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UniProtKB - P31321 (KAP1_HUMAN)

Entry version 196 (07 Apr 2021)
Sequence version 4 (05 May 2009)
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Protein

cAMP-dependent protein kinase type I-beta regulatory subunit

Gene

PRKAR1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei202cAMP 11
Binding sitei211cAMP 11
Binding sitei326cAMP 21
Binding sitei335cAMP 21

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi137 – 254cAMP 1Add BLAST118
Nucleotide bindingi255 – 381cAMP 2Add BLAST127

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandcAMP, cAMP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P31321

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-163615, PKA activation
R-HSA-164378, PKA activation in glucagon signalling
R-HSA-180024, DARPP-32 events
R-HSA-381676, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-432040, Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-442720, CREB1 phosphorylation through the activation of Adenylate Cyclase
R-HSA-5610787, Hedgehog 'off' state
R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production
R-HSA-9664323, FCGR3A-mediated IL10 synthesis
R-HSA-983231, Factors involved in megakaryocyte development and platelet production

SIGNOR Signaling Network Open Resource

More...SIGNORi		P31321

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
cAMP-dependent protein kinase type I-beta regulatory subunit
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRKAR1B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:9390, PRKAR1B

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		176911, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P31321

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000188191.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		5575

MalaCards human disease database

More...MalaCardsi		PRKAR1B

Open Targets

More...OpenTargetsi		ENSG00000188191

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		412066, PRKAR1B-related neurodegenerative dementia with intermediate filaments

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33756

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P31321, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2320

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		1473

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PRKAR1B

Domain mapping of disease mutations (DMDM)

More...DMDMi		229463042

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002053812 – 381cAMP-dependent protein kinase type I-beta regulatory subunitAdd BLAST380

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei3PhosphoserineCombined sources1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi18Interchain (with C-39)By similarity
Modified residuei213'-nitrotyrosineCombined sources1
Disulfide bondi39Interchain (with C-18)By similarity
Modified residuei77PhosphoserineCombined sources1
Modified residuei83PhosphoserineCombined sources1
Modified residuei85PhosphothreonineBy similarity1
Modified residuei97Omega-N-methylarginineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The pseudophosphorylation site binds to the substrate-binding region of the catalytic chain, resulting in the inhibition of its activity.

Keywords - PTMi

Disulfide bond, Methylation, Nitration, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P31321

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P31321

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P31321

MaxQB - The MaxQuant DataBase

More...MaxQBi		P31321

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P31321

PeptideAtlas

More...PeptideAtlasi		P31321

PRoteomics IDEntifications database

More...PRIDEi		P31321

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		54780

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P31321

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P31321

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000188191, Expressed in anterior cingulate cortex and 230 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P31321, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P31321, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000188191, Tissue enriched (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The inactive holoenzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP releases the two active catalytic monomers and the regulatory dimer.

Interacts with PRKX; regulates this cAMP-dependent protein kinase.

Interacts with C2orf88/smAKAP; this interaction may target PRKAR1B to the plasma membrane.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

