UniProtKB - P31213 (S5A2_HUMAN)
Protein
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Gene
SRD5A2
Organism
Homo sapiens (Human)
Status
Functioni
Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.1 Publication
Catalytic activityi
- EC:1.3.1.221 Publication
Kineticsi
- KM=0.9 µM for testosterone (at pH 6.0)1 Publication
- KM=8 µM for NADPH (at pH 6.0)1 Publication
- Vmax=1.9 nmol/min/mg enzyme with testosterone as substrate with NADPH as cofactor (at pH 6.0)1 Publication
pH dependencei
Optimally active at acidic pHs.
GO - Molecular functioni
- 3-oxo-5-alpha-steroid 4-dehydrogenase activity Source: GO_Central
- cholestenone 5-alpha-reductase activity Source: UniProtKB-EC
- oxidoreductase activity Source: GO_Central
- sterol 5-alpha reductase activity Source: UniProtKB
- testosterone dehydrogenase [NAD(P)] activity Source: UniProtKB
GO - Biological processi
- androgen biosynthetic process Source: Reactome
- androgen metabolic process Source: UniProtKB
- cell-cell signaling Source: UniProtKB
- cell differentiation Source: UniProtKB-KW
- male genitalia development Source: Ensembl
- male gonad development Source: UniProtKB
- steroid biosynthetic process Source: GO_Central
- testosterone biosynthetic process Source: UniProtKB
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Differentiation, Sexual differentiation |
Ligand | NADP |
Enzyme and pathway databases
BioCyci | MetaCyc:HS00619-MONOMER |
BRENDAi | 1.3.1.22, 2681 1.3.99.5, 2681 |
PathwayCommonsi | P31213 |
Reactomei | R-HSA-193048, Androgen biosynthesis |
Names & Taxonomyi
Protein namesi | Recommended name: 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (EC:1.3.1.221 Publication)Alternative name(s): 5 alpha-SR2 SR type 2 Steroid 5-alpha-reductase 2 Short name: S5AR 2 Type II 5-alpha reductase |
Gene namesi | Name:SRD5A2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11285, SRD5A2 |
MIMi | 607306, gene |
neXtProti | NX_P31213 |
VEuPathDBi | HostDB:ENSG00000277893.1 |
Subcellular locationi
Endoplasmic reticulum
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 8 – 28 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 72 – 92 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 146 – 166 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 206 – 226 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, MicrosomePathology & Biotechi
Involvement in diseasei
Pseudovaginal perineoscrotal hypospadias (PPSH)16 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of male pseudohermaphroditism in which 46,XY males show ambiguous genitalia at birth, including perineal hypospadias and a blind perineal pouch, and develop masculinization at puberty. The name of the disorder stems from the finding of a blind-ending perineal opening resembling a vagina and a severely hypospadiac penis with the urethra opening onto the perineum.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_013105 | 55 | L → Q in PPSH. 1 PublicationCorresponds to variant dbSNP:rs121434245EnsemblClinVar. | 1 | |
Natural variantiVAR_013130 | 85 | G → D in PPSH. 1 PublicationCorresponds to variant dbSNP:rs1351269392Ensembl. | 1 | |
Natural variantiVAR_013106 | 115 | G → D in PPSH. 3 PublicationsCorresponds to variant dbSNP:rs121434246EnsemblClinVar. | 1 | |
Natural variantiVAR_025854 | 123 | G → R in PPSH. 1 PublicationCorresponds to variant dbSNP:rs1331249320Ensembl. | 1 | |
Natural variantiVAR_025855 | 126 | Q → R in PPSH. 1 PublicationCorresponds to variant dbSNP:rs368386747EnsemblClinVar. | 1 | |
Natural variantiVAR_025851 | 145 | R → W in PPSH. 1 PublicationCorresponds to variant dbSNP:rs759561106Ensembl. | 1 | |
Natural variantiVAR_013107 | 157 | Missing in PPSH. 1 Publication | 1 | |
Natural variantiVAR_025856 | 158 | G → R in PPSH. 1 Publication | 1 | |
Natural variantiVAR_025852 | 181 | P → L in PPSH. 1 PublicationCorresponds to variant dbSNP:rs1057517829EnsemblClinVar. | 1 | |
Natural variantiVAR_013108 | 183 | G → S in PPSH. 2 PublicationsCorresponds to variant dbSNP:rs121434247EnsemblClinVar. | 1 | |
