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Protein

POU domain, class 2, transcription factor 3

Gene

Pou2f3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3').

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi274 – 333HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • epidermis development Source: MGI
  • keratinocyte differentiation Source: MGI
  • negative regulation by host of viral transcription Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • regulation of transcription by RNA polymerase II Source: MGI
  • wound healing Source: MGI

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 2, transcription factor 3
Alternative name(s):
Epoc-1
Octamer-binding protein 11
Short name:
Oct-11
Octamer-binding transcription factor 11
Short name:
OTF-11
Gene namesi
Name:Pou2f3
Synonyms:Epoc1, Oct11, Otf-11, Otf11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:102565 Pou2f3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001007181 – 431POU domain, class 2, transcription factor 3Add BLAST431

Proteomic databases

MaxQBiP31362
PaxDbiP31362
PRIDEiP31362

PTM databases

iPTMnetiP31362
PhosphoSitePlusiP31362

Expressioni

Tissue specificityi

Skin, thymus, stomach and testis.

Developmental stagei

During embryogenesis and in adults.

Gene expression databases

CleanExiMM_POU2F3

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000135115

Structurei

3D structure databases

ProteinModelPortaliP31362
SMRiP31362
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini176 – 250POU-specificPROSITE-ProRule annotationAdd BLAST75

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi347 – 420Ser-richAdd BLAST74

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG3802 Eukaryota
ENOG410XQ7X LUCA
HOGENOMiHOG000220842
HOVERGENiHBG052783
InParanoidiP31362
PhylomeDBiP31362

Family and domain databases

CDDicd00086 homeodomain, 1 hit
cd00093 HTH_XRE, 1 hit
InterProiView protein in InterPro
IPR001387 Cro/C1-type_HTH
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR010982 Lambda_DNA-bd_dom_sf
IPR013847 POU
IPR000327 POU_dom
IPR000972 TF_octamer
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF00157 Pou, 1 hit
PRINTSiPR00029 OCTAMER
PR00028 POUDOMAIN
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00352 POU, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF47413 SSF47413, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS00035 POU_1, 1 hit
PS00465 POU_2, 1 hit
PS51179 POU_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P31362-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVNLEPMHTE IKMSGDVADS TDTRSTFGQV EPGNDRNGLD FNRQIKTEDL
60 70 80 90 100
GDSLQQTLSH RPCHLSQGPT MMPGNQMSGD MASLHPLQQL VLVPGHLQSV
110 120 130 140 150
SQFLLSQTPP GQQGLQPNLL SFPQQQSTLL LPQTGPGLRS QAVGRPGLSG
160 170 180 190 200
SSLEPHLDAP QHLPGPKHLP GPGGNDEPTD LEELEKFAKT FKQRRIKLGF
210 220 230 240 250
TQGDVGLAMG KLYGNDFSQT TISRFEALNL SFKNMCKLKP LLEKWLNDPE
260 270 280 290 300
SSPSDPSAST PSSYPTLSEV FGRKRKKRTS IETNIRLTLE KRFQDNPKPS
310 320 330 340 350
SEEISMIAEQ LSMEKEVVRV WFCNRRQKEK RINCPVATPV KPPIYNSRLV
360 370 380 390 400
SPSGSLGPLS VPPVHSTMPG TVTSSCSPGN NSRPSSPGSG LHASSPTASQ
410 420 430
NNSKAAMNSS SSSSFNSSGS WYRWNHPTYL H
Length:431
Mass (Da):47,071
Last modified:November 1, 1997 - v2
Checksum:i7E283E797EA8D3FA
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BJT4H3BJT4_MOUSE
POU domain protein
Pou2f3 mCG_1529
431Annotation score:
Q3U5D1Q3U5D1_MOUSE
POU domain protein
Pou2f3
419Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti139R → A in CAA79222 (PubMed:8441607).Curated1
Sequence conflicti249P → A in CAA79222 (PubMed:8441607).Curated1
Sequence conflicti396 – 431PTASQ…PTYLH → SQVWALLT in CAA79222 (PubMed:8441607).CuratedAdd BLAST36

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z18537 mRNA Translation: CAA79222.1
L14677 mRNA Translation: AAA16855.1
CCDSiCCDS40596.1
PIRiS35541
UniGeneiMm.436650

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z18537 mRNA Translation: CAA79222.1
L14677 mRNA Translation: AAA16855.1
CCDSiCCDS40596.1
PIRiS35541
UniGeneiMm.436650

3D structure databases

ProteinModelPortaliP31362
SMRiP31362
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000135115

PTM databases

iPTMnetiP31362
PhosphoSitePlusiP31362

Proteomic databases

MaxQBiP31362
PaxDbiP31362
PRIDEiP31362

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:102565 Pou2f3

Phylogenomic databases

eggNOGiKOG3802 Eukaryota
ENOG410XQ7X LUCA
HOGENOMiHOG000220842
HOVERGENiHBG052783
InParanoidiP31362
PhylomeDBiP31362

Miscellaneous databases

PROiPR:P31362
SOURCEiSearch...

Gene expression databases

CleanExiMM_POU2F3

Family and domain databases

CDDicd00086 homeodomain, 1 hit
cd00093 HTH_XRE, 1 hit
InterProiView protein in InterPro
IPR001387 Cro/C1-type_HTH
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR010982 Lambda_DNA-bd_dom_sf
IPR013847 POU
IPR000327 POU_dom
IPR000972 TF_octamer
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF00157 Pou, 1 hit
PRINTSiPR00029 OCTAMER
PR00028 POUDOMAIN
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00352 POU, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF47413 SSF47413, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS00035 POU_1, 1 hit
PS00465 POU_2, 1 hit
PS51179 POU_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPO2F3_MOUSE
AccessioniPrimary (citable) accession number: P31362
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: November 1, 1997
Last modified: November 7, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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