Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 200 (18 Sep 2019)
Sequence version 2 (01 Oct 1996)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Rab GDP dissociation inhibitor alpha

Gene

GDI1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-194840 Rho GTPase cycle
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rab GDP dissociation inhibitor alpha
Short name:
Rab GDI alpha
Alternative name(s):
Guanosine diphosphate dissociation inhibitor 1
Short name:
GDI-1
Oligophrenin-2
Protein XAP-4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GDI1
Synonyms:GDIL, OPHN2, RABGDIA, XAP4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4226 GDI1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300104 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P31150

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Mental retardation, X-linked 41 (MRX41)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00813092L → P in MRX41; causes reduced binding and recycling of RAB3A. 1 PublicationCorresponds to variant dbSNP:rs121434607EnsemblClinVar.1
Natural variantiVAR_008131423R → P in MRX41. 1 PublicationCorresponds to variant dbSNP:rs121434609EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
2664

MalaCards human disease database

More...
MalaCardsi
GDI1
MIMi300849 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000203879

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
777 X-linked non-syndromic intellectual disability

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28641

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P31150

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GDI1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1707886

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000566711 – 447Rab GDP dissociation inhibitor alphaAdd BLAST447

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P31150

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P31150

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P31150

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P31150

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P31150

PeptideAtlas

More...
PeptideAtlasi
P31150

PRoteomics IDEntifications database

More...
PRIDEi
P31150

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
54760

2D gel databases

USC-OGP 2-DE database

More...
OGPi
P31150

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00010154

University College Dublin 2-DE Proteome Database

More...
UCD-2DPAGEi
P31150

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P31150

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P31150

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P31150

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Brain; predominant in neural and sensory tissues.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000203879 Expressed in 234 organ(s), highest expression level in frontal cortex

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P31150 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P31150 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB012979
HPA049290
HPA057668

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RHOH (PubMed:11809807).

Interacts with the non-phosphorylated forms of RAB1A, RAB3A, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB35, and RAB43 (PubMed:19570034, PubMed:23815289, PubMed:26824392, PubMed:29125462).

5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108932, 89 interactors

Protein interaction database and analysis system

More...
IntActi
P31150, 61 interactors

Molecular INTeraction database

More...
MINTi
P31150

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000394071

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P31150

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Rab GDI family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1439 Eukaryota
COG5044 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182994

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P31150

KEGG Orthology (KO)

More...
KOi
K17255

Identification of Orthologs from Complete Genome Data

More...
OMAi
DFLGHAV

Database of Orthologous Groups

More...
OrthoDBi
763627at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P31150

TreeFam database of animal gene trees

More...
TreeFami
TF300449

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.50.50.60, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR018203 GDP_dissociation_inhibitor
IPR000806 RabGDI

The PANTHER Classification System

More...
PANTHERi
PTHR11787 PTHR11787, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00996 GDI, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00892 RABGDI
PR00891 RABGDIREP

