UniProtKB - P31269 (HXA9_HUMAN)
Protein
Homeobox protein Hox-A9
Gene
HOXA9
Organism
Homo sapiens (Human)
Status
Functioni
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 206 – 265 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
- DNA-binding transcription factor activity Source: GO_Central
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- enzyme binding Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- anterior/posterior pattern specification Source: GO_Central
- definitive hemopoiesis Source: Ensembl
- embryonic forelimb morphogenesis Source: Ensembl
- embryonic skeletal system morphogenesis Source: GO_Central
- endothelial cell activation Source: UniProtKB
- male gonad development Source: Ensembl
- mammary gland development Source: Ensembl
- multicellular organism development Source: ProtInc
- negative regulation of myeloid cell differentiation Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: GO_Central
- proximal/distal pattern formation Source: GO_Central
- single fertilization Source: Ensembl
- spermatogenesis Source: Ensembl
- transcription, DNA-templated Source: InterPro
- uterus development Source: Ensembl
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | P31269 |
SignaLinki | P31269 |
SIGNORi | P31269 |
Names & Taxonomyi
Protein namesi | Recommended name: Homeobox protein Hox-A9Alternative name(s): Homeobox protein Hox-1G |
Gene namesi | Name:HOXA9 Synonyms:HOX1G |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:5109, HOXA9 |
MIMi | 142956, gene |
neXtProti | NX_P31269 |
VEuPathDBi | HostDB:ENSG00000078399.15 |
Subcellular locationi
Nucleus
Nucleus
- nuclear chromatin Source: NTNU_SB
- nucleoplasm Source: HPA
- nucleus Source: LIFEdb
Other locations
- transcription regulator complex Source: Ensembl
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
A chromosomal aberration involving HOXA9 is found in a form of acute myeloid leukemia. Translocation t(7;11)(p15;p15) with NUP98.1 Publication
A chromosomal aberration involving HOXA9 may contribute to disease progression in chronic myeloid leukemia. Translocation t(7;17)(p15;q23) with MSI2.
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 140 | R → A: Results in loss of methylation. 1 Publication | 1 |
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 163 – 164 | Breakpoint for translocation to form MSI2/HOXA9 fusion protein | 2 | |
Sitei | 163 – 164 | Breakpoint for translocation to form the NUP98-HOXA9 fusion protein1 Publication | 2 |
Keywords - Diseasei
Proto-oncogeneOrganism-specific databases
DisGeNETi | 3205 |
OpenTargetsi | ENSG00000078399 |
PharmGKBi | PA29386 |
Miscellaneous databases
Pharosi | P31269, Tbio |
Genetic variation databases
BioMutai | HOXA9 |
DMDMi | 6166219 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000200081 | 1 – 272 | Homeobox protein Hox-A9Add BLAST | 272 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 140 | Symmetric dimethylarginine1 Publication | 1 |
Post-translational modificationi
Methylated on Arg-140 by PRMT5; methylation is critical for E-selectin induction.1 Publication
Keywords - PTMi
MethylationProteomic databases
EPDi | P31269 |
jPOSTi | P31269 |
MassIVEi | P31269 |
MaxQBi | P31269 |
PaxDbi | P31269 |
PeptideAtlasi | P31269 |
PRIDEi | P31269 |
ProteomicsDBi | 54770 |
PTM databases
iPTMneti | P31269 |
PhosphoSitePlusi | P31269 |
Expressioni
Gene expression databases
Bgeei | ENSG00000078399, Expressed in metanephros and 165 other tissues |
ExpressionAtlasi | P31269, baseline and differential |
Genevisiblei | P31269, HS |
Organism-specific databases
HPAi | ENSG00000078399, Tissue enhanced (kidney) |
Interactioni
Subunit structurei
Transiently interacts with PRMT5 in TNF-alpha stimulated endothelial cells.
1 PublicationBinary interactionsi
Hide detailsP31269
With | #Exp. | IntAct |
---|---|---|
KRTAP9-3 [Q9BYQ3] | 3 | EBI-742314,EBI-1043191 |
PRMT5 [O14744] | 4 | EBI-742314,EBI-351098 |
TRIP6 [Q15654] | 4 | EBI-742314,EBI-742327 |
GO - Molecular functioni
- enzyme binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 109445, 20 interactors |
CORUMi | P31269 |
IntActi | P31269, 8 interactors |
MINTi | P31269 |
STRINGi | 9606.ENSP00000343619 |
Miscellaneous databases
RNActi | P31269, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the Abd-B homeobox family.Curated
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0487, Eukaryota |
GeneTreei | ENSGT00940000161864 |
HOGENOMi | CLU_071854_0_0_1 |
InParanoidi | P31269 |
OMAi | WSHVPAQ |
OrthoDBi | 976319at2759 |
PhylomeDBi | P31269 |
TreeFami | TF317819 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa IPR006711, Hox9_activation_N IPR017112, HXA9/HXB9/HXC9 |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit PF04617, Hox9_act, 1 hit |
