UniProtKB - P31126 (YDEE_ECOLI)
Protein
Uncharacterized MFS-type transporter YdeE
Gene
ydeE
Organism
Escherichia coli (strain K12)
Status
Functioni
A transporter able to export peptides. When overexpressed, allows cells deleted for multiple peptidases (pepA, pepB, pepD and pepN) to grow in the presence of dipeptides Ala-Gln or Gly-Tyr which otherwise inhibit growth (PubMed:20067529). Cells overexpressing this protein have decreased intracellular levels of Ala-Gln dipeptide, and in a system that produces the Ala-Gln dipeptide overproduction of this protein increases export of the dipeptide (PubMed:20067529).1 Publication
GO - Molecular functioni
- dipeptide transmembrane transporter activity Source: EcoCyc
GO - Biological processi
- dipeptide transmembrane transport Source: EcoCyc
- protein transport Source: UniProtKB-KW
- transmembrane transport Source: GO_Central
Keywordsi
Biological process | Peptide transport, Protein transport, Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:YDEF-MONOMER |
Protein family/group databases
TCDBi | 2.A.1.2.55, the major facilitator superfamily (mfs) |
Names & Taxonomyi
Protein namesi | Recommended name: Uncharacterized MFS-type transporter YdeE |
Gene namesi | Name:ydeE Synonyms:ydeF Ordered Locus Names:b1534, JW1527 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell inner membrane Curated; Multi-pass membrane protein Curated
Plasma Membrane
- plasma membrane Source: EcoCyc
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 12 – 34 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 44 – 66 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 75 – 94 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 99 – 121 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 134 – 156 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 160 – 182 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 208 – 230 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 245 – 264 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 271 – 293 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 298 – 320 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 341 – 360 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 364 – 381 | HelicalSequence analysisAdd BLAST | 18 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000084896 | 1 – 395 | Uncharacterized MFS-type transporter YdeEAdd BLAST | 395 |
Proteomic databases
PaxDbi | P31126 |
PRIDEi | P31126 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4259113, 150 interactors |
STRINGi | 511145.b1534 |
Family & Domainsi
Sequence similaritiesi
Belongs to the major facilitator superfamily.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG2814, Bacteria |
HOGENOMi | CLU_001265_60_0_6 |
InParanoidi | P31126 |
PhylomeDBi | P31126 |
Family and domain databases
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
i Sequence
Sequence statusi: Complete.
P31126-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNLSLRRSTS ALLASSLLLT IGRGATLPFM TIYLSRQYSL SVDLIGYAMT
60 70 80 90 100
IALTIGVVFS LGFGILADKF DKKRYMLLAI TAFASGFIAI TLVNNVTLVV
110 120 130 140 150
LFFALINCAY SVFATVLKAW FADNLSSTSK TKIFSINYTM LNIGWTIGPP
160 170 180 190 200
LGTLLVMQSI NLPFWLAAIC SAFPMLFIQI WVKRSEKIIA TETGSVWSPK
210 220 230 240 250
VLLQDKALLW FTCSGFLASF VSGAFASCIS QYVMVIADGD FAEKVVAVVL
260 270 280 290 300
PVNAAMVVTL QYSVGRRLNP ANIRALMTAG TLCFVIGLVG FIFSGNSLLL
310 320 330 340 350
WGMSAAVFTV GEIIYAPGEY MLIDHIAPPE MKASYFSAQS LGWLGAAINP
360 370 380 390
LVSGVVLTSL PPSSLFVILA LVIIAAWVLM LKGIRARPWG QPALC
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 27 | L → V in M96235 (PubMed:8383113).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M96235 Genomic DNA No translation available. U00096 Genomic DNA Translation: AAC74607.1 AP009048 Genomic DNA Translation: BAA15224.2 |
PIRi | A64908 |
RefSeqi | NP_416051.1, NC_000913.3 WP_001054204.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC74607; AAC74607; b1534 BAA15224; BAA15224; BAA15224 |
GeneIDi | 946083 |
KEGGi | ecj:JW1527 eco:b1534 |
PATRICi | fig|1411691.4.peg.732 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M96235 Genomic DNA No translation available. U00096 Genomic DNA Translation: AAC74607.1 AP009048 Genomic DNA Translation: BAA15224.2 |
PIRi | A64908 |
RefSeqi | NP_416051.1, NC_000913.3 WP_001054204.1, NZ_LN832404.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4259113, 150 interactors |
STRINGi | 511145.b1534 |
Protein family/group databases
TCDBi | 2.A.1.2.55, the major facilitator superfamily (mfs) |
Proteomic databases
PaxDbi | P31126 |
PRIDEi | P31126 |
Genome annotation databases
EnsemblBacteriai | AAC74607; AAC74607; b1534 BAA15224; BAA15224; BAA15224 |
GeneIDi | 946083 |
KEGGi | ecj:JW1527 eco:b1534 |
PATRICi | fig|1411691.4.peg.732 |
Organism-specific databases
EchoBASEi | EB1595 |
Phylogenomic databases
eggNOGi | COG2814, Bacteria |
HOGENOMi | CLU_001265_60_0_6 |
InParanoidi | P31126 |
PhylomeDBi | P31126 |
Enzyme and pathway databases
BioCyci | EcoCyc:YDEF-MONOMER |
Miscellaneous databases
PROi | PR:P31126 |
Family and domain databases
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | YDEE_ECOLI | |
Accessioni | P31126Primary (citable) accession number: P31126 Secondary accession number(s): P31127, P76151 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | November 1, 1997 | |
Last modified: | April 7, 2021 | |
This is version 141 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families