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51905 SSF51905, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P31150-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDEEYDVIVL GTGLTECILS GIMSVNGKKV LHMDRNPYYG GESSSITPLE
60 70 80 90 100
ELYKRFQLLE GPPESMGRGR DWNVDLIPKF LMANGQLVKM LLYTEVTRYL
110 120 130 140 150
DFKVVEGSFV YKGGKIYKVP STETEALASN LMGMFEKRRF RKFLVFVANF
160 170 180 190 200
DENDPKTFEG VDPQTTSMRD VYRKFDLGQD VIDFTGHALA LYRTDDYLDQ
210 220 230 240 250
PCLETVNRIK LYSESLARYG KSPYLYPLYG LGELPQGFAR LSAIYGGTYM
260 270 280 290 300
LNKPVDDIIM ENGKVVGVKS EGEVARCKQL ICDPSYIPDR VRKAGQVIRI
310 320 330 340 350
ICILSHPIKN TNDANSCQII IPQNQVNRKS DIYVCMISYA HNVAAQGKYI
360 370 380 390 400
AIASTTVETT DPEKEVEPAL ELLEPIDQKF VAISDLYEPI DDGCESQVFC
410 420 430 440
SCSYDATTHF ETTCNDIKDI YKRMAGTAFD FENMKRKQND VFGEAEQ
Length:447
Mass (Da):50,583
Last modified:October 1, 1996 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBC283A445E50A652
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E9U5G5E9U5_HUMAN
Rab GDP dissociation inhibitor
GDI1 hCG_2039440
147Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WE59F8WE59_HUMAN
Rab GDP dissociation inhibitor alph...
GDI1
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WCU0F8WCU0_HUMAN
Rab GDP dissociation inhibitor alph...
GDI1
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti34D → G in BAA08078 (PubMed:7585614).Curated1
Sequence conflicti36N → K in BAA08078 (PubMed:7585614).Curated1
Sequence conflicti149 – 151NFD → GTY in BAA08078 (PubMed:7585614).Curated3
Sequence conflicti347G → V in AAC15851 (Ref. 13) Curated1
Sequence conflicti409H → Q in AAC15851 (Ref. 13) Curated1
Sequence conflicti416D → G in AAC15851 (Ref. 13) Curated1
Sequence conflicti442F → S in BAA08078 (PubMed:7585614).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00813092L → P in MRX41; causes reduced binding and recycling of RAB3A. 1 PublicationCorresponds to variant dbSNP:rs121434607EnsemblClinVar.1
Natural variantiVAR_008131423R → P in MRX41. 1 PublicationCorresponds to variant dbSNP:rs121434609EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X79353 mRNA Translation: CAA55908.1
X79354
, X79355, X79356, X79357, X79358, X79359, X79360, X79364, X79361, X79362, X79363 Genomic DNA Translation: CAA55909.1
D45021 mRNA Translation: BAA08078.1
L44140 Genomic DNA Translation: AAA92648.1
AF400433 mRNA Translation: AAK92482.1
AB101741 Genomic DNA Translation: BAC80330.1
AB101742 Genomic DNA Translation: BAC80331.1
AB101743 Genomic DNA Translation: BAC80332.1
AB101744 Genomic DNA Translation: BAC80333.1
AB101745 Genomic DNA Translation: BAC80334.1
AB101746 Genomic DNA Translation: BAC80335.1
AB101747 Genomic DNA Translation: BAC80336.1
AB101748 Genomic DNA Translation: BAC80337.1
AB101749 Genomic DNA Translation: BAC80338.1
AB101750 Genomic DNA Translation: BAC80339.1
AB101751 Genomic DNA Translation: BAC80340.1
AB101752 Genomic DNA Translation: BAC80341.1
AB101753 Genomic DNA Translation: BAC80342.1
AB101754 Genomic DNA Translation: BAC80343.1
AB101755 Genomic DNA Translation: BAC80344.1
AB101756 Genomic DNA Translation: BAC80345.1
AB101757 Genomic DNA Translation: BAC80346.1
AB101758 Genomic DNA Translation: BAC80347.1
AB101759 Genomic DNA Translation: BAC80348.1
AB101760 Genomic DNA Translation: BAC80349.1
AB101771 Genomic DNA Translation: BAC80360.1
AB101772 Genomic DNA Translation: BAC80361.1
AB101773 Genomic DNA Translation: BAC80362.1
AB101774 Genomic DNA Translation: BAC80363.1
AB101775 Genomic DNA Translation: BAC80364.1
AB101776 Genomic DNA Translation: BAC80365.1
AB101777 Genomic DNA Translation: BAC80366.1
AB101778 Genomic DNA Translation: BAC80367.1
AB101779 Genomic DNA Translation: BAC80368.1
AB101780 Genomic DNA Translation: BAC80369.1
AB101781 Genomic DNA Translation: BAC80370.1
AB101782 Genomic DNA Translation: BAC80371.1
AB101783 Genomic DNA Translation: BAC80372.1
AB101784 Genomic DNA Translation: BAC80373.1
AB101785 Genomic DNA Translation: BAC80374.1
AB101786 Genomic DNA Translation: BAC80375.1
AB101787 Genomic DNA Translation: BAC80376.1
AB101788 Genomic DNA Translation: BAC80377.1
AB101789 Genomic DNA Translation: BAC80378.1
AB101790 Genomic DNA Translation: BAC80379.1
AB101801 Genomic DNA Translation: BAC80390.1
AB101802 Genomic DNA Translation: BAC80391.1
AB101803 Genomic DNA Translation: BAC80392.1
AB101804 Genomic DNA Translation: BAC80393.1
AB101805 Genomic DNA Translation: BAC80394.1
AB101806 Genomic DNA Translation: BAC80395.1
AB101807 Genomic DNA Translation: BAC80396.1
AB101808 Genomic DNA Translation: BAC80397.1
AB101809 Genomic DNA Translation: BAC80398.1
AB101810 Genomic DNA Translation: BAC80399.1
AB101811 Genomic DNA Translation: BAC80400.1
AB101812 Genomic DNA Translation: BAC80401.1
AB101813 Genomic DNA Translation: BAC80402.1
AB101814 Genomic DNA Translation: BAC80403.1
AB101815 Genomic DNA Translation: BAC80404.1
AB101816 Genomic DNA Translation: BAC80405.1
AB101817 Genomic DNA Translation: BAC80406.1
AB101818 Genomic DNA Translation: BAC80407.1
AB101819 Genomic DNA Translation: BAC80408.1
AB101820 Genomic DNA Translation: BAC80409.1
AB101831 Genomic DNA Translation: BAC80420.1
AB101832 Genomic DNA Translation: BAC80421.1
AB101833 Genomic DNA Translation: BAC80422.1
AB101834 Genomic DNA Translation: BAC80423.1
AB101835 Genomic DNA Translation: BAC80424.1
AB101836 Genomic DNA Translation: BAC80425.1
AB101837 Genomic DNA Translation: BAC80426.1
AB101838 Genomic DNA Translation: BAC80427.1
AB101839 Genomic DNA Translation: BAC80428.1
AB101840 Genomic DNA Translation: BAC80429.1
AB101841 Genomic DNA Translation: BAC80430.1
AB101842 Genomic DNA Translation: BAC80431.1
AB101843 Genomic DNA Translation: BAC80432.1
AB101844 Genomic DNA Translation: BAC80433.1
AB101845 Genomic DNA Translation: BAC80434.1
AB101846 Genomic DNA Translation: BAC80435.1
AB101847 Genomic DNA Translation: BAC80436.1
AB101848 Genomic DNA Translation: BAC80437.1
AB101849 Genomic DNA Translation: BAC80438.1
AB101850 Genomic DNA Translation: BAC80439.1
AB102647 mRNA Translation: BAC81116.1
CR542258 mRNA Translation: CAG47054.1
CR542276 mRNA Translation: CAG47072.1
BT019884 mRNA Translation: AAV38687.1
BX936385 Genomic DNA No translation available.
CH471172 Genomic DNA Translation: EAW72710.1
BC000317 mRNA Translation: AAH00317.1
BC012201 mRNA Translation: AAH12201.1
U14623 Genomic DNA Translation: AAA21558.1
L05086 mRNA Translation: AAC15851.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS35452.1

Protein sequence database of the Protein Information Resource

More...
PIRi
I37082

NCBI Reference Sequences

More...
RefSeqi
NP_001484.1, NM_001493.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000447750; ENSP00000394071; ENSG00000203879

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2664

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2664

UCSC genome browser

More...
UCSCi
uc004fli.5 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79353 mRNA Translation: CAA55908.1
X79354
, X79355, X79356, X79357, X79358, X79359, X79360, X79364, X79361, X79362, X79363 Genomic DNA Translation: CAA55909.1
D45021 mRNA Translation: BAA08078.1
L44140 Genomic DNA Translation: AAA92648.1
AF400433 mRNA Translation: AAK92482.1
AB101741 Genomic DNA Translation: BAC80330.1
AB101742 Genomic DNA Translation: BAC80331.1
AB101743 Genomic DNA Translation: BAC80332.1
AB101744 Genomic DNA Translation: BAC80333.1
AB101745 Genomic DNA Translation: BAC80334.1
AB101746 Genomic DNA Translation: BAC80335.1
AB101747 Genomic DNA Translation: BAC80336.1
AB101748 Genomic DNA Translation: BAC80337.1
AB101749 Genomic DNA Translation: BAC80338.1
AB101750 Genomic DNA Translation: BAC80339.1
AB101751 Genomic DNA Translation: BAC80340.1
AB101752 Genomic DNA Translation: BAC80341.1
AB101753 Genomic DNA Translation: BAC80342.1
AB101754 Genomic DNA Translation: BAC80343.1
AB101755 Genomic DNA Translation: BAC80344.1
AB101756 Genomic DNA Translation: BAC80345.1
AB101757 Genomic DNA Translation: BAC80346.1
AB101758 Genomic DNA Translation: BAC80347.1
AB101759 Genomic DNA Translation: BAC80348.1
AB101760 Genomic DNA Translation: BAC80349.1
AB101771 Genomic DNA Translation: BAC80360.1
AB101772 Genomic DNA Translation: BAC80361.1
AB101773 Genomic DNA Translation: BAC80362.1
AB101774 Genomic DNA Translation: BAC80363.1
AB101775 Genomic DNA Translation: BAC80364.1
AB101776 Genomic DNA Translation: BAC80365.1
AB101777 Genomic DNA Translation: BAC80366.1
AB101778 Genomic DNA Translation: BAC80367.1
AB101779 Genomic DNA Translation: BAC80368.1
AB101780 Genomic DNA Translation: BAC80369.1
AB101781 Genomic DNA Translation: BAC80370.1
AB101782 Genomic DNA Translation: BAC80371.1
AB101783 Genomic DNA Translation: BAC80372.1
AB101784 Genomic DNA Translation: BAC80373.1
AB101785 Genomic DNA Translation: BAC80374.1
AB101786 Genomic DNA Translation: BAC80375.1
AB101787 Genomic DNA Translation: BAC80376.1
AB101788 Genomic DNA Translation: BAC80377.1
AB101789 Genomic DNA Translation: BAC80378.1
AB101790 Genomic DNA Translation: BAC80379.1
AB101801 Genomic DNA Translation: BAC80390.1
AB101802 Genomic DNA Translation: BAC80391.1
AB101803 Genomic DNA Translation: BAC80392.1
AB101804 Genomic DNA Translation: BAC80393.1
AB101805 Genomic DNA Translation: BAC80394.1
AB101806 Genomic DNA Translation: BAC80395.1
AB101807 Genomic DNA Translation: BAC80396.1
AB101808 Genomic DNA Translation: BAC80397.1
AB101809 Genomic DNA Translation: BAC80398.1
AB101810 Genomic DNA Translation: BAC80399.1
AB101811 Genomic DNA Translation: BAC80400.1
AB101812 Genomic DNA Translation: BAC80401.1
AB101813 Genomic DNA Translation: BAC80402.1
AB101814 Genomic DNA Translation: BAC80403.1
AB101815 Genomic DNA Translation: BAC80404.1
AB101816 Genomic DNA Translation: BAC80405.1
AB101817 Genomic DNA Translation: BAC80406.1
AB101818 Genomic DNA Translation: BAC80407.1
AB101819 Genomic DNA Translation: BAC80408.1
AB101820 Genomic DNA Translation: BAC80409.1
AB101831 Genomic DNA Translation: BAC80420.1
AB101832 Genomic DNA Translation: BAC80421.1
AB101833 Genomic DNA Translation: BAC80422.1
AB101834 Genomic DNA Translation: BAC80423.1
AB101835 Genomic DNA Translation: BAC80424.1
AB101836 Genomic DNA Translation: BAC80425.1
AB101837 Genomic DNA Translation: BAC80426.1
AB101838 Genomic DNA Translation: BAC80427.1
AB101839 Genomic DNA Translation: BAC80428.1
AB101840 Genomic DNA Translation: BAC80429.1
AB101841 Genomic DNA Translation: BAC80430.1
AB101842 Genomic DNA Translation: BAC80431.1
AB101843 Genomic DNA Translation: BAC80432.1
AB101844 Genomic DNA Translation: BAC80433.1
AB101845 Genomic DNA Translation: BAC80434.1
AB101846 Genomic DNA Translation: BAC80435.1
AB101847 Genomic DNA Translation: BAC80436.1
AB101848 Genomic DNA Translation: BAC80437.1
AB101849 Genomic DNA Translation: BAC80438.1
AB101850 Genomic DNA Translation: BAC80439.1
AB102647 mRNA Translation: BAC81116.1
CR542258 mRNA Translation: CAG47054.1
CR542276 mRNA Translation: CAG47072.1
BT019884 mRNA Translation: AAV38687.1
BX936385 Genomic DNA No translation available.
CH471172 Genomic DNA Translation: EAW72710.1
BC000317 mRNA Translation: AAH00317.1
BC012201 mRNA Translation: AAH12201.1
U14623 Genomic DNA Translation: AAA21558.1
L05086 mRNA Translation: AAC15851.1
CCDSiCCDS35452.1
PIRiI37082
RefSeqiNP_001484.1, NM_001493.2

3D structure databases

SMRiP31150
ModBaseiSearch...

Protein-protein interaction databases

BioGridi108932, 89 interactors
IntActiP31150, 61 interactors
MINTiP31150
STRINGi9606.ENSP00000394071

PTM databases

iPTMnetiP31150
PhosphoSitePlusiP31150
SwissPalmiP31150

Polymorphism and mutation databases

BioMutaiGDI1
DMDMi1707886

2D gel databases

OGPiP31150
REPRODUCTION-2DPAGEiIPI00010154
UCD-2DPAGEiP31150

Proteomic databases

EPDiP31150
jPOSTiP31150
MassIVEiP31150
MaxQBiP31150
PaxDbiP31150
PeptideAtlasiP31150
PRIDEiP31150
ProteomicsDBi54760

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
2664

Genome annotation databases

EnsembliENST00000447750; ENSP00000394071; ENSG00000203879
GeneIDi2664
KEGGihsa:2664
UCSCiuc004fli.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2664
DisGeNETi2664

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GDI1
HGNCiHGNC:4226 GDI1
HPAiCAB012979
HPA049290
HPA057668
MalaCardsiGDI1
MIMi300104 gene
300849 phenotype
neXtProtiNX_P31150
OpenTargetsiENSG00000203879
Orphaneti777 X-linked non-syndromic intellectual disability
PharmGKBiPA28641

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1439 Eukaryota
COG5044 LUCA
GeneTreeiENSGT00950000182994
InParanoidiP31150
KOiK17255
OMAiDFLGHAV
OrthoDBi763627at2759
PhylomeDBiP31150
TreeFamiTF300449

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
GDI1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
GDI1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
2664
PharosiP31150

Protein Ontology

More...
PROi
PR:P31150

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000203879 Expressed in 234 organ(s), highest expression level in frontal cortex
ExpressionAtlasiP31150 baseline and differential
GenevisibleiP31150 HS

Family and domain databases

Gene3Di3.50.50.60, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR018203 GDP_dissociation_inhibitor
IPR000806 RabGDI
PANTHERiPTHR11787 PTHR11787, 1 hit
PfamiView protein in Pfam
PF00996 GDI, 1 hit
PRINTSiPR00892 RABGDI
PR00891 RABGDIREP
SUPFAMiSSF51905 SSF51905, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGDIA_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P31150
Secondary accession number(s): P50394
, Q6FG50, Q7Z2G6, Q7Z2G9, Q7Z2H5, Q7Z2I6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: October 1, 1996
Last modified: September 18, 2019
This is version 200 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again