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UniProtKB - P31275 (HXC12_HUMAN)
Protein
Homeobox protein Hox-C12
Gene
HOXC12
Organism
Homo sapiens (Human)
Status
Functioni
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 214 – 273 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: InterPro
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | P31275 |
Names & Taxonomyi
Protein namesi | Recommended name: Homeobox protein Hox-C12Alternative name(s): Homeobox protein Hox-3F |
Gene namesi | Name:HOXC12 Synonyms:HOC3F, HOX3F |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:5124, HOXC12 |
MIMi | 142975, gene |
neXtProti | NX_P31275 |
VEuPathDBi | HostDB:ENSG00000123407 |
Subcellular locationi
Nucleus
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 3228 |
OpenTargetsi | ENSG00000123407 |
PharmGKBi | PA29399 |
Miscellaneous databases
Pharosi | P31275, Tbio |
Genetic variation databases
BioMutai | HOXC12 |
DMDMi | 20141538 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000200194 | 1 – 282 | Homeobox protein Hox-C12Add BLAST | 282 |
Proteomic databases
MassIVEi | P31275 |
PaxDbi | P31275 |
PeptideAtlasi | P31275 |
PRIDEi | P31275 |
ProteomicsDBi | 54775 |
PTM databases
iPTMneti | P31275 |
PhosphoSitePlusi | P31275 |
Expressioni
Gene expression databases
Bgeei | ENSG00000123407, Expressed in sural nerve and 21 other tissues |
Genevisiblei | P31275, HS |
Organism-specific databases
HPAi | ENSG00000123407, Tissue enhanced (skin) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 109468, 5 interactors |
STRINGi | 9606.ENSP00000243103 |
Miscellaneous databases
RNActi | P31275, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 94 – 129 | DisorderedSequence analysisAdd BLAST | 36 | |
Regioni | 147 – 214 | DisorderedSequence analysisAdd BLAST | 68 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 163 – 178 | Polar residuesSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Belongs to the Abd-B homeobox family.Curated
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0487, Eukaryota |
GeneTreei | ENSGT01040000240513 |
HOGENOMi | CLU_087968_1_0_1 |
InParanoidi | P31275 |
OMAi | SYYREPC |
OrthoDBi | 1154178at2759 |
PhylomeDBi | P31275 |
TreeFami | TF351604 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P31275-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGEHNLLNPG FVGPLVNIHT GDTFYFPNFR ASGAQLPGLP SLSYPRRDNV
60 70 80 90 100
CSLSWPSAEP CNGYPQPYLG SPVSLNPPFG RTCELARVED GKGYYREPCA
110 120 130 140 150
EGGGGGLKRE ERGRDPGAGP GAALLPLEPS GPPALGFKYD YAAGGGGGDG
160 170 180 190 200
GGGAGPPHDP PSCQSLESDS SSSLLNEGNK GAGAGDPGSL VSPLNPGGGL
210 220 230 240 250
SASGAPWYPI NSRSRKKRKP YSKLQLAELE GEFLVNEFIT RQRRRELSDR
260 270 280
LNLSDQQVKI WFQNRRMKKK RLLLREQALS FF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF328962, AF328963 Genomic DNA Translation: AAK16717.1 |
CCDSi | CCDS8866.1 |
PIRi | S14933 |
RefSeqi | NP_776272.1, NM_173860.2 |
Genome annotation databases
Ensembli | ENST00000243103; ENSP00000243103; ENSG00000123407 |
GeneIDi | 3228 |
KEGGi | hsa:3228 |
MANE-Selecti | ENST00000243103.4; ENSP00000243103.3; NM_173860.3; NP_776272.1 |
UCSCi | uc010soq.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF328962, AF328963 Genomic DNA Translation: AAK16717.1 |
CCDSi | CCDS8866.1 |
PIRi | S14933 |
RefSeqi | NP_776272.1, NM_173860.2 |
3D structure databases
SMRi | P31275 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 109468, 5 interactors |
STRINGi | 9606.ENSP00000243103 |
PTM databases
iPTMneti | P31275 |
PhosphoSitePlusi | P31275 |
Genetic variation databases
BioMutai | HOXC12 |
DMDMi | 20141538 |
Proteomic databases
MassIVEi | P31275 |
PaxDbi | P31275 |
PeptideAtlasi | P31275 |
PRIDEi | P31275 |
ProteomicsDBi | 54775 |
Protocols and materials databases
Antibodypediai | 27304, 182 antibodies from 24 providers |
DNASUi | 3228 |
Genome annotation databases
Ensembli | ENST00000243103; ENSP00000243103; ENSG00000123407 |
GeneIDi | 3228 |
KEGGi | hsa:3228 |
MANE-Selecti | ENST00000243103.4; ENSP00000243103.3; NM_173860.3; NP_776272.1 |
UCSCi | uc010soq.3, human |
Organism-specific databases
CTDi | 3228 |
DisGeNETi | 3228 |
GeneCardsi | HOXC12 |
HGNCi | HGNC:5124, HOXC12 |
HPAi | ENSG00000123407, Tissue enhanced (skin) |
MIMi | 142975, gene |
neXtProti | NX_P31275 |
OpenTargetsi | ENSG00000123407 |
PharmGKBi | PA29399 |
VEuPathDBi | HostDB:ENSG00000123407 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0487, Eukaryota |
GeneTreei | ENSGT01040000240513 |
HOGENOMi | CLU_087968_1_0_1 |
InParanoidi | P31275 |
OMAi | SYYREPC |
OrthoDBi | 1154178at2759 |
PhylomeDBi | P31275 |
TreeFami | TF351604 |
Enzyme and pathway databases
PathwayCommonsi | P31275 |
Miscellaneous databases
BioGRID-ORCSi | 3228, 5 hits in 1057 CRISPR screens |
GeneWikii | HOXC12 |
GenomeRNAii | 3228 |
Pharosi | P31275, Tbio |
PROi | PR:P31275 |
RNActi | P31275, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000123407, Expressed in sural nerve and 21 other tissues |
Genevisiblei | P31275, HS |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HXC12_HUMAN | |
Accessioni | P31275Primary (citable) accession number: P31275 Secondary accession number(s): Q9BXJ6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | January 23, 2002 | |
Last modified: | February 23, 2022 | |
This is version 175 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Vertebrate homeotic Hox proteins
Nomenclature of vertebrate homeotic Hox proteins and list of entries - Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families