SRD5A2

Functionⁱ

Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.1 Publication

Catalytic activityⁱ

A 3-oxo-5-alpha-steroid + NADP⁺ = a 3-oxo-Delta₄-steroid + NADPH.1 Publication

Kineticsⁱ

K_M=
0.9 µM for testosterone (at pH 6.0)
1 Publication
Manual assertion based on experiment inⁱ
- Ref.19
  "Biochemical and pharmacogenetic dissection of human steroid 5 alpha-reductase type II."
  Makridakis N.M., di Salle E., Reichardt J.K.
  Pharmacogenetics 10:407-413(2000) [PubMed] [Europe PMC] [Abstract]
  Cited for: VARIANTS ARG-5; LEU-30; ARG-48; THR-49; THR-51; LEU-89; MET-187; LEU-194 AND LEU-234, VARIANT PPSH GLN-227, FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES.
K_M=
8 µM for NADPH (at pH 6.0)
1 Publication
Manual assertion based on experiment inⁱ
- Ref.19
  "Biochemical and pharmacogenetic dissection of human steroid 5 alpha-reductase type II."
  Makridakis N.M., di Salle E., Reichardt J.K.
  Pharmacogenetics 10:407-413(2000) [PubMed] [Europe PMC] [Abstract]
  Cited for: VARIANTS ARG-5; LEU-30; ARG-48; THR-49; THR-51; LEU-89; MET-187; LEU-194 AND LEU-234, VARIANT PPSH GLN-227, FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES.

V_max=
1.9 nmol/min/mg enzyme with testosterone as substrate with NADPH as cofactor (at pH 6.0)
1 Publication
Manual assertion based on experiment inⁱ
- Ref.19
  "Biochemical and pharmacogenetic dissection of human steroid 5 alpha-reductase type II."
  Makridakis N.M., di Salle E., Reichardt J.K.
  Pharmacogenetics 10:407-413(2000) [PubMed] [Europe PMC] [Abstract]
  Cited for: VARIANTS ARG-5; LEU-30; ARG-48; THR-49; THR-51; LEU-89; MET-187; LEU-194 AND LEU-234, VARIANT PPSH GLN-227, FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES.

pH dependenceⁱ

Optimally active at acidic pHs.

GO - Molecular functionⁱ

3-oxo-5-alpha-steroid 4-dehydrogenase activity Source: GO_Central
amide binding Source: Ensembl
cholestenone 5-alpha-reductase activity Source: UniProtKB-EC
sterol 5-alpha reductase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 1944596
testosterone dehydrogenase [NAD(P)] activity
Source: UniProtKB
Inferred from direct assayⁱ
- 10898110

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

androgen biosynthetic process Source: GO_Central
androgen metabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 1944596
biphenyl metabolic process Source: Ensembl
bone development Source: Ensembl
cell-cell signaling
Source: UniProtKB
Traceable author statementⁱ
- 1944596
cell differentiation Source: UniProtKB-KW
dibenzo-p-dioxin metabolic process Source: Ensembl
female genitalia development Source: GO_Central
hippocampus development Source: Ensembl
hypothalamus development Source: Ensembl
male genitalia development Source: GO_Central
male gonad development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 1944596
phthalate metabolic process Source: Ensembl
progesterone metabolic process Source: GO_Central
response to drug Source: Ensembl
response to follicle-stimulating hormone Source: Ensembl
response to nutrient levels Source: Ensembl
response to peptide hormone Source: Ensembl
response to steroid hormone Source: Ensembl
response to testosterone Source: Ensembl
steroid catabolic process Source: Ensembl
testosterone biosynthetic process
Source: UniProtKB
Inferred from direct assayⁱ
- 10898110

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Oxidoreductase
Biological process	Differentiation, Sexual differentiation
Ligand	NADP

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS00619-MONOMER
BRENDAⁱ	1.3.1.22 2681 1.3.99.5 2681
Reactomeⁱ	R-HSA-193048 Androgen biosynthesis

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (EC:1.3.1.221 Publication) Alternative name(s): 5 alpha-SR2 SR type 2 Steroid 5-alpha-reductase 2 Short name: S5AR 2 Type II 5-alpha reductase
Gene namesⁱ	Name:SRD5A2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000277893.1
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11285 SRD5A2
MIMⁱ	607306 gene
neXtProtⁱ	NX_P31213

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	8 – 28	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	72 – 92	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	146 – 166	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	206 – 226	HelicalSequence analysisAdd BLAST	21

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Pseudovaginal perineoscrotal hypospadias (PPSH)16 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of male pseudohermaphroditism in which 46,XY males show ambiguous genitalia at birth, including perineal hypospadias and a blind perineal pouch, and develop masculinization at puberty. The name of the disorder stems from the finding of a blind-ending perineal opening resembling a vagina and a severely hypospadiac penis with the urethra opening onto the perineum.

