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Entry version 166 (02 Jun 2021)
Sequence version 1 (01 Jul 1993)
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Protein

Voltage-gated potassium channel Kch

Gene

kch

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

K+-specific ion channel. May play a role in the defense against osmotic shock.

2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • identical protein binding Source: EcoCyc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:KCH-MONOMER
MetaCyc:KCH-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.1.13.1, the voltage-gated ion channel (vic) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Voltage-gated potassium channel Kch
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:kch
Ordered Locus Names:b1250, JW1242
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 21CytoplasmicSequence analysisAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei22 – 41Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini42 – 63PeriplasmicSequence analysisAdd BLAST22
Transmembranei64 – 83Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini84 – 86CytoplasmicSequence analysis3
Transmembranei87 – 104Helical; Name=3Sequence analysisAdd BLAST18
Topological domaini105 – 110PeriplasmicSequence analysis6
Transmembranei111 – 127Helical; Name=4Sequence analysisAdd BLAST17
Topological domaini128 – 140CytoplasmicSequence analysisAdd BLAST13
Transmembranei141 – 160Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini161 – 199PeriplasmicSequence analysisAdd BLAST39
Transmembranei200 – 220Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini221 – 417Cytoplasmic2 PublicationsAdd BLAST197

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000540961 – 417Voltage-gated potassium channel KchAdd BLAST417

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P31069

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P31069

PRoteomics IDEntifications database

More...
PRIDEi
P31069

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Dimer.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
4261503, 47 interactors

Database of interacting proteins

More...
DIPi
DIP-10055N

Protein interaction database and analysis system

More...
IntActi
P31069, 1 interactor

STRING: functional protein association networks

More...
STRINGi
511145.b1250

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1417
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P31069

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P31069

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini245 – 371RCK N-terminalPROSITE-ProRule annotationAdd BLAST127

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi185 – 190Selectivity filter6

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the potassium channel family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG1226, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_057267_1_0_6

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P31069

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P31069

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013099, K_chnl_dom
IPR036291, NAD(P)-bd_dom_sf
IPR003148, RCK_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07885, Ion_trans_2, 1 hit
PF02254, TrkA_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51735, SSF51735, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51201, RCK_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P31069-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSHWATFKQT ATNLWVTLRH DILALAVFLN GLLIFKTIYG MSVNLLDIFH
60 70 80 90 100
IKAFSELDLS LLANAPLFML GVFLVLNSIG LLFRAKLAWA ISIILLLIAL
110 120 130 140 150
IYTLHFYPWL KFSIGFCIFT LVFLLILRKD FSHSSAAAGT IFAFISFTTL
160 170 180 190 200
LFYSTYGALY LSEGFNPRIE SLMTAFYFSI ETMSTVGYGD IVPVSESARL
210 220 230 240 250
FTISVIISGI TVFATSMTSI FGPLIRGGFN KLVKGNNHTM HRKDHFIVCG
260 270 280 290 300
HSILAINTIL QLNQRGQNVT VISNLPEDDI KQLEQRLGDN ADVIPGDSND
310 320 330 340 350
SSVLKKAGID RCRAILALSD NDADNAFVVL SAKDMSSDVK TVLAVSDSKN
360 370 380 390 400
LNKIKMVHPD IILSPQLFGS EILARVLNGE EINNDMLVSM LLNSGHGIFS
410
DNDELETKAD SKESAQK
Length:417
Mass (Da):46,063
Last modified:July 1, 1993 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB2F803435001FB6E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti5A → T in strain: ECOR 52 and ECOR 60. 1
Natural varianti13N → K in strain: ECOR 52 and ECOR 60. 1
Natural varianti223P → S in strain: ECOR 4. 1
Natural varianti405L → Q in strain: ECOR 4, ECOR 16, ECOR 28, ECOR 31, ECOR 37, ECOR 46, ECOR 50, ECOR 52, ECOR 60 and ECOR 71. 1
Natural varianti406E → K in strain: ECOR 46. 1
Natural varianti411S → N in strain: ECOR 46. 1
Natural varianti414S → L in strain: ECOR 46. 1
Natural varianti415A → V in strain: ECOR 28. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L12044 Genomic DNA Translation: AAA66947.1
U24195 Genomic DNA Translation: AAB60071.1
U24196 Genomic DNA Translation: AAB60079.1
U24197 Genomic DNA Translation: AAB60087.1
U24198 Genomic DNA Translation: AAB60095.1
U24199 Genomic DNA Translation: AAB60103.1
U24200 Genomic DNA Translation: AAB60111.1
U24201 Genomic DNA Translation: AAB60119.1
U24202 Genomic DNA Translation: AAB60127.1
U24203 Genomic DNA Translation: AAB60135.1
U24204 Genomic DNA Translation: AAB60143.1
U24205 Genomic DNA Translation: AAB60151.1
U24206 Genomic DNA Translation: AAB60159.1
U00096 Genomic DNA Translation: AAC74332.1
AP009048 Genomic DNA Translation: BAA14782.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A55252
T45507

NCBI Reference Sequences

More...
RefSeqi
NP_415766.1, NC_000913.3
WP_001295624.1, NZ_SSZK01000031.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC74332; AAC74332; b1250
BAA14782; BAA14782; BAA14782

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
945841

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW1242
eco:b1250

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.1033

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12044 Genomic DNA Translation: AAA66947.1
U24195 Genomic DNA Translation: AAB60071.1
U24196 Genomic DNA Translation: AAB60079.1
U24197 Genomic DNA Translation: AAB60087.1
U24198 Genomic DNA Translation: AAB60095.1
U24199 Genomic DNA Translation: AAB60103.1
U24200 Genomic DNA Translation: AAB60111.1
U24201 Genomic DNA Translation: AAB60119.1
U24202 Genomic DNA Translation: AAB60127.1
U24203 Genomic DNA Translation: AAB60135.1
U24204 Genomic DNA Translation: AAB60143.1
U24205 Genomic DNA Translation: AAB60151.1
U24206 Genomic DNA Translation: AAB60159.1
U00096 Genomic DNA Translation: AAC74332.1
AP009048 Genomic DNA Translation: BAA14782.1
PIRiA55252
T45507
RefSeqiNP_415766.1, NC_000913.3
WP_001295624.1, NZ_SSZK01000031.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ID1X-ray2.40A/B241-393[»]
SMRiP31069
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi4261503, 47 interactors
DIPiDIP-10055N
IntActiP31069, 1 interactor
STRINGi511145.b1250

Protein family/group databases

TCDBi1.A.1.13.1, the voltage-gated ion channel (vic) superfamily

Proteomic databases

jPOSTiP31069
PaxDbiP31069
PRIDEiP31069

Genome annotation databases

EnsemblBacteriaiAAC74332; AAC74332; b1250
BAA14782; BAA14782; BAA14782
GeneIDi945841
KEGGiecj:JW1242
eco:b1250
PATRICifig|1411691.4.peg.1033

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB1563

Phylogenomic databases

eggNOGiCOG1226, Bacteria
HOGENOMiCLU_057267_1_0_6
InParanoidiP31069
PhylomeDBiP31069

Enzyme and pathway databases

BioCyciEcoCyc:KCH-MONOMER
MetaCyc:KCH-MONOMER

Miscellaneous databases

EvolutionaryTraceiP31069

Protein Ontology

More...
PROi
PR:P31069

Family and domain databases

InterProiView protein in InterPro
IPR013099, K_chnl_dom
IPR036291, NAD(P)-bd_dom_sf
IPR003148, RCK_N
PfamiView protein in Pfam
PF07885, Ion_trans_2, 1 hit
PF02254, TrkA_N, 1 hit
SUPFAMiSSF51735, SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS51201, RCK_N, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKCH_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P31069
Secondary accession number(s): P94716
, P94717, P94723, P94729, P97198, P97225
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: June 2, 2021
This is version 166 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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