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Protein

Homeobox protein Hox-A6

Gene

HOXA6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi155 – 214HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A6
Alternative name(s):
Homeobox protein Hox-1B
Gene namesi
Name:HOXA6
Synonyms:HOX1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000106006.6
HGNCiHGNC:5107 HOXA6
MIMi142951 gene
neXtProtiNX_P31267

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3203
OpenTargetsiENSG00000106006
PharmGKBiPA29384

Polymorphism and mutation databases

BioMutaiHOXA6
DMDMi17378385

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002000671 – 233Homeobox protein Hox-A6Add BLAST233

Proteomic databases

MaxQBiP31267
PaxDbiP31267
PeptideAtlasiP31267
PRIDEiP31267
ProteomicsDBi54768

PTM databases

iPTMnetiP31267
PhosphoSitePlusiP31267

Expressioni

Gene expression databases

BgeeiENSG00000106006 Expressed in 77 organ(s), highest expression level in left uterine tube
CleanExiHS_HOXA6
GenevisibleiP31267 HS

Organism-specific databases

HPAiHPA004203

Interactioni

Protein-protein interaction databases

BioGridi109443, 1 interactor
STRINGi9606.ENSP00000222728

Structurei

3D structure databases

ProteinModelPortaliP31267
SMRiP31267
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi136 – 141Antp-type hexapeptide6

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000231181
HOVERGENiHBG016849
InParanoidiP31267
KOiK09306
OMAiIACNRAS
OrthoDBiEOG091G09XD
PhylomeDBiP31267
TreeFamiTF316310

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017995 Homeobox_antennapedia
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00025 ANTENNAPEDIA
PR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P31267-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSYFVNPTF PGSLPSGQDS FLGQLPLYQA GYDALRPFPA SYGASSLPDK
60 70 80 90 100
TYTSPCFYQQ SNSVLACNRA SYEYGASCFY SDKDLSGASP SGSGKQRGPG
110 120 130 140 150
DYLHFSPEQQ YKPDSSSGQG KALHDEGADR KYTSPVYPWM QRMNSCAGAV
160 170 180 190 200
YGSHGRRGRQ TYTRYQTLEL EKEFHFNRYL TRRRRIEIAN ALCLTERQIK
210 220 230
IWFQNRRMKW KKENKLINST QPSGEDSEAK AGE
Length:233
Mass (Da):26,339
Last modified:May 30, 2000 - v2
Checksum:i9D9DFD03FAF25967
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004080 Genomic DNA No translation available.
CH236948 Genomic DNA Translation: EAL24222.1
CH471073 Genomic DNA Translation: EAW93875.1
BC069497 mRNA Translation: AAH69497.1
BC104915 mRNA Translation: AAI04916.1
BC104917 mRNA Translation: AAI04918.1
CCDSiCCDS5407.1
PIRiS15538
RefSeqiNP_076919.1, NM_024014.3
UniGeneiHs.679517

Genome annotation databases

EnsembliENST00000222728; ENSP00000222728; ENSG00000106006
GeneIDi3203
KEGGihsa:3203
UCSCiuc003syo.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004080 Genomic DNA No translation available.
CH236948 Genomic DNA Translation: EAL24222.1
CH471073 Genomic DNA Translation: EAW93875.1
BC069497 mRNA Translation: AAH69497.1
BC104915 mRNA Translation: AAI04916.1
BC104917 mRNA Translation: AAI04918.1
CCDSiCCDS5407.1
PIRiS15538
RefSeqiNP_076919.1, NM_024014.3
UniGeneiHs.679517

3D structure databases

ProteinModelPortaliP31267
SMRiP31267
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109443, 1 interactor
STRINGi9606.ENSP00000222728

PTM databases

iPTMnetiP31267
PhosphoSitePlusiP31267

Polymorphism and mutation databases

BioMutaiHOXA6
DMDMi17378385

Proteomic databases

MaxQBiP31267
PaxDbiP31267
PeptideAtlasiP31267
PRIDEiP31267
ProteomicsDBi54768

Protocols and materials databases

DNASUi3203
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000222728; ENSP00000222728; ENSG00000106006
GeneIDi3203
KEGGihsa:3203
UCSCiuc003syo.3 human

Organism-specific databases

CTDi3203
DisGeNETi3203
EuPathDBiHostDB:ENSG00000106006.6
GeneCardsiHOXA6
HGNCiHGNC:5107 HOXA6
HPAiHPA004203
MIMi142951 gene
neXtProtiNX_P31267
OpenTargetsiENSG00000106006
PharmGKBiPA29384
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000231181
HOVERGENiHBG016849
InParanoidiP31267
KOiK09306
OMAiIACNRAS
OrthoDBiEOG091G09XD
PhylomeDBiP31267
TreeFamiTF316310

Miscellaneous databases

GeneWikiiHOXA6
GenomeRNAii3203
PROiPR:P31267
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000106006 Expressed in 77 organ(s), highest expression level in left uterine tube
CleanExiHS_HOXA6
GenevisibleiP31267 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017995 Homeobox_antennapedia
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00025 ANTENNAPEDIA
PR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHXA6_HUMAN
AccessioniPrimary (citable) accession number: P31267
Secondary accession number(s): A4D192, Q2M3G3, Q9UPM0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: May 30, 2000
Last modified: November 7, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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