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Protein

ADP,ATP carrier protein 1, mitochondrial

Gene

AAC1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei153ADPBy similarity1
Binding sitei165ADPBy similarity1
Binding sitei311ADPBy similarity1

GO - Molecular functioni

  • ATP:ADP antiporter activity Source: TAIR
  • copper ion binding Source: TAIR

GO - Biological processi

Keywordsi

Biological processTransport

Protein family/group databases

TCDBi2.A.29.1.5 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
ADP,ATP carrier protein 1, mitochondrial
Alternative name(s):
ADP/ATP translocase 1
Adenine nucleotide translocator 1
Short name:
ANT 1
Gene namesi
Name:AAC1
Synonyms:ANT1
Ordered Locus Names:At3g08580
ORF Names:F17O14.5
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G08580
TAIRilocus:2077778 AT3G08580

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei80 – 107Helical; Name=1By similarityAdd BLAST28
Transmembranei148 – 172Helical; Name=2By similarityAdd BLAST25
Transmembranei181 – 201Helical; Name=3By similarityAdd BLAST21
Transmembranei252 – 273Helical; Name=4By similarityAdd BLAST22
Transmembranei287 – 307Helical; Name=5By similarityAdd BLAST21
Transmembranei347 – 367Helical; Name=6By similarityAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 70MitochondrionSequence analysisAdd BLAST70
ChainiPRO_000001924571 – 381ADP,ATP carrier protein 1, mitochondrialAdd BLAST311

Proteomic databases

PaxDbiP31167
PRIDEiP31167

PTM databases

iPTMnetiP31167

Expressioni

Gene expression databases

ExpressionAtlasiP31167 baseline and differential
GenevisibleiP31167 AT

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi5340, 12 interactors
IntActiP31167, 7 interactors
MINTiP31167
STRINGi3702.AT3G08580.1

Structurei

3D structure databases

ProteinModelPortaliP31167
SMRiP31167
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati78 – 171Solcar 1Add BLAST94
Repeati183 – 276Solcar 2Add BLAST94
Repeati284 – 370Solcar 3Add BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni311 – 316Important for transport activityBy similarity6

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi311 – 316Nucleotide carrier signature motifBy similarity6

Domaini

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. At least 2 of the odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat, Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0749 Eukaryota
ENOG410XNW0 LUCA
HOGENOMiHOG000165727
InParanoidiP31167
KOiK05863
OMAiFALDFLM
OrthoDBiEOG09360DZB
PhylomeDBiP31167

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002113 Aden_trnslctor
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00927 ADPTRNSLCASE
PR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31167-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDQVQHPTI AQKAAGQFMR SSVSKDVQVG YQRPSMYQRH ATYGNYSNAA
60 70 80 90 100
FQFPPTSRML ATTASPVFVQ TPGEKGFTNF ALDFLMGGVS AAVSKTAAAP
110 120 130 140 150
IERVKLLIQN QDEMIKAGRL SEPYKGIGDC FGRTIKDEGF GSLWRGNTAN
160 170 180 190 200
VIRYFPTQAL NFAFKDYFKR LFNFKKDRDG YWKWFAGNLA SGGAAGASSL
210 220 230 240 250
LFVYSLDYAR TRLANDAKAA KKGGGGRQFD GLVDVYRKTL KTDGIAGLYR
260 270 280 290 300
GFNISCVGII VYRGLYFGLY DSVKPVLLTG DLQDSFFASF ALGWVITNGA
310 320 330 340 350
GLASYPIDTV RRRMMMTSGE AVKYKSSLDA FKQILKNEGA KSLFKGAGAN
360 370 380
ILRAVAGAGV LSGYDKLQLI VFGKKYGSGG A
Length:381
Mass (Da):41,476
Last modified:December 1, 2000 - v2
Checksum:iFF39C3D1E1ED5B58
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3D → H in CAA46518 (PubMed:16653021).Curated1
Sequence conflicti319G → N in CAA46518 (PubMed:16653021).Curated1
Sequence conflicti368Q → T in CAA46518 (PubMed:16653021).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012562 Genomic DNA Translation: AAG51358.1
CP002686 Genomic DNA Translation: AEE74648.1
CP002686 Genomic DNA Translation: AEE74649.1
AY034933 mRNA Translation: AAK59440.1
AY042814 mRNA Translation: AAK68754.1
AY054248 mRNA Translation: AAL06907.1
AY074529 mRNA Translation: AAL69497.1
BT000381 mRNA Translation: AAN15700.1
BT002387 mRNA Translation: AAO00747.1
X65549 mRNA Translation: CAA46518.1
Z26399 mRNA Translation: CAA81237.1
PIRiS21313
RefSeqiNP_187470.1, NM_111692.3
NP_850541.1, NM_180210.2
UniGeneiAt.15439
At.23909
At.67047

Genome annotation databases

EnsemblPlantsiAT3G08580.1; AT3G08580.1; AT3G08580
AT3G08580.2; AT3G08580.2; AT3G08580
GeneIDi820005
GrameneiAT3G08580.1; AT3G08580.1; AT3G08580
AT3G08580.2; AT3G08580.2; AT3G08580
KEGGiath:AT3G08580

Similar proteinsi

Entry informationi

Entry nameiADT1_ARATH
AccessioniPrimary (citable) accession number: P31167
Secondary accession number(s): Q9M9K2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: December 1, 2000
Last modified: April 25, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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