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Protein

S-modulin

Gene
N/A
Organism
Lithobates catesbeiana (American bullfrog) (Rana catesbeiana)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium-dependent regulator of light sensitivity of cGMP phosphodiesterase in rod outer segments. Control rhodopsin phosphorylation in a Ca2+-dependent manner.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi74 – 851PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi110 – 1212PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processSensory transduction, Vision
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
S-modulin
Alternative name(s):
Sensitivity-modulating protein
OrganismiLithobates catesbeiana (American bullfrog) (Rana catesbeiana)
Taxonomic identifieri8400 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaRanoideaRanidaeRanaAquarana

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000737992 – 202S-modulinAdd BLAST201

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1

Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PRIDEiP31227

Structurei

3D structure databases

ProteinModelPortaliP31227
SMRiP31227
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 60EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini61 – 96EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini97 – 132EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini147 – 182EF-hand 4PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the recoverin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG108179

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
PF13833 EF-hand_8, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31227-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNTKSGALS KEILEELQLN TKFTQEELCT WYQSFLKECP SGRISKKQFE
60 70 80 90 100
SIYSKFFPDA DPKAYAQHVF RSFDANNDGT LDFKEYMIAL MMTSSGKANQ
110 120 130 140 150
KLEWAFCLYD VDGNGTINKK EVLEIITAIF KMINAEDQKH LPEDENTPEK
160 170 180 190 200
RTNKIWVYFG KKDDDKLTEG EFIQGIVKNK EILRLIQYEP QKVKDKLKEK

KH
Length:202
Mass (Da):23,527
Last modified:January 23, 2007 - v4
Checksum:i5FFE379649904A2B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti91M → H in BAA19728 (PubMed:8392055).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83641 mRNA Translation: BAA19728.1
PIRiJC1107
T10531

Similar proteinsi

Entry informationi

Entry nameiSMOD_LITCT
AccessioniPrimary (citable) accession number: P31227
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 92 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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