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Protein

Homeobox protein Hox-D3

Gene

HOXD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Caution

It is uncertain whether Met-1 or Met-17 is the initiator.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi194 – 253HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis
SIGNORiP31249

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-D3
Alternative name(s):
Homeobox protein Hox-4A
Gene namesi
Name:HOXD3
Synonyms:HOX1D, HOX4A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000128652.11
HGNCiHGNC:5137 HOXD3
MIMi142980 gene
neXtProtiNX_P31249

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3232
OpenTargetsiENSG00000128652
PharmGKBiPA29411

Polymorphism and mutation databases

BioMutaiHOXD3
DMDMi224471887

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002002041 – 432Homeobox protein Hox-D3Add BLAST432

Proteomic databases

EPDiP31249
PaxDbiP31249
PeptideAtlasiP31249
PRIDEiP31249
ProteomicsDBi54765

PTM databases

iPTMnetiP31249
PhosphoSitePlusiP31249

Expressioni

Gene expression databases

BgeeiENSG00000128652 Expressed in 75 organ(s), highest expression level in kidney
CleanExiHS_HOXD3
ExpressionAtlasiP31249 baseline and differential
GenevisibleiP31249 HS

Organism-specific databases

HPAiHPA051831
HPA063671

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Hoxa1P090223EBI-3957655,EBI-3957603From Mus musculus.

Protein-protein interaction databases

BioGridi109472, 5 interactors
IntActiP31249, 6 interactors
MINTiP31249
STRINGi9606.ENSP00000249440

Structurei

3D structure databases

ProteinModelPortaliP31249
SMRiP31249
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi160 – 165Antp-type hexapeptide6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi100 – 104Poly-Gly5
Compositional biasi116 – 124Poly-Pro9
Compositional biasi150 – 153Poly-Ser4

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000144005
HOGENOMiHOG000252944
HOVERGENiHBG107984
InParanoidiP31249
KOiK09303
OMAiPSFAKPQ
OrthoDBiEOG091G0PFO
PhylomeDBiP31249
TreeFamiTF315938

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR025281 DUF4074
IPR009057 Homeobox-like_sf
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF13293 DUF4074, 1 hit
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P31249-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLFEQGQQAL ELPECTMQKA AYYENPGLFG GYGYSKTTDT YGYSTPHQPY
60 70 80 90 100
PPPAAASSLD TDYPGSACSI QSSAPLRAPA HKGAELNGSC MRPGTGNSQG
110 120 130 140 150
GGGGSQPPGL NSEQQPPQPP PPPPTLPPSS PTNPGGGVPA KKPKGGPNAS
160 170 180 190 200
SSSATISKQI FPWMKESRQN SKQKNSCATA GESCEDKSPP GPASKRVRTA
210 220 230 240 250
YTSAQLVELE KEFHFNRYLC RPRRVEMANL LNLTERQIKI WFQNRRMKYK
260 270 280 290 300
KDQKAKGILH SPASQSPERS PPLGGAAGHV AYSGQLPPVP GLAYDAPSPP
310 320 330 340 350
AFAKSQPNMY GLAAYTAPLS SCLPQQKRYA APEFEPHPMA SNGGGFASAN
360 370 380 390 400
LQGSPVYVGG NFVESMAPAS GPVFNLGHLS HPSSASVDYS CAAQIPGNHH
410 420 430
HGPCDPHPTY TDLSAHHSSQ GRLPEAPKLT HL
Length:432
Mass (Da):45,730
Last modified:March 3, 2009 - v3
Checksum:iBC962D2AA076B87B
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J1M3C9J1M3_HUMAN
Homeobox protein Hox-D3
HOXD3
100Annotation score:

Sequence cautioni

The sequence BAA01891 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti257G → A (PubMed:2576652).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_011881129S → C. Corresponds to variant dbSNP:rs1051932Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D11117 Genomic DNA Translation: BAA01891.1 Different initiation.
Y09980 Genomic DNA Translation: CAA71102.1
AC009336 Genomic DNA No translation available.
BC005124 mRNA Translation: AAH05124.1
BC008789 mRNA Translation: AAH08789.1
CCDSiCCDS2270.1
PIRiS15548
S27198
RefSeqiNP_008829.3, NM_006898.4
XP_005246566.1, XM_005246509.3
XP_005246567.1, XM_005246510.4
XP_005246568.1, XM_005246511.3
XP_005246570.1, XM_005246513.4
XP_006712540.1, XM_006712477.2
XP_011509367.1, XM_011511065.2
XP_011509368.1, XM_011511066.2
UniGeneiHs.93574

Genome annotation databases

EnsembliENST00000249440; ENSP00000249440; ENSG00000128652
ENST00000410016; ENSP00000386498; ENSG00000128652
GeneIDi3232
KEGGihsa:3232
UCSCiuc002ukt.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D11117 Genomic DNA Translation: BAA01891.1 Different initiation.
Y09980 Genomic DNA Translation: CAA71102.1
AC009336 Genomic DNA No translation available.
BC005124 mRNA Translation: AAH05124.1
BC008789 mRNA Translation: AAH08789.1
CCDSiCCDS2270.1
PIRiS15548
S27198
RefSeqiNP_008829.3, NM_006898.4
XP_005246566.1, XM_005246509.3
XP_005246567.1, XM_005246510.4
XP_005246568.1, XM_005246511.3
XP_005246570.1, XM_005246513.4
XP_006712540.1, XM_006712477.2
XP_011509367.1, XM_011511065.2
XP_011509368.1, XM_011511066.2
UniGeneiHs.93574

3D structure databases

ProteinModelPortaliP31249
SMRiP31249
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109472, 5 interactors
IntActiP31249, 6 interactors
MINTiP31249
STRINGi9606.ENSP00000249440

PTM databases

iPTMnetiP31249
PhosphoSitePlusiP31249

Polymorphism and mutation databases

BioMutaiHOXD3
DMDMi224471887

Proteomic databases

EPDiP31249
PaxDbiP31249
PeptideAtlasiP31249
PRIDEiP31249
ProteomicsDBi54765

Protocols and materials databases

DNASUi3232
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000249440; ENSP00000249440; ENSG00000128652
ENST00000410016; ENSP00000386498; ENSG00000128652
GeneIDi3232
KEGGihsa:3232
UCSCiuc002ukt.2 human

Organism-specific databases

CTDi3232
DisGeNETi3232
EuPathDBiHostDB:ENSG00000128652.11
GeneCardsiHOXD3
HGNCiHGNC:5137 HOXD3
HPAiHPA051831
HPA063671
MIMi142980 gene
neXtProtiNX_P31249
OpenTargetsiENSG00000128652
PharmGKBiPA29411
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000144005
HOGENOMiHOG000252944
HOVERGENiHBG107984
InParanoidiP31249
KOiK09303
OMAiPSFAKPQ
OrthoDBiEOG091G0PFO
PhylomeDBiP31249
TreeFamiTF315938

Enzyme and pathway databases

ReactomeiR-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis
SIGNORiP31249

Miscellaneous databases

GeneWikiiHOXD3
GenomeRNAii3232
PROiPR:P31249
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000128652 Expressed in 75 organ(s), highest expression level in kidney
CleanExiHS_HOXD3
ExpressionAtlasiP31249 baseline and differential
GenevisibleiP31249 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR025281 DUF4074
IPR009057 Homeobox-like_sf
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF13293 DUF4074, 1 hit
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHXD3_HUMAN
AccessioniPrimary (citable) accession number: P31249
Secondary accession number(s): Q99955, Q9BSC5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: March 3, 2009
Last modified: November 7, 2018
This is version 186 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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