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Protein

Recombining binding protein suppressor of hairless

Gene

Rbpj

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations (PubMed:7566092). Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen) (By similarity). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by repressing transcription of NADPH oxidase subunits (PubMed:26194095).By similarity2 Publications

Caution

Despite some similarity with the "phage" integrase family, it has no recombinase activity.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi84 – 91By similarity8
DNA bindingi218 – 22710
DNA bindingi291 – 323Add BLAST33

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processNotch signaling pathway, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-2122947 NOTCH1 Intracellular Domain Regulates Transcription
R-MMU-2197563 NOTCH2 intracellular domain regulates transcription
R-MMU-350054 Notch-HLH transcription pathway
R-MMU-8941856 RUNX3 regulates NOTCH signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Recombining binding protein suppressor of hairless
Alternative name(s):
J kappa-recombination signal-binding protein
RBP-J kappa
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RbpjImported
Synonyms:Igkjrb1, Igkrsbp, Rbpsuh
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:96522 Rbpj

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002085681 – 526Recombining binding protein suppressor of hairlessAdd BLAST526

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei201N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P31266

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P31266

PeptideAtlas

More...
PeptideAtlasi
P31266

PRoteomics IDEntifications database

More...
PRIDEi
P31266

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P31266

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P31266

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P31266

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000039191 Expressed in 293 organ(s), highest expression level in ureter smooth muscle

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P31266 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P31266 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RITA1, leading to nuclear export, prevent the interaction between RBPJ and NICD product and subsequent down-regulation of the Notch signaling pathway (By similarity). Interacts with activated NOTCH1, NOTCH2 and NOTCH3. Interacts with MINT/SHARP. This interaction may mediate the recruitment of large corepressor complexes containing proteins such as HDAC1, HDAC2, NCOR2, SAP30, FHL1/KYOT2 and CIR1. Interacts with EP300, MAML1 and PTF1A. Interacts with SNW1. Interacts with CHCHD2 and CXXC5. Interacts with BEND6 (via BEN domain) (By similarity). Interacts with NKAPL (PubMed:25875095). Interacts with ZMIZ1 (By similarity). Interacts with RBM15 (PubMed:17283045).By similarity7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
202832, 9 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P31266

Database of interacting proteins

More...
DIPi
DIP-171N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
P31266

Protein interaction database and analysis system

More...
IntActi
P31266, 7 interactors

Molecular INTeraction database

More...
MINTi
P31266

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000040694

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1526
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P31266

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P31266

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P31266

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini381 – 471IPT/TIGAdd BLAST91

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Su(H) family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3743 Eukaryota
ENOG410XV7K LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000005197

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000253907

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG006618

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P31266

KEGG Orthology (KO)

More...
KOi
K06053

Database of Orthologous Groups

More...
OrthoDBi
EOG091G057S

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P31266

TreeFam database of animal gene trees

More...
TreeFami
TF314117

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01176 IPT_RBP-Jkappa, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
2.60.40.1450, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015350 Beta-trefoil_DNA-bd_dom
IPR036358 BTD_sf
IPR040159 CLS_fam
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR008967 p53-like_TF_DNA-bd
IPR015351 RBP-J/Cbf11/Cbf12_DNA-bd
IPR037095 RBP-J/Cbf11/Cbf12_DNA-bd_sf
IPR038007 RBP-Jkappa_IPT

The PANTHER Classification System

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PANTHERi
PTHR10665 PTHR10665, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09270 BTD, 1 hit
PF09271 LAG1-DNAbind, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01268 BTD, 1 hit
SM01267 LAG1_DNAbind, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF110217 SSF110217, 1 hit
SSF49417 SSF49417, 1 hit
SSF81296 SSF81296, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P31266-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPSGFPQSPR TSPRARPKTR ITGALPMDYS EGLSAEERPA HAPSAGKFGE
60 70 80 90 100
RPPPKRLTRE AMRNYLKERG DQTVLILHAK VAQKSYGNEK RFFCPPPCVY
110 120 130 140 150
LMGSGWKKKK EQMERDGCSE QESQPCAFIG IGNSDQEMQQ LNLEGKNYCT
160 170 180 190 200
AKTLYISDSD KRKHFMLSVK MFYGNSDDIG VFLSKRIKVI SKPSKKKQSL
210 220 230 240 250
KNADLCIASG TKVALFNRLR SQTVSTRYLH VEGGNFHASS QQWGAFYIHL
260 270 280 290 300
LDDDESEGEE FTVRDGYIHY GQTVKLVCSV TGMALPRLII RKVDKQTALL
310 320 330 340 350
DADDPVSQLH KCAFYLKDTE RMYLCLSQER IIQFQATPCP KEQNKEMIND
360 370 380 390 400
GASWTIISTD KAEYTFYEGM GPVLAPVTPV PVVESLQLNG GGDVAMLELT
410 420 430 440 450
GQNFTPNLRV WFGDVEAETM YRCGESMLCV VPDISAFREG WRWVRQPVQV
460 470 480 490 500
PVTLVRNDGV IYSTSLTFTY TPEPGPRPHC SAAGAILRAN SSQVPSNESN
510 520
TNSEGNYTNA STNSTSVTSS TATVVS
Length:526
Mass (Da):58,537
Last modified:July 1, 1993 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8BF517CC24099E03
GO
Isoform 2 (identifier: P31266-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-39: Missing.
     40-45: AHAPSA → MAPVVT

Note: No experimental confirmation available.
Show »
Length:487
Mass (Da):54,347
Checksum:i88C0D1DCECACC9E2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3U6F1Q3U6F1_MOUSE
Recombining-binding protein suppres...
Rbpj Rbpsuh
465Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YTV5A0A0J9YTV5_MOUSE
Recombining binding protein suppres...
Rbpj Rbpsuh, mCG_16305
507Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q7W0E9Q7W0_MOUSE
Recombining-binding protein suppres...
Rbpj
485Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YVE0A0A0J9YVE0_MOUSE
Recombining-binding protein suppres...
Rbpj
180Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0083921 – 39Missing in isoform 2. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_00839340 – 45AHAPSA → MAPVVT in isoform 2. 1 Publication6

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
S63463 mRNA Translation: AAB20195.1
X17459 mRNA Translation: CAA35501.1
X58337 Genomic DNA No translation available.
M81867, M81865, M81866 Genomic DNA Translation: AAA39018.1
M81868 Genomic DNA Translation: AAA39019.1
M81870, M81869 Genomic DNA Translation: AAA39020.1 Sequence problems.
M81873, M81872 Genomic DNA Translation: AAA39021.1
M81875, M81874 Genomic DNA Translation: AAA39022.1
M81876 Genomic DNA Translation: AAA39023.1
M81877 Genomic DNA No translation available.
BC051387 mRNA Translation: AAH51387.1
AK080359 mRNA Translation: BAC37889.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS19292.1 [P31266-1]
CCDS51504.1 [P31266-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
A42267
A43567

NCBI Reference Sequences

More...
RefSeqi
NP_001074396.1, NM_001080927.2 [P31266-2]
NP_033061.3, NM_009035.5 [P31266-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.209292
Mm.488709

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000037618; ENSMUSP00000040694; ENSMUSG00000039191 [P31266-1]
ENSMUST00000113865; ENSMUSP00000109496; ENSMUSG00000039191 [P31266-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
19664

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:19664

UCSC genome browser

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UCSCi
uc008xli.2 mouse [P31266-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S63463 mRNA Translation: AAB20195.1
X17459 mRNA Translation: CAA35501.1
X58337 Genomic DNA No translation available.
M81867, M81865, M81866 Genomic DNA Translation: AAA39018.1
M81868 Genomic DNA Translation: AAA39019.1
M81870, M81869 Genomic DNA Translation: AAA39020.1 Sequence problems.
M81873, M81872 Genomic DNA Translation: AAA39021.1
M81875, M81874 Genomic DNA Translation: AAA39022.1
M81876 Genomic DNA Translation: AAA39023.1
M81877 Genomic DNA No translation available.
BC051387 mRNA Translation: AAH51387.1
AK080359 mRNA Translation: BAC37889.1
CCDSiCCDS19292.1 [P31266-1]
CCDS51504.1 [P31266-2]
PIRiA42267
A43567
RefSeqiNP_001074396.1, NM_001080927.2 [P31266-2]
NP_033061.3, NM_009035.5 [P31266-1]
UniGeneiMm.209292
Mm.488709

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BRGX-ray2.20C53-474[»]
3IAGX-ray2.00C53-474[»]
4J2XX-ray2.85A/C53-474[»]
5EG6X-ray2.09C53-474[»]
ProteinModelPortaliP31266
SMRiP31266
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202832, 9 interactors
CORUMiP31266
DIPiDIP-171N
ELMiP31266
IntActiP31266, 7 interactors
MINTiP31266
STRINGi10090.ENSMUSP00000040694

PTM databases

iPTMnetiP31266
PhosphoSitePlusiP31266
SwissPalmiP31266

Proteomic databases

MaxQBiP31266
PaxDbiP31266
PeptideAtlasiP31266
PRIDEiP31266

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037618; ENSMUSP00000040694; ENSMUSG00000039191 [P31266-1]
ENSMUST00000113865; ENSMUSP00000109496; ENSMUSG00000039191 [P31266-2]
GeneIDi19664
KEGGimmu:19664
UCSCiuc008xli.2 mouse [P31266-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3516
MGIiMGI:96522 Rbpj

Phylogenomic databases

eggNOGiKOG3743 Eukaryota
ENOG410XV7K LUCA
GeneTreeiENSGT00390000005197
HOGENOMiHOG000253907
HOVERGENiHBG006618
InParanoidiP31266
KOiK06053
OrthoDBiEOG091G057S
PhylomeDBiP31266
TreeFamiTF314117

Enzyme and pathway databases

ReactomeiR-MMU-2122947 NOTCH1 Intracellular Domain Regulates Transcription
R-MMU-2197563 NOTCH2 intracellular domain regulates transcription
R-MMU-350054 Notch-HLH transcription pathway
R-MMU-8941856 RUNX3 regulates NOTCH signaling

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Rbpj mouse
EvolutionaryTraceiP31266

Protein Ontology

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PROi
PR:P31266

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000039191 Expressed in 293 organ(s), highest expression level in ureter smooth muscle
ExpressionAtlasiP31266 baseline and differential
GenevisibleiP31266 MM

Family and domain databases

CDDicd01176 IPT_RBP-Jkappa, 1 hit
Gene3Di2.60.40.10, 1 hit
2.60.40.1450, 1 hit
InterProiView protein in InterPro
IPR015350 Beta-trefoil_DNA-bd_dom
IPR036358 BTD_sf
IPR040159 CLS_fam
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR008967 p53-like_TF_DNA-bd
IPR015351 RBP-J/Cbf11/Cbf12_DNA-bd
IPR037095 RBP-J/Cbf11/Cbf12_DNA-bd_sf
IPR038007 RBP-Jkappa_IPT
PANTHERiPTHR10665 PTHR10665, 1 hit
PfamiView protein in Pfam
PF09270 BTD, 1 hit
PF09271 LAG1-DNAbind, 1 hit
SMARTiView protein in SMART
SM01268 BTD, 1 hit
SM01267 LAG1_DNAbind, 1 hit
SUPFAMiSSF110217 SSF110217, 1 hit
SSF49417 SSF49417, 1 hit
SSF81296 SSF81296, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSUH_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P31266
Secondary accession number(s): Q80UN8, Q8C4Z3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: December 5, 2018
This is version 191 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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