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UniProtKB - P31313 (HXC11_MOUSE)
Protein
Homeobox protein Hox-C11
Gene
Hoxc11
Organism
Mus musculus (Mouse)
Status
Functioni
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 232 – 291 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGI
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- anatomical structure development Source: GO_Central
- anterior/posterior pattern specification Source: MGI
- embryonic digit morphogenesis Source: MGI
- embryonic skeletal joint morphogenesis Source: MGI
- metanephros development Source: MGI
- organ induction Source: MGI
- positive regulation of transcription by RNA polymerase II Source: MGI
- proximal/distal pattern formation Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
- skeletal system development Source: MGI
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Homeobox protein Hox-C11Alternative name(s): Homeobox protein Hox-3.7 |
Gene namesi | Name:Hoxc11 Synonyms:Hox-3.7, Hoxc-11 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:96193, Hoxc11 |
VEuPathDBi | HostDB:ENSMUSG00000001656 |
Subcellular locationi
Nucleus
Cytosol
- cytosol Source: MGI
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000200195 | 1 – 304 | Homeobox protein Hox-C11Add BLAST | 304 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 82 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 116 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 178 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
PaxDbi | P31313 |
PRIDEi | P31313 |
ProteomicsDBi | 266932 |
PTM databases
PhosphoSitePlusi | P31313 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000001656, Expressed in embryo and 55 other tissues |
Interactioni
Protein-protein interaction databases
BioGRIDi | 224942, 1 interactor |
STRINGi | 10090.ENSMUSP00000001701 |
Miscellaneous databases
RNActi | P31313, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 167 – 237 | DisorderedSequence analysisAdd BLAST | 71 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 203 – 218 | Polar residuesSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Belongs to the Abd-B homeobox family.Curated
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0487, Eukaryota |
GeneTreei | ENSGT00940000160009 |
HOGENOMi | CLU_079662_0_0_1 |
InParanoidi | P31313 |
OMAi | AFPNFPL |
OrthoDBi | 976319at2759 |
PhylomeDBi | P31313 |
TreeFami | TF350668 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR021918, DUF3528 IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF12045, DUF3528, 1 hit PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P31313-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFNSVNLGNF CSPSRKERGA DFGERGSCTS NLYLPSCTYY VPEFSTVSSF
60 70 80 90 100
LPQAPSRQIS YPYSAQVPPV REVSYGLEPS GKWHHRNSYS SCYAAADELM
110 120 130 140 150
HRECLPPSTV TEILMKNEGS YGGHHHPSAP HAAPAGFYSS VNKNSVLPQA
160 170 180 190 200
FDRFFDNAYC GGGDAPAEPP CSGKGEAKGE PEAPPASGLA SRAEAGAEAE
210 220 230 240 250
AEEENTNPSS SGSSHSATKE PAKGAAPNAP RTRKKRCPYS KFQIRELERE
260 270 280 290 300
FFFNVYINKE KRLQLSRMLN LTDRQVKIWF QNRRMKEKKL SRDRLQYFSG
NPLL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC160979 Genomic DNA No translation available. CH466550 Genomic DNA Translation: EDL03950.1 BC139233 mRNA Translation: AAI39234.1 BC139269 mRNA Translation: AAI39270.1 |
CCDSi | CCDS27892.1 |
PIRi | I37290 |
RefSeqi | NP_001020013.1, NM_001024842.1 |
Genome annotation databases
Ensembli | ENSMUST00000001701; ENSMUSP00000001701; ENSMUSG00000001656 |
GeneIDi | 109663 |
KEGGi | mmu:109663 |
UCSCi | uc007xwy.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC160979 Genomic DNA No translation available. CH466550 Genomic DNA Translation: EDL03950.1 BC139233 mRNA Translation: AAI39234.1 BC139269 mRNA Translation: AAI39270.1 |
CCDSi | CCDS27892.1 |
PIRi | I37290 |
RefSeqi | NP_001020013.1, NM_001024842.1 |
3D structure databases
SMRi | P31313 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 224942, 1 interactor |
STRINGi | 10090.ENSMUSP00000001701 |
PTM databases
PhosphoSitePlusi | P31313 |
Proteomic databases
PaxDbi | P31313 |
PRIDEi | P31313 |
ProteomicsDBi | 266932 |
Protocols and materials databases
Antibodypediai | 15309, 306 antibodies from 28 providers |
Genome annotation databases
Ensembli | ENSMUST00000001701; ENSMUSP00000001701; ENSMUSG00000001656 |
GeneIDi | 109663 |
KEGGi | mmu:109663 |
UCSCi | uc007xwy.1, mouse |
Organism-specific databases
CTDi | 3227 |
MGIi | MGI:96193, Hoxc11 |
VEuPathDBi | HostDB:ENSMUSG00000001656 |
Phylogenomic databases
eggNOGi | KOG0487, Eukaryota |
GeneTreei | ENSGT00940000160009 |
HOGENOMi | CLU_079662_0_0_1 |
InParanoidi | P31313 |
OMAi | AFPNFPL |
OrthoDBi | 976319at2759 |
PhylomeDBi | P31313 |
TreeFami | TF350668 |
Miscellaneous databases
BioGRID-ORCSi | 109663, 0 hits in 64 CRISPR screens |
PROi | PR:P31313 |
RNActi | P31313, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000001656, Expressed in embryo and 55 other tissues |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR021918, DUF3528 IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF12045, DUF3528, 1 hit PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HXC11_MOUSE | |
Accessioni | P31313Primary (citable) accession number: P31313 Secondary accession number(s): B9EI74 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | October 3, 2012 | |
Last modified: | February 23, 2022 | |
This is version 161 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Vertebrate homeotic Hox proteins
Nomenclature of vertebrate homeotic Hox proteins and list of entries - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families