Hoxc11

Functionⁱ

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	232 – 291	HomeoboxPROSITE-ProRule annotationAdd BLAST		60

GO - Molecular functionⁱ

proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
RNA polymerase II proximal promoter sequence-specific DNA binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

anterior/posterior pattern specification
Source: MGI
Inferred from genetic interactionⁱ
- 12869760
embryonic digit morphogenesis
Source: MGI
Inferred from genetic interactionⁱ
- 12869760
embryonic skeletal joint morphogenesis
Source: MGI
Inferred from genetic interactionⁱ
- 20978074
metanephros development
Source: MGI
Inferred from genetic interactionⁱ
- 12050119
organ induction
Source: MGI
Inferred from genetic interactionⁱ
- 12050119
positive regulation of transcription by RNA polymerase II Source: MGI
proximal/distal pattern formation
Source: MGI
Inferred from genetic interactionⁱ
- 12869760
skeletal system development
Source: MGI
Inferred from genetic interactionⁱ
- 12869760

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Homeobox protein Hox-C11 Alternative name(s): Homeobox protein Hox-3.7
Gene namesⁱ	Name:Hoxc11 Synonyms:Hox-3.7, Hoxc-11
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 15

Organism-specific databases

MGIⁱ	MGI:96193 Hoxc11

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000200195	1 – 304	Homeobox protein Hox-C11Add BLAST		304

Amino acid modifications

Feature key	Position(s)	DescriptionActions
Cross-linkⁱ	82	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	116	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	178	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMⁱ

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbⁱ	P31313
PRIDEⁱ	P31313

PTM databases

PhosphoSitePlusⁱ	P31313

PhosphoSitePlusⁱ

P31313

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000001656 Expressed in 37 organ(s), highest expression level in embryo
CleanExⁱ	MM_HOXC11

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000001701

STRINGⁱ

10090.ENSMUSP00000001701

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P31313
SMRⁱ	P31313
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the Abd-B homeobox family.Curated

Keywords - Domainⁱ

Homeobox

Phylogenomic databases

eggNOGⁱ	KOG0487 Eukaryota ENOG4111FJP LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000143984
HOGENOMⁱ	HOG000231898
HOVERGENⁱ	HBG052048
InParanoidⁱ	P31313
KEGG Orthology (KO) More...KOⁱ	K09296
OMAⁱ	GKWHPRN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0CZ4
TreeFamⁱ	TF350668

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR021918 DUF3528 IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR020479 Homeobox_metazoa
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12045 DUF3528, 1 hit PF00046 Homeobox, 1 hit
PRINTSⁱ	PR00024 HOMEOBOX
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P31313-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MFNSVNLGNF CSPSRKERGA DFGERGSCTS NLYLPSCTYY VPEFSTVSSF 
        60         70         80         90        100
LPQAPSRQIS YPYSAQVPPV REVSYGLEPS GKWHHRNSYS SCYAAADELM 
       110        120        130        140        150
HRECLPPSTV TEILMKNEGS YGGHHHPSAP HAAPAGFYSS VNKNSVLPQA 
       160        170        180        190        200
FDRFFDNAYC GGGDAPAEPP CSGKGEAKGE PEAPPASGLA SRAEAGAEAE 
       210        220        230        240        250
AEEENTNPSS SGSSHSATKE PAKGAAPNAP RTRKKRCPYS KFQIRELERE 
       260        270        280        290        300
FFFNVYINKE KRLQLSRMLN LTDRQVKIWF QNRRMKEKKL SRDRLQYFSG 

NPLL

Length:304

Mass (Da):33,708

Last modified:October 3, 2012 - v3

Checksum:ⁱCD91F6D2212751F4

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC160979 Genomic DNA No translation available. CH466550 Genomic DNA Translation: EDL03950.1 BC139233 mRNA Translation: AAI39234.1 BC139269 mRNA Translation: AAI39270.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS27892.1
PIRⁱ	I37290
NCBI Reference Sequences More...RefSeqⁱ	NP_001020013.1, NM_001024842.1
UniGeneⁱ	Mm.37692

Genome annotation databases

Ensemblⁱ	ENSMUST00000001701; ENSMUSP00000001701; ENSMUSG00000001656
GeneIDⁱ	109663
KEGGⁱ	mmu:109663
UCSC genome browser More...UCSCⁱ	uc007xwy.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P31313	Homeobox C11		RAT		304	UniRef100_P31313

Protein	Similar proteins		Species	Score	Length	Source
P31313	Homeobox protein Hox-C11		HUMAN		304	UniRef90_O43248
Uncharacterized protein		RABIT		309
LOW QUALITY PROTEIN: homeobox protein Hox-C11		Yangtze finless porpoise		308
Homeobox protein Hox-C11		HETGA		306
Uncharacterized protein		MYOLU		306
+92

Protein	Similar proteins		Species	Score	Length	Source
P31313	Homeobox protein Hox-C11		HUMAN		304	UniRef50_O43248
Uncharacterized protein		RABIT		309
LOW QUALITY PROTEIN: homeobox protein Hox-C11		Yangtze finless porpoise		308
Uncharacterized protein		MYOLU		306
Homeobox C11 (Fragment)		Chinese water myotis		177
+125

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC160979 Genomic DNA No translation available. CH466550 Genomic DNA Translation: EDL03950.1 BC139233 mRNA Translation: AAI39234.1 BC139269 mRNA Translation: AAI39270.1
CCDSⁱ	CCDS27892.1
PIRⁱ	I37290
RefSeqⁱ	NP_001020013.1, NM_001024842.1
UniGeneⁱ	Mm.37692

3D structure databases

ProteinModelPortalⁱ	P31313
SMRⁱ	P31313
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000001701

STRINGⁱ

10090.ENSMUSP00000001701

PTM databases

PhosphoSitePlusⁱ	P31313

PhosphoSitePlusⁱ

P31313

Proteomic databases

PaxDbⁱ	P31313
PRIDEⁱ	P31313

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000001701; ENSMUSP00000001701; ENSMUSG00000001656
GeneIDⁱ	109663
KEGGⁱ	mmu:109663
UCSCⁱ	uc007xwy.1 mouse

Organism-specific databases

CTDⁱ	3227
MGIⁱ	MGI:96193 Hoxc11

Phylogenomic databases

eggNOGⁱ	KOG0487 Eukaryota ENOG4111FJP LUCA
GeneTreeⁱ	ENSGT00910000143984
HOGENOMⁱ	HOG000231898
HOVERGENⁱ	HBG052048
InParanoidⁱ	P31313
KOⁱ	K09296
OMAⁱ	GKWHPRN
OrthoDBⁱ	EOG091G0CZ4
TreeFamⁱ	TF350668

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P31313
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000001656 Expressed in 37 organ(s), highest expression level in embryo
CleanExⁱ	MM_HOXC11

Family and domain databases

CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR021918 DUF3528 IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR020479 Homeobox_metazoa
Pfamⁱ	View protein in Pfam PF12045 DUF3528, 1 hit PF00046 Homeobox, 1 hit
PRINTSⁱ	PR00024 HOMEOBOX
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HXC11_MOUSE
Accessionⁱ	P31313Primary (citable) accession number: P31313 Secondary accession number(s): B9EI74
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
	Last sequence update:	October 3, 2012
	Last modified:	November 7, 2018
	This is version 144 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Vertebrate homeotic Hox proteins
Nomenclature of vertebrate homeotic Hox proteins and list of entries
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P31313 (HXC11_MOUSE)

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Homeobox protein Hox-C11

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