Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - P31224 (ACRB_ECOLI)

Entry version 183 (11 Dec 2019)
Sequence version 1 (01 Jul 1993)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Multidrug efflux pump subunit AcrB

Gene

acrB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates.4 Publications
(Microbial infection) Involved in contact-dependent growth inhibition (CDI), acts downstream of BamA, the receptor for CDI. Its role in CDI is independent of the AcrA-AcrB-TolC efflux pump complex.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:ACRB-MONOMER
ECOL316407:JW0451-MONOMER
MetaCyc:ACRB-MONOMER

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.6.2.2 the resistance-nodulation-cell division (rnd) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Multidrug efflux pump subunit AcrB
Alternative name(s):
AcrAB-TolC multidrug efflux pump subunit AcrB
Acridine resistance protein B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:acrB
Synonyms:acrE
Ordered Locus Names:b0462, JW0451
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 9Cytoplasmic1 Publication9
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei10 – 28Helical; Name=1Add BLAST19
Topological domaini29 – 336Periplasmic1 PublicationAdd BLAST308
Transmembranei337 – 356Helical; Name=2Add BLAST20
Topological domaini357 – 365Cytoplasmic1 Publication9
Transmembranei366 – 385Helical; Name=3Add BLAST20
Topological domaini386 – 391Periplasmic1 Publication6
Transmembranei392 – 413Helical; Name=4Add BLAST22
Topological domaini414 – 438Cytoplasmic1 PublicationAdd BLAST25
Transmembranei439 – 457Helical; Name=5Add BLAST19
Topological domaini458 – 465Periplasmic1 Publication8
Transmembranei466 – 490Helical; Name=6Add BLAST25
Topological domaini491 – 538Cytoplasmic1 PublicationAdd BLAST48
Transmembranei539 – 555Helical; Name=7Add BLAST17
Topological domaini556 – 871Periplasmic1 PublicationAdd BLAST316
Transmembranei872 – 888Helical; Name=8Add BLAST17
Topological domaini889 – 898Cytoplasmic1 Publication10
Transmembranei899 – 918Helical; Name=9Add BLAST20
Topological domaini919 – 924Periplasmic1 Publication6
Transmembranei925 – 943Helical; Name=10Add BLAST19
Topological domaini944 – 972Cytoplasmic1 PublicationAdd BLAST29
Transmembranei973 – 992Helical; Name=11Add BLAST20
Topological domaini993 – 998Periplasmic1 Publication6
Transmembranei999 – 1018Helical; Name=12Add BLAST20
Topological domaini1019 – 1049Cytoplasmic1 PublicationAdd BLAST31

GO - Cellular componenti

Complete GO annotation on QuickGO ...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Loss of susceptibility to contact-dependent growth inhibition (CDI); inhibiting cells still contact the target.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi526H → Y: Partially restores chloramphenicol resistance to an AcrZ G30R mutant. 1 Publication1

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1681614

Drug and drug target database

More...DrugBanki		DB03619 Deoxycholic Acid
DB04209 Dequalinium
DB03825 Rhodamine 6G

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001618111 – 1049Multidrug efflux pump subunit AcrBAdd BLAST1049

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P31224

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P31224

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P31224

PRoteomics IDEntifications database

More...PRIDEi		P31224

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Positively regulated by MarA, Rob and SoxS transcriptional regulators (at protein level).1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer, with large domains that extend into the periplasm, interacts with AcrA and TolC. AcrA may be required to stably link this protein and TolC.

Interacts with AcrZ. Part of the AcrA-AcrB-AcrZ-TolC efflux pump.

9 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		4259859, 386 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-4263 AcrAB-TolC multidrug efflux transport complex

Database of interacting proteins

More...DIPi		DIP-9049N

Protein interaction database and analysis system

More...IntActi		P31224, 9 interactors

Molecular INTeraction database

More...MINTi		P31224

STRING: functional protein association networks

More...STRINGi		511145.b0462

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11049
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P31224

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P31224

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG4105BZS Bacteria
COG0841 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000158129

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P31224

KEGG Orthology (KO)

More...KOi		K18138

Database for complete collections of gene phylogenies

More...PhylomeDBi		P31224

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.2090.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR027463 AcrB_DN_DC_subdom
IPR001036 Acrflvin-R
IPR004764 HAE1

The PANTHER Classification System

More...PANTHERi		PTHR32063 PTHR32063, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00873 ACR_tran, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00702 ACRIFLAVINRP

