UniProtKB - P31161 (SODM1_CAEEL)
Protein
Superoxide dismutase [Mn] 1, mitochondrial
Gene
sod-2
Organism
Caenorhabditis elegans
Status
Functioni
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
Catalytic activityi
- EC:1.15.1.1
Cofactori
Mn2+By similarityNote: Binds 1 Mn2+ ion per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 50 | ManganeseBy similarity | 1 | |
Metal bindingi | 98 | ManganeseBy similarity | 1 | |
Metal bindingi | 182 | ManganeseBy similarity | 1 | |
Metal bindingi | 186 | ManganeseBy similarity | 1 |
GO - Molecular functioni
- manganese ion binding Source: GO_Central
- metal ion binding Source: GO_Central
- protein homodimerization activity Source: WormBase
- superoxide dismutase activity Source: WormBase
GO - Biological processi
- removal of superoxide radicals Source: WormBase
Keywordsi
Molecular function | Oxidoreductase |
Ligand | Manganese, Metal-binding |
Enzyme and pathway databases
Reactomei | R-CEL-3299685, Detoxification of Reactive Oxygen Species |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:sod-2 Synonyms:sdm-1 ORF Names:F10D11.1 |
Organismi | Caenorhabditis elegans |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | F10D11.1 ; CE09323 ; WBGene00004931 ; sod-2 |
Subcellular locationi
Mitochondrion
Mitochondrion
- mitochondrial matrix Source: UniProtKB-SubCell
- mitochondrial respirasome Source: WormBase
- mitochondrion Source: WormBase
Keywords - Cellular componenti
MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 24 | MitochondrionBy similarityAdd BLAST | 24 | |
ChainiPRO_0000032876 | 25 – 221 | Superoxide dismutase [Mn] 1, mitochondrialAdd BLAST | 197 |
Proteomic databases
EPDi | P31161 |
PaxDbi | P31161 |
PeptideAtlasi | P31161 |
PTM databases
iPTMneti | P31161 |
Expressioni
Gene expression databases
Bgeei | WBGene00004931, Expressed in multi-cellular organism and 5 other tissues |
Interactioni
Subunit structurei
Homotetramer.
GO - Molecular functioni
- protein homodimerization activity Source: WormBase
Protein-protein interaction databases
BioGRIDi | 38065, 13 interactors |
STRINGi | 6239.F10D11.1.2 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P31161 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P31161 |
Family & Domainsi
Sequence similaritiesi
Belongs to the iron/manganese superoxide dismutase family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG0876, Eukaryota |
GeneTreei | ENSGT00390000011877 |
HOGENOMi | CLU_031625_2_1_1 |
InParanoidi | P31161 |
OMAi | KWGSFDK |
OrthoDBi | 1353361at2759 |
PhylomeDBi | P31161 |
Family and domain databases
Gene3Di | 1.10.287.990, 1 hit 2.40.500.20, 1 hit |
InterProi | View protein in InterPro IPR001189, Mn/Fe_SOD IPR019833, Mn/Fe_SOD_BS IPR019832, Mn/Fe_SOD_C IPR019831, Mn/Fe_SOD_N IPR036324, Mn/Fe_SOD_N_sf IPR036314, SOD_C_sf |
Pfami | View protein in Pfam PF02777, Sod_Fe_C, 1 hit PF00081, Sod_Fe_N, 1 hit |
PIRSFi | PIRSF000349, SODismutase, 1 hit |
PRINTSi | PR01703, MNSODISMTASE |
SUPFAMi | SSF46609, SSF46609, 1 hit SSF54719, SSF54719, 1 hit |
PROSITEi | View protein in PROSITE PS00088, SOD_MN, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P31161-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLQNTVRCVS KLVQPITGVA AVRSKHSLPD LPYDYADLEP VISHEIMQLH
60 70 80 90 100
HQKHHATYVN NLNQIEEKLH EAVSKGNVKE AIALQPALKF NGGGHINHSI
110 120 130 140 150
FWTNLAKDGG EPSAELLTAI KSDFGSLDNL QKQLSASTVA VQGSGWGWLG
160 170 180 190 200
YCPKGKILKV ATCANQDPLE ATTGLVPLFG IDVWEHAYYL QYKNVRPDYV
210 220
NAIWKIANWK NVSERFAKAQ Q
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D12984 mRNA Translation: BAA02363.1 D85499 Genomic DNA Translation: BAA12821.1 Z81057 Genomic DNA Translation: CAB02913.1 |
PIRi | JC5122 |
RefSeqi | NP_492290.1, NM_059889.4 |
Genome annotation databases
EnsemblMetazoai | F10D11.1.1; F10D11.1.1; WBGene00004931 F10D11.1.2; F10D11.1.2; WBGene00004931 F10D11.1.3; F10D11.1.3; WBGene00004931 |
GeneIDi | 172632 |
KEGGi | cel:CELE_F10D11.1 |
UCSCi | F10D11.1.1, c. elegans |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D12984 mRNA Translation: BAA02363.1 D85499 Genomic DNA Translation: BAA12821.1 Z81057 Genomic DNA Translation: CAB02913.1 |
PIRi | JC5122 |
RefSeqi | NP_492290.1, NM_059889.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3DC6 | X-ray | 1.80 | A/C | 25-221 | [»] | |
SMRi | P31161 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 38065, 13 interactors |
STRINGi | 6239.F10D11.1.2 |
PTM databases
iPTMneti | P31161 |
Proteomic databases
EPDi | P31161 |
PaxDbi | P31161 |
PeptideAtlasi | P31161 |
Genome annotation databases
EnsemblMetazoai | F10D11.1.1; F10D11.1.1; WBGene00004931 F10D11.1.2; F10D11.1.2; WBGene00004931 F10D11.1.3; F10D11.1.3; WBGene00004931 |
GeneIDi | 172632 |
KEGGi | cel:CELE_F10D11.1 |
UCSCi | F10D11.1.1, c. elegans |
Organism-specific databases
CTDi | 172632 |
WormBasei | F10D11.1 ; CE09323 ; WBGene00004931 ; sod-2 |
Phylogenomic databases
eggNOGi | KOG0876, Eukaryota |
GeneTreei | ENSGT00390000011877 |
HOGENOMi | CLU_031625_2_1_1 |
InParanoidi | P31161 |
OMAi | KWGSFDK |
OrthoDBi | 1353361at2759 |
PhylomeDBi | P31161 |
Enzyme and pathway databases
Reactomei | R-CEL-3299685, Detoxification of Reactive Oxygen Species |
Miscellaneous databases
EvolutionaryTracei | P31161 |
PROi | PR:P31161 |
Gene expression databases
Bgeei | WBGene00004931, Expressed in multi-cellular organism and 5 other tissues |
Family and domain databases
Gene3Di | 1.10.287.990, 1 hit 2.40.500.20, 1 hit |
InterProi | View protein in InterPro IPR001189, Mn/Fe_SOD IPR019833, Mn/Fe_SOD_BS IPR019832, Mn/Fe_SOD_C IPR019831, Mn/Fe_SOD_N IPR036324, Mn/Fe_SOD_N_sf IPR036314, SOD_C_sf |
Pfami | View protein in Pfam PF02777, Sod_Fe_C, 1 hit PF00081, Sod_Fe_N, 1 hit |
PIRSFi | PIRSF000349, SODismutase, 1 hit |
PRINTSi | PR01703, MNSODISMTASE |
SUPFAMi | SSF46609, SSF46609, 1 hit SSF54719, SSF54719, 1 hit |
PROSITEi | View protein in PROSITE PS00088, SOD_MN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SODM1_CAEEL | |
Accessioni | P31161Primary (citable) accession number: P31161 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | July 1, 1993 | |
Last modified: | December 2, 2020 | |
This is version 140 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families