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UniProtKB - P31311 (HXA11_MOUSE)
Protein
Homeobox protein Hox-A11
Gene
Hoxa11
Organism
Mus musculus (Mouse)
Status
Functioni
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 241 – 300 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA binding Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- anatomical structure development Source: GO_Central
- anterior/posterior pattern specification Source: MGI
- bone development Source: MGI
- branching involved in ureteric bud morphogenesis Source: MGI
- cartilage development involved in endochondral bone morphogenesis Source: MGI
- developmental growth Source: MGI
- dorsal/ventral pattern formation Source: MGI
- embryonic digit morphogenesis Source: MGI
- embryonic forelimb morphogenesis Source: MGI
- embryonic limb morphogenesis Source: MGI
- embryonic skeletal joint morphogenesis Source: MGI
- male gonad development Source: MGI
- mesodermal cell fate specification Source: UniProtKB
- metanephros development Source: MGI
- organ induction Source: MGI
- positive regulation of cell development Source: MGI
- positive regulation of chondrocyte differentiation Source: MGI
- positive regulation of transcription, DNA-templated Source: UniProtKB
- prostate gland development Source: Ensembl
- proximal/distal pattern formation Source: MGI
- regulation of chondrocyte differentiation Source: MGI
- regulation of gene expression Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
- response to estrogen Source: Ensembl
- response to testosterone Source: Ensembl
- single fertilization Source: MGI
- skeletal system development Source: MGI
- spermatogenesis Source: MGI
- uterus development Source: MGI
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Homeobox protein Hox-A11Alternative name(s): Homeobox protein Hox-1.9 |
Gene namesi | Name:Hoxa11 Synonyms:Hox-1.9, Hoxa-11 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:96172, Hoxa11 |
VEuPathDBi | HostDB:ENSMUSG00000038210 |
Subcellular locationi
Nucleus
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: GO_Central
Other locations
- protein-containing complex Source: UniProtKB
- protein-DNA complex Source: UniProtKB
- transcription regulator complex Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000200096 | 1 – 313 | Homeobox protein Hox-A11Add BLAST | 313 |
Proteomic databases
PaxDbi | P31311 |
PRIDEi | P31311 |
ProteomicsDBi | 273228 |
PTM databases
iPTMneti | P31311 |
PhosphoSitePlusi | P31311 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000038210, Expressed in decidua and 114 other tissues |
Genevisiblei | P31311, MM |
Interactioni
Binary interactionsi
P31311
With | #Exp. | IntAct |
---|---|---|
Gmnn [O88513] | 2 | EBI-445941,EBI-445922 |
Protein-protein interaction databases
BioGRIDi | 200364, 8 interactors |
IntActi | P31311, 7 interactors |
STRINGi | 10090.ENSMUSP00000040920 |
Miscellaneous databases
RNActi | P31311, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 188 – 246 | DisorderedSequence analysisAdd BLAST | 59 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 205 – 219 | Basic and acidic residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the Abd-B homeobox family.Curated
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0487, Eukaryota |
GeneTreei | ENSGT00940000158311 |
HOGENOMi | CLU_079662_0_0_1 |
InParanoidi | P31311 |
OMAi | NVYHHPS |
OrthoDBi | 976319at2759 |
PhylomeDBi | P31311 |
TreeFami | TF350668 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR021918, DUF3528 IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF12045, DUF3528, 1 hit PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P31311-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMDFDERGPC SSNMYLPSCT YYVSGPDFSS LPSFLPQTPS SRPMTYSYSS
60 70 80 90 100
NLPQVQPVRE VTFREYAIEP ATKWHPRGNL AHCYSAEELV HRDCLQAPSA
110 120 130 140 150
AGVPGDVLAK SSANVYHHPT PAVSSNFYST VGRNGVLPQA FDQFFETAYG
160 170 180 190 200
TPENLASSDY PGDKNAEKGP QAAAATSAAA VAAAATGAPA TSSSDGGGGG
210 220 230 240 250
GCQEAAAEEK ERRRRPESSS SPESSSGHTE DKAGGSGGQR TRKKRCPYTK
260 270 280 290 300
YQIRELEREF FFSVYINKEK RLQLSRMLNL TDRQVKIWFQ NRRMKEKKIN
310
RDRLQYYSAN PLL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U20371 Genomic DNA Translation: AAA85711.1 U20370 mRNA Translation: AAA85710.1 AK133481 mRNA Translation: BAE21679.1 BC119302 mRNA Translation: AAI19303.1 |
CCDSi | CCDS20148.1 |
PIRi | G37290 |
RefSeqi | NP_034580.1, NM_010450.3 |
Genome annotation databases
Ensembli | ENSMUST00000048026; ENSMUSP00000040920; ENSMUSG00000038210 |
GeneIDi | 15396 |
KEGGi | mmu:15396 |
UCSCi | uc009byn.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U20371 Genomic DNA Translation: AAA85711.1 U20370 mRNA Translation: AAA85710.1 AK133481 mRNA Translation: BAE21679.1 BC119302 mRNA Translation: AAI19303.1 |
CCDSi | CCDS20148.1 |
PIRi | G37290 |
RefSeqi | NP_034580.1, NM_010450.3 |
3D structure databases
AlphaFoldDBi | P31311 |
SMRi | P31311 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 200364, 8 interactors |
IntActi | P31311, 7 interactors |
STRINGi | 10090.ENSMUSP00000040920 |
PTM databases
iPTMneti | P31311 |
PhosphoSitePlusi | P31311 |
Proteomic databases
PaxDbi | P31311 |
PRIDEi | P31311 |
ProteomicsDBi | 273228 |
Protocols and materials databases
Antibodypediai | 12408, 366 antibodies from 33 providers |
DNASUi | 15396 |
Genome annotation databases
Ensembli | ENSMUST00000048026; ENSMUSP00000040920; ENSMUSG00000038210 |
GeneIDi | 15396 |
KEGGi | mmu:15396 |
UCSCi | uc009byn.2, mouse |
Organism-specific databases
CTDi | 3207 |
MGIi | MGI:96172, Hoxa11 |
VEuPathDBi | HostDB:ENSMUSG00000038210 |
Phylogenomic databases
eggNOGi | KOG0487, Eukaryota |
GeneTreei | ENSGT00940000158311 |
HOGENOMi | CLU_079662_0_0_1 |
InParanoidi | P31311 |
OMAi | NVYHHPS |
OrthoDBi | 976319at2759 |
PhylomeDBi | P31311 |
TreeFami | TF350668 |
Miscellaneous databases
BioGRID-ORCSi | 15396, 2 hits in 75 CRISPR screens |
ChiTaRSi | Hoxa11, mouse |
PROi | PR:P31311 |
RNActi | P31311, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000038210, Expressed in decidua and 114 other tissues |
Genevisiblei | P31311, MM |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR021918, DUF3528 IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF12045, DUF3528, 1 hit PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HXA11_MOUSE | |
Accessioni | P31311Primary (citable) accession number: P31311 Secondary accession number(s): Q3V026 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | October 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 168 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Vertebrate homeotic Hox proteins
Nomenclature of vertebrate homeotic Hox proteins and list of entries - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families