HOXA7

Functionⁱ

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	130 – 189	HomeoboxPROSITE-ProRule annotationAdd BLAST		60

GO - Molecular functionⁱ

RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 11435435
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
sequence-specific DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 11435435
transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 11435435
transcription factor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 18973687

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

angiogenesis
Source: UniProtKB
Inferred from expression patternⁱ
- 17972163
anterior/posterior pattern specification Source: Ensembl
embryonic skeletal system morphogenesis Source: Ensembl
negative regulation of cell-matrix adhesion
Source: UniProtKB
Inferred from direct assayⁱ
- 14704364
negative regulation of keratinocyte differentiation
Source: MGI
Inferred from direct assayⁱ
- 11435435
negative regulation of leukocyte migration
Source: UniProtKB
Inferred from direct assayⁱ
- 14704364
negative regulation of monocyte differentiation
Source: UniProtKB
Inferred from direct assayⁱ
- 14704364
negative regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 11435435
negative regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 11435435
- 14704364
positive regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from direct assayⁱ
- 11435435
stem cell differentiation Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

SIGNORⁱ	P31268

SIGNORⁱ

P31268

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Homeobox protein Hox-A7 Alternative name(s): Homeobox protein Hox 1.1 Homeobox protein Hox-1A
Gene namesⁱ	Name:HOXA7 Synonyms:HOX1A
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000122592.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5108 HOXA7
MIMⁱ	142950 gene
neXtProtⁱ	NX_P31268

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3204
Open Targets More...OpenTargetsⁱ	ENSG00000122592
PharmGKBⁱ	PA29385

Polymorphism and mutation databases

BioMutaⁱ	HOXA7
DMDMⁱ	311033439

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000200071	1 – 230	Homeobox protein Hox-A7Add BLAST		230

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P31268
PaxDbⁱ	P31268
PeptideAtlas More...PeptideAtlasⁱ	P31268
PRIDEⁱ	P31268
ProteomicsDBⁱ	54769

PTM databases

iPTMnetⁱ	P31268
PhosphoSitePlusⁱ	P31268

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000122592 Expressed in 137 organ(s), highest expression level in vagina
CleanExⁱ	HS_HOXA7
ExpressionAtlasⁱ	P31268 baseline and differential
Genevisibleⁱ	P31268 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA074048

HPAⁱ

HPA074048

Interactionⁱ

GO - Molecular functionⁱ

transcription factor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 18973687

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	109444, 3 interactors
IntActⁱ	P31268, 4 interactors
STRINGⁱ	9606.ENSP00000242159

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P31268
SMRⁱ	P31268
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	119 – 124	Antp-type hexapeptide		6

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	157 – 160	Poly-Arg	4
Compositional biasⁱ	196 – 199	Poly-Ala	4
Compositional biasⁱ	214 – 230	Asp/Glu-rich (highly acidic)Add BLAST	17
Compositional biasⁱ	223 – 230	Poly-Glu	8

Sequence similaritiesⁱ

Belongs to the Antp homeobox family.Curated

Keywords - Domainⁱ

Homeobox

Phylogenomic databases

eggNOGⁱ	KOG0489 Eukaryota ENOG410ZTBY LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000143983
HOGENOMⁱ	HOG000231181
HOVERGENⁱ	HBG016849
InParanoidⁱ	P31268
KEGG Orthology (KO) More...KOⁱ	K09307
OMAⁱ	WKKEHKD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09XD
PhylomeDBⁱ	P31268
TreeFamⁱ	TF316310

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017995 Homeobox_antennapedia IPR001827 Homeobox_Antennapedia_CS IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR020479 Homeobox_metazoa
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit
PRINTSⁱ	PR00025 ANTENNAPEDIA PR00024 HOMEOBOX
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00032 ANTENNAPEDIA, 1 hit PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P31268-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSSSYYVNAL FSKYTAGASL FQNAEPTSCS FAPNSQRSGY GAGAGAFAST 
        60         70         80         90        100
VPGLYNVNSP LYQSPFASGY GLGADAYGNL PCASYDQNIP GLCSDLAKGA 
       110        120        130        140        150
CDKTDEGALH GAAEANFRIY PWMRSSGPDR KRGRQTYTRY QTLELEKEFH 
       160        170        180        190        200
FNRYLTRRRR IEIAHALCLT ERQIKIWFQN RRMKWKKEHK DEGPTAAAAP 
       210        220        230
EGAVPSAAAT AAADKADEED DDEEEEDEEE

Length:230

Mass (Da):25,355

Last modified:November 2, 2010 - v3

Checksum:ⁱ8F77A6B0AFB516D5

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	E5RHM9	E5RHM9_HUMAN		Homeobox protein Hox-A7 Homeobox protein Hox-A7	HOXA7	30	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	75 – 76	DA → RR in AAD00727 (Ref. 8) Curated	2
Sequence conflictⁱ	78	Missing in CAA59270 (Ref. 4) Curated	1
Sequence conflictⁱ	174	I → V in AAD01939 (PubMed:10911612).Curated	1
Sequence conflictⁱ	194 – 195	PT → RL in CAA59270 (Ref. 4) Curated	2
Sequence conflictⁱ	195	T → I no nucleotide entry (PubMed:2576652).Curated	1
Sequence conflictⁱ	222	D → Y in CAA59270 (Ref. 4) Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_028001	18	A → T5 PublicationsCorresponds to variant dbSNP:rs2301721Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF026397 mRNA Translation: AAB94604.1 AJ005814 mRNA Translation: CAA06713.1 AF032095 Genomic DNA Translation: AAD01939.2 X84803, X84804 Genomic DNA Translation: CAA59270.1 CH236948 Genomic DNA Translation: EAL24221.1 AC004080 Genomic DNA No translation available. CH471073 Genomic DNA Translation: EAW93877.1 U92543 Genomic DNA Translation: AAD00727.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5408.1
PIRⁱ	S15536
NCBI Reference Sequences More...RefSeqⁱ	NP_008827.2, NM_006896.3
UniGeneⁱ	Hs.610216 Hs.660918