Natural variantiVAR_013109 | 196 | G → S in PPSH. 3 PublicationsCorresponds to variant dbSNP:rs121434250EnsemblClinVar. | 1 | |
Natural variantiVAR_013110 | 197 | E → D in PPSH. 1 PublicationCorresponds to variant dbSNP:rs121434253EnsemblClinVar. | 1 | |
Natural variantiVAR_013132 | 200 | E → K in PPSH. 1 PublicationCorresponds to variant dbSNP:rs756853742EnsemblClinVar. | 1 | |
Natural variantiVAR_025857 | 207 | A → D in PPSH. 1 PublicationCorresponds to variant dbSNP:rs767564684EnsemblClinVar. | 1 | |
Natural variantiVAR_013111 | 212 | P → R in PPSH. 2 PublicationsCorresponds to variant dbSNP:rs121434252EnsemblClinVar. | 1 | |
Natural variantiVAR_037586 | 227 | R → Q in PPSH; also in individuals with micropenis; increased affinity for testosterone; increased affinity for NADPH; decreased Vmax. 3 PublicationsCorresponds to variant dbSNP:rs9332964EnsemblClinVar. | 1 | |
Natural variantiVAR_013112 | 228 | A → T in PPSH. 1 PublicationCorresponds to variant dbSNP:rs121434249EnsemblClinVar. | 1 | |
Natural variantiVAR_013113 | 231 | H → R in PPSH. 1 PublicationCorresponds to variant dbSNP:rs121434251EnsemblClinVar. | 1 | |
Natural variantiVAR_025853 | 235 | Y → F in PPSH. 1 PublicationCorresponds to variant dbSNP:rs772283403EnsemblClinVar. | 1 | |
Natural variantiVAR_013133 | 245 | S → Y in PPSH. 1 PublicationCorresponds to variant dbSNP:rs145712014Ensembl. | 1 | |
Natural variantiVAR_013134 | 246 | R → Q in PPSH. 2 PublicationsCorresponds to variant dbSNP:rs9332967EnsemblClinVar. | 1 | |
Natural variantiVAR_005609 | 246 | R → W in PPSH. 4 PublicationsCorresponds to variant dbSNP:rs121434244EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variant, PseudohermaphroditismOrganism-specific databases
DisGeNETi | 6716 |
MalaCardsi | SRD5A2 |
MIMi | 264600, phenotype |
Orphaneti | 753, 46,XY disorder of sex development due to 5-alpha-reductase 2 deficiency 1331, Familial prostate cancer |
PharmGKBi | PA36113 |
Miscellaneous databases
Pharosi | P31213, Tclin |
Chemistry databases
ChEMBLi | CHEMBL1856 |
DrugBanki | DB00548, Azelaic acid DB01126, Dutasteride DB01216, Finasteride DB00741, Hydrocortisone DB00717, Norethisterone DB00421, Spironolactone DB13943, Testosterone cypionate DB13944, Testosterone enanthate DB01420, Testosterone propionate DB13946, Testosterone undecanoate |
DrugCentrali | P31213 |
GuidetoPHARMACOLOGYi | 2633 |
Genetic variation databases
BioMutai | SRD5A2 |
DMDMi | 401056 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000213676 | 1 – 254 | 3-oxo-5-alpha-steroid 4-dehydrogenase 2Add BLAST | 254 |
Proteomic databases
MassIVEi | P31213 |
PeptideAtlasi | P31213 |
PRIDEi | P31213 |
ProteomicsDBi | 54764 |
PTM databases
iPTMneti | P31213 |
PhosphoSitePlusi | P31213 |
Expressioni
Tissue specificityi
Expressed in high levels in the prostate and many other androgen-sensitive tissues.
Gene expression databases
Bgeei | ENSG00000277893, Expressed in oviduct epithelium and 62 other tissues |
Genevisiblei | P31213, HS |
Organism-specific databases
HPAi | ENSG00000277893, Tissue enhanced (epididymis, liver, prostate) |
Interactioni
Binary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 112594, 3 interactors |
IntActi | P31213, 2 interactors |
STRINGi | 9606.ENSP00000477587 |
Chemistry databases
BindingDBi | P31213 |
Miscellaneous databases
RNActi | P31213, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the steroid 5-alpha reductase family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1638, Eukaryota |
HOGENOMi | CLU_065395_1_1_1 |
InParanoidi | P31213 |
OrthoDBi | 1574389at2759 |
PhylomeDBi | P31213 |
Family and domain databases
InterProi | View protein in InterPro IPR016636, 3-oxo-5-alpha-steroid_4-DH IPR001104, 3-oxo-5_a-steroid_4-DH_C IPR039357, SRD5A/TECR |
PANTHERi | PTHR10556, PTHR10556, 1 hit |
Pfami | View protein in Pfam PF02544, Steroid_dh, 1 hit |
PIRSFi | PIRSF015596, 5_alpha-SR2, 1 hit |
PROSITEi | View protein in PROSITE PS50244, S5A_REDUCTASE, 1 hit |
i Sequence
Sequence statusi: Complete.
