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Protein

T-cell leukemia homeobox protein 1

Gene

TLX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'.

Miscellaneous

TLX1 is oriented in a head-to-head manner with TDI. Both genes share the same promoter with robust bidirectional activity.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi201 – 260HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Enzyme and pathway databases

SignaLinkiP31314
SIGNORiP31314

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell leukemia homeobox protein 1
Alternative name(s):
Homeobox protein Hox-11
Proto-oncogene TCL-3
T-cell leukemia/lymphoma protein 3
Gene namesi
Name:TLX1
Synonyms:HOX11, TCL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000107807.12
HGNCiHGNC:5056 TLX1
MIMi186770 gene+phenotype
neXtProtiNX_P31314

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving TLX1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(10;14)(q24;q11) with TCRD.3 Publications

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi3195
MalaCardsiTLX1
MIMi186770 gene+phenotype
OpenTargetsiENSG00000107807
Orphaneti99861 Precursor T-cell acute lymphoblastic leukemia
PharmGKBiPA35095

Polymorphism and mutation databases

BioMutaiTLX1
DMDMi399982

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000493331 – 330T-cell leukemia homeobox protein 1Add BLAST330

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei236N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP31314
PRIDEiP31314
ProteomicsDBi54778
54779 [P31314-2]

PTM databases

iPTMnetiP31314
PhosphoSitePlusiP31314

Expressioni

Gene expression databases

BgeeiENSG00000107807
CleanExiHS_TLX1
ExpressionAtlasiP31314 baseline and differential
GenevisibleiP31314 HS

Interactioni

Subunit structurei

Interacts with MEIS1, MEIS2, PBX1, PBX2 and PBX3.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi109435, 4 interactors
DIPiDIP-155N
ELMiP31314
IntActiP31314, 9 interactors
STRINGi9606.ENSP00000359215

Structurei

3D structure databases

ProteinModelPortaliP31314
SMRiP31314
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0488 Eukaryota
ENOG411188D LUCA
GeneTreeiENSGT00910000143996
HOGENOMiHOG000116280
HOVERGENiHBG036206
InParanoidiP31314
KOiK09340
OMAiGEYGLGC
OrthoDBiEOG091G0RNV
PhylomeDBiP31314
TreeFamiTF325347

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P31314-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEHLGPHHLH PGHAEPISFG IDQILNSPDQ GGCMGPASRL QDGEYGLGCL
60 70 80 90 100
VGGAYTYGGG GSAAATGAGG AGAYGTGGPG GPGGPAGGGG ACSMGPLTGS
110 120 130 140 150
YNVNMALAGG PGPGGGGGSS GGAGALSAAG VIRVPAHRPL AGAVAHPQPL
160 170 180 190 200
ATGLPTVPSV PAMPGVNNLT GLTFPWMESN RRYTKDRFTG HPYQNRTPPK
210 220 230 240 250
KKKPRTSFTR LQICELEKRF HRQKYLASAE RAALAKALKM TDAQVKTWFQ
260 270 280 290 300
NRRTKWRRQT AEEREAERQQ ANRILLQLQQ EAFQKSLAQP LPADPLCVHN
310 320 330
SSLFALQNLQ PWSDDSTKIT SVTSVASACE
Length:330
Mass (Da):34,365
Last modified:July 1, 1993 - v1
Checksum:i09A518FB5271F7ED
GO
Isoform 2 (identifier: P31314-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     258-330: Missing.

Note: No experimental confirmation available.
Show »
Length:257
Mass (Da):26,245
Checksum:iA8072D76E4FC6CC7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti71A → T in CAA08834 (PubMed:10393251).Curated1
Sequence conflicti276L → R in AAB19293 (PubMed:1676542).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_043068258 – 330Missing in isoform 2. 1 PublicationAdd BLAST73

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62626 mRNA Translation: AAA36719.1
M75952 mRNA Translation: AAA58662.1
S38742 mRNA Translation: AAB19293.1
AJ009794 Genomic DNA Translation: CAA08834.1
AL357395 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49778.1
BC130530 mRNA Translation: AAI30531.1
AF067443 Genomic DNA Translation: AAG10096.1
CCDSiCCDS55725.1 [P31314-2]
CCDS7510.1 [P31314-1]
PIRiA40855
RefSeqiNP_001182446.1, NM_001195517.1 [P31314-2]
NP_005512.1, NM_005521.3 [P31314-1]
UniGeneiHs.89583

Genome annotation databases

EnsembliENST00000370196; ENSP00000359215; ENSG00000107807 [P31314-1]
ENST00000467928; ENSP00000434914; ENSG00000107807 [P31314-2]
GeneIDi3195
KEGGihsa:3195
UCSCiuc001ksw.4 human [P31314-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

Similar proteinsi

Entry informationi

Entry nameiTLX1_HUMAN
AccessioniPrimary (citable) accession number: P31314
Secondary accession number(s): A1L4G3
, O75699, Q5VXP2, Q9HCA0, Q9UD59
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: June 20, 2018
This is version 167 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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