P31321
With#Exp.IntAct
AKAP14 [Q86UN6]3EBI-2805516,EBI-2119626
AKAP7 - isoform Alpha [O43687-2]5EBI-2805516,EBI-10185182
ANKS1A [Q49AR9]3EBI-2805516,EBI-11954519
BAG3 [O95817]3EBI-2805516,EBI-747185
BAG6 - isoform 2 [P46379-2]3EBI-2805516,EBI-10988864
BOD1L2 [Q8IYS8]3EBI-2805516,EBI-12118438
CAMSAP1 - isoform 3 [Q5T5Y3-3]6EBI-2805516,EBI-12036363
CBX8 [Q9HC52]3EBI-2805516,EBI-712912
CCDC103 [Q8IW40]5EBI-2805516,EBI-10261970
CDC37 [Q16543]3EBI-2805516,EBI-295634
CDKN1A [P38936]3EBI-2805516,EBI-375077
CEP19 [Q96LK0]5EBI-2805516,EBI-741885
COX5B [P10606]5EBI-2805516,EBI-1053725
DACH1 - isoform 2 [Q9UI36-2]3EBI-2805516,EBI-10186082
DTNB - isoform 5 [O60941-5]3EBI-2805516,EBI-11984733
EEF2KMT [Q96G04]3EBI-2805516,EBI-747840
FAM161A [Q3B820]3EBI-2805516,EBI-719941
FAM90A1 [Q86YD7]3EBI-2805516,EBI-6658203
FCHSD2 - isoform 3 [O94868-3]3EBI-2805516,EBI-11958845
GAS2L2 [Q8NHY3]3EBI-2805516,EBI-7960826
GLIS2 [Q9BZE0]3EBI-2805516,EBI-7251368
GNL3L [Q9NVN8]3EBI-2805516,EBI-746682
GOLGA1 [Q92805]3EBI-2805516,EBI-6164177
GPKOW [Q92917]3EBI-2805516,EBI-746309
GUCA1A [P43080]3EBI-2805516,EBI-6873005
hCG_1987119 [A0A024R8L2]3EBI-2805516,EBI-14103818
IGFN1 - isoform 5 [Q86VF2-5]3EBI-2805516,EBI-11955401
INPP5J [Q15735]3EBI-2805516,EBI-10236940
KANK2 [Q63ZY3]3EBI-2805516,EBI-2556193
KIF5B [P33176]3EBI-2805516,EBI-355878
L3MBTL2 [Q969R5]3EBI-2805516,EBI-739909
LENG1 [Q96BZ8]3EBI-2805516,EBI-726510
LNX1 [Q8TBB1]3EBI-2805516,EBI-739832
MBD3 - isoform 2 [O95983-2]3EBI-2805516,EBI-11978579
MED8 - isoform 2 [Q96G25-2]3EBI-2805516,EBI-10286267
MGC50722 [Q8IVT4]3EBI-2805516,EBI-14086479
NTAQ1 [Q96HA8]3EBI-2805516,EBI-741158
NXF1 [Q9UBU9]3EBI-2805516,EBI-398874
PIK3R3 [Q92569]3EBI-2805516,EBI-79893
POLE4 [Q9NR33]3EBI-2805516,EBI-867034
PRKAA2 [P54646]3EBI-2805516,EBI-1383852
PRKACA [P17612]7EBI-2805516,EBI-476586
PRKAR1A [P10644]6EBI-2805516,EBI-476431
PRPF18 [Q99633]3EBI-2805516,EBI-2798416
PSMG1 [O95456]3EBI-2805516,EBI-6286129
QRICH1 [Q2TAL8]3EBI-2805516,EBI-2798044
RARG [P13631]5EBI-2805516,EBI-2568901
RUNX1T1 - isoform MTG8A [Q06455-2]3EBI-2805516,EBI-11984663
SAP30BP [Q9UHR5]3EBI-2805516,EBI-751683
SH2D4A [Q9H788]3EBI-2805516,EBI-747035
SHC3 [Q92529]3EBI-2805516,EBI-79084
SMG9 [Q9H0W8]3EBI-2805516,EBI-2872322
SNW1 [Q13573]3EBI-2805516,EBI-632715
STK16 [O75716]3EBI-2805516,EBI-749295
SYTL4 [Q96C24]3EBI-2805516,EBI-747142
TASOR2 [Q5VWN6]3EBI-2805516,EBI-745958
TEAD4 [Q15561]3EBI-2805516,EBI-747736
THRA [P10827]5EBI-2805516,EBI-286285
TSGA10IP [Q3SY00]3EBI-2805516,EBI-10241197
UACA [Q9BZF9]3EBI-2805516,EBI-350510
VEZF1 [Q14119]3EBI-2805516,EBI-11980193
ZBTB16 [Q05516]3EBI-2805516,EBI-711925
ZMYND19 [Q96E35]3EBI-2805516,EBI-746595
ZNF177 - isoform 2 [Q13360-2]3EBI-2805516,EBI-12272076
ZNF329 [Q86UD4]3EBI-2805516,EBI-7233259
ZNF35 [P13682]3EBI-2805516,EBI-11041653
ZNF410 - isoform 3 [Q86VK4-3]3EBI-2805516,EBI-11741890
ZNF76 [P36508]3EBI-2805516,EBI-7254550

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111561, 119 interactors

Protein interaction database and analysis system

More...IntActi		P31321, 100 interactors

Molecular INTeraction database

More...MINTi		P31321

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000385749

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P31321, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1381
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P31321

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 136Dimerization and phosphorylationAdd BLAST135

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi96 – 100Pseudophosphorylation motif5

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cAMP-dependent kinase regulatory chain family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1113, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157513

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_018310_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P31321

Identification of Orthologs from Complete Genome Data

More...OMAi		XVYVNGE

Database of Orthologous Groups

More...OrthoDBi		1047290at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P31321