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF82714 SSF82714, 2 hits

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00915 2A0602, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P31224-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPNFFIDRPI FAWVIAIIIM LAGGLAILKL PVAQYPTIAP PAVTISASYP 
        60         70         80         90        100
GADAKTVQDT VTQVIEQNMN GIDNLMYMSS NSDSTGTVQI TLTFESGTDA 
       110        120        130        140        150
DIAQVQVQNK LQLAMPLLPQ EVQQQGVSVE KSSSSFLMVV GVINTDGTMT 
       160        170        180        190        200
QEDISDYVAA NMKDAISRTS GVGDVQLFGS QYAMRIWMNP NELNKFQLTP 
       210        220        230        240        250
VDVITAIKAQ NAQVAAGQLG GTPPVKGQQL NASIIAQTRL TSTEEFGKIL 
       260        270        280        290        300
LKVNQDGSRV LLRDVAKIEL GGENYDIIAE FNGQPASGLG IKLATGANAL 
       310        320        330        340        350
DTAAAIRAEL AKMEPFFPSG LKIVYPYDTT PFVKISIHEV VKTLVEAIIL 
       360        370        380        390        400
VFLVMYLFLQ NFRATLIPTI AVPVVLLGTF AVLAAFGFSI NTLTMFGMVL 
       410        420        430        440        450
AIGLLVDDAI VVVENVERVM AEEGLPPKEA TRKSMGQIQG ALVGIAMVLS 
       460        470        480        490        500
AVFVPMAFFG GSTGAIYRQF SITIVSAMAL SVLVALILTP ALCATMLKPI 
       510        520        530        540        550
AKGDHGEGKK GFFGWFNRMF EKSTHHYTDS VGGILRSTGR YLVLYLIIVV 
       560        570        580        590        600
GMAYLFVRLP SSFLPDEDQG VFMTMVQLPA GATQERTQKV LNEVTHYYLT 
       610        620        630        640        650
KEKNNVESVF AVNGFGFAGR GQNTGIAFVS LKDWADRPGE ENKVEAITMR 
       660        670        680        690        700
ATRAFSQIKD AMVFAFNLPA IVELGTATGF DFELIDQAGL GHEKLTQARN 
       710        720        730        740        750
QLLAEAAKHP DMLTSVRPNG LEDTPQFKID IDQEKAQALG VSINDINTTL 
       760        770        780        790        800
GAAWGGSYVN DFIDRGRVKK VYVMSEAKYR MLPDDIGDWY VRAADGQMVP 
       810        820        830        840        850
FSAFSSSRWE YGSPRLERYN GLPSMEILGQ AAPGKSTGEA MELMEQLASK 
       860        870        880        890        900
LPTGVGYDWT GMSYQERLSG NQAPSLYAIS LIVVFLCLAA LYESWSIPFS 
       910        920        930        940        950
VMLVVPLGVI GALLAATFRG LTNDVYFQVG LLTTIGLSAK NAILIVEFAK 
       960        970        980        990       1000
DLMDKEGKGL IEATLDAVRM RLRPILMTSL AFILGVMPLV ISTGAGSGAQ 
      1010       1020       1030       1040 
NAVGTGVMGG MVTATVLAIF FVPVFFVVVR RRFSRKNEDI EHSHTVDHH
Length:1,049
Mass (Da):113,574
Last modified:July 1, 1993 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i19670E3C4CC29055
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M94248 Genomic DNA Translation: AAA23411.1
U00734 Genomic DNA Translation: AAA67135.1
U82664 Genomic DNA Translation: AAB40216.1
U00096 Genomic DNA Translation: AAC73564.1
AP009048 Genomic DNA Translation: BAE76241.1

Protein sequence database of the Protein Information Resource

More...PIRi		B36938

NCBI Reference Sequences

More...RefSeqi		NP_414995.1, NC_000913.3
WP_001132469.1, NZ_STEB01000007.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC73564; AAC73564; b0462
BAE76241; BAE76241; BAE76241