Genome annotation databases

Ensemblⁱ	ENST00000242159; ENSP00000242159; ENSG00000122592
GeneIDⁱ	3204
KEGGⁱ	hsa:3204
UCSC genome browser More...UCSCⁱ	uc003sys.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P31268	Homeobox protein Hox-A7		PANPA		230	UniRef90_P31268
Homeobox protein Hox-A7		PANTR		230
Homeobox protein Hox-A7		MOUSE		229
Homeobox protein Hox-A7 (Fragment)		SHEEP		71
homeobox protein Hox-A7		PHYCD		240
+115

Protein	Similar proteins		Species	Score	Length	Source
P31268	Homeobox protein Hox-A7		PANTR		230	UniRef50_P31268
Homeobox protein Hox-A7		PANPA		230
Homeobox protein Hox-A7		MOUSE		229
Homeobox protein Hox-A7 (Fragment)		SHEEP		71
Homeobox protein Hox-A7		CHICK		219
+230

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF026397 mRNA Translation: AAB94604.1 AJ005814 mRNA Translation: CAA06713.1 AF032095 Genomic DNA Translation: AAD01939.2 X84803, X84804 Genomic DNA Translation: CAA59270.1 CH236948 Genomic DNA Translation: EAL24221.1 AC004080 Genomic DNA No translation available. CH471073 Genomic DNA Translation: EAW93877.1 U92543 Genomic DNA Translation: AAD00727.1
CCDSⁱ	CCDS5408.1
PIRⁱ	S15536
RefSeqⁱ	NP_008827.2, NM_006896.3
UniGeneⁱ	Hs.610216 Hs.660918

3D structure databases

ProteinModelPortalⁱ	P31268
SMRⁱ	P31268
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109444, 3 interactors
IntActⁱ	P31268, 4 interactors
STRINGⁱ	9606.ENSP00000242159

PTM databases

iPTMnetⁱ	P31268
PhosphoSitePlusⁱ	P31268

Polymorphism and mutation databases

BioMutaⁱ	HOXA7
DMDMⁱ	311033439

Proteomic databases

MaxQBⁱ	P31268
PaxDbⁱ	P31268
PeptideAtlasⁱ	P31268
PRIDEⁱ	P31268
ProteomicsDBⁱ	54769

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3204
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000242159; ENSP00000242159; ENSG00000122592
GeneIDⁱ	3204
KEGGⁱ	hsa:3204
UCSCⁱ	uc003sys.4 human

Organism-specific databases

CTDⁱ	3204
DisGeNETⁱ	3204
EuPathDBⁱ	HostDB:ENSG00000122592.7
GeneCardsⁱ	HOXA7
HGNCⁱ	HGNC:5108 HOXA7
HPAⁱ	HPA074048
MIMⁱ	142950 gene
neXtProtⁱ	NX_P31268
OpenTargetsⁱ	ENSG00000122592
PharmGKBⁱ	PA29385
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0489 Eukaryota ENOG410ZTBY LUCA
GeneTreeⁱ	ENSGT00910000143983
HOGENOMⁱ	HOG000231181
HOVERGENⁱ	HBG016849
InParanoidⁱ	P31268
KOⁱ	K09307
OMAⁱ	WKKEHKD
OrthoDBⁱ	EOG091G09XD
PhylomeDBⁱ	P31268
TreeFamⁱ	TF316310

Enzyme and pathway databases

SIGNORⁱ	P31268

SIGNORⁱ

P31268

Miscellaneous databases

GeneWikiⁱ	HOXA7
GenomeRNAiⁱ	3204
Protein Ontology More...PROⁱ	PR:P31268
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000122592 Expressed in 137 organ(s), highest expression level in vagina
CleanExⁱ	HS_HOXA7
ExpressionAtlasⁱ	P31268 baseline and differential
Genevisibleⁱ	P31268 HS

Family and domain databases

CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017995 Homeobox_antennapedia IPR001827 Homeobox_Antennapedia_CS IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR020479 Homeobox_metazoa
Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit
PRINTSⁱ	PR00025 ANTENNAPEDIA PR00024 HOMEOBOX
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00032 ANTENNAPEDIA, 1 hit PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HXA7_HUMAN
Accessionⁱ	P31268Primary (citable) accession number: P31268 Secondary accession number(s): A4D191 , O43368, O43486, O95655, Q9NSC8, Q9UDM1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
	Last sequence update:	November 2, 2010
	Last modified:	September 12, 2018
	This is version 168 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Vertebrate homeotic Hox proteins
Nomenclature of vertebrate homeotic Hox proteins and list of entries
SIMILARITY comments
Index of protein domains and families
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P31268 (HXA7_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Homeobox protein Hox-A7

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