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_013105	55	L → Q in PPSH. 1 Publication	1
Natural variantⁱVAR_013130	85	G → D in PPSH. 1 Publication	1
Natural variantⁱVAR_013106	115	G → D in PPSH. 3 Publications	1
Natural variantⁱVAR_025854	123	G → R in PPSH. 1 Publication	1
Natural variantⁱVAR_025855	126	Q → R in PPSH. 1 Publication	1
Natural variantⁱVAR_025851	145	R → W in PPSH. 1 Publication	1
Natural variantⁱVAR_013107	157	Missing in PPSH. 1 Publication	1
Natural variantⁱVAR_025856	158	G → R in PPSH. 1 Publication	1
Natural variantⁱVAR_025852	181	P → L in PPSH. 1 Publication	1
Natural variantⁱVAR_013108	183	G → S in PPSH. 2 Publications	1
Natural variantⁱVAR_013109	196	G → S in PPSH. 3 Publications	1
Natural variantⁱVAR_013110	197	E → D in PPSH. 1 Publication	1
Natural variantⁱVAR_013132	200	E → K in PPSH. 1 Publication	1
Natural variantⁱVAR_025857	207	A → D in PPSH. 1 Publication	1
Natural variantⁱVAR_013111	212	P → R in PPSH. 2 Publications	1
Natural variantⁱVAR_037586	227	R → Q in PPSH; also in individuals with micropenis; increased affinity for testosterone; increased affinity for NADPH; decreased Vmax. 3 PublicationsCorresponds to variant dbSNP:rs9332964EnsemblClinVar.	1
Natural variantⁱVAR_013112	228	A → T in PPSH. 1 Publication	1
Natural variantⁱVAR_013113	231	H → R in PPSH. 1 Publication	1
Natural variantⁱVAR_025853	235	Y → F in PPSH. 1 Publication	1
Natural variantⁱVAR_013133	245	S → Y in PPSH. 1 Publication	1
Natural variantⁱVAR_013134	246	R → Q in PPSH. 2 PublicationsCorresponds to variant dbSNP:rs9332967EnsemblClinVar.	1
Natural variantⁱVAR_005609	246	R → W in PPSH. 4 Publications	1

Keywords - Diseaseⁱ

Disease mutation, Pseudohermaphroditism

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6716
MalaCards human disease database More...MalaCardsⁱ	SRD5A2
MIMⁱ	264600 phenotype
Orphanetⁱ	753 46,XY disorder of sex development due to 5-alpha-reductase 2 deficiency 1331 Familial prostate cancer
PharmGKBⁱ	PA36113

Chemistry databases

ChEMBLⁱ	CHEMBL1856
Drug and drug target database More...DrugBankⁱ	DB00548 Azelaic Acid DB01126 Dutasteride DB01216 Finasteride DB00421 Spironolactone
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2633

Polymorphism and mutation databases

BioMutaⁱ	SRD5A2
DMDMⁱ	401056

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000213676	1 – 254	3-oxo-5-alpha-steroid 4-dehydrogenase 2Add BLAST		254

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	P31213
PRIDEⁱ	P31213
ProteomicsDBⁱ	54764

PTM databases

iPTMnetⁱ	P31213
PhosphoSitePlusⁱ	P31213

Expressionⁱ

Tissue specificityⁱ

Expressed in high levels in the prostate and many other androgen-sensitive tissues.

Gene expression databases

Bgeeⁱ	ENSG00000277893 Expressed in 51 organ(s), highest expression level in liver
CleanExⁱ	HS_SRD5A2
Genevisibleⁱ	P31213 HS

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	112594, 1 interactor
IntActⁱ	P31213, 2 interactors

Chemistry databases

BindingDBⁱ

P31213

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P31213
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the steroid 5-alpha reductase family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENⁱ	HBG003402
InParanoidⁱ	P31213
KEGG Orthology (KO) More...KOⁱ	K12344
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0KU4
PhylomeDBⁱ	P31213

Family and domain databases

InterProⁱ	View protein in InterPro IPR016636 3-oxo-5-alpha-steroid_4-DH IPR001104 3-oxo-5_a-steroid_4-DH_C IPR039357 SRD5A/TECR
PANTHERⁱ	PTHR10556 PTHR10556, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02544 Steroid_dh, 1 hit
PIRSFⁱ	PIRSF015596 5_alpha-SR2, 1 hit
PROSITEⁱ	View protein in PROSITE PS50244 S5A_REDUCTASE, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P31213-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MQVQCQQSPV LAGSATLVAL GALALYVAKP SGYGKHTESL KPAATRLPAR 
        60         70         80         90        100
AAWFLQELPS FAVPAGILAR QPLSLFGPPG TVLLGLFCVH YFHRTFVYSL 
       110        120        130        140        150
LNRGRPYPAI LILRGTAFCT GNGVLQGYYL IYCAEYPDGW YTDIRFSLGV 
       160        170        180        190        200
FLFILGMGIN IHSDYILRQL RKPGEISYRI PQGGLFTYVS GANFLGEIIE 
       210        220        230        240        250
WIGYALATWS LPALAFAFFS LCFLGLRAFH HHRFYLKMFE DYPKSRKALI 

PFIF

Length:254

Mass (Da):28,393

Last modified:July 1, 1993 - v1

Checksum:ⁱE65A19C8600DED05

GO

Polymorphismⁱ

Individuals with Thr-49 have an increased risk of prostate cancer (PubMed:10501358). The enzyme with Thr-49 has a higher in vitro V(max) than the Ala-49 enzyme (PubMed:10501358).1 Publication

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_077546	5	C → R No effect on affinity for testosterone; no effect on affinity for NADPH; no effect on Vmax. 1 Publication	1
Natural variantⁱVAR_077547	30	P → L Increased affinity for testosterone; increased affinity for NADPH; decreased Vmax. 1 Publication	1
Natural variantⁱVAR_077548	48	P → R Increased affinity for testosterone; increased affinity for NADPH; decreased Vmax. 1 Publication	1
Natural variantⁱVAR_013104	49	A → T Increased affinity for testosterone; no effect on affinity for NADPH; increased Vmax; no effect on affinity for testosterone when associated with L-89; no effect on affinity for NADPH when associated with L-89; increased Vmax when associated with L-89. 6 PublicationsCorresponds to variant dbSNP:rs9282858EnsemblClinVar.	1
Natural variantⁱVAR_077549	51	A → T No effect on affinity for testosterone; increased affinity for NADPH; decreased Vmax. 1 Publication	1
Natural variantⁱVAR_013105	55	L → Q in PPSH. 1 Publication	1
Natural variantⁱVAR_013130	85	G → D in PPSH. 1 Publication	1
Natural variantⁱVAR_013131	89	V → L No effect on affinity for testosterone; no effect on affinity for NADPH; decreased Vmax; no effect on affinity for testosterone when associated with T-49; no effect on affinity for NADPH when associated with T-49; increased Vmax when associated with T-49; decreased affinity for testosterone when associated with M-187; increased affinity for NADPH when associated with M-187; decreased Vmax when associated with M-187; no effect on affinity for testosterone when associated with L-234; increased affinity for NADPH when associated with L-234; decreased Vmax when associated with L-234. 8 PublicationsCorresponds to variant dbSNP:rs523349Ensembl.	1
Natural variantⁱVAR_022302	113	L → V1 PublicationCorresponds to variant dbSNP:rs28383048EnsemblClinVar.	1
Natural variantⁱVAR_013106	115	G → D in PPSH. 3 Publications	1
Natural variantⁱVAR_025854	123	G → R in PPSH. 1 Publication	1
Natural variantⁱVAR_025855	126	Q → R in PPSH. 1 Publication	1
Natural variantⁱVAR_025851	145	R → W in PPSH. 1 Publication	1
Natural variantⁱVAR_013107	157	Missing in PPSH. 1 Publication	1
Natural variantⁱVAR_025856	158	G → R in PPSH. 1 Publication	1
Natural variantⁱVAR_025852	181	P → L in PPSH. 1 Publication	1
Natural variantⁱVAR_013108	183	G → S in PPSH. 2 Publications	1
Natural variantⁱVAR_077550	187	T → M No effect on affinity for testosterone; increased affinity for NADPH; decreased Vmax; decreased affinity for testosterone when associated with L-89; increased affinity for NADPH when associated with L-89; decreased Vmax when associated with L-89. 1 Publication	1
Natural variantⁱVAR_077551	194	F → L No effect on affinity for testosterone; increased affinity for NADPH; increased Vmax. 1 Publication	1
Natural variantⁱVAR_013109	196	G → S in PPSH. 3 Publications	1
Natural variantⁱVAR_013110	197	E → D in PPSH. 1 Publication	1
Natural variantⁱVAR_013132	200	E → K in PPSH. 1 Publication	1
Natural variantⁱVAR_059791	203	G → S. Corresponds to variant dbSNP:rs9332961EnsemblClinVar.	1
Natural variantⁱVAR_025857	207	A → D in PPSH. 1 Publication	1
Natural variantⁱVAR_013111	212	P → R in PPSH. 2 Publications	1
Natural variantⁱVAR_059792	224	L → H. Corresponds to variant dbSNP:rs9332963Ensembl.	1
Natural variantⁱVAR_037585	224	L → M. Corresponds to variant dbSNP:rs9332963Ensembl.	1
Natural variantⁱVAR_037586	227	R → Q in PPSH; also in individuals with micropenis; increased affinity for testosterone; increased affinity for NADPH; decreased Vmax. 3 PublicationsCorresponds to variant dbSNP:rs9332964EnsemblClinVar.	1
Natural variantⁱVAR_013112	228	A → T in PPSH. 1 Publication	1
Natural variantⁱVAR_013113	231	H → R in PPSH. 1 Publication	1
Natural variantⁱVAR_077552	234	F → L Increased affinity for testosterone; increased affinity for NADPH; decreased Vmax; no effect on affinity for testosterone when associated with L-89; increased affinity for NADPH when associated with L-89; decreased Vmax when associated with L-89. 1 Publication	1
Natural variantⁱVAR_025853	235	Y → F in PPSH. 1 Publication	1
Natural variantⁱVAR_013133	245	S → Y in PPSH. 1 Publication	1
Natural variantⁱVAR_013134	246	R → Q in PPSH. 2 PublicationsCorresponds to variant dbSNP:rs9332967EnsemblClinVar.	1
Natural variantⁱVAR_005609	246	R → W in PPSH. 4 Publications	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M74047 mRNA Translation: AAA60586.1 AB047857 Genomic DNA Translation: BAB40419.1 EF560740 mRNA Translation: ABQ59050.1 AY884245 Genomic DNA Translation: AAW56942.1 AK316597 mRNA Translation: BAG38184.1 CH471053 Genomic DNA Translation: EAX00478.1 BC112252 mRNA Translation: AAI12253.1 BC113641 mRNA Translation: AAI13642.1 L03843 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS74503.1
PIRⁱ	A49169
NCBI Reference Sequences More...RefSeqⁱ	NP_000339.2, NM_000348.3
UniGeneⁱ	Hs.458345

Genome annotation databases

Ensemblⁱ	ENST00000622030; ENSP00000477587; ENSG00000277893
GeneIDⁱ	6716
KEGGⁱ	hsa:6716
UCSC genome browser More...UCSCⁱ	uc032nip.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P31213	3-oxo-5-alpha-steroid 4-dehydrogenase 2		MACFA		254	UniRef90_P31213
Steroid 5 alpha-reductase 2		NOMLE		254
Steroid 5 alpha-reductase 2		CHLSB		254
Steroid 5 alpha-reductase 2		PAPAN		254
Steroid 5 alpha-reductase 2		CERAT		254
+20

Protein	Similar proteins		Species	Score	Length	Source
P31213	3-oxo-5-alpha-steroid 4-dehydrogenase 2		MACFA		254	UniRef50_P31213
3-oxo-5-alpha-steroid 4-dehydrogenase 2		MOUSE		254
3-oxo-5-alpha-steroid 4-dehydrogenase 2		RAT		254
3-oxo-5-alpha-steroid 4-dehydrogenase 2		PIG		254
Steroid 5 alpha-reductase 2		PAPAN		254
+101

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Wikipedia

5-alpha reductase entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M74047 mRNA Translation: AAA60586.1 AB047857 Genomic DNA Translation: BAB40419.1 EF560740 mRNA Translation: ABQ59050.1 AY884245 Genomic DNA Translation: AAW56942.1 AK316597 mRNA Translation: BAG38184.1 CH471053 Genomic DNA Translation: EAX00478.1 BC112252 mRNA Translation: AAI12253.1 BC113641 mRNA Translation: AAI13642.1 L03843 Genomic DNA No translation available.
CCDSⁱ	CCDS74503.1
PIRⁱ	A49169
RefSeqⁱ	NP_000339.2, NM_000348.3
UniGeneⁱ	Hs.458345

3D structure databases

ProteinModelPortalⁱ	P31213
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112594, 1 interactor
IntActⁱ	P31213, 2 interactors

Chemistry databases

BindingDBⁱ	P31213
ChEMBLⁱ	CHEMBL1856
DrugBankⁱ	DB00548 Azelaic Acid DB01126 Dutasteride DB01216 Finasteride DB00421 Spironolactone
GuidetoPHARMACOLOGYⁱ	2633

PTM databases

iPTMnetⁱ	P31213
PhosphoSitePlusⁱ	P31213

Polymorphism and mutation databases

BioMutaⁱ	SRD5A2
DMDMⁱ	401056

Proteomic databases

PeptideAtlasⁱ	P31213
PRIDEⁱ	P31213
ProteomicsDBⁱ	54764

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6716
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000622030; ENSP00000477587; ENSG00000277893
GeneIDⁱ	6716
KEGGⁱ	hsa:6716
UCSCⁱ	uc032nip.2 human

Organism-specific databases

CTDⁱ	6716
DisGeNETⁱ	6716
EuPathDBⁱ	HostDB:ENSG00000277893.1
GeneCardsⁱ	SRD5A2
H-InvDBⁱ	HIX0030017
HGNCⁱ	HGNC:11285 SRD5A2
MalaCardsⁱ	SRD5A2
MIMⁱ	264600 phenotype 607306 gene
neXtProtⁱ	NX_P31213
Orphanetⁱ	753 46,XY disorder of sex development due to 5-alpha-reductase 2 deficiency 1331 Familial prostate cancer
PharmGKBⁱ	PA36113
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

HOVERGENⁱ	HBG003402
InParanoidⁱ	P31213
KOⁱ	K12344
OrthoDBⁱ	EOG091G0KU4
PhylomeDBⁱ	P31213

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS00619-MONOMER
BRENDAⁱ	1.3.1.22 2681 1.3.99.5 2681
Reactomeⁱ	R-HSA-193048 Androgen biosynthesis

Miscellaneous databases

ChiTaRSⁱ	SRD5A2 human
GeneWikiⁱ	SRD5A2
GenomeRNAiⁱ	6716
Protein Ontology More...PROⁱ	PR:P31213
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000277893 Expressed in 51 organ(s), highest expression level in liver
CleanExⁱ	HS_SRD5A2
Genevisibleⁱ	P31213 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR016636 3-oxo-5-alpha-steroid_4-DH IPR001104 3-oxo-5_a-steroid_4-DH_C IPR039357 SRD5A/TECR
PANTHERⁱ	PTHR10556 PTHR10556, 1 hit
Pfamⁱ	View protein in Pfam PF02544 Steroid_dh, 1 hit
PIRSFⁱ	PIRSF015596 5_alpha-SR2, 1 hit
PROSITEⁱ	View protein in PROSITE PS50244 S5A_REDUCTASE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	S5A2_HUMAN
Accessionⁱ	P31213Primary (citable) accession number: P31213 Secondary accession number(s): B2RE87, Q2M1R4, Q9BYE6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
	Last sequence update:	July 1, 1993
	Last modified:	September 12, 2018
	This is version 168 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P31213 (S5A2_HUMAN)

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3-oxo-5-alpha-steroid 4-dehydrogenase 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

pH dependencei

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Endoplasmic reticulum

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

Kineticsⁱ

pH dependenceⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