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Protein

Homeobox protein Hox-C11

Gene

Hoxc11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi232 – 291HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-C11
Alternative name(s):
Homeobox protein Hox-3.7
Gene namesi
Name:Hoxc11
Synonyms:Hox-3.7, Hoxc-11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:96193 Hoxc11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002001951 – 304Homeobox protein Hox-C11Add BLAST304

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki82Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki116Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki178Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiP31313
PRIDEiP31313

PTM databases

PhosphoSitePlusiP31313

Expressioni

Gene expression databases

BgeeiENSMUSG00000001656 Expressed in 37 organ(s), highest expression level in embryo
CleanExiMM_HOXC11

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000001701

Structurei

3D structure databases

ProteinModelPortaliP31313
SMRiP31313
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0487 Eukaryota
ENOG4111FJP LUCA
GeneTreeiENSGT00910000143984
HOGENOMiHOG000231898
HOVERGENiHBG052048
InParanoidiP31313
KOiK09296
OMAiGKWHPRN
OrthoDBiEOG091G0CZ4
TreeFamiTF350668

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR021918 DUF3528
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF12045 DUF3528, 1 hit
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P31313-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFNSVNLGNF CSPSRKERGA DFGERGSCTS NLYLPSCTYY VPEFSTVSSF
60 70 80 90 100
LPQAPSRQIS YPYSAQVPPV REVSYGLEPS GKWHHRNSYS SCYAAADELM
110 120 130 140 150
HRECLPPSTV TEILMKNEGS YGGHHHPSAP HAAPAGFYSS VNKNSVLPQA
160 170 180 190 200
FDRFFDNAYC GGGDAPAEPP CSGKGEAKGE PEAPPASGLA SRAEAGAEAE
210 220 230 240 250
AEEENTNPSS SGSSHSATKE PAKGAAPNAP RTRKKRCPYS KFQIRELERE
260 270 280 290 300
FFFNVYINKE KRLQLSRMLN LTDRQVKIWF QNRRMKEKKL SRDRLQYFSG

NPLL
Length:304
Mass (Da):33,708
Last modified:October 3, 2012 - v3
Checksum:iCD91F6D2212751F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC160979 Genomic DNA No translation available.
CH466550 Genomic DNA Translation: EDL03950.1
BC139233 mRNA Translation: AAI39234.1
BC139269 mRNA Translation: AAI39270.1
CCDSiCCDS27892.1
PIRiI37290
RefSeqiNP_001020013.1, NM_001024842.1
UniGeneiMm.37692

Genome annotation databases

EnsembliENSMUST00000001701; ENSMUSP00000001701; ENSMUSG00000001656
GeneIDi109663
KEGGimmu:109663
UCSCiuc007xwy.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC160979 Genomic DNA No translation available.
CH466550 Genomic DNA Translation: EDL03950.1
BC139233 mRNA Translation: AAI39234.1
BC139269 mRNA Translation: AAI39270.1
CCDSiCCDS27892.1
PIRiI37290
RefSeqiNP_001020013.1, NM_001024842.1
UniGeneiMm.37692

3D structure databases

ProteinModelPortaliP31313
SMRiP31313
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000001701

PTM databases

PhosphoSitePlusiP31313

Proteomic databases

PaxDbiP31313
PRIDEiP31313

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001701; ENSMUSP00000001701; ENSMUSG00000001656
GeneIDi109663
KEGGimmu:109663
UCSCiuc007xwy.1 mouse

Organism-specific databases

CTDi3227
MGIiMGI:96193 Hoxc11

Phylogenomic databases

eggNOGiKOG0487 Eukaryota
ENOG4111FJP LUCA
GeneTreeiENSGT00910000143984
HOGENOMiHOG000231898
HOVERGENiHBG052048
InParanoidiP31313
KOiK09296
OMAiGKWHPRN
OrthoDBiEOG091G0CZ4
TreeFamiTF350668

Miscellaneous databases

PROiPR:P31313
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001656 Expressed in 37 organ(s), highest expression level in embryo
CleanExiMM_HOXC11

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR021918 DUF3528
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF12045 DUF3528, 1 hit
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHXC11_MOUSE
AccessioniPrimary (citable) accession number: P31313
Secondary accession number(s): B9EI74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: October 3, 2012
Last modified: November 7, 2018
This is version 144 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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