UniProtKB - P31111 (ZIP1_YEAST)
Protein
Synaptonemal complex protein ZIP1
Gene
ZIP1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Required for meiotic chromosome synapsis and cell cycle progression. May act as a molecular zipper to bring homologous chromosomes in close apposition. ZIP1 may encode the transverse filaments of the synaptonemal complex.
Miscellaneous
Present with 391 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- SUMO polymer binding Source: SGD
GO - Biological processi
- homologous chromosome pairing at meiosis Source: SGD
- negative regulation of reciprocal meiotic recombination Source: SGD
- positive regulation of protein sumoylation Source: SGD
- protein localization to site of double-strand break Source: SGD
- reciprocal meiotic recombination Source: SGD
Keywordsi
Biological process | Meiosis |
Names & Taxonomyi
Protein namesi | Recommended name: Synaptonemal complex protein ZIP1 |
Gene namesi | Name:ZIP1 Ordered Locus Names:YDR285W ORF Names:D9819.9 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YDR285W |
SGDi | S000002693, ZIP1 |
Subcellular locationi
Nucleus
Other locations
Note: Synapsed meiotic chromosomes.
Nucleus
- synaptonemal complex Source: SGD
- transverse filament Source: SGD
Other locations
- chromosome, centromeric region Source: SGD
Keywords - Cellular componenti
Chromosome, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000066584 | 1 – 875 | Synaptonemal complex protein ZIP1Add BLAST | 875 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 481 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | P31111 |
PRIDEi | P31111 |
PTM databases
iPTMneti | P31111 |
Interactioni
Binary interactionsi
P31111
With | #Exp. | IntAct |
---|---|---|
CST9 [Q06032] | 3 | EBI-29645,EBI-30044 |
GO - Molecular functioni
- SUMO polymer binding Source: SGD
Protein-protein interaction databases
BioGRIDi | 32338, 97 interactors |
ComplexPortali | CPX-1387, Synaptonemal complex |
DIPi | DIP-1240N |
IntActi | P31111, 4 interactors |
MINTi | P31111 |
STRINGi | 4932.YDR285W |
Miscellaneous databases
RNActi | P31111, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 177 – 333 | Sequence analysisAdd BLAST | 157 | |
Coiled coili | 397 – 438 | Sequence analysisAdd BLAST | 42 | |
Coiled coili | 456 – 752 | Sequence analysisAdd BLAST | 297 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502R6M6, Eukaryota |
HOGENOMi | CLU_341332_0_0_1 |
InParanoidi | P31111 |
OMAi | WKNENEE |
i Sequence
Sequence statusi: Complete.
P31111-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSNFFRDSSM GFKPRPNIFA KLRVRDVDSD SSANTVVENS SNCLDVGSSI
60 70 80 90 100
EGDDTFKKPH KTSTEQELIT SMSLSQRNHG YSDDMEIGSP KKTTSTDQYN
110 120 130 140 150
RILKNDVAAI ENDTDEDFEI TEVREVSEGV AKETKESHGD PNDSETTLKD
160 170 180 190 200
SKMHEYTMTN GKAPLHTSIN NSSTSSNDVL LEAFTNTQRI CSNLKQELQK
210 220 230 240 250
QQQDNAKLKV RLQSYASNSD KINEKVGKYK SCLETLQERI ATLTSHKNNQ
260 270 280 290 300
ETKLKDLRQN HQLYQRRISG FKTSIENLNK TINDLGKNKK EADAELMKKG
310 320 330 340 350
KEIEYLKREL DDCSGQLSEE KIKNSSLIQE MGKNREEMIK SIENFFSEDK
360 370 380 390 400
AHHLLQFNKF EERVHDLFEK KLQKHFDVAK DTLNVGLRNT TVELSSNTET
410 420 430 440 450
MLKQQYEDIK ENLEQKMSSS KDEMAKTINE LSVTQKGLIM GVQEELLTSS
460 470 480 490 500
GNIQTALVSE MNNTRQELLD DASQTAKNYA SLENLVKAYK AEIVQSNEYE
510 520 530 540 550
ERIKHLESER STLSSQKNQI ISSLGTKEAQ YEDLVKKLEA KNIEISQISG
560 570 580 590 600
KEQSLTEKNE NLSNELKKVQ DQLEKLNNLN ITTKSNYENK ISSQNEIVKA
610 620 630 640 650
LVSENDTLKQ RIQQLVEIKE NEQKDHTTKL EAFQKNNEQL QKLNVEVVQL
660 670 680 690 700
KAHELELEEQ NRHLKNCLEK KETGVEESLS DVKTLKQQVI VLKSEKQDIT
710 720 730 740 750
AEKLELQDNL ESLEEVTKNL QQKVQSQKRE LEQKIKELEE IKNHKRNEPS
760 770 780 790 800
KKGTQNFTKP SDSPKKNATT SNLFPNNSAA IHSPMKKCPK VDHISKSRIN
810 820 830 840 850
SSKETSKFND EFDLSSSSND DLELTNPSPI QIKPVRGKIK KGSNCMKPPI
860 870
SSRKKLLLVE DEDQSLKISK KRRRK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 55 | T → A in AAA35239 (PubMed:7916652).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L06487 Genomic DNA Translation: AAA35239.1 U51031 Genomic DNA Translation: AAB64474.1 BK006938 Genomic DNA Translation: DAA12125.1 |
PIRi | S70115 |
RefSeqi | NP_010571.1, NM_001180593.1 |
Genome annotation databases
EnsemblFungii | YDR285W_mRNA; YDR285W; YDR285W |
GeneIDi | 851879 |
KEGGi | sce:YDR285W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L06487 Genomic DNA Translation: AAA35239.1 U51031 Genomic DNA Translation: AAB64474.1 BK006938 Genomic DNA Translation: DAA12125.1 |
PIRi | S70115 |
RefSeqi | NP_010571.1, NM_001180593.1 |
3D structure databases
SMRi | P31111 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 32338, 97 interactors |
ComplexPortali | CPX-1387, Synaptonemal complex |
DIPi | DIP-1240N |
IntActi | P31111, 4 interactors |
MINTi | P31111 |
STRINGi | 4932.YDR285W |
PTM databases
iPTMneti | P31111 |
Proteomic databases
PaxDbi | P31111 |
PRIDEi | P31111 |
Genome annotation databases
EnsemblFungii | YDR285W_mRNA; YDR285W; YDR285W |
GeneIDi | 851879 |
KEGGi | sce:YDR285W |
Organism-specific databases
EuPathDBi | FungiDB:YDR285W |
SGDi | S000002693, ZIP1 |
Phylogenomic databases
eggNOGi | ENOG502R6M6, Eukaryota |
HOGENOMi | CLU_341332_0_0_1 |
InParanoidi | P31111 |
OMAi | WKNENEE |
Miscellaneous databases
PROi | PR:P31111 |
RNActi | P31111, protein |
Family and domain databases
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZIP1_YEAST | |
Accessioni | P31111Primary (citable) accession number: P31111 Secondary accession number(s): D6VSR5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | October 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 161 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome IV
Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names