P31213-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQVQCQQSPV LAGSATLVAL GALALYVAKP SGYGKHTESL KPAATRLPAR
60 70 80 90 100
AAWFLQELPS FAVPAGILAR QPLSLFGPPG TVLLGLFCVH YFHRTFVYSL
110 120 130 140 150
LNRGRPYPAI LILRGTAFCT GNGVLQGYYL IYCAEYPDGW YTDIRFSLGV
160 170 180 190 200
FLFILGMGIN IHSDYILRQL RKPGEISYRI PQGGLFTYVS GANFLGEIIE
210 220 230 240 250
WIGYALATWS LPALAFAFFS LCFLGLRAFH HHRFYLKMFE DYPKSRKALI
PFIF
Polymorphismi
Individuals with Thr-49 have an increased risk of prostate cancer (PubMed:10501358). The enzyme with Thr-49 has a higher in vitro V(max) than the Ala-49 enzyme (PubMed:10501358).1 Publication
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_077546 | 5 | C → R No effect on affinity for testosterone; no effect on affinity for NADPH; no effect on Vmax. 1 PublicationCorresponds to variant dbSNP:rs61748120EnsemblClinVar. | 1 | |
Natural variantiVAR_077547 | 30 | P → L Increased affinity for testosterone; increased affinity for NADPH; decreased Vmax. 1 Publication | 1 | |
Natural variantiVAR_077548 | 48 | P → R Increased affinity for testosterone; increased affinity for NADPH; decreased Vmax. 1 PublicationCorresponds to variant dbSNP:rs61748122EnsemblClinVar. | 1 | |
Natural variantiVAR_013104 | 49 | A → T Increased affinity for testosterone; no effect on affinity for NADPH; increased Vmax; no effect on affinity for testosterone when associated with L-89; no effect on affinity for NADPH when associated with L-89; increased Vmax when associated with L-89. 6 PublicationsCorresponds to variant dbSNP:rs9282858EnsemblClinVar. | 1 | |
Natural variantiVAR_077549 | 51 | A → T No effect on affinity for testosterone; increased affinity for NADPH; decreased Vmax. 1 PublicationCorresponds to variant dbSNP:rs61748123EnsemblClinVar. | 1 | |
Natural variantiVAR_013105 | 55 | L → Q in PPSH. 1 PublicationCorresponds to variant dbSNP:rs121434245EnsemblClinVar. | 1 | |
Natural variantiVAR_013130 | 85 | G → D in PPSH. 1 PublicationCorresponds to variant dbSNP:rs1351269392Ensembl. | 1 | |
Natural variantiVAR_013131 | 89 | V → L No effect on affinity for testosterone; no effect on affinity for NADPH; decreased Vmax; no effect on affinity for testosterone when associated with T-49; no effect on affinity for NADPH when associated with T-49; increased Vmax when associated with T-49; decreased affinity for testosterone when associated with M-187; increased affinity for NADPH when associated with M-187; decreased Vmax when associated with M-187; no effect on affinity for testosterone when associated with L-234; increased affinity for NADPH when associated with L-234; decreased Vmax when associated with L-234. 8 PublicationsCorresponds to variant dbSNP:rs523349Ensembl. | 1 | |
Natural variantiVAR_022302 | 113 | L → V1 PublicationCorresponds to variant dbSNP:rs28383048EnsemblClinVar. | 1 | |
Natural variantiVAR_013106 | 115 | G → D in PPSH. 3 PublicationsCorresponds to variant dbSNP:rs121434246EnsemblClinVar. | 1 | |
Natural variantiVAR_025854 | 123 | G → R in PPSH. 1 PublicationCorresponds to variant dbSNP:rs1331249320Ensembl. | 1 | |
Natural variantiVAR_025855 | 126 | Q → R in PPSH. 1 PublicationCorresponds to variant dbSNP:rs368386747EnsemblClinVar. | 1 | |
Natural variantiVAR_025851 | 145 | R → W in PPSH. 1 PublicationCorresponds to variant dbSNP:rs759561106Ensembl. | 1 | |
Natural variantiVAR_013107 | 157 | Missing in PPSH. 1 Publication | 1 | |
Natural variantiVAR_025856 | 158 | G → R in PPSH. 1 Publication | 1 | |
Natural variantiVAR_025852 | 181 | P → L in PPSH. 1 PublicationCorresponds to variant dbSNP:rs1057517829EnsemblClinVar. | 1 | |
Natural variantiVAR_013108 | 183 | G → S in PPSH. 2 PublicationsCorresponds to variant dbSNP:rs121434247EnsemblClinVar. | 1 | |
Natural variantiVAR_077550 | 187 | T → M No effect on affinity for testosterone; increased affinity for NADPH; decreased Vmax; decreased affinity for testosterone when associated with L-89; increased affinity for NADPH when associated with L-89; decreased Vmax when associated with L-89. 1 PublicationCorresponds to variant dbSNP:rs61748125EnsemblClinVar. | 1 | |
Natural variantiVAR_077551 | 194 | F → L No effect on affinity for testosterone; increased affinity for NADPH; increased Vmax. 1 PublicationCorresponds to variant dbSNP:rs61748126EnsemblClinVar. | 1 | |
Natural variantiVAR_013109 | 196 | G → S in PPSH. 3 PublicationsCorresponds to variant dbSNP:rs121434250EnsemblClinVar. | 1 | |
Natural variantiVAR_013110 | 197 | E → D in PPSH. 1 PublicationCorresponds to variant dbSNP:rs121434253EnsemblClinVar. | 1 | |
Natural variantiVAR_013132 | 200 | E → K in PPSH. 1 PublicationCorresponds to variant dbSNP:rs756853742EnsemblClinVar. | 1 | |
Natural variantiVAR_059791 | 203 | G → S. Corresponds to variant dbSNP:rs9332961EnsemblClinVar. | 1 | |
Natural variantiVAR_025857 | 207 | A → D in PPSH. 1 PublicationCorresponds to variant dbSNP:rs767564684EnsemblClinVar. | 1 | |
Natural variantiVAR_013111 | 212 | P → R in PPSH. 2 PublicationsCorresponds to variant dbSNP:rs121434252EnsemblClinVar. | 1 | |
Natural variantiVAR_059792 | 224 | L → H. Corresponds to variant dbSNP:rs9332963Ensembl. | 1 | |
Natural variantiVAR_037585 | 224 | L → M. Corresponds to variant dbSNP:rs9332963Ensembl. | 1 | |
Natural variantiVAR_037586 | 227 | R → Q in PPSH; also in individuals with micropenis; increased affinity for testosterone; increased affinity for NADPH; decreased Vmax. 3 PublicationsCorresponds to variant dbSNP:rs9332964EnsemblClinVar. | 1 | |
Natural variantiVAR_013112 | 228 | A → T in PPSH. 1 PublicationCorresponds to variant dbSNP:rs121434249EnsemblClinVar. | 1 | |
Natural variantiVAR_013113 | 231 | H → R in PPSH. 1 PublicationCorresponds to variant dbSNP:rs121434251EnsemblClinVar. | 1 | |
Natural variantiVAR_077552 | 234 | F → L Increased affinity for testosterone; increased affinity for NADPH; decreased Vmax; no effect on affinity for testosterone when associated with L-89; increased affinity for NADPH when associated with L-89; decreased Vmax when associated with L-89. 1 PublicationCorresponds to variants dbSNP:rs9332966 and dbSNP:rs1378704759EnsemblClinVarEnsembl. | 1 | |
Natural variantiVAR_025853 | 235 | Y → F in PPSH. 1 PublicationCorresponds to variant dbSNP:rs772283403EnsemblClinVar. | 1 | |
Natural variantiVAR_013133 | 245 | S → Y in PPSH. 1 PublicationCorresponds to variant dbSNP:rs145712014Ensembl. | 1 | |
Natural variantiVAR_013134 | 246 | R → Q in PPSH. 2 PublicationsCorresponds to variant dbSNP:rs9332967EnsemblClinVar. | 1 | |
Natural variantiVAR_005609 | 246 | R → W in PPSH. 4 PublicationsCorresponds to variant dbSNP:rs121434244EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M74047 mRNA Translation: AAA60586.1 AB047857 Genomic DNA Translation: BAB40419.1 EF560740 mRNA Translation: ABQ59050.1 AY884245 Genomic DNA Translation: AAW56942.1 AK316597 mRNA Translation: BAG38184.1 CH471053 Genomic DNA Translation: EAX00478.1 BC112252 mRNA Translation: AAI12253.1 BC113641 mRNA Translation: AAI13642.1 L03843 Genomic DNA No translation available. |
CCDSi | CCDS74503.1 |
PIRi | A49169 |
RefSeqi | NP_000339.2, NM_000348.3 |
Genome annotation databases
Ensembli | ENST00000622030; ENSP00000477587; ENSG00000277893 |
GeneIDi | 6716 |
KEGGi | hsa:6716 |
UCSCi | uc032nip.2, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Wikipedia 5-alpha reductase entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M74047 mRNA Translation: AAA60586.1 AB047857 Genomic DNA Translation: BAB40419.1 EF560740 mRNA Translation: ABQ59050.1 AY884245 Genomic DNA Translation: AAW56942.1 AK316597 mRNA Translation: BAG38184.1 CH471053 Genomic DNA Translation: EAX00478.1 BC112252 mRNA Translation: AAI12253.1 BC113641 mRNA Translation: AAI13642.1 L03843 Genomic DNA No translation available. |
CCDSi | CCDS74503.1 |
PIRi | A49169 |
RefSeqi | NP_000339.2, NM_000348.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
7BW1 | X-ray | 2.80 | A | 1-254 | [»] | |
SMRi | P31213 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112594, 3 interactors |
IntActi | P31213, 2 interactors |
STRINGi | 9606.ENSP00000477587 |
Chemistry databases
BindingDBi | P31213 |
ChEMBLi | CHEMBL1856 |
DrugBanki | DB00548, Azelaic acid DB01126, Dutasteride DB01216, Finasteride DB00741, Hydrocortisone DB00717, Norethisterone DB00421, Spironolactone DB13943, Testosterone cypionate DB13944, Testosterone enanthate DB01420, Testosterone propionate DB13946, Testosterone undecanoate |
DrugCentrali | P31213 |
GuidetoPHARMACOLOGYi | 2633 |
PTM databases
iPTMneti | P31213 |
PhosphoSitePlusi | P31213 |
Genetic variation databases
BioMutai | SRD5A2 |
DMDMi | 401056 |
Proteomic databases
MassIVEi | P31213 |
PeptideAtlasi | P31213 |
PRIDEi | P31213 |
ProteomicsDBi | 54764 |
Protocols and materials databases
Antibodypediai | 72759, 230 antibodies |
DNASUi | 6716 |
Genome annotation databases
Ensembli | ENST00000622030; ENSP00000477587; ENSG00000277893 |
GeneIDi | 6716 |
KEGGi | hsa:6716 |
UCSCi | uc032nip.2, human |
Organism-specific databases
CTDi | 6716 |
DisGeNETi | 6716 |
GeneCardsi | SRD5A2 |
HGNCi | HGNC:11285, SRD5A2 |
HPAi | ENSG00000277893, Tissue enhanced (epididymis, liver, prostate) |
MalaCardsi | SRD5A2 |
MIMi | 264600, phenotype 607306, gene |
neXtProti | NX_P31213 |
Orphaneti | 753, 46,XY disorder of sex development due to 5-alpha-reductase 2 deficiency 1331, Familial prostate cancer |
PharmGKBi | PA36113 |
VEuPathDBi | HostDB:ENSG00000277893.1 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1638, Eukaryota |
HOGENOMi | CLU_065395_1_1_1 |
InParanoidi | P31213 |
OrthoDBi | 1574389at2759 |
PhylomeDBi | P31213 |
Enzyme and pathway databases
BioCyci | MetaCyc:HS00619-MONOMER |
BRENDAi | 1.3.1.22, 2681 1.3.99.5, 2681 |
PathwayCommonsi | P31213 |
Reactomei | R-HSA-193048, Androgen biosynthesis |
Miscellaneous databases
BioGRID-ORCSi | 6716, 2 hits in 97 CRISPR screens |
ChiTaRSi | SRD5A2, human |
GeneWikii | SRD5A2 |
GenomeRNAii | 6716 |
Pharosi | P31213, Tclin |
PROi | PR:P31213 |
RNActi | P31213, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000277893, Expressed in oviduct epithelium and 62 other tissues |
Genevisiblei | P31213, HS |
Family and domain databases
InterProi | View protein in InterPro IPR016636, 3-oxo-5-alpha-steroid_4-DH IPR001104, 3-oxo-5_a-steroid_4-DH_C IPR039357, SRD5A/TECR |
PANTHERi | PTHR10556, PTHR10556, 1 hit |
Pfami | View protein in Pfam PF02544, Steroid_dh, 1 hit |
PIRSFi | PIRSF015596, 5_alpha-SR2, 1 hit |
PROSITEi | View protein in PROSITE PS50244, S5A_REDUCTASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | S5A2_HUMAN | |
Accessioni | P31213Primary (citable) accession number: P31213 Secondary accession number(s): B2RE87, Q2M1R4, Q9BYE6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | July 1, 1993 | |
Last modified: | February 10, 2021 | |
This is version 185 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM