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Protein

Homeobox protein Hox-A2

Gene

Hoxa2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi139 – 198HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A2
Alternative name(s):
Homeobox protein Hox-1.11
Short name:
Hox1.11
Gene namesi
Name:Hoxa2
Synonyms:Hox-1.11, Hoxa-2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:96174 Hoxa2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002000371 – 372Homeobox protein Hox-A2Add BLAST372

Proteomic databases

PaxDbiP31245
PRIDEiP31245

PTM databases

PhosphoSitePlusiP31245

Expressioni

Gene expression databases

BgeeiENSMUSG00000014704 Expressed in 92 organ(s), highest expression level in liver
CleanExiMM_HOXA2
GenevisibleiP31245 MM

Interactioni

Protein-protein interaction databases

BioGridi200367, 14 interactors
IntActiP31245, 1 interactor
STRINGi10090.ENSMUSP00000014848

Structurei

3D structure databases

ProteinModelPortaliP31245
SMRiP31245
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi96 – 101Antp-type hexapeptide6

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000144005
HOGENOMiHOG000063664
HOVERGENiHBG006088
InParanoidiP31245
KOiK09302
OMAiNCGSGLN
OrthoDBiEOG091G0IJ4
PhylomeDBiP31245
TreeFamiTF317730

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P31245-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNYEFEREIG FINSQPSLAE CLTSFPPVAD TFQSSSIKTS TLSHSTLIPP
60 70 80 90 100
PFEQTIPSLN PGSHPRHGAG VGGRPKSSPA GSRGSPVPAG ALQPPEYPWM
110 120 130 140 150
KEKKAAKKTA LPPAAASTGP ACLGHKESLE IADGSGGGSR RLRTAYTNTQ
160 170 180 190 200
LLELEKEFHF NKYLCRPRRV EIAALLDLTE RQVKVWFQNR RMKHKRQTQC
210 220 230 240 250
KENQNSEGKF KNLEDSDKVE EDEEEKSLFE QALSVSGALL EREGYTFQQN
260 270 280 290 300
ALSQQQAPNG HNGDSQTFPV SPLTSNEKNL KHFQHQSPTV PNCLSTMGQN
310 320 330 340 350
CGAGLNNDSP EAIEVPSLQD FNVFSTDSCL QLSDALSPSL PGSLDSPVDI
360 370
SADSFDFFTD TLTTIDLQHL NY
Length:372
Mass (Da):40,793
Last modified:July 1, 1993 - v1
Checksum:i0ADA79113DB72726
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95599 mRNA Translation: AAA37827.1
M93148 Genomic DNA Translation: AAA37835.1
M93292 mRNA Translation: AAA37836.1
BC117105 mRNA Translation: AAI17106.1
BC117107 mRNA Translation: AAI17108.1
M87801 Genomic DNA Translation: AAA37834.1
AB039191 Genomic DNA Translation: BAB68715.1
CCDSiCCDS20139.1
PIRiA42694
A46037
RefSeqiNP_034581.1, NM_010451.2
UniGeneiMm.131

Genome annotation databases

EnsembliENSMUST00000014848; ENSMUSP00000014848; ENSMUSG00000014704
GeneIDi15399
KEGGimmu:15399
UCSCiuc009bxz.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95599 mRNA Translation: AAA37827.1
M93148 Genomic DNA Translation: AAA37835.1
M93292 mRNA Translation: AAA37836.1
BC117105 mRNA Translation: AAI17106.1
BC117107 mRNA Translation: AAI17108.1
M87801 Genomic DNA Translation: AAA37834.1
AB039191 Genomic DNA Translation: BAB68715.1
CCDSiCCDS20139.1
PIRiA42694
A46037
RefSeqiNP_034581.1, NM_010451.2
UniGeneiMm.131

3D structure databases

ProteinModelPortaliP31245
SMRiP31245
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200367, 14 interactors
IntActiP31245, 1 interactor
STRINGi10090.ENSMUSP00000014848

PTM databases

PhosphoSitePlusiP31245

Proteomic databases

PaxDbiP31245
PRIDEiP31245

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000014848; ENSMUSP00000014848; ENSMUSG00000014704
GeneIDi15399
KEGGimmu:15399
UCSCiuc009bxz.2 mouse

Organism-specific databases

CTDi3199
MGIiMGI:96174 Hoxa2

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000144005
HOGENOMiHOG000063664
HOVERGENiHBG006088
InParanoidiP31245
KOiK09302
OMAiNCGSGLN
OrthoDBiEOG091G0IJ4
PhylomeDBiP31245
TreeFamiTF317730

Miscellaneous databases

PROiPR:P31245
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000014704 Expressed in 92 organ(s), highest expression level in liver
CleanExiMM_HOXA2
GenevisibleiP31245 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHXA2_MOUSE
AccessioniPrimary (citable) accession number: P31245
Secondary accession number(s): Q149U3, Q920T8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 7, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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