TreeFam database of animal gene trees

More...TreeFami		TF314920

Family and domain databases

Conserved Domains Database

More...CDDi		cd00038, CAP_ED, 2 hits
cd12102, DD_RIbeta_PKA, 1 hit

Database of protein disorder

More...DisProti		DP02632

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.120.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR012198, cAMP_dep_PK_reg_su
IPR003117, cAMP_dep_PK_reg_su_I/II_a/b
IPR018490, cNMP-bd-like
IPR018488, cNMP-bd_CS
IPR000595, cNMP-bd_dom
IPR042818, RIbeta_DD
IPR014710, RmlC-like_jellyroll

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00027, cNMP_binding, 2 hits
PF02197, RIIa, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000548, PK_regulatory, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00100, cNMP, 2 hits
SM00394, RIIa, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51206, SSF51206, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00888, CNMP_BINDING_1, 2 hits
PS00889, CNMP_BINDING_2, 2 hits
PS50042, CNMP_BINDING_3, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

P31321-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASPPACPSE EDESLKGCEL YVQLHGIQQV LKDCIVHLCI SKPERPMKFL 
        60         70         80         90        100
REHFEKLEKE ENRQILARQK SNSQSDSHDE EVSPTPPNPV VKARRRRGGV 
       110        120        130        140        150
SAEVYTEEDA VSYVRKVIPK DYKTMTALAK AISKNVLFAH LDDNERSDIF 
       160        170        180        190        200
DAMFPVTHIA GETVIQQGNE GDNFYVVDQG EVDVYVNGEW VTNISEGGSF 
       210        220        230        240        250
GELALIYGTP RAATVKAKTD LKLWGIDRDS YRRILMGSTL RKRKMYEEFL 
       260        270        280        290        300
SKVSILESLE KWERLTVADA LEPVQFEDGE KIVVQGEPGD DFYIITEGTA 
       310        320        330        340        350
SVLQRRSPNE EYVEVGRLGP SDYFGEIALL LNRPRAATVV ARGPLKCVKL 
       360        370        380 
DRPRFERVLG PCSEILKRNI QRYNSFISLT V
Length:381
Mass (Da):43,073
Last modified:May 5, 2009 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1ED7BFEC30897191
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JSK5C9JSK5_HUMAN
cAMP-dependent protein kinase type ...
PRKAR1B
297Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9IZL8C9IZL8_HUMAN
cAMP-dependent protein kinase type ...
PRKAR1B
165Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JR00C9JR00_HUMAN
cAMP-dependent protein kinase type ...
PRKAR1B
169Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J4C2C9J4C2_HUMAN
cAMP-dependent protein kinase type ...
PRKAR1B
116Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BYW5H7BYW5_HUMAN
cAMP-dependent protein kinase type ...
PRKAR1B
242Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti270A → R in AAC37564 (PubMed:1708242).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M65066 mRNA Translation: AAC37564.1
AK315951 mRNA Translation: BAH14322.1
AK315990 mRNA Translation: BAH14361.1
BC026734 mRNA Translation: AAH26734.1
BC036828 mRNA Translation: AAH36828.2

The Consensus CDS (CCDS) project

More...CCDSi		CCDS34579.1

Protein sequence database of the Protein Information Resource

More...PIRi		JH0392, OKHUR1

NCBI Reference Sequences

More...RefSeqi		NP_001158230.1, NM_001164758.1
NP_001158231.1, NM_001164759.1
NP_001158232.1, NM_001164760.1
NP_001158233.1, NM_001164761.1
NP_001158234.1, NM_001164762.1
NP_002726.1, NM_002735.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000360274; ENSP00000353415; ENSG00000188191
ENST00000403562; ENSP00000385349; ENSG00000188191
ENST00000406797; ENSP00000385749; ENSG00000188191
ENST00000537384; ENSP00000440449; ENSG00000188191
ENST00000544935; ENSP00000444487; ENSG00000188191

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5575

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5575

UCSC genome browser

More...UCSCi		uc003siu.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65066 mRNA Translation: AAC37564.1
AK315951 mRNA Translation: BAH14322.1
AK315990 mRNA Translation: BAH14361.1
BC026734 mRNA Translation: AAH26734.1
BC036828 mRNA Translation: AAH36828.2
CCDSiCCDS34579.1
PIRiJH0392, OKHUR1
RefSeqiNP_001158230.1, NM_001164758.1
NP_001158231.1, NM_001164759.1
NP_001158232.1, NM_001164760.1
NP_001158233.1, NM_001164761.1
NP_001158234.1, NM_001164762.1
NP_002726.1, NM_002735.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4DINX-ray3.70B1-381[»]
4F9KX-ray2.80A/B/C/D11-73[»]
SMRiP31321
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111561, 119 interactors
IntActiP31321, 100 interactors
MINTiP31321
STRINGi9606.ENSP00000385749

