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Protein

Homeobox protein Hox-C9

Gene

HOXC9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi192 – 251HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-C9
Alternative name(s):
Homeobox protein Hox-3B
Gene namesi
Name:HOXC9
Synonyms:HOX3B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000180806.4
HGNCiHGNC:5130 HOXC9
MIMi142971 gene
neXtProtiNX_P31274

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3225
OpenTargetsiENSG00000180806
PharmGKBiPA29405

Polymorphism and mutation databases

BioMutaiHOXC9
DMDMi20141537

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002001841 – 260Homeobox protein Hox-C9Add BLAST260

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei159PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP31274
MaxQBiP31274
PaxDbiP31274
PeptideAtlasiP31274
PRIDEiP31274
ProteomicsDBi54774

PTM databases

iPTMnetiP31274
PhosphoSitePlusiP31274

Expressioni

Gene expression databases

BgeeiENSG00000180806
CleanExiHS_HOXC9
ExpressionAtlasiP31274 baseline and differential
GenevisibleiP31274 HS

Organism-specific databases

HPAiHPA063965
HPA072160

Interactioni

Subunit structurei

Interacts with Geminin/GMNN, which inhibits transcriptional activity.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi109465, 24 interactors
IntActiP31274, 24 interactors
MINTiP31274
STRINGi9606.ENSP00000302836

Structurei

Secondary structure

1260
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi186 – 188Combined sources3
Beta strandi194 – 196Combined sources3
Helixi201 – 213Combined sources13
Helixi219 – 228Combined sources10
Helixi233 – 248Combined sources16

3D structure databases

ProteinModelPortaliP31274
SMRiP31274
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0487 Eukaryota
ENOG4111FJP LUCA
GeneTreeiENSGT00910000143984
HOVERGENiHBG016849
InParanoidiP31274
KOiK09294
OMAiSGPISNY
OrthoDBiEOG091G0ECO
PhylomeDBiP31274
TreeFamiTF317819

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR006711 Hox9_activation_N
IPR017112 HXA9/HXB9/HXC9
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF04617 Hox9_act, 1 hit
PIRSFiPIRSF037109 Homeobox_Hox9, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P31274-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSATGPISNY YVDSLISHDN EDLLASRFPA TGAHPAAARP SGLVPDCSDF
60 70 80 90 100
PSCSFAPKPA VFSTSWAPVP SQSSVVYHPY GPQPHLGADT RYMRTWLEPL
110 120 130 140 150
SGAVSFPSFP AGGRHYALKP DAYPGRRADC GPGEGRSYPD YMYGSPGELR
160 170 180 190 200
DRAPQTLPSP EADALAGSKH KEEKADLDPS NPVANWIHAR STRKKRCPYT
210 220 230 240 250
KYQTLELEKE FLFNMYLTRD RRYEVARVLN LTERQVKIWF QNRRMKMKKM
260
NKEKTDKEQS
Length:260
Mass (Da):29,248
Last modified:January 23, 2002 - v3
Checksum:i0B278FF94945BC1E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti47C → R in AK000445 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03626787G → S in a colorectal cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY014302, AY014301 Genomic DNA Translation: AAG42151.1
AK000445 mRNA No translation available.
AK315194 mRNA Translation: BAG37634.1
CH471054 Genomic DNA Translation: EAW96741.1
BC053894 mRNA Translation: AAH53894.1
CCDSiCCDS8869.1
PIRiS15532
RefSeqiNP_008828.1, NM_006897.2
UniGeneiHs.658823

Genome annotation databases

EnsembliENST00000303450; ENSP00000302836; ENSG00000180806
ENST00000508190; ENSP00000423861; ENSG00000180806
GeneIDi3225
KEGGihsa:3225
UCSCiuc001seq.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiHXC9_HUMAN
AccessioniPrimary (citable) accession number: P31274
Secondary accession number(s): B2RCN7, Q9H1I0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2002
Last modified: July 18, 2018
This is version 173 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

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