HOXC12

Functionⁱ

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	214 – 273	HomeoboxPROSITE-ProRule annotationAdd BLAST		60

GO - Molecular functionⁱ

DNA-binding transcription factor activity, RNA polymerase II-specific
Source: NTNU_SB
Inferred from sequence modelⁱ
- 19274049
sequence-specific DNA binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

multicellular organism development Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Homeobox protein Hox-C12 Alternative name(s): Homeobox protein Hox-3F
Gene namesⁱ	Name:HOXC12 Synonyms:HOC3F, HOX3F
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000123407.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5124 HOXC12
MIMⁱ	142975 gene
neXtProtⁱ	NX_P31275

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3228
Open Targets More...OpenTargetsⁱ	ENSG00000123407
PharmGKBⁱ	PA29399

Polymorphism and mutation databases

BioMutaⁱ	HOXC12
DMDMⁱ	20141538

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000200194	1 – 282	Homeobox protein Hox-C12Add BLAST		282

Proteomic databases

PaxDbⁱ	P31275
PeptideAtlas More...PeptideAtlasⁱ	P31275
PRIDEⁱ	P31275
ProteomicsDBⁱ	54775

PTM databases

iPTMnetⁱ	P31275
PhosphoSitePlusⁱ	P31275

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000123407 Expressed in 15 organ(s), highest expression level in skin of leg
CleanExⁱ	HS_HOXC12
Genevisibleⁱ	P31275 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA055632

HPAⁱ

HPA055632

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P31275
SMRⁱ	P31275
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the Abd-B homeobox family.Curated

Keywords - Domainⁱ

Homeobox

Phylogenomic databases

eggNOGⁱ	KOG0487 Eukaryota ENOG4111FJP LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000143984
HOGENOMⁱ	HOG000231177
HOVERGENⁱ	HBG052050
InParanoidⁱ	P31275
KEGG Orthology (KO) More...KOⁱ	K09297
OMAⁱ	EPCNGYS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0HNN
PhylomeDBⁱ	P31275
TreeFamⁱ	TF351604

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR020479 Homeobox_metazoa
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit
PRINTSⁱ	PR00024 HOMEOBOX
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P31275-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGEHNLLNPG FVGPLVNIHT GDTFYFPNFR ASGAQLPGLP SLSYPRRDNV 
        60         70         80         90        100
CSLSWPSAEP CNGYPQPYLG SPVSLNPPFG RTCELARVED GKGYYREPCA 
       110        120        130        140        150
EGGGGGLKRE ERGRDPGAGP GAALLPLEPS GPPALGFKYD YAAGGGGGDG 
       160        170        180        190        200
GGGAGPPHDP PSCQSLESDS SSSLLNEGNK GAGAGDPGSL VSPLNPGGGL 
       210        220        230        240        250
SASGAPWYPI NSRSRKKRKP YSKLQLAELE GEFLVNEFIT RQRRRELSDR 
       260        270        280 
LNLSDQQVKI WFQNRRMKKK RLLLREQALS FF

Length:282

Mass (Da):30,171

Last modified:January 23, 2002 - v2

Checksum:ⁱ493C53C511054A4D

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF328962, AF328963 Genomic DNA Translation: AAK16717.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8866.1
PIRⁱ	S14933
NCBI Reference Sequences More...RefSeqⁱ	NP_776272.1, NM_173860.2
UniGeneⁱ	Hs.381267 Hs.587727

Genome annotation databases

Ensemblⁱ	ENST00000243103; ENSP00000243103; ENSG00000123407
GeneIDⁱ	3228
KEGGⁱ	hsa:3228
UCSC genome browser More...UCSCⁱ	uc010soq.3 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P31275	Homeobox protein Hox-C12		MOUSE		280	UniRef90_P31275
Homeobox C12		MUSPF		283
homeobox protein Hox-C12		BALAS		282
homeobox protein Hox-C12		Enhydra lutris kenyoni		282
homeobox protein Hox-C12		PHYCD		282
+111

Protein	Similar proteins		Species	Score	Length	Source
P31275	Homeobox protein Hox-C12		MOUSE		280	UniRef50_P31275
Homeobox protein Hox-C12a		TAKRU		275
Homeobox C12		MUSPF		283
Uncharacterized protein		PIG		282
Uncharacterized protein		LOXAF		282
+312

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF328962, AF328963 Genomic DNA Translation: AAK16717.1
CCDSⁱ	CCDS8866.1
PIRⁱ	S14933
RefSeqⁱ	NP_776272.1, NM_173860.2
UniGeneⁱ	Hs.381267 Hs.587727

3D structure databases

ProteinModelPortalⁱ	P31275
SMRⁱ	P31275
ModBaseⁱ	Search...
MobiDBⁱ	Search...

PTM databases

iPTMnetⁱ	P31275
PhosphoSitePlusⁱ	P31275

Polymorphism and mutation databases

BioMutaⁱ	HOXC12
DMDMⁱ	20141538

Proteomic databases

PaxDbⁱ	P31275
PeptideAtlasⁱ	P31275
PRIDEⁱ	P31275
ProteomicsDBⁱ	54775

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3228
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000243103; ENSP00000243103; ENSG00000123407
GeneIDⁱ	3228
KEGGⁱ	hsa:3228
UCSCⁱ	uc010soq.3 human

Organism-specific databases

CTDⁱ	3228
DisGeNETⁱ	3228
EuPathDBⁱ	HostDB:ENSG00000123407.3
GeneCardsⁱ	HOXC12
HGNCⁱ	HGNC:5124 HOXC12
HPAⁱ	HPA055632
MIMⁱ	142975 gene
neXtProtⁱ	NX_P31275
OpenTargetsⁱ	ENSG00000123407
PharmGKBⁱ	PA29399
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0487 Eukaryota ENOG4111FJP LUCA
GeneTreeⁱ	ENSGT00910000143984
HOGENOMⁱ	HOG000231177
HOVERGENⁱ	HBG052050
InParanoidⁱ	P31275
KOⁱ	K09297
OMAⁱ	EPCNGYS
OrthoDBⁱ	EOG091G0HNN
PhylomeDBⁱ	P31275
TreeFamⁱ	TF351604

Miscellaneous databases

GeneWikiⁱ	HOXC12
GenomeRNAiⁱ	3228
Protein Ontology More...PROⁱ	PR:P31275
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000123407 Expressed in 15 organ(s), highest expression level in skin of leg
CleanExⁱ	HS_HOXC12
Genevisibleⁱ	P31275 HS

Family and domain databases

CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR020479 Homeobox_metazoa
Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit
PRINTSⁱ	PR00024 HOMEOBOX
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HXC12_HUMAN
Accessionⁱ	P31275Primary (citable) accession number: P31275 Secondary accession number(s): Q9BXJ6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
	Last sequence update:	January 23, 2002
	Last modified:	November 7, 2018
	This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Vertebrate homeotic Hox proteins
Nomenclature of vertebrate homeotic Hox proteins and list of entries
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P31275 (HXC12_HUMAN)

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Homeobox protein Hox-C12

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