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Entry version 178 (02 Jun 2021)
Sequence version 2 (09 Jan 2007)
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Protein

Ubiquitin-like modifier-activating enzyme 1 Y

Gene

Uba1y

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (By similarity).

The Y chromosome form could be involved in the survival and proliferation of differentiating spermatogonia.

By similarityCurated

Miscellaneous

There are two active sites within the E1 molecule, allowing it to accommodate two ubiquitin moieties at a time, with a new ubiquitin forming an adenylate intermediate as the previous one is transferred to the thiol site.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.By similarity EC:6.2.1.45

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.By similarity
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei477ATP; via amide nitrogenBy similarity1
Binding sitei503ATPBy similarity1
Binding sitei514ATPBy similarity1
Binding sitei527ATPBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei631Glycyl thioester intermediatePROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi575 – 576ATPBy similarity2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ubiquitin activating enzyme activity Source: MGI

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase
Biological processUbl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ubiquitin-like modifier-activating enzyme 1 Y (EC:6.2.1.45By similarity)
Alternative name(s):
Ubiquitin-activating enzyme E1
Ubiquitin-activating enzyme E1 Y
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Uba1y
Synonyms:Sby, Ube1ay, Ube1y, Ube1y1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome Y

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:98891, Uba1y

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001949391 – 1058Ubiquitin-like modifier-activating enzyme 1 YAdd BLAST1058

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P31254

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P31254

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P31254

PeptideAtlas

More...
PeptideAtlasi
P31254

PRoteomics IDEntifications database

More...
PRIDEi
P31254

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
297779

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P31254

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P31254

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P31254

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in testis in A spermatogonia and spermatids but not (or at very low levels) in pachytene spermatocytes. Also expressed in Y-bearing ovaries and at very low levels in adrenal gland.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

In testis, expression detected at 12.5 days post coitum (dpc) and peaking at 14.5 dpc, with expression dropping to low levels at the day of birth. After birth, levels increase 4-fold to a peak at 10 days post partum (dpp) and fall again thereafter.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000069053, Expressed in spermatid and 28 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P31254, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
204411, 5 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000111560

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P31254, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P31254

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 22DisorderedSequence analysisAdd BLAST22

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ubiquitin-activating E1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2012, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158975

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002556_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P31254

Identification of Orthologs from Complete Genome Data

More...
OMAi
THEYEAV

Database of Orthologous Groups

More...
OrthoDBi
91748at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P31254

TreeFam database of animal gene trees

More...
TreeFami
TF300586

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.2660, 1 hit
2.40.30.180, 1 hit
3.10.290.60, 1 hit
3.50.50.80, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032420, E1_4HB
IPR032418, E1_FCCH
IPR042302, E1_FCCH_sf
IPR000594, ThiF_NAD_FAD-bd
IPR018965, Ub-activating_enz_E1_C
IPR042449, Ub-E1_IAD_1
IPR038252, UBA_E1_C_sf
IPR019572, UBA_E1_Cys
IPR042063, Ubi_acti_E1_SCCH
IPR035985, Ubiquitin-activating_enz
IPR018075, UBQ-activ_enz_E1
IPR018074, UBQ-activ_enz_E1_CS
IPR033127, UBQ-activ_enz_E1_Cys_AS
IPR000011, UBQ/SUMO-activ_enz_E1-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16191, E1_4HB, 1 hit
PF16190, E1_FCCH, 1 hit
PF09358, E1_UFD, 1 hit
PF00899, ThiF, 2 hits
PF10585, UBA_e1_thiolCys, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01849, UBIQUITINACT

