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UniProtKB - P31271 (HXA13_HUMAN)

Entry version 193 (02 Dec 2020)
Sequence version 3 (17 Oct 2006)
Previous versions | rss
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Protein

Homeobox protein Hox-A13

Gene

HOXA13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sequence-specific, AT-rich binding transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi322 – 381HomeoboxPROSITE-ProRule annotationAdd BLAST60

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P31271

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P31271

SIGNOR Signaling Network Open Resource

More...SIGNORi		P31271

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Homeobox protein Hox-A13
Alternative name(s):
Homeobox protein Hox-1J
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HOXA13
Synonyms:HOX1J
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000106031.7

Human Gene Nomenclature Database

More...HGNCi		HGNC:5102, HOXA13

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		142959, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P31271

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Hand-foot-genital syndrome (HFG)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by limb and genitourinary anomalies. Clinical features include small feet with unusually short great toes and abnormal thumbs. Females with the disorder have duplication of the genital tract.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_017773125A → AAAAAAA in HFG. 1 Publication1
Natural variantiVAR_017774129A → AAAAAAAAA in HFG. 1
Natural variantiVAR_075341368I → F in HFG; severe phenotype overlapping with Guttmacher syndrome. 1 Publication1
Natural variantiVAR_017776372N → H in HFG; severe. 1 PublicationCorresponds to variant dbSNP:rs121912542EnsemblClinVar.1
Natural variantiVAR_075342375V → F in HFG. 1 Publication1
Guttmacher syndrome (GUTTS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionDominantly inherited combination of distal limb and genital tract abnormalities. It has several features in common with hand-foot-genital syndrome, including hypoplastic first digits and hypospadias. Typical features not seen in hand-foot-genital syndrome include postaxial polydactyly of the hands and uniphalangeal second toes with absent nails.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_017775371Q → L in GUTTS. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...DisGeNETi		3209

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		HOXA13

MalaCards human disease database

More...MalaCardsi		HOXA13
MIMi140000, phenotype
176305, phenotype

Open Targets

More...OpenTargetsi		ENSG00000106031

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		2957, Guttmacher syndrome
2438, Hand-foot-genital syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29379

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P31271, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		HOXA13

Domain mapping of disease mutations (DMDM)

More...DMDMi		116242513

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002001011 – 388Homeobox protein Hox-A13Add BLAST388

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P31271

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P31271

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P31271

MaxQB - The MaxQuant DataBase

More...MaxQBi		P31271

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P31271

PeptideAtlas

More...PeptideAtlasi		P31271

PRoteomics IDEntifications database

More...PRIDEi		P31271

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		54772

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P31271

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P31271

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000106031, Expressed in ectocervix and 61 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P31271, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000106031, Tissue enhanced (cervix, uterine, prostate)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds DNA as a homodimer.

Interacts with MEIS1, MEIS2 and MEIS3 (By similarity).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109449, 1 interactor

Protein interaction database and analysis system

More...IntActi		P31271, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000222753

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P31271, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1388
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		P31271

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P31271

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi38 – 53Poly-AlaAdd BLAST16
Compositional biasi62 – 66Poly-Ala5
Compositional biasi73 – 84Poly-AlaAdd BLAST12
Compositional biasi116 – 133Poly-AlaAdd BLAST18
Compositional biasi200 – 207Poly-Ala8

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0487, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162322

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_059940_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P31271

Identification of Orthologs from Complete Genome Data

More...OMAi		KNMEGFP

Database of Orthologous Groups

More...OrthoDBi		1190384at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P31271

TreeFam database of animal gene trees

More...TreeFami		TF330813

Family and domain databases

Conserved Domains Database

More...CDDi		cd00086, homeodomain, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR009057, Homeobox-like_sf
IPR017970, Homeobox_CS
IPR001356, Homeobox_dom
IPR022067, HoxA13_N