Chemistry databases

ChEMBLiCHEMBL2320
GuidetoPHARMACOLOGYi1473

PTM databases

iPTMnetiP31321
PhosphoSitePlusiP31321

Genetic variation databases

BioMutaiPRKAR1B
DMDMi229463042

Proteomic databases

EPDiP31321
jPOSTiP31321
MassIVEiP31321
MaxQBiP31321
PaxDbiP31321
PeptideAtlasiP31321
PRIDEiP31321
ProteomicsDBi54780

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		10769, 349 antibodies

The DNASU plasmid repository

More...DNASUi		5575

Genome annotation databases

EnsembliENST00000360274; ENSP00000353415; ENSG00000188191
ENST00000403562; ENSP00000385349; ENSG00000188191
ENST00000406797; ENSP00000385749; ENSG00000188191
ENST00000537384; ENSP00000440449; ENSG00000188191
ENST00000544935; ENSP00000444487; ENSG00000188191
GeneIDi5575
KEGGihsa:5575
UCSCiuc003siu.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5575
DisGeNETi5575

GeneCards: human genes, protein and diseases

More...GeneCardsi		PRKAR1B
HGNCiHGNC:9390, PRKAR1B
HPAiENSG00000188191, Tissue enriched (brain)
MalaCardsiPRKAR1B
MIMi176911, gene
neXtProtiNX_P31321
OpenTargetsiENSG00000188191
Orphaneti412066, PRKAR1B-related neurodegenerative dementia with intermediate filaments
PharmGKBiPA33756
VEuPathDBiHostDB:ENSG00000188191.14

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1113, Eukaryota
GeneTreeiENSGT00940000157513
HOGENOMiCLU_018310_1_1_1
InParanoidiP31321
OMAiXVYVNGE
OrthoDBi1047290at2759
PhylomeDBiP31321
TreeFamiTF314920

Enzyme and pathway databases

PathwayCommonsiP31321
ReactomeiR-HSA-163615, PKA activation
R-HSA-164378, PKA activation in glucagon signalling
R-HSA-180024, DARPP-32 events
R-HSA-381676, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-432040, Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-442720, CREB1 phosphorylation through the activation of Adenylate Cyclase
R-HSA-5610787, Hedgehog 'off' state
R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production
R-HSA-9664323, FCGR3A-mediated IL10 synthesis
R-HSA-983231, Factors involved in megakaryocyte development and platelet production
SIGNORiP31321

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5575, 10 hits in 994 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PRKAR1B, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		PRKAR1B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5575
PharosiP31321, Tbio

Protein Ontology

More...PROi		PR:P31321
RNActiP31321, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000188191, Expressed in anterior cingulate cortex and 230 other tissues
ExpressionAtlasiP31321, baseline and differential
GenevisibleiP31321, HS

Family and domain databases

CDDicd00038, CAP_ED, 2 hits
cd12102, DD_RIbeta_PKA, 1 hit
DisProtiDP02632
Gene3Di2.60.120.10, 2 hits
InterProiView protein in InterPro
IPR012198, cAMP_dep_PK_reg_su
IPR003117, cAMP_dep_PK_reg_su_I/II_a/b
IPR018490, cNMP-bd-like
IPR018488, cNMP-bd_CS
IPR000595, cNMP-bd_dom
IPR042818, RIbeta_DD
IPR014710, RmlC-like_jellyroll
PfamiView protein in Pfam
PF00027, cNMP_binding, 2 hits
PF02197, RIIa, 1 hit
PIRSFiPIRSF000548, PK_regulatory, 1 hit
SMARTiView protein in SMART
SM00100, cNMP, 2 hits
SM00394, RIIa, 1 hit
SUPFAMiSSF51206, SSF51206, 2 hits
PROSITEiView protein in PROSITE
PS00888, CNMP_BINDING_1, 2 hits
PS00889, CNMP_BINDING_2, 2 hits
PS50042, CNMP_BINDING_3, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKAP1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P31321
Secondary accession number(s): Q8N422
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: May 5, 2009
Last modified: April 7, 2021
This is version 196 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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