Database of genes from NCBI RefSeq genomes

More...GeneIDi		945108

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW0451
eco:b0462

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|1411691.4.peg.1814

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94248 Genomic DNA Translation: AAA23411.1
U00734 Genomic DNA Translation: AAA67135.1
U82664 Genomic DNA Translation: AAB40216.1
U00096 Genomic DNA Translation: AAC73564.1
AP009048 Genomic DNA Translation: BAE76241.1
PIRiB36938
RefSeqiNP_414995.1, NC_000913.3
WP_001132469.1, NZ_STEB01000007.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IWGX-ray3.50A1-1049[»]
1OY6X-ray3.68A1-1049[»]
1OY8X-ray3.63A1-1049[»]
1OY9X-ray3.80A1-1049[»]
1OYDX-ray3.80A1-1049[»]
1OYEX-ray3.48A1-1049[»]
1T9TX-ray3.23A1-1049[»]
1T9UX-ray3.11A1-1049[»]
1T9VX-ray3.80A1-1049[»]
1T9WX-ray3.23A1-1049[»]
1T9XX-ray3.08A1-1049[»]
1T9YX-ray3.64A1-1049[»]
2DHHX-ray2.80A/B/C1-1049[»]
2DR6X-ray3.30A/B/C1-1049[»]
2DRDX-ray3.10A/B/C1-1049[»]
2GIFX-ray2.90A/B/C1-1049[»]
2HQCX-ray3.56A1-1049[»]
2HQDX-ray3.65A1-1049[»]
2HQFX-ray3.38A1-1049[»]
2HQGX-ray3.38A1-1049[»]
2HRTX-ray3.00A/B/C/D/E/F1-1049[»]
2I6WX-ray3.10A1-1049[»]
2J8SX-ray2.54A/B/C1-1049[»]
2RDDX-ray3.50A1-1049[»]
2W1BX-ray3.85A1-1049[»]
3AOAX-ray3.35A/B/C1-1049[»]
3AOBX-ray3.35A/B/C1-1049[»]
3AOCX-ray3.34A/B/C1-1049[»]
3AODX-ray3.30A/B/C1-1049[»]
3D9BX-ray3.42A1-1049[»]
3NOCX-ray2.70A/B/C1-1049[»]
3NOGX-ray3.34A/B/C1-1049[»]
3W9HX-ray3.05A/B/C1-1033[»]
4C48X-ray3.30A1-1047[»]
4CDIX-ray3.70A1-1049[»]
4DX5X-ray1.90A/B/C1-1049[»]
4DX6X-ray2.90A/B/C1-1049[»]
4DX7X-ray2.25A/B/C1-1049[»]
4K7QX-ray3.50A1-1049[»]
4U8VX-ray2.30A/B/C1-1049[»]
4U8YX-ray2.10A/B/C1-1049[»]
4U95X-ray2.00A/B/C1-1049[»]
4U96X-ray2.20A/B/C1-1049[»]
4ZITX-ray3.30A/B/C/D/E/F1-1049[»]
4ZIVX-ray3.16A/B/C/D/E/F1-1049[»]
4ZIWX-ray3.40A/B/C/D/E/F1-1049[»]
4ZJLX-ray3.47A/B/C/D/E/F1-1049[»]
4ZJOX-ray3.60A/B/C/D/E/F1-1049[»]
4ZJQX-ray3.59A/B/C/D/E/F1-1049[»]
4ZLJX-ray3.26A1-1049[»]
4ZLLX-ray3.36A1-1049[»]
4ZLNX-ray3.56A1-1049[»]
5EN5X-ray2.30A/B/C39-329[»]
A/B/C561-869[»]
5ENOX-ray2.20A/B/C39-329[»]
A/B/C561-869[»]
5ENPX-ray1.90A/B/C39-329[»]
A/B/C561-869[»]
5ENQX-ray1.80A/B/C39-329[»]
A/B/C561-869[»]
5ENRX-ray2.30A/B/C39-329[»]
A/B/C561-869[»]
5ENSX-ray2.80A/B/C39-329[»]
A/B/C561-869[»]
5ENTX-ray2.50A/B/C39-329[»]
A/B/C561-869[»]
5JMNX-ray2.50A/B/C1-1049[»]
5NC5X-ray3.20A/B/C1-1049[»]
5NG5electron microscopy6.50J/K/L1-1049[»]
5O66electron microscopy5.90J/K/L1-1049[»]
5V5Selectron microscopy6.50J/K/L1-1049[»]
5YILX-ray3.00A/B/C1-1049[»]
6BAJelectron microscopy3.20A/B/C1-1049[»]
6CSXelectron microscopy3.00A/B/C1-1049[»]
SMRiP31224
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi4259859, 386 interactors
ComplexPortaliCPX-4263 AcrAB-TolC multidrug efflux transport complex
DIPiDIP-9049N
IntActiP31224, 9 interactors
MINTiP31224
STRINGi511145.b0462

Chemistry databases

ChEMBLiCHEMBL1681614
DrugBankiDB03619 Deoxycholic Acid
DB04209 Dequalinium
DB03825 Rhodamine 6G

Protein family/group databases

TCDBi2.A.6.2.2 the resistance-nodulation-cell division (rnd) superfamily

Proteomic databases

EPDiP31224
jPOSTiP31224
PaxDbiP31224
PRIDEiP31224

Genome annotation databases

EnsemblBacteriaiAAC73564; AAC73564; b0462
BAE76241; BAE76241; BAE76241
GeneIDi945108
KEGGiecj:JW0451
eco:b0462
PATRICifig|1411691.4.peg.1814

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB1655

Phylogenomic databases

eggNOGiENOG4105BZS Bacteria
COG0841 LUCA
HOGENOMiHOG000158129
InParanoidiP31224
KOiK18138
PhylomeDBiP31224

Enzyme and pathway databases

BioCyciEcoCyc:ACRB-MONOMER
ECOL316407:JW0451-MONOMER
MetaCyc:ACRB-MONOMER

Miscellaneous databases

EvolutionaryTraceiP31224

Protein Ontology

More...PROi		PR:P31224

Family and domain databases

Gene3Di3.30.2090.10, 2 hits
InterProiView protein in InterPro
IPR027463 AcrB_DN_DC_subdom
IPR001036 Acrflvin-R
IPR004764 HAE1
PANTHERiPTHR32063 PTHR32063, 1 hit
PfamiView protein in Pfam
PF00873 ACR_tran, 1 hit
PRINTSiPR00702 ACRIFLAVINRP
SUPFAMiSSF82714 SSF82714, 2 hits
TIGRFAMsiTIGR00915 2A0602, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiACRB_ECOLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P31224
Secondary accession number(s): Q2MBW5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: December 11, 2019
This is version 183 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again