PIRSFi | PIRSF037109, Homeobox_Hox9, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
P31269-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATTGALGNY YVDSFLLGAD AADELSVGRY APGTLGQPPR QAATLAEHPD
60 70 80 90 100
FSPCSFQSKA TVFGASWNPV HAAGANAVPA AVYHHHHHHP YVHPQAPVAA
110 120 130 140 150
AAPDGRYMRS WLEPTPGALS FAGLPSSRPY GIKPEPLSAR RGDCPTLDTH
160 170 180 190 200
TLSLTDYACG SPPVDREKQP SEGAFSENNA ENESGGDKPP IDPNNPAANW
210 220 230 240 250
LHARSTRKKR CPYTKHQTLE LEKEFLFNMY LTRDRRYEVA RLLNLTERQV
260 270
KIWFQNRRMK MKKINKDRAK DE
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A669K9T0 | A0A669K9T0_HUMAN | Homeobox protein Hox-A9 | HOXA9 | 225 | Annotation score: | ||
A0A669KBC8 | A0A669KBC8_HUMAN | Homeobox protein Hox-A9 | HOXA9 | 213 | Annotation score: | ||
A8MVF3 | A8MVF3_HUMAN | Homeobox protein Hox-A9 | HOXA9 | 106 | Annotation score: |
Sequence cautioni
The sequence AAC50364 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 64 | G → V in AAB40867 (Ref. 1) Curated | 1 | |
Sequence conflicti | 67 | W → R in AAD08713 (PubMed:9880515).Curated | 1 | |
Sequence conflicti | 80 | Missing in AAB40867 (Ref. 1) Curated | 1 | |
Sequence conflicti | 243 | L → F in AAB40867 (Ref. 1) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U82759 mRNA Translation: AAB40867.1 AF010258 Genomic DNA Translation: AAD08713.1 BT006990 mRNA Translation: AAP35636.1 AC004080 Genomic DNA No translation available. BC006537 mRNA Translation: AAH06537.1 BC010023 mRNA Translation: AAH10023.1 U41813 mRNA Translation: AAC50364.1 Different initiation. |
CCDSi | CCDS5409.1 |
PIRi | S14929 |
RefSeqi | NP_689952.1, NM_152739.3 |
Genome annotation databases
Ensembli | ENST00000343483; ENSP00000343619; ENSG00000078399 |
GeneIDi | 3205 |
KEGGi | hsa:3205 |
UCSCi | uc003syt.4, human |
Keywords - Coding sequence diversityi
Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U82759 mRNA Translation: AAB40867.1 AF010258 Genomic DNA Translation: AAD08713.1 BT006990 mRNA Translation: AAP35636.1 AC004080 Genomic DNA No translation available. BC006537 mRNA Translation: AAH06537.1 BC010023 mRNA Translation: AAH10023.1 U41813 mRNA Translation: AAC50364.1 Different initiation. |
CCDSi | CCDS5409.1 |
PIRi | S14929 |
RefSeqi | NP_689952.1, NM_152739.3 |
3D structure databases
SMRi | P31269 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 109445, 20 interactors |
CORUMi | P31269 |
IntActi | P31269, 8 interactors |
MINTi | P31269 |
STRINGi | 9606.ENSP00000343619 |
PTM databases
iPTMneti | P31269 |
PhosphoSitePlusi | P31269 |
Genetic variation databases
BioMutai | HOXA9 |
DMDMi | 6166219 |
Proteomic databases
EPDi | P31269 |
jPOSTi | P31269 |
MassIVEi | P31269 |
MaxQBi | P31269 |
PaxDbi | P31269 |
PeptideAtlasi | P31269 |
PRIDEi | P31269 |
ProteomicsDBi | 54770 |
Protocols and materials databases
Antibodypediai | 12395, 337 antibodies |
DNASUi | 3205 |
Genome annotation databases
Ensembli | ENST00000343483; ENSP00000343619; ENSG00000078399 |
GeneIDi | 3205 |
KEGGi | hsa:3205 |
UCSCi | uc003syt.4, human |
Organism-specific databases
CTDi | 3205 |
DisGeNETi | 3205 |
GeneCardsi | HOXA9 |
HGNCi | HGNC:5109, HOXA9 |
HPAi | ENSG00000078399, Tissue enhanced (kidney) |
MIMi | 142956, gene |
neXtProti | NX_P31269 |
OpenTargetsi | ENSG00000078399 |
PharmGKBi | PA29386 |
VEuPathDBi | HostDB:ENSG00000078399.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0487, Eukaryota |
GeneTreei | ENSGT00940000161864 |
HOGENOMi | CLU_071854_0_0_1 |
InParanoidi | P31269 |
OMAi | WSHVPAQ |
OrthoDBi | 976319at2759 |
PhylomeDBi | P31269 |
TreeFami | TF317819 |
Enzyme and pathway databases
PathwayCommonsi | P31269 |
SignaLinki | P31269 |
SIGNORi | P31269 |
Miscellaneous databases
BioGRID-ORCSi | 3205, 29 hits in 898 CRISPR screens |
GeneWikii | HOXA9 |
GenomeRNAii | 3205 |
Pharosi | P31269, Tbio |
PROi | PR:P31269 |
RNActi | P31269, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000078399, Expressed in metanephros and 165 other tissues |
ExpressionAtlasi | P31269, baseline and differential |
Genevisiblei | P31269, HS |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa IPR006711, Hox9_activation_N IPR017112, HXA9/HXB9/HXC9 |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit PF04617, Hox9_act, 1 hit |
PIRSFi | PIRSF037109, Homeobox_Hox9, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HXA9_HUMAN | |
Accessioni | P31269Primary (citable) accession number: P31269 Secondary accession number(s): O43369, O43429, Q99820 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | July 15, 1999 | |
Last modified: | February 10, 2021 | |
This is version 203 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Vertebrate homeotic Hox proteins
Nomenclature of vertebrate homeotic Hox proteins and list of entries