Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

3-oxo-5-beta-steroid 4-dehydrogenase

Gene

Akr1d1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4-cholesten-3-one can also act as substrates.By similarity

Catalytic activityi

5-beta-cholestan-3-one + NADP+ = cholest-4-en-3-one + NADPH.By similarity
17,21-dihydroxy-5-beta-pregnane-3,11,20-trione + NADP+ = cortisone + NADPH.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei26SubstrateBy similarity1
Binding sitei52NADPBy similarity1
Active sitei57Proton donorBy similarity1
Binding sitei57SubstrateBy similarity1
Binding sitei88SubstrateBy similarity1
Binding sitei119SubstrateBy similarity1
Binding sitei131SubstrateBy similarity1
Binding sitei192NADPBy similarity1
Binding sitei230SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi22 – 26NADPBy similarity5
Nucleotide bindingi168 – 169NADPBy similarity2
Nucleotide bindingi219 – 224NADPBy similarity6
Nucleotide bindingi273 – 283NADPBy similarityAdd BLAST11

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processBile acid catabolism, Lipid degradation, Lipid metabolism, Steroid metabolism
LigandNADP

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14304
SABIO-RKiP31210

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxo-5-beta-steroid 4-dehydrogenase (EC:1.3.1.3)
Alternative name(s):
Aldo-keto reductase family 1 member D1
Delta(4)-3-ketosteroid 5-beta-reductase
Delta(4)-3-oxosteroid 5-beta-reductase
Gene namesi
Name:Akr1d1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620752 Akr1d1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5760

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001246721 – 3263-oxo-5-beta-steroid 4-dehydrogenaseAdd BLAST326

Post-translational modificationi

The N-terminus is blocked.

Proteomic databases

PaxDbiP31210
PRIDEiP31210

PTM databases

iPTMnetiP31210
PhosphoSitePlusiP31210

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017675

Structurei

3D structure databases

ProteinModelPortaliP31210
SMRiP31210
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldo/keto reductase family.Curated

Phylogenomic databases

eggNOGiKOG1577 Eukaryota
COG0656 LUCA
HOGENOMiHOG000250272
HOVERGENiHBG000020
InParanoidiP31210
KOiK00251
PhylomeDBiP31210

Family and domain databases

CDDicd06660 Aldo_ket_red, 1 hit
Gene3Di3.20.20.100, 1 hit
InterProiView protein in InterPro
IPR018170 Aldo/ket_reductase_CS
IPR020471 Aldo/keto_reductase
IPR023210 NADP_OxRdtase_dom
IPR036812 NADP_OxRdtase_dom_sf
PANTHERiPTHR11732 PTHR11732, 1 hit
PfamiView protein in Pfam
PF00248 Aldo_ket_red, 1 hit
PIRSFiPIRSF000097 AKR, 1 hit
PRINTSiPR00069 ALDKETRDTASE
SUPFAMiSSF51430 SSF51430, 1 hit
PROSITEiView protein in PROSITE
PS00798 ALDOKETO_REDUCTASE_1, 1 hit
PS00062 ALDOKETO_REDUCTASE_2, 1 hit
PS00063 ALDOKETO_REDUCTASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

P31210-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLSTANHHI PLNDGNSIPI IGLGTYSDPR PVPGKTFIAV KTAIDEGYRH
60 70 80 90 100
IDGAYVYRNE HEVGEAIREK VAEGKVKREE IFYCGKLWST DHDPEMVRPA
110 120 130 140 150
LERTLQTLKL DYIDLYIIEM PMAFKPGEEF YPKDENGRVI YHKSNLCATW
160 170 180 190 200
EALEACKDAG LVKSLGVSNF NRRQLEVILN KPGLKYKPVT NQVECHPYFT
210 220 230 240 250
QTKLLEVSAS SMTSFIVAYS PLGTCRNPLW VNVSSPPLLK DELLTSLGKK
260 270 280 290 300
YNKTQAQIVL RFDIQRGLVV IPKSTTPERI KENFQIFDFS LTKEEMKDIE
310 320
ALNKNVRFVE MLMWSDHPEY PFHDEY
Length:326
Mass (Da):37,378
Last modified:July 1, 1993 - v1
Checksum:i32D8266BFA62CE99
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17309 mRNA Translation: BAA04131.1
S80431 mRNA Translation: AAB35916.2
PIRiS15835
RefSeqiNP_620239.1, NM_138884.1
UniGeneiRn.25716

Genome annotation databases

GeneIDi192242
KEGGirno:192242
UCSCiRGD:620752 rat

Similar proteinsi

Entry informationi

Entry nameiAK1D1_RAT
AccessioniPrimary (citable) accession number: P31210
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: May 23, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health