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Protein

Homeobox protein Hox-C8

Gene

HOXC8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi149 – 208HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SignaLinkiP31273
SIGNORiP31273

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-C8
Alternative name(s):
Homeobox protein Hox-3A
Gene namesi
Name:HOXC8
Synonyms:HOX3A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000037965.5
HGNCiHGNC:5129 HOXC8
MIMi142970 gene
neXtProtiNX_P31273

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3224
OpenTargetsiENSG00000037965
PharmGKBiPA29404

Polymorphism and mutation databases

BioMutaiHOXC8
DMDMi13124745

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002001801 – 242Homeobox protein Hox-C8Add BLAST242

Proteomic databases

EPDiP31273
MaxQBiP31273
PaxDbiP31273
PeptideAtlasiP31273
PRIDEiP31273
ProteomicsDBi54773

PTM databases

iPTMnetiP31273
PhosphoSitePlusiP31273

Expressioni

Gene expression databases

BgeeiENSG00000037965 Expressed in 122 organ(s), highest expression level in gastrocnemius
CleanExiHS_HOXC8
GenevisibleiP31273 HS

Organism-specific databases

HPAiCAB037020
HPA028911

Interactioni

Subunit structurei

Interacts with SMAD1 and HOMEZ.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
LDLRAP1Q5SW964EBI-1752118,EBI-747813

Protein-protein interaction databases

BioGridi109464, 19 interactors
CORUMiP31273
DIPiDIP-52312N
ELMiP31273
IntActiP31273, 100 interactors
MINTiP31273
STRINGi9606.ENSP00000040584

Structurei

3D structure databases

ProteinModelPortaliP31273
SMRiP31273
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi138 – 143Antp-type hexapeptide6

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000231181
HOVERGENiHBG016849
InParanoidiP31273
KOiK09308
OMAiFHHGTSS
OrthoDBiEOG091G09XD
PhylomeDBiP31273
TreeFamiTF316310

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR000047 HTH_motif
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
PR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P31273-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSYFVNPLF SKYKAGESLE PAYYDCRFPQ SVGRSHALVY GPGGSAPGFQ
60 70 80 90 100
HASHHVQDFF HHGTSGISNS GYQQNPCSLS CHGDASKFYG YEALPRQSLY
110 120 130 140 150
GAQQEASVVQ YPDCKSSANT NSSEGQGHLN QNSSPSLMFP WMRPHAPGRR
160 170 180 190 200
SGRQTYSRYQ TLELEKEFLF NPYLTRKRRI EVSHALGLTE RQVKIWFQNR
210 220 230 240
RMKWKKENNK DKLPGARDEE KVEEEGNEEE EKEEEEKEEN KD
Length:242
Mass (Da):27,755
Last modified:February 21, 2001 - v2
Checksum:i30C1FD06228833FC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti165E → Q in CAA67997 (PubMed:2576652).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY014300, AY014299 Genomic DNA Translation: AAG42146.1
AK290959 mRNA Translation: BAF83648.1
CH471054 Genomic DNA Translation: EAW96743.1
BC053898 mRNA Translation: AAH53898.1
X99680 mRNA Translation: CAA67996.1
X99681 mRNA Translation: CAA67997.1
CCDSiCCDS8870.1
PIRiS15534
RefSeqiNP_073149.1, NM_022658.3
UniGeneiHs.664500

Genome annotation databases

EnsembliENST00000040584; ENSP00000040584; ENSG00000037965
GeneIDi3224
KEGGihsa:3224
UCSCiuc001ser.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY014300, AY014299 Genomic DNA Translation: AAG42146.1
AK290959 mRNA Translation: BAF83648.1
CH471054 Genomic DNA Translation: EAW96743.1
BC053898 mRNA Translation: AAH53898.1
X99680 mRNA Translation: CAA67996.1
X99681 mRNA Translation: CAA67997.1
CCDSiCCDS8870.1
PIRiS15534
RefSeqiNP_073149.1, NM_022658.3
UniGeneiHs.664500

3D structure databases

ProteinModelPortaliP31273
SMRiP31273
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109464, 19 interactors
CORUMiP31273
DIPiDIP-52312N
ELMiP31273
IntActiP31273, 100 interactors
MINTiP31273
STRINGi9606.ENSP00000040584

PTM databases

iPTMnetiP31273
PhosphoSitePlusiP31273

Polymorphism and mutation databases

BioMutaiHOXC8
DMDMi13124745

Proteomic databases

EPDiP31273
MaxQBiP31273
PaxDbiP31273
PeptideAtlasiP31273
PRIDEiP31273
ProteomicsDBi54773

Protocols and materials databases

DNASUi3224
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000040584; ENSP00000040584; ENSG00000037965
GeneIDi3224
KEGGihsa:3224
UCSCiuc001ser.4 human

Organism-specific databases

CTDi3224
DisGeNETi3224
EuPathDBiHostDB:ENSG00000037965.5
GeneCardsiHOXC8
HGNCiHGNC:5129 HOXC8
HPAiCAB037020
HPA028911
MIMi142970 gene
neXtProtiNX_P31273
OpenTargetsiENSG00000037965
PharmGKBiPA29404
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000231181
HOVERGENiHBG016849
InParanoidiP31273
KOiK09308
OMAiFHHGTSS
OrthoDBiEOG091G09XD
PhylomeDBiP31273
TreeFamiTF316310

Enzyme and pathway databases

SignaLinkiP31273
SIGNORiP31273

Miscellaneous databases

ChiTaRSiHOXC8 human
GeneWikiiHOXC8
GenomeRNAii3224
PROiPR:P31273
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000037965 Expressed in 122 organ(s), highest expression level in gastrocnemius
CleanExiHS_HOXC8
GenevisibleiP31273 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR000047 HTH_motif
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
PR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHXC8_HUMAN
AccessioniPrimary (citable) accession number: P31273
Secondary accession number(s): A8K4J4, O15221, O15362
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: February 21, 2001
Last modified: November 7, 2018
This is version 177 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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