR00028 POUDOMAIN
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00352 POU, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF47413 SSF47413, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS00035 POU_1, 1 hit
PS00465 POU_2, 1 hit
PS51179 POU_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

P31368-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVMSELRWHT ASPEDNKNSL KRDLLKSTPT SAREAAVHIM QNRYISRLSR
60 70 80 90 100
SPSPLQSNAS DCDDNNSSVG TSSDRCRSPL SPALSLSHQQ AKRQLMSLQP
110 120 130 140 150
HPAHHHHNPH HLNHLNHHQY KQEEDYDDAN GGALNLTSDN SRHSTQSPSN
160 170 180 190 200
SVKSATASPV PVISVPSPVP PMISPVLAPS GCGSTTPNSM AAAAAAAAAV
210 220 230 240 250
ASTMGSGISP LLALPGMSSP QAQLAAAGLG MNNPLLTGSL SPQDFAQFHQ
260 270 280 290 300
LLQQRQVALT QQFNSYMELL RSGSLGLAQD DPALTAQVAA AQFLMQSQLQ
310 320 330 340 350
ALSQASQQLQ ALQKQQQRQV DEPLQLNHKM TQQPRSSTPH SIRSPIAIRS
360 370 380 390 400
PASSPQQLHH HHHHPLQITP PSSAASLKLS GMLTPSTPTS GTQMSQGTTT
410 420 430 440 450
PQPKTVASAA AARAAGEPSP EETTDLEELE QFAKTFKQRR IKLGFTQGDV
460 470 480 490 500
GLAMGKLYGN DFSQTTISRF EALNLSFKNM CKLKPLLQKW LDDADRTIQA
510 520 530 540 550
TGGVFDPAAL QATVSTPEII GRRRKKRTSI ETTIRGALEK AFLANQKPTS
560 570 580 590 600
EEITQLADRL SMEKEVVRVW FCNRRQKEKR INPSLDSPTG ADDDESSYMM

H
Length:601
Mass (Da):65,202
Last modified:July 1, 1993 - v1
Checksum:i8FFCD7B3C162D2B2
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8DYZ8A8DYZ8_DROME
POU domain protein
nub CG15488, CG15489, CG34395, CG6246, Dmel\CG34395 nub CG15488, CG15489, CG34395, CG6246, Dmel\CG34395, dOct1, dPOU-19, dPOU19, Nb, nb, NUB, Nub, Oct-1, Oct1, Pdm, pdm, PDM-1, Pdm-1, pdm-1, PDM1, Pdm1, pdm1, POU33F1, twn, CG34395, Dmel_CG34395
961Annotation score:
X2JDY7X2JDY7_DROME
POU domain protein
nub CG15488, CG15489, CG34395, CG6246, Dmel\CG34395 nub CG15488, CG15489, CG34395, CG6246, Dmel\CG34395, dOct1, dPOU-19, dPOU19, Nb, nb, NUB, Nub, Oct-1, Oct1, Pdm, pdm, PDM-1, Pdm-1, pdm-1, PDM1, Pdm1, pdm1, POU33F1, twn, CG34395, Dmel_CG34395
601Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti420P → R in AAB21409 (PubMed:1685891).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81957 mRNA Translation: AAA28829.1
S80561 mRNA Translation: AAB21409.1
M65015 mRNA Translation: AAA28480.1
AE014134 Genomic DNA Translation: AAF53205.2
AY118387 mRNA Translation: AAM48416.1
PIRiB56564
RefSeqiNP_001285876.1, NM_001298947.1
NP_476659.1, NM_057311.5
UniGeneiDm.4744

Genome annotation databases

EnsemblMetazoaiFBtr0112643; FBpp0111555; FBgn0085424
FBtr0342628; FBpp0309559; FBgn0085424
GeneIDi34669
KEGGidme:Dmel_CG34395

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81957 mRNA Translation: AAA28829.1
S80561 mRNA Translation: AAB21409.1
M65015 mRNA Translation: AAA28480.1
AE014134 Genomic DNA Translation: AAF53205.2
AY118387 mRNA Translation: AAM48416.1
PIRiB56564
RefSeqiNP_001285876.1, NM_001298947.1
NP_476659.1, NM_057311.5
UniGeneiDm.4744

3D structure databases

ProteinModelPortaliP31368
SMRiP31368
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi60715, 32 interactors
IntActiP31368, 4 interactors
STRINGi7227.FBpp0111554

Proteomic databases

PaxDbiP31368
PRIDEiP31368

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0112643; FBpp0111555; FBgn0085424
FBtr0342628; FBpp0309559; FBgn0085424
GeneIDi34669
KEGGidme:Dmel_CG34395

Organism-specific databases

CTDi34669
FlyBaseiFBgn0085424 nub

Phylogenomic databases

eggNOGiKOG3802 Eukaryota
ENOG410XQ7X LUCA
InParanoidiP31368
KOiK09364
OMAiQNRYISR
OrthoDBiEOG091G0U0S

Enzyme and pathway databases

ReactomeiR-DME-6807505 RNA polymerase II transcribes snRNA genes
SignaLinkiP31368

Miscellaneous databases

GenomeRNAii34669
PROiPR:P31368

Gene expression databases

BgeeiFBgn0085424 Expressed in 67 organ(s), highest expression level in embryo
ExpressionAtlasiP31368 baseline and differential
GenevisibleiP31368 DM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR010982 Lambda_DNA-bd_dom_sf
IPR013847 POU
IPR000327 POU_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF00157 Pou, 1 hit
PRINTSiPR00028 POUDOMAIN
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00352 POU, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF47413 SSF47413, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS00035 POU_1, 1 hit
PS00465 POU_2, 1 hit
PS51179 POU_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPDM1_DROME
AccessioniPrimary (citable) accession number: P31368
Secondary accession number(s): Q9VK74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: September 12, 2018
This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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