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Entry version 156 (07 Apr 2021)
Sequence version 2 (01 Dec 2000)
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Protein

Translationally-controlled tumor protein 1

Gene

TCTP1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

General regulator required for the development of the entire plant. Regulates the duration of cell cycle (PubMed:20736351). Probable activator of Rab GTPases and upstream regulator of the cell growth-regulating TOR (target of rapamycin) network (PubMed:19060111, PubMed:20736351). Might also control spatial growth in pollen tubes or root hairs via the TORC2 signaling branch (PubMed:19060111). Involved in the regulation of abscisic acid- and calcium-mediated stomatal closure, but not in light or H+-pumping induced stomatal opening. May regulate microtubules depolymerization (PubMed:22610367). Binds calcium and has a cytoprotective function (PubMed:24040826).4 Publications

Miscellaneous

Knockdown mutants have retarded growth due to decreased cell size.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium ion binding Source: GO_Central
  • microtubule binding Source: TAIR
  • protein domain specific binding Source: CAFA

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Translationally-controlled tumor protein 11 Publication
Short name:
TCTP11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TCTP11 Publication
Synonyms:TXTP
Ordered Locus Names:At3g16640Imported
ORF Names:MGL6.10Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT3G16640

The Arabidopsis Information Resource

More...
TAIRi
locus:2089378, AT3G16640

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Male gametophytic phenotype with normal pollen formation and germination but impaired pollen tube growth (PubMed:19060111). Embryonic lethality when homozygous due to a retarded development of the embryos that eventually collapse at the silique dehiscence stage (PubMed:20736351).2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi12E → V: Loss of function. 1 Publication1
Mutagenesisi35 – 47Missing : Gain of regeneration capacity. 1 PublicationAdd BLAST13

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002112971 – 168Translationally-controlled tumor protein 1Add BLAST168

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P31265

PRoteomics IDEntifications database

More...
PRIDEi
P31265

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
234209

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P31265

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in flowers, leaves and stems (PubMed:16902407, PubMed:19060111). Expressed in roots and siliques. Detected in seeds. Highest expression in actively dividing and differentiating cell types, such as the meristematic and division zones of the root, the embryo or the elongating tube of germinating pollen (PubMed:19060111). Expressed in cotyledons, leaves, hypocotyls and roots. Detected in mitotically active tissues such as shoot apical meristems, root tips, lateral root initiation regions and anthers, and in guard cells (PubMed:22610367).3 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by momilactone B (PubMed:26058145). Not regulated by light (PubMed:19060111). Up-regulated by abscisic acid (PubMed:22610367).3 Publications

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P31265, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P31265, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with the Rab GTPases RABA4A, RABA4B, RABF1 and RABF2B (PubMed:20736351).

Interacts with microtubules and heterodimers of alpha- and beta-tubulins. Cytosolic calcium positively regulates this interaction (PubMed:22610367).

2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
6250, 4 interactors

Protein interaction database and analysis system

More...
IntActi
P31265, 4 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT3G16640.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P31265

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 168TCTPPROSITE-ProRule annotationAdd BLAST168

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TCTP family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1727, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_095877_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P31265

Identification of Orthologs from Complete Genome Data

More...
OMAi
RLVEMNC

Database of Orthologous Groups

More...
OrthoDBi
1439384at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P31265

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.170.150.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011057, Mss4-like_sf
IPR011323, Mss4/transl-control_tumour
IPR034737, TCTP
IPR018103, Translation_control_tumour_CS
IPR018105, Translational_control_tumour_p

The PANTHER Classification System

More...
PANTHERi
PTHR11991, PTHR11991, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00838, TCTP, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01653, TCTPROTEIN

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51316, SSF51316, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01002, TCTP_1, 1 hit
PS01003, TCTP_2, 1 hit
PS51797, TCTP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P31265-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLVYQDLLTG DELLSDSFPY KEIENGILWE VEGKWVTVGA VDVNIGANPS
60 70 80 90 100
AEEGGEDEGV DDSTQKVVDI VDTFRLQEQP TYDKKGFIAY IKKYIKLLTP
110 120 130 140 150
KLSEEDQAVF KKGIEGATKF LLPRLSDFQF FVGEGMHDDS TLVFAYYKEG
160
STNPTFLYFA HGLKEVKC
Length:168
Mass (Da):18,910
Last modified:December 1, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3A86AB8DFEBBE166
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti64T → A in AAM66134 (Ref. 5) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF215897 mRNA Translation: AAG44002.1
AB022217 Genomic DNA Translation: BAB02755.1
CP002686 Genomic DNA Translation: AEE75847.1
AF361815 mRNA Translation: AAK32828.1
AY045802 mRNA Translation: AAK76476.1
AY056065 mRNA Translation: AAL06965.1
AY072337 mRNA Translation: AAL61944.1
AY079333 mRNA Translation: AAL85064.1
AY114601 mRNA Translation: AAM47920.1
AY088605 mRNA Translation: AAM66134.1
Z18387 mRNA Translation: CAA79177.1

NCBI Reference Sequences

More...
RefSeqi
NP_188286.1, NM_112537.4

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT3G16640.1; AT3G16640.1; AT3G16640

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
820916

Gramene; a comparative resource for plants

More...
Gramenei
AT3G16640.1; AT3G16640.1; AT3G16640

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT3G16640

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF215897 mRNA Translation: AAG44002.1
AB022217 Genomic DNA Translation: BAB02755.1
CP002686 Genomic DNA Translation: AEE75847.1
AF361815 mRNA Translation: AAK32828.1
AY045802 mRNA Translation: AAK76476.1
AY056065 mRNA Translation: AAL06965.1
AY072337 mRNA Translation: AAL61944.1
AY079333 mRNA Translation: AAL85064.1
AY114601 mRNA Translation: AAM47920.1
AY088605 mRNA Translation: AAM66134.1
Z18387 mRNA Translation: CAA79177.1
RefSeqiNP_188286.1, NM_112537.4

3D structure databases

SMRiP31265
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi6250, 4 interactors
IntActiP31265, 4 interactors
STRINGi3702.AT3G16640.1

PTM databases

iPTMnetiP31265

Proteomic databases

PaxDbiP31265
PRIDEiP31265
ProteomicsDBi234209

Genome annotation databases

EnsemblPlantsiAT3G16640.1; AT3G16640.1; AT3G16640
GeneIDi820916
GrameneiAT3G16640.1; AT3G16640.1; AT3G16640
KEGGiath:AT3G16640

Organism-specific databases

AraportiAT3G16640
TAIRilocus:2089378, AT3G16640

Phylogenomic databases

eggNOGiKOG1727, Eukaryota
HOGENOMiCLU_095877_1_1_1
InParanoidiP31265
OMAiRLVEMNC
OrthoDBi1439384at2759
PhylomeDBiP31265

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P31265

Gene expression databases

ExpressionAtlasiP31265, baseline and differential
GenevisibleiP31265, AT

Family and domain databases

Gene3Di2.170.150.10, 1 hit
InterProiView protein in InterPro
IPR011057, Mss4-like_sf
IPR011323, Mss4/transl-control_tumour
IPR034737, TCTP
IPR018103, Translation_control_tumour_CS
IPR018105, Translational_control_tumour_p
PANTHERiPTHR11991, PTHR11991, 1 hit
PfamiView protein in Pfam
PF00838, TCTP, 1 hit
PRINTSiPR01653, TCTPROTEIN
SUPFAMiSSF51316, SSF51316, 1 hit
PROSITEiView protein in PROSITE
PS01002, TCTP_1, 1 hit
PS01003, TCTP_2, 1 hit
PS51797, TCTP_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTCTP1_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P31265
Secondary accession number(s): Q8L973, Q9LUS0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: December 1, 2000
Last modified: April 7, 2021
This is version 156 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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