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Protein

Protein Wnt-3a

Gene

wnt3a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube.By similarity

GO - Molecular functioni

GO - Biological processi

  • canonical Wnt signaling pathway Source: BHF-UCL
  • neural crest cell differentiation Source: BHF-UCL
  • positive regulation of DNA binding transcription factor activity Source: BHF-UCL

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-3a
Short name:
XWnt-3a
Gene namesi
Name:wnt3a
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-1217290 wnt3a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000004142019 – 352Protein Wnt-3aAdd BLAST334

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi77 ↔ 88By similarity
Glycosylationi87N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi128 ↔ 136By similarity
Disulfide bondi138 ↔ 155By similarity
Disulfide bondi203 ↔ 217By similarity
Disulfide bondi205 ↔ 212By similarity
Lipidationi209O-palmitoleoyl serineBy similarity1
Disulfide bondi297 ↔ 312By similarity
Glycosylationi298N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi327 ↔ 342By similarity
Disulfide bondi329 ↔ 339By similarity
Disulfide bondi334 ↔ 335By similarity

Post-translational modificationi

Disulfide bonds have critical and distinct roles in secretion and activity. Loss of each conserved cysteine results in high molecular weight oxidized Wnt oligomers, which are formed through inter-Wnt disulfide bonding.By similarity
Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Expressioni

Tissue specificityi

At neurula in anterior neural fold; at tailbud in dorsal midline of midbrain.

Developmental stagei

Neurula onwards.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ptk7Q6PA072EBI-7036309,EBI-7036323

GO - Molecular functioni

Protein-protein interaction databases

IntActiP31285, 3 interactors
MINTiP31285

Structurei

3D structure databases

SMRiP31285
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG001595
KOiK00312

Family and domain databases

InterProiView protein in InterPro
IPR005817 Wnt
IPR009141 Wnt3
IPR018161 Wnt_CS
PANTHERiPTHR12027 PTHR12027, 1 hit
PfamiView protein in Pfam
PF00110 wnt, 1 hit
PRINTSiPR01843 WNT3PROTEIN
PR01349 WNTPROTEIN
SMARTiView protein in SMART
SM00097 WNT1, 1 hit
PROSITEiView protein in PROSITE
PS00246 WNT1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31285-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCFGYLLLI IGLHQVLATY PIWWSLAVGQ QYSSLGTQPI PCGTIPGLVA
60 70 80 90 100
KQMRFCRNYM EIMPSVAEGV KIGIQECQHQ FRGRRWNCTT VNDNLAIFGP
110 120 130 140 150
VLDKATRESA FVHAIASAGV AFAVTRSCAE GSATICGCDT HHKGPPGEGW
160 170 180 190 200
KWGGCSEDMD FGSMVSREFA DARENRPDAR SAMNRHNNEA GRTSILDHRH
210 220 230 240 250
LKCKCHGLSG SCEVKTCWWS QPDFRVIGDY LKDKYDSASE MVVEKHRESR
260 270 280 290 300
GWVETLRPKY TFFKPPIERD LIYYESSPNF CEPNPETGSF GTRDRECNVT
310 320 330 340 350
SHGIDGCDLL CCGRGQNTRT EKRKEKCHCI FHWCCYVSCQ ECMRVYDVHT

CK
Length:352
Mass (Da):39,715
Last modified:July 1, 1993 - v1
Checksum:i4B5F93F5DF08D6C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07538 mRNA Translation: AAA50009.1
PIRiA48828
RefSeqiNP_001079343.1, NM_001085874.1
UniGeneiXl.880

Genome annotation databases

GeneIDi378679
KEGGixla:378679

Similar proteinsi

Entry informationi

Entry nameiWNT3A_XENLA
AccessioniPrimary (citable) accession number: P31285
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: June 20, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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