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Protein

Homeobox protein Hox-C12

Gene

HOXC12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi214 – 273HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-C12
Alternative name(s):
Homeobox protein Hox-3F
Gene namesi
Name:HOXC12
Synonyms:HOC3F, HOX3F
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000123407.3
HGNCiHGNC:5124 HOXC12
MIMi142975 gene
neXtProtiNX_P31275

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3228
OpenTargetsiENSG00000123407
PharmGKBiPA29399

Polymorphism and mutation databases

BioMutaiHOXC12
DMDMi20141538

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002001941 – 282Homeobox protein Hox-C12Add BLAST282

Proteomic databases

PaxDbiP31275
PeptideAtlasiP31275
PRIDEiP31275
ProteomicsDBi54775

PTM databases

iPTMnetiP31275
PhosphoSitePlusiP31275

Expressioni

Gene expression databases

BgeeiENSG00000123407 Expressed in 15 organ(s), highest expression level in skin of leg
CleanExiHS_HOXC12
GenevisibleiP31275 HS

Organism-specific databases

HPAiHPA055632

Structurei

3D structure databases

ProteinModelPortaliP31275
SMRiP31275
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0487 Eukaryota
ENOG4111FJP LUCA
GeneTreeiENSGT00910000143984
HOGENOMiHOG000231177
HOVERGENiHBG052050
InParanoidiP31275
KOiK09297
OMAiEPCNGYS
OrthoDBiEOG091G0HNN
PhylomeDBiP31275
TreeFamiTF351604

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P31275-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGEHNLLNPG FVGPLVNIHT GDTFYFPNFR ASGAQLPGLP SLSYPRRDNV
60 70 80 90 100
CSLSWPSAEP CNGYPQPYLG SPVSLNPPFG RTCELARVED GKGYYREPCA
110 120 130 140 150
EGGGGGLKRE ERGRDPGAGP GAALLPLEPS GPPALGFKYD YAAGGGGGDG
160 170 180 190 200
GGGAGPPHDP PSCQSLESDS SSSLLNEGNK GAGAGDPGSL VSPLNPGGGL
210 220 230 240 250
SASGAPWYPI NSRSRKKRKP YSKLQLAELE GEFLVNEFIT RQRRRELSDR
260 270 280
LNLSDQQVKI WFQNRRMKKK RLLLREQALS FF
Length:282
Mass (Da):30,171
Last modified:January 23, 2002 - v2
Checksum:i493C53C511054A4D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF328962, AF328963 Genomic DNA Translation: AAK16717.1
CCDSiCCDS8866.1
PIRiS14933
RefSeqiNP_776272.1, NM_173860.2
UniGeneiHs.381267
Hs.587727

Genome annotation databases

EnsembliENST00000243103; ENSP00000243103; ENSG00000123407
GeneIDi3228
KEGGihsa:3228
UCSCiuc010soq.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF328962, AF328963 Genomic DNA Translation: AAK16717.1
CCDSiCCDS8866.1
PIRiS14933
RefSeqiNP_776272.1, NM_173860.2
UniGeneiHs.381267
Hs.587727

3D structure databases

ProteinModelPortaliP31275
SMRiP31275
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiP31275
PhosphoSitePlusiP31275

Polymorphism and mutation databases

BioMutaiHOXC12
DMDMi20141538

Proteomic databases

PaxDbiP31275
PeptideAtlasiP31275
PRIDEiP31275
ProteomicsDBi54775

Protocols and materials databases

DNASUi3228
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000243103; ENSP00000243103; ENSG00000123407
GeneIDi3228
KEGGihsa:3228
UCSCiuc010soq.3 human

Organism-specific databases

CTDi3228
DisGeNETi3228
EuPathDBiHostDB:ENSG00000123407.3
GeneCardsiHOXC12
HGNCiHGNC:5124 HOXC12
HPAiHPA055632
MIMi142975 gene
neXtProtiNX_P31275
OpenTargetsiENSG00000123407
PharmGKBiPA29399
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0487 Eukaryota
ENOG4111FJP LUCA
GeneTreeiENSGT00910000143984
HOGENOMiHOG000231177
HOVERGENiHBG052050
InParanoidiP31275
KOiK09297
OMAiEPCNGYS
OrthoDBiEOG091G0HNN
PhylomeDBiP31275
TreeFamiTF351604

Miscellaneous databases

GeneWikiiHOXC12
GenomeRNAii3228
PROiPR:P31275
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000123407 Expressed in 15 organ(s), highest expression level in skin of leg
CleanExiHS_HOXC12
GenevisibleiP31275 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHXC12_HUMAN
AccessioniPrimary (citable) accession number: P31275
Secondary accession number(s): Q9BXJ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2002
Last modified: November 7, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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