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00046, Homeodomain, 1 hit
PF12284, HoxA13_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00389, HOX, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46689, SSF46689, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00027, HOMEOBOX_1, 1 hit
PS50071, HOMEOBOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P31271-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTASVLLHPR WIEPTVMFLY DNGGGLVADE LNKNMEGAAA AAAAAAAAAA 
        60         70         80         90        100
AGAGGGGFPH PAAAAAGGNF SVAAAAAAAA AAAANQCRNL MAHPAPLAPG 
       110        120        130        140        150
AASAYSSAPG EAPPSAAAAA AAAAAAAAAA AAASSSGGPG PAGPAGAEAA 
       160        170        180        190        200
KQCSPCSAAA QSSSGPAALP YGYFGSGYYP CARMGPHPNA IKSCAQPASA 
       210        220        230        240        250
AAAAAFADKY MDTAGPAAEE FSSRAKEFAF YHQGYAAGPY HHHQPMPGYL 
       260        270        280        290        300
DMPVVPGLGG PGESRHEPLG LPMESYQPWA LPNGWNGQMY CPKEQAQPPH 
       310        320        330        340        350
LWKSTLPDVV SHPSDASSYR RGRKKRVPYT KVQLKELERE YATNKFITKD 
       360        370        380 
KRRRISATTN LSERQVTIWF QNRRVKEKKV INKLKTTS
Length:388
Mass (Da):39,727
Last modified:October 17, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3512E7622FA931C4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti146G → A in AAC50993 (PubMed:9020844).Curated1
Sequence conflicti187H → P in AAC50993 (PubMed:9020844).Curated1
Sequence conflicti195A → P in AAC50993 (PubMed:9020844).Curated1
Sequence conflicti198A → P in AAC50993 (PubMed:9020844).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_017773125A → AAAAAAA in HFG. 1 Publication1
Natural variantiVAR_017774129A → AAAAAAAAA in HFG. 1
Natural variantiVAR_075341368I → F in HFG; severe phenotype overlapping with Guttmacher syndrome. 1 Publication1
Natural variantiVAR_017775371Q → L in GUTTS. 1 Publication1
Natural variantiVAR_017776372N → H in HFG; severe. 1 PublicationCorresponds to variant dbSNP:rs121912542EnsemblClinVar.1
Natural variantiVAR_075342375V → F in HFG. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U82827 Genomic DNA Translation: AAC50993.1
AC004080 Genomic DNA No translation available.
CH471073 Genomic DNA Translation: EAW93890.1
CH236948 Genomic DNA Translation: EAL24218.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS5412.1

Protein sequence database of the Protein Information Resource

More...PIRi		S14932

NCBI Reference Sequences

More...RefSeqi		NP_000513.2, NM_000522.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000649031; ENSP00000497112; ENSG00000106031

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3209

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3209

UCSC genome browser

More...UCSCi		uc003szb.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82827 Genomic DNA Translation: AAC50993.1
AC004080 Genomic DNA No translation available.
CH471073 Genomic DNA Translation: EAW93890.1
CH236948 Genomic DNA Translation: EAL24218.1
CCDSiCCDS5412.1
PIRiS14932
RefSeqiNP_000513.2, NM_000522.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2L7ZNMR-A322-388[»]
BMRBiP31271
SMRiP31271
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109449, 1 interactor
IntActiP31271, 2 interactors
STRINGi9606.ENSP00000222753

PTM databases

iPTMnetiP31271
PhosphoSitePlusiP31271

Polymorphism and mutation databases

BioMutaiHOXA13
DMDMi116242513

Proteomic databases

EPDiP31271
jPOSTiP31271
MassIVEiP31271
MaxQBiP31271
PaxDbiP31271
PeptideAtlasiP31271
PRIDEiP31271
ProteomicsDBi54772

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		12410, 144 antibodies

Genome annotation databases

EnsembliENST00000649031; ENSP00000497112; ENSG00000106031
GeneIDi3209
KEGGihsa:3209
UCSCiuc003szb.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3209
DisGeNETi3209
EuPathDBiHostDB:ENSG00000106031.7

GeneCards: human genes, protein and diseases

More...GeneCardsi		HOXA13
GeneReviewsiHOXA13
HGNCiHGNC:5102, HOXA13
HPAiENSG00000106031, Tissue enhanced (cervix, uterine, prostate)
MalaCardsiHOXA13
MIMi140000, phenotype
142959, gene
176305, phenotype
neXtProtiNX_P31271
OpenTargetsiENSG00000106031
Orphaneti2957, Guttmacher syndrome
2438, Hand-foot-genital syndrome
PharmGKBiPA29379

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0487, Eukaryota
GeneTreeiENSGT00940000162322
HOGENOMiCLU_059940_1_0_1
InParanoidiP31271
OMAiKNMEGFP
OrthoDBi1190384at2759
PhylomeDBiP31271
TreeFamiTF330813

Enzyme and pathway databases

PathwayCommonsiP31271
SignaLinkiP31271
SIGNORiP31271

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3209, 46 hits in 867 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		HOXA13

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3209
PharosiP31271, Tbio

Protein Ontology

More...PROi		PR:P31271
RNActiP31271, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000106031, Expressed in ectocervix and 61 other tissues
GenevisibleiP31271, HS

Family and domain databases

CDDicd00086, homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057, Homeobox-like_sf
IPR017970, Homeobox_CS
IPR001356, Homeobox_dom
IPR022067, HoxA13_N
PfamiView protein in Pfam
PF00046, Homeodomain, 1 hit
PF12284, HoxA13_N, 1 hit
SMARTiView protein in SMART
SM00389, HOX, 1 hit
SUPFAMiSSF46689, SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027, HOMEOBOX_1, 1 hit
PS50071, HOMEOBOX_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHXA13_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P31271
Secondary accession number(s): A4D188, O43371
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: October 17, 2006
Last modified: December 2, 2020
This is version 193 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
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