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00985, UBA_e1_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF69572, SSF69572, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01408, Ube1, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00536, UBIQUITIN_ACTIVAT_1, 1 hit
PS00865, UBIQUITIN_ACTIVAT_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P31254-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSSVLSKKR KVSGPDSSLD SSWSPTYSVM FGVPPGPTNE MSKNKEMDID
60 70 80 90 100
ESLYSRQLYV LGHEAMKHLQ ASSVLISGLQ GLGVEIAKNI ILGGVKAVTL
110 120 130 140 150
HDQGIAQWAD LSSQFCLREE DIGKNRAEIS QPRLAELNSY VPVFAYTGPL
160 170 180 190 200
IEEFLSGFQV VVLTNTPLEY QLQVGEFCHS HGIKLVVADT RGLVGQLFCD
210 220 230 240 250
FGEEMILTDS NGEQPLSAMV SMITKENPGI VTCLEDSRHG FESGDFISFT
260 270 280 290 300
EVQGMSELNG IGPIEIKVLG PYTFSICDTS SFSEYIRGGI VSQVKVPRKI
310 320 330 340 350
NFKPLLASLA EPEFVVTDFA KCCHPAQLHI GFQALHQFCT QHSRPPRPHN
360 370 380 390 400
EEDAEELVTL AQSVNAQALP AVQQDCLDID LIRKLAYVAA GDLAPMNAFF
410 420 430 440 450
GGLAAQEVMK ACSGKFMPIR QWLYFDALEC LPEHRVAFME DKCLPHQNRY
460 470 480 490 500
DGQVAVFGSD LQEKLGKQKY FLVGAGAIGC ELLKNFAMIG LGCGEDGEIT
510 520 530 540 550
VTDMDTIEKS NLNRQFLFRP WDITKLKSET AAAAVRDINP HIRIFSHQNR
560 570 580 590 600
VGPETEHVYD DDFFQKLDGV ANALDNVDAR LYVDRRCVYY RKPLLESGTL
610 620 630 640 650
GTKGNVQVVV PFLTESYSSS QDPPEKSIPI CTLKNFPNAI EHTVQWARDE
660 670 680 690 700
FEGLFKQSAE NVNQYLTDPK FMERTLQLAG TQPLEVLEAI HCSLVLQRPQ
710 720 730 740 750
TWADCVTWAY QHWHTQYSHN IQQLLHNFPP AQLTSSGALF WSGPKRCPHP
760 770 780 790 800
LTFDINNPLH LDYVMAAANL FAQTYGLGGS QDCAVVAKLL QSLPVPKFAP
810 820 830 840 850
KSGIRIHVSE QELQSTSATT IDDSHLEELK TALPTPDKLL GFKMYPIDFE
860 870 880 890 900
KDDDSNFHMD FIVAASNLRA ENYGISPADR HKSKLIAGKI IPAIATTTSA
910 920 930 940 950
IVGLVCLELY KVVQGHQQLE SYKNSFINLA LPLFSFSAPL APECHQYYDQ
960 970 980 990 1000
EWTLWDRFDV QGLQPSGEEM TLKQFLDYFK TEHKLEVIML SQGVSMLYSV
1010 1020 1030 1040 1050
FMPASKLKER LDQPMTEIVS CVSKQKLGHH VKSLVFELCC NSDSGDDIEV

PYVRYIIR
Length:1,058
Mass (Da):118,038
Last modified:January 9, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB5C5AD66534B0350
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti93G → C in AAF00149 (PubMed:10656933).Curated1
Sequence conflicti498E → V in BAC26749 (PubMed:16141072).Curated1
Sequence conflicti635N → Y in CAA44466 (PubMed:1684224).Curated1
Sequence conflicti713W → R in AAC52170 (PubMed:7714913).Curated1
Sequence conflicti947Y → F in CAA44466 (PubMed:1684224).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF127490 AF127489 Genomic DNA Translation: AAD56603.1
AF150963 mRNA Translation: AAF00149.1
AK030031 mRNA Translation: BAC26749.1
X62581 mRNA Translation: CAA44466.1
U09052 Genomic DNA Translation: AAC52170.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS30540.1

Protein sequence database of the Protein Information Resource

More...
PIRi
I49011
S19712

NCBI Reference Sequences

More...
RefSeqi
NP_035797.1, NM_011667.2
XP_006531645.1, XM_006531582.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000115894; ENSMUSP00000111560; ENSMUSG00000069053
ENSMUST00000190013; ENSMUSP00000140543; ENSMUSG00000069053

UCSC genome browser

More...
UCSCi
uc009uyw.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF127490 AF127489 Genomic DNA Translation: AAD56603.1
AF150963 mRNA Translation: AAF00149.1
AK030031 mRNA Translation: BAC26749.1
X62581 mRNA Translation: CAA44466.1
U09052 Genomic DNA Translation: AAC52170.1
CCDSiCCDS30540.1
PIRiI49011
S19712
RefSeqiNP_035797.1, NM_011667.2
XP_006531645.1, XM_006531582.2

3D structure databases

SMRiP31254
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi204411, 5 interactors
STRINGi10090.ENSMUSP00000111560

PTM databases

iPTMnetiP31254
PhosphoSitePlusiP31254
SwissPalmiP31254

Proteomic databases

jPOSTiP31254
MaxQBiP31254
PaxDbiP31254
PeptideAtlasiP31254
PRIDEiP31254
ProteomicsDBi297779

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
22202

Genome annotation databases

EnsembliENSMUST00000115894; ENSMUSP00000111560; ENSMUSG00000069053
ENSMUST00000190013; ENSMUSP00000140543; ENSMUSG00000069053
UCSCiuc009uyw.1, mouse

Organism-specific databases

MGIiMGI:98891, Uba1y

Phylogenomic databases

eggNOGiKOG2012, Eukaryota
GeneTreeiENSGT00940000158975
HOGENOMiCLU_002556_0_0_1
InParanoidiP31254
OMAiTHEYEAV
OrthoDBi91748at2759
PhylomeDBiP31254
TreeFamiTF300586

Enzyme and pathway databases

UniPathwayiUPA00143

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
22202, 0 hits in 53 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Uba1y-ps1, mouse

Protein Ontology

More...
PROi
PR:P31254
RNActiP31254, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000069053, Expressed in spermatid and 28 other tissues
GenevisibleiP31254, MM

Family and domain databases

Gene3Di1.10.10.2660, 1 hit
2.40.30.180, 1 hit
3.10.290.60, 1 hit
3.50.50.80, 1 hit
InterProiView protein in InterPro
IPR032420, E1_4HB
IPR032418, E1_FCCH
IPR042302, E1_FCCH_sf
IPR000594, ThiF_NAD_FAD-bd
IPR018965, Ub-activating_enz_E1_C
IPR042449, Ub-E1_IAD_1
IPR038252, UBA_E1_C_sf
IPR019572, UBA_E1_Cys
IPR042063, Ubi_acti_E1_SCCH
IPR035985, Ubiquitin-activating_enz
IPR018075, UBQ-activ_enz_E1
IPR018074, UBQ-activ_enz_E1_CS
IPR033127, UBQ-activ_enz_E1_Cys_AS
IPR000011, UBQ/SUMO-activ_enz_E1-like
PfamiView protein in Pfam
PF16191, E1_4HB, 1 hit
PF16190, E1_FCCH, 1 hit
PF09358, E1_UFD, 1 hit
PF00899, ThiF, 2 hits
PF10585, UBA_e1_thiolCys, 1 hit
PRINTSiPR01849, UBIQUITINACT
SMARTiView protein in SMART
SM00985, UBA_e1_C, 1 hit
SUPFAMiSSF69572, SSF69572, 2 hits
TIGRFAMsiTIGR01408, Ube1, 1 hit
PROSITEiView protein in PROSITE
PS00536, UBIQUITIN_ACTIVAT_1, 1 hit
PS00865, UBIQUITIN_ACTIVAT_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUBA1Y_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P31254
Secondary accession number(s): Q60639
, Q8CDH7, Q9QYS4, Q9QZX2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 9, 2007
Last modified: June 2, 2021
This is version 178 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
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