UniProtKB - P31268 (HXA7_HUMAN)
Protein
Homeobox protein Hox-A7
Gene
HOXA7
Organism
Homo sapiens (Human)
Status
Functioni
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 130 – 189 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
- sequence-specific DNA binding Source: UniProtKB
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
- transcription factor binding Source: UniProtKB
GO - Biological processi
- angiogenesis Source: UniProtKB
- anterior/posterior pattern specification Source: GO_Central
- embryonic skeletal system morphogenesis Source: Ensembl
- negative regulation of cell-matrix adhesion Source: UniProtKB
- negative regulation of keratinocyte differentiation Source: MGI
- negative regulation of leukocyte migration Source: UniProtKB
- negative regulation of monocyte differentiation Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- stem cell differentiation Source: Ensembl
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | P31268 |
SIGNORi | P31268 |
Names & Taxonomyi
Protein namesi | Recommended name: Homeobox protein Hox-A7Alternative name(s): Homeobox protein Hox 1.1 Homeobox protein Hox-1A |
Gene namesi | Name:HOXA7 Synonyms:HOX1A |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000122592.7 |
HGNCi | HGNC:5108, HOXA7 |
MIMi | 142950, gene |
neXtProti | NX_P31268 |
Subcellular locationi
Nucleus
Nucleus
- nuclear chromatin Source: NTNU_SB
- nuclear membrane Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 3204 |
OpenTargetsi | ENSG00000122592 |
PharmGKBi | PA29385 |
Miscellaneous databases
Pharosi | P31268, Tbio |
Polymorphism and mutation databases
BioMutai | HOXA7 |
DMDMi | 311033439 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000200071 | 1 – 230 | Homeobox protein Hox-A7Add BLAST | 230 |
Proteomic databases
jPOSTi | P31268 |
MassIVEi | P31268 |
MaxQBi | P31268 |
PaxDbi | P31268 |
PeptideAtlasi | P31268 |
PRIDEi | P31268 |
ProteomicsDBi | 54769 |
PTM databases
iPTMneti | P31268 |
PhosphoSitePlusi | P31268 |
Expressioni
Gene expression databases
Bgeei | ENSG00000122592, Expressed in vagina and 155 other tissues |
ExpressionAtlasi | P31268, baseline and differential |
Genevisiblei | P31268, HS |
Organism-specific databases
HPAi | ENSG00000122592, Tissue enhanced (skeletal) |
Interactioni
Binary interactionsi
P31268
With | #Exp. | IntAct |
---|---|---|
SDCBP [O00560] | 3 | EBI-3910421,EBI-727004 |
GO - Molecular functioni
- transcription factor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 109444, 4 interactors |
IntActi | P31268, 4 interactors |
STRINGi | 9606.ENSP00000242159 |
Miscellaneous databases
RNActi | P31268, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 119 – 124 | Antp-type hexapeptide | 6 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 157 – 160 | Poly-Arg | 4 | |
Compositional biasi | 196 – 199 | Poly-Ala | 4 | |
Compositional biasi | 214 – 230 | Asp/Glu-rich (highly acidic)Add BLAST | 17 | |
Compositional biasi | 223 – 230 | Poly-Glu | 8 |
Sequence similaritiesi
Belongs to the Antp homeobox family.Curated
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0489, Eukaryota |
GeneTreei | ENSGT00940000161013 |
HOGENOMi | CLU_061398_1_1_1 |
InParanoidi | P31268 |
OMAi | WKKDHKD |
OrthoDBi | 1203627at2759 |
PhylomeDBi | P31268 |
TreeFami | TF316310 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017995, Homeobox_antennapedia IPR001827, Homeobox_Antennapedia_CS IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00025, ANTENNAPEDIA PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00032, ANTENNAPEDIA, 1 hit PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P31268-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSSYYVNAL FSKYTAGASL FQNAEPTSCS FAPNSQRSGY GAGAGAFAST
60 70 80 90 100
VPGLYNVNSP LYQSPFASGY GLGADAYGNL PCASYDQNIP GLCSDLAKGA
110 120 130 140 150
CDKTDEGALH GAAEANFRIY PWMRSSGPDR KRGRQTYTRY QTLELEKEFH
160 170 180 190 200
FNRYLTRRRR IEIAHALCLT ERQIKIWFQN RRMKWKKEHK DEGPTAAAAP
210 220 230
EGAVPSAAAT AAADKADEED DDEEEEDEEE
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE5RHM9 | E5RHM9_HUMAN | Homeobox protein Hox-A7 | HOXA7 | 30 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 75 – 76 | DA → RR in AAD00727 (Ref. 8) Curated | 2 | |
Sequence conflicti | 78 | Missing in CAA59270 (Ref. 4) Curated | 1 | |
Sequence conflicti | 174 | I → V in AAD01939 (PubMed:10911612).Curated | 1 | |
Sequence conflicti | 194 – 195 | PT → RL in CAA59270 (Ref. 4) Curated | 2 | |
Sequence conflicti | 195 | T → I no nucleotide entry (PubMed:2576652).Curated | 1 | |
Sequence conflicti | 222 | D → Y in CAA59270 (Ref. 4) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_028001 | 18 | A → T5 PublicationsCorresponds to variant dbSNP:rs2301721Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF026397 mRNA Translation: AAB94604.1 AJ005814 mRNA Translation: CAA06713.1 AF032095 Genomic DNA Translation: AAD01939.2 X84803, X84804 Genomic DNA Translation: CAA59270.1 CH236948 Genomic DNA Translation: EAL24221.1 AC004080 Genomic DNA No translation available. CH471073 Genomic DNA Translation: EAW93877.1 U92543 Genomic DNA Translation: AAD00727.1 |
CCDSi | CCDS5408.1 |
PIRi | S15536 |
RefSeqi | NP_008827.2, NM_006896.3 |
Genome annotation databases
Ensembli | ENST00000242159; ENSP00000242159; ENSG00000122592 |
GeneIDi | 3204 |
KEGGi | hsa:3204 |
UCSCi | uc003sys.4, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF026397 mRNA Translation: AAB94604.1 AJ005814 mRNA Translation: CAA06713.1 AF032095 Genomic DNA Translation: AAD01939.2 X84803, X84804 Genomic DNA Translation: CAA59270.1 CH236948 Genomic DNA Translation: EAL24221.1 AC004080 Genomic DNA No translation available. CH471073 Genomic DNA Translation: EAW93877.1 U92543 Genomic DNA Translation: AAD00727.1 |
CCDSi | CCDS5408.1 |
PIRi | S15536 |
RefSeqi | NP_008827.2, NM_006896.3 |
3D structure databases
SMRi | P31268 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 109444, 4 interactors |
IntActi | P31268, 4 interactors |
STRINGi | 9606.ENSP00000242159 |
PTM databases
iPTMneti | P31268 |
PhosphoSitePlusi | P31268 |
Polymorphism and mutation databases
BioMutai | HOXA7 |
DMDMi | 311033439 |
Proteomic databases
jPOSTi | P31268 |
MassIVEi | P31268 |
MaxQBi | P31268 |
PaxDbi | P31268 |
PeptideAtlasi | P31268 |
PRIDEi | P31268 |
ProteomicsDBi | 54769 |
Protocols and materials databases
Antibodypediai | 12389, 170 antibodies |
DNASUi | 3204 |
Genome annotation databases
Ensembli | ENST00000242159; ENSP00000242159; ENSG00000122592 |
GeneIDi | 3204 |
KEGGi | hsa:3204 |
UCSCi | uc003sys.4, human |
Organism-specific databases
CTDi | 3204 |
DisGeNETi | 3204 |
EuPathDBi | HostDB:ENSG00000122592.7 |
GeneCardsi | HOXA7 |
HGNCi | HGNC:5108, HOXA7 |
HPAi | ENSG00000122592, Tissue enhanced (skeletal) |
MIMi | 142950, gene |
neXtProti | NX_P31268 |
OpenTargetsi | ENSG00000122592 |
PharmGKBi | PA29385 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0489, Eukaryota |
GeneTreei | ENSGT00940000161013 |
HOGENOMi | CLU_061398_1_1_1 |
InParanoidi | P31268 |
OMAi | WKKDHKD |
OrthoDBi | 1203627at2759 |
PhylomeDBi | P31268 |
TreeFami | TF316310 |
Enzyme and pathway databases
PathwayCommonsi | P31268 |
SIGNORi | P31268 |
Miscellaneous databases
BioGRID-ORCSi | 3204, 11 hits in 867 CRISPR screens |
GeneWikii | HOXA7 |
GenomeRNAii | 3204 |
Pharosi | P31268, Tbio |
PROi | PR:P31268 |
RNActi | P31268, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000122592, Expressed in vagina and 155 other tissues |
ExpressionAtlasi | P31268, baseline and differential |
Genevisiblei | P31268, HS |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017995, Homeobox_antennapedia IPR001827, Homeobox_Antennapedia_CS IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00025, ANTENNAPEDIA PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00032, ANTENNAPEDIA, 1 hit PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HXA7_HUMAN | |
Accessioni | P31268Primary (citable) accession number: P31268 Secondary accession number(s): A4D191 Q9UDM1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | November 2, 2010 | |
Last modified: | December 2, 2020 | |
This is version 183 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Vertebrate homeotic Hox proteins
Nomenclature of vertebrate homeotic Hox proteins